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Volumn 38, Issue 6, 2004, Pages 1006-1014

Emtricitabine: A once-daily nucleoside reverse transcriptase inhibitor

Author keywords

Antiretroviral therapy; Emtricitabine; HIV; Nucleoside reverse transcriptase inhibitor

Indexed keywords

DIDANOSINE; EFAVIRENZ; EMTRICITABINE; FAMCICLOVIR; INDINAVIR; LAMIVUDINE; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE; TENOFOVIR DISOPROXIL;

EID: 2442698141     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1D302     Document Type: Review
Times cited : (22)

References (65)
  • 1
    • 2442669128 scopus 로고    scopus 로고
    • National center for HIV, STD, and TB prevention, Division of HIV/AIDS Prevention. Last updated September 23
    • US HIV and AIDS cases reported through December 2001 year-end edition. Vol. 13, no. 2. National center for HIV, STD, and TB prevention, Division of HIV/AIDS Prevention. Last updated September 23, 2002. www.cdc.gov/hiv/stats/hasr1302.htm (accessed 2003 Oct 10).
    • (2002) US HIV and AIDS Cases Reported Through December 2001 Year-End Edition , vol.13 , Issue.2
  • 2
    • 2642709177 scopus 로고    scopus 로고
    • Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection
    • HIV Outpatient Study Investigators
    • Palella FJ Jr, Delaney KM, Moorman AC, Loveless MO, Fuhrer J, Satten GA, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med 1998;338:853-60.
    • (1998) N Engl J Med , vol.338 , pp. 853-860
    • Palella Jr., F.J.1    Delaney, K.M.2    Moorman, A.C.3    Loveless, M.O.4    Fuhrer, J.5    Satten, G.A.6
  • 4
    • 0003258422 scopus 로고    scopus 로고
    • Once-daily combination therapy with emtricitabine, didanosine and efavirenz in treatment-naive HIV-infected adults: 24-Month follow-up of the ANRS 091 trial
    • Athens, October 28-31
    • Molina JM, Ferchal F, Journot V, Maillard A, Noe E, Raffi F. Once-daily combination therapy with emtricitabine, didanosine and efavirenz in treatment-naive HIV-infected adults: 24-month follow-up of the ANRS 091 trial (poster). Presented at: 8th European Conference on Clinical Aspects and Treatment of HIV-Infection, Athens, October 28-31, 2001.
    • (2001) 8th European Conference on Clinical Aspects and Treatment of HIV-Infection
    • Molina, J.M.1    Ferchal, F.2    Journot, V.3    Maillard, A.4    Noe, E.5    Raffi, F.6
  • 6
    • 2442695362 scopus 로고    scopus 로고
    • Once-daily emtricitabine compared to twice-daily abacavir within a HAART regimen in antiretroviral drug-naive HIV-1 infected patients (ODECTA)
    • Paris, July 13-16
    • Shaw A, Shen G, Wakeford C, Quinn JB, Rousseau F. Once-daily emtricitabine compared to twice-daily abacavir within a HAART regimen in antiretroviral drug-naive HIV-1 infected patients (ODECTA) (poster). Presented at: 2nd International AIDS Society Conference on HIV Pathogenesis and Treatment, 2003, Paris, July 13-16, 2003.
    • (2003) 2nd International AIDS Society Conference on HIV Pathogenesis and Treatmen
    • Shaw, A.1    Shen, G.2    Wakeford, C.3    Quinn, J.B.4    Rousseau, F.5
  • 8
    • 0346277507 scopus 로고    scopus 로고
    • PACTG 1021: An ongoing phase I/II study of once-daily emtricitabine, didanosine, and efavirenz in therapy-naive or minimally treated pediatric patients
    • Boston, February 10-14
    • McKinney R, Rathore M, Jankelovich S, Mofenson L, Wang L, Reynolds L, et al. PACTG 1021: an ongoing phase I/II study of once-daily emtricitabine, didanosine, and efavirenz in therapy-naive or minimally treated pediatric patients (poster). Presented at: 10th Conference on Retroviruses and Opportunistic Infections, Boston, February 10-14, 2003.
