The conserved lysine 860 in the additional fatty-acylation site of Bordetella pertussis adenylate cyclase is crucial for toxin function independently of its acylation status

Journal of Biological Chemistry

Volumn 274, Issue 16, 1999, Pages 10777-10783

  Basar, Tümay ^a   Havlícek, Vladimír ^a   Bezoušková, Silvia ^a   Halada, Petr ^a   Hackett, Murray ^b   Šebo, Peter ^a  

^a INSTITUTE OF MICROBIOLOGY   (Czech Republic)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE; ADENYLATE CYCLASE; ARGININE; BACTERIAL TOXIN; CYSTEINE; HEMOLYSIN; LYSINE;

ACYLATION; ARTICLE; BACTERIAL VIRULENCE; BORDETELLA PERTUSSIS; ESCHERICHIA COLI; GENE MUTATION; NONHUMAN; PALMITOYLATION; PERTUSSIS; PRIORITY JOURNAL; PROTEIN FAMILY;

ACYLATION; ADENYLATE CYCLASE; ADENYLATE CYCLASE TOXIN; BACTERIAL PROTEINS; BASE SEQUENCE; BORDETELLA PERTUSSIS; CONSERVED SEQUENCE; DNA PRIMERS; FATTY ACIDS; LYSINE; MUTAGENESIS, SITE-DIRECTED; PROTEIN PRECURSORS; VIRULENCE FACTORS, BORDETELLA;

BACTERIA (MICROORGANISMS); BORDETELLA PERTUSSIS; ESCHERICHIA COLI;

EID: 0344609226     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.16.10777     Document Type: Article

References (43)

1. Weiss, A. A., and Hewlett, E. L. (1986) Annu. Rev. Microbiol. 40, 661-686
2. Goodwin, M. S., and Weiss, A. A. (1990) Infect. Immun. 58, 3445-3447
3. Khelef, N., Sakamoto, H., and Guiso, N. (1992) Microbial Pathogen. 12, 227-235
4. Betsou, F., Šebo, P., and Guiso, N. (1995) Infect. Immun. 63, 3309-3315
5. Betsou, F., Šebo, P., and Guiso, N. (1993) Infect. Immun. 61, 3583-3589
6. Welch, R. A. (1991) Mol. Microbiol. 5, 521-528
7. Biemann, K. (1992) Annu. Rev. Biochem. 61, 977-1010
8. Szabo, G., Gray, M. C., and Hewlett, E. L. (1994) J. Biol. Chem. 269, 22496-22499
9. Glaser, P., Sakamoto, H., Bellalou, J., Ullmann, A., and Danchin, A. (1988) EMBO J. 7, 3997-4004
10. Benz, R., Maier, E., Ladant, D., Ullmann, A., and Šebo, P. (1994) J. Biol. Chem. 269, 27231-27239
11. Bellalou, J., Sakamoto, H., Ladant, D., Geoffroy, C., and Ullmann, A. (1990) Infect. Immun. 58, 3242-3247
12. Gordon, V. M., Young, W. W., Jr., Lechler, S. M., Gray, M. C., Leppla, S. H., and Hewlett, E. L. (1989) J. Biol. Chem. 264, 14792-14796
13. Hanski, E. (1989) Trends Biochem. Sci. 14, 459-463
14. Hanski, E., and Coote, J. G. (1991) in Sourcebook of Bacterial Toxins (Alouf, J. E., and Freer, J. H., eds) pp. 349-366, Academic Press, New York
15. Hanski, E., and Farfel, Z. (1985) J. Biol. Chem. 260, 5526-5532
16. Hewlett, E. L., Smith, D. L., Myers, G. A., Pearson, R. D., and Kay, H. D. (1983) Clin. Res. 31, 365A
17. Confer, D. L., and Eaton, J. W. (1982) Science 217, 948-950
18. Wolff, J., Cook, G. H., Goldhammer, A. R., and Berkowitz, S. A. (1980) Proc. Natl. Acad. Sci. U. S. A. 77, 3841-3844
19. Khelef, N., and Guiso, N. (1995) FEMS Microbiol. Lett. 134, 27-32
20. Šebo, P., Glaser. P., Sakamoto, H., and Ullmann, A. (1991) Gene (Amst.) 104, 19-24
21. Barry, E. M., Weiss, A. A., Ehrmann, I. E., Gray, M. C., Hewlett, E. L., and Goodwin, M. S. (1991) J. Bacteriol. 173, 720-726
22. Issartel, J.-P., Koronakis, V., and Hughes, C. (1991) Nature 351, 759-761
23. Hackett, M., Guo, L., Shabanowitz, J., Hunt, D. F., and Hewlett, E. L. (1994) Science 266, 433-435
24. Ludwig, A., Garcia, F., Bauer, S., Jarchau, T., Benz, R., Hoppe, J., and Goebel, W. (1996) J. Bacteriol. 178, 5422-5430
25. Stanley, P., Packman, L. C., Koronakis, V., and Hughes, C. (1994) Science 266, 1992-1996
26. Hackett, M., Walker, C. B., Guo, L., Gray, M. C., Van Cuyk, C. S., Ullmann, A., Shabanowitz, J., Hunt, D. F., Hewlett, E. L., and Šebo, P. (1995) J. Biol. Chem. 270, 20250-20253
27. Tabor, S., and Richardson, C. (1985) Proc. Natl. Acad. Sci. U. S. A. 82, 1074-1078
28. Sakamoto, H., Bellalou, J., Šebo, P., and Ladant, D. (1992) J. Biol. Chem. 267, 13598-13602
29. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd Ed., Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
30. O'Farrell, P. H. (1975) J. Biol. Chem. 250, 4007-4021
31. Wang, H., and Hackett, M. (1998) Anal. Chem. 70, 205-212
32. Wang, H., Lim, K. B., Lawrence, R. F., Howald, W. N., Taylor, J. A., Ericsson, L. H., Walsh, K. A., and Hackett, M. (1997) Anal. Biochem. 250, 162-168
33. Beavis, R. C., Chaudhary, T., and Chait, B. (1991) Org. Mass Spectrom. 27, 156-158
34. Lepage, G., and Roy, C. C. (1986) J. Lipid Res. 27, 114-120
35. Glaser, P., Ladant, D., Sezer, O., Pichot, F., Ullmann, A., and Danchin, A. (1988) Mol. Microbiol. 2, 19-30
36. Iwaki, M., Ullmann, A., and Šebo, P. (1995) Mol. Microbiol. 17, 1015-1024
37. Hewlett, E. L., Gray, L., Allietta, M., Ehrmann, I. E., Gordon, V. M., and Gray, M. C. (1991) J. Biol. Chem. 266, 17503-17508
38. Gray, M., Szabo, G., Otero, A., Gray, L., and Hewlett, E. (1998) J. Biol. Chem. 273, 18260-18267
39. Rogel, A., and Hanski, E. (1992) J. Biol. Chem. 267, 22599-22605
40. Rose, T., Šebo, P., Bellalou, J., and Ladant, D. (1995) J. Biol. Chem. 270, 26370-26376
41. Pellett, S., and Welch, R. A. (1996) Infect. Immun. 64, 3081-3087
42. Guzmán-Verri, C., Garcia, F., and Arvidson, S. (1997) J. Bacteriol. 179, 5959-5962
43. Ducret, A., Van Oostveen, I., Eng, J. K., Yates, J. R., and Aebersold, R. (1998) Protein Sci. 7, 706-719