    • (2003) 10th Conference on Retroviruses and Opportunistic Infections
    • McKinney, R.1    Rathore, M.2    Jankelovich, S.3    Mofenson, L.4    Wang, L.5    Reynolds, L.6
  • 10
    • 0037748559 scopus 로고    scopus 로고
    • Antiviral activity, safety, and incidence of resistance in chronically infected hepatitis B patients given once daily emtricitabine (Coviracil®, FTC) for 2 years
    • Presented at: 53rd Annual Meeting of the American Association for the Study of Liver Diseases, November 1-5, 2002, Boston, MA
    • Gish R, Leung N, Wang C, Corey L, Sacks S, Fried M. Antiviral activity, safety, and incidence of resistance in chronically infected hepatitis B patients given once daily emtricitabine (Coviracil®, FTC) for 2 years (poster). Presented at: 53rd Annual Meeting of the American Association for the Study of Liver Diseases, November 1-5, 2002, Boston, MA. Hepatology 2002;36(4 part 2):167A-840A.
    • (2002) Hepatology , vol.36 , Issue.4 PART 2
    • Gish, R.1    Leung, N.2    Wang, C.3    Corey, L.4    Sacks, S.5    Fried, M.6
  • 11
    • 0036093269 scopus 로고    scopus 로고
    • Dose range study of pharmacokinetics, safety, and preliminary antiviral activity of emtricitabine in adults with hepatitis B virus infection
    • Gish RG, Leung NW, Wright TL, Trinh H, Lang W, Kessler HA, et al. Dose range study of pharmacokinetics, safety, and preliminary antiviral activity of emtricitabine in adults with hepatitis B virus infection. Antimicrob Agents Chemother 2002;46:1734-40.
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 1734-1740
    • Gish, R.G.1    Leung, N.W.2    Wright, T.L.3    Trinh, H.4    Lang, W.5    Kessler, H.A.6
  • 15
    • 0032874225 scopus 로고    scopus 로고
    • Quantitation of intracellular triphosphate of emtricitabine in peripheral blood mononuclear cells from human immunodeficiency virus-infected patients
    • Darque A, Valette G, Rousseau F, Wang LH, Sommadossi JP, Zhou XJ. Quantitation of intracellular triphosphate of emtricitabine in peripheral blood mononuclear cells from human immunodeficiency virus-infected patients. Antimicrob Agents Chemother 1999;43:2245-50.
    • (1999) Antimicrob Agents Chemother , vol.43 , pp. 2245-2250
    • Darque, A.1    Valette, G.2    Rousseau, F.3    Wang, L.H.4    Sommadossi, J.P.5    Zhou, X.J.6
  • 17
    • 0032829089 scopus 로고    scopus 로고
    • Mechanistic studies show that (-)-FTC-TP is a better inhibitor of HIV-1 reverse transcriptase than 3TC-TP
    • Feng JY, Shi J, Schinazi RF, Anderson KS. Mechanistic studies show that (-)-FTC-TP is a better inhibitor of HIV-1 reverse transcriptase than 3TC-TP. FASEB J 1999;13:1511-7.
    • (1999) FASEB J , vol.13 , pp. 1511-1517
    • Feng, J.Y.1    Shi, J.2    Schinazi, R.F.3    Anderson, K.S.4
  • 18
    • 0033524447 scopus 로고    scopus 로고
    • Mechanistic studies comparing the incorporation of (+) and (-) isomers of 3TCTP by HIV-1 reverse transcriptase
    • Feng JY, Anderson KS. Mechanistic studies comparing the incorporation of (+) and (-) isomers of 3TCTP by HIV-1 reverse transcriptase. Biochemistry 1999;38:55-63.
    • (1999) Biochemistry , vol.38 , pp. 55-63
    • Feng, J.Y.1    Anderson, K.S.2
  • 19
    • 0001024860 scopus 로고    scopus 로고
    • The pharmacokinetics of lamivudine phosphorylation in peripheral blood mononuclear cells from patients infected with HIV-1
    • Moore KH, Barrett JE, Shaw S, Pakes GE, Churchus R, Kapoor A, et al. The pharmacokinetics of lamivudine phosphorylation in peripheral blood mononuclear cells from patients infected with HIV-1. AIDS 1999;13:2239-50.
    • (1999) AIDS , vol.13 , pp. 2239-2250
    • Moore, K.H.1    Barrett, J.E.2    Shaw, S.3    Pakes, G.E.4    Churchus, R.5    Kapoor, A.6
  • 20
    • 3242682132 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic characteristics of emtricitabine support its once daily dosing
    • Barcelona, July 7-12
    • Wang L, Begly J, Feng JY, Quinn JB, Rousseau F. Pharmacokinetic and pharmacodynamic characteristics of emtricitabine support its once daily dosing (poster). Presented at: The XIV International AIDS Conference, Barcelona, July 7-12, 2002.
    • (2002) The XIV International AIDS Conference
    • Wang, L.1    Begly, J.2    Feng, J.Y.3    Quinn, J.B.4    Rousseau, F.5
  • 21
    • 0026480950 scopus 로고
    • Selective inhibition of human immunodeficiency viruses by racemates and enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
    • Schinazi RF, McMillan A, Cannon D, Mathis R, Lloyd RM, Peck A, et al. Selective inhibition of human immunodeficiency viruses by racemates and enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine. Antimicrob Agents Chemother 1992;36:2423-31.
    • (1992) Antimicrob Agents Chemother , vol.36 , pp. 2423-2431
    • Schinazi, R.F.1    McMillan, A.2    Cannon, D.3    Mathis, R.4    Lloyd, R.M.5    Peck, A.6
  • 22
    • 0027379732 scopus 로고
    • Infectious amplification of wild-type human immunodeficiency virus from patients' lymphocytes and modulation by reverse transcriptase inhibitors in vitro
    • Mathez D, Schinazi RF, Liotta DC, Leibowitch J. Infectious amplification of wild-type human immunodeficiency virus from patients' lymphocytes and modulation by reverse transcriptase inhibitors in vitro. Antimicrob Agents Chemother 1993;37:2206-11.
    • (1993) Antimicrob Agents Chemother , vol.37 , pp. 2206-2211
    • Mathez, D.1    Schinazi, R.F.2    Liotta, D.C.3    Leibowitch, J.4
  • 23
    • 2442691667 scopus 로고    scopus 로고
    • Last updated. Center for Drug Evaluation and Research
    • Microbiology review, emtricitabine FDA approval package. Last updated 2003. Center for Drug Evaluation and Research. www.fda.gov/ cder/foi/nda/2003/021500_emtriva-toc.htm (accessed 2003 Sept 26).
    • (2003) Microbiology Review, Emtricitabine FDA Approval Package
  • 24
    • 0037340618 scopus 로고    scopus 로고
    • Relative anti-HIV-1 efficacy of lamivudine and emtricitabine in vitro is dependent on cell type
    • Hazen R, Lanier ER. Relative anti-HIV-1 efficacy of lamivudine and emtricitabine in vitro is dependent on cell type. J Acquir Immune Defic Syndr 2003;32:255-8.
    • (2003) J Acquir Immune Defic Syndr , vol.32 , pp. 255-258
    • Hazen, R.1    Lanier, E.R.2
  • 25
    • 0036822850 scopus 로고    scopus 로고
    • Might the M184V substitution in HIV-1 RT confer clinical benefit?
    • Petrella M, Wainberg MA. Might the M184V substitution in HIV-1 RT confer clinical benefit? AIDS Reviews 2002;4:224-32.
    • (2002) AIDS Reviews , vol.4 , pp. 224-232
    • Petrella, M.1    Wainberg, M.A.2
  • 26
    • 0028057581 scopus 로고
    • Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 27prime;,3′-dideoxycytidine and 2′,3′-dideoxy-3′ -thiacytidine
    • Gu Z, Gao Q, Fang H, Salomon H, Parniak MA, Goldberg E, et al. Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 27prime;,3′-dideoxycytidine and 2′,3′-dideoxy-3′ -thiacytidine. Antimicrob Agents Chemother 1994;38:275-81.
    • (1994) Antimicrob Agents Chemother , vol.38 , pp. 275-281
    • Gu, Z.1    Gao, Q.2    Fang, H.3    Salomon, H.4    Parniak, M.A.5    Goldberg, E.6
  • 27
    • 0028034266 scopus 로고
    • The K65R mutant reverse transcriptase of HIV-1 cross-resistant to 2′, 3′-dideoxycytidine, 2′,3′-dideoxy-3′ -thiacytidine, and 2′,3′-dideoxyinosine shows reduced sensitivity to specific dideoxynucleoside triphosphate inhibitors in vitro
    • Gu Z, Fletcher RS, Arts EJ, Wainberg MA, Parniak MA. The K65R mutant reverse transcriptase of HIV-1 cross-resistant to 2′, 3′ -dideoxycytidine, 2′,3′-dideoxy-3′-thiacytidine, and 2′,3′-dideoxyinosine shows reduced sensitivity to specific dideoxynucleoside triphosphate inhibitors in vitro. J Biol Chem 1994;269:28118-22.
    • (1994) J Biol Chem , vol.269 , pp. 28118-28122
    • Gu, Z.1    Fletcher, R.S.2    Arts, E.J.3    Wainberg, M.A.4    Parniak, M.A.5
  • 28
    • 17544391491 scopus 로고    scopus 로고
    • A novel human immunodeficiency virus type 1 reverse transcriptase mutational pattern confers phenotypic lamivudine resistance in the absence of mutation 184V
    • Hertogs K, Bloor S, De Vroey V, van Den EC, Dehertogh P, van Cauwenberge A, et al. A novel human immunodeficiency virus type 1 reverse transcriptase mutational pattern confers phenotypic lamivudine resistance in the absence of mutation 184V. Antimicrob Agents Chemother 2000;44:568-73.
    • (2000) Antimicrob Agents Chemother , vol.44 , pp. 568-573
    • Hertogs, K.1    Bloor, S.2    De Vroey, V.3    Van Den, E.C.4    Dehertogh, P.5    Van Cauwenberge, A.6
  • 30
    • 0347284087 scopus 로고    scopus 로고
    • Virologic efficacy and patterns of resistance mutations in ART-naïve patients receiving combination therapy with once-daily emtricitabine compared to twice-daily stavudine in a randomized, double-blind, multicenter clinical trial
    • Boston, February 10-14
    • Cahn P, Raffi F, Wolff M, Pearce D, Molina JM, Borroto-Esoda KE, et al. Virologic efficacy and patterns of resistance mutations in ART-naïve patients receiving combination therapy with once-daily emtricitabine compared to twice-daily stavudine in a randomized, double-blind, multicenter clinical trial (poster). Presented at: 10th Conference on Retroviruses and Opportunistic Infections, Boston, February 10-14, 2003.
    • (2003) 10th Conference on Retroviruses and Opportunistic Infections
    • Cahn, P.1    Raffi, F.2    Wolff, M.3    Pearce, D.4    Molina, J.M.5    Borroto-Esoda, K.E.6
  • 31
    • 1642495262 scopus 로고    scopus 로고
    • Genotypic analysis of HIV-1 infected ART-naive patients receiving emtricitabine (FTC) or lamivudine (3TC) in a double blind equivalence trial
    • Barcelona, July 7-12
    • Sanne I, Quinn JB, Harris J, Shaw A, Hinkle J, Borroto-Esoda K, et al. Genotypic analysis of HIV-1 infected ART-naive patients receiving emtricitabine (FTC) or lamivudine (3TC) in a double blind equivalence trial (poster). Presented at: XIV International AIDS Conference, Barcelona, July 7-12, 2002.
    • (2002) XIV International AIDS Conference
    • Sanne, I.1    Quinn, J.B.2    Harris, J.3    Shaw, A.4    Hinkle, J.5    Borroto-Esoda, K.6
  • 32
    • 23544446838 scopus 로고    scopus 로고
    • Characterization of baseline and treatment-emergent resistance mutations following 1 year of therapy on an entirely once a day regimen including emtricitabine
    • Presented at: XII International HIV Drug Resistance Workshop, Los Cabos, Mexico, June 10-14, 2003
    • Borroto-Esoda K, Waters J, Quinn JB, Shaw A, Hinkle J, Rousseau F. Characterization of baseline and treatment-emergent resistance mutations following 1 year of therapy on an entirely once a day regimen including emtricitabine (poster). Presented at: XII International HIV Drug Resistance Workshop, Los Cabos, Mexico, June 10-14, 2003. Antiviral Ther 2003;8:S10.
    • (2003) Antiviral Ther , vol.8
    • Borroto-Esoda, K.1    Waters, J.2    Quinn, J.B.3    Shaw, A.4    Hinkle, J.5    Rousseau, F.6
  • 33
    • 0034752631 scopus 로고    scopus 로고
    • Prototype trial design for rapid dose selection of antiretroviral drugs: An example using emtricitabine (Coviracil)
    • Rousseau FS, Kahn JO, Thompson M, Mildvan D, Shepp D, Sommadossi JP, et al. Prototype trial design for rapid dose selection of antiretroviral drugs: an example using emtricitabine (Coviracil). J Antimicrob Chemother 2001;48:507-13.
    • (2001) J Antimicrob Chemother , vol.48 , pp. 507-513
    • Rousseau, F.S.1    Kahn, J.O.2    Thompson, M.3    Mildvan, D.4    Shepp, D.5    Sommadossi, J.P.6
  • 44
    • 0242550128 scopus 로고    scopus 로고
    • A steady-state evaluation of the potential pharmacokinetic interaction between emtricitabine and zidovudine in healthy volunteers
    • Chicago, September 14-17
    • Zong J. A steady-state evaluation of the potential pharmacokinetic interaction between emtricitabine and zidovudine in healthy volunteers (poster). Presented at: 43rd Annual Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, September 14-17, 2003.
    • (2003) 43rd Annual Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Zong, J.1
  • 45
    • 0346791180 scopus 로고    scopus 로고
    • Multiple-dose pharmacokinetics (PK) and initial antiviral effect of once daily (QD) lopinavir/ritonavir (LPV/r) in combination with tenofovir (TDF) and emtricitabine (FTC) in HIV-infected antiretroviral (ARV)-naive subjects
    • Paris, July 13-16
    • Chiu YL, Foit C, Gathe J, Podzamczer D, Johnson M, Clotet B, et al. Multiple-dose pharmacokinetics (PK) and initial antiviral effect of once daily (QD) lopinavir/ritonavir (LPV/r) in combination with tenofovir (TDF) and emtricitabine (FTC) in HIV-infected antiretroviral (ARV)-naive subjects (abstract). Presented at: 2nd International AIDS Society Conference on HIV Pathogenesis and Treatment, Paris, July 13-16, 2003.
    • (2003) 2nd International AIDS Society Conference on HIV Pathogenesis and Treatment
    • Chiu, Y.L.1    Foit, C.2    Gathe, J.3    Podzamczer, D.4    Johnson, M.5    Clotet, B.6
  • 47
    • 0033847883 scopus 로고    scopus 로고
    • Once-daily combination therapy with emtricitabine, didanosine, and efavirenz in human immunodeficiency virus-infected patients
    • Molina JM, Ferchal F, Rancinan C, Raffi F, Rozenbaum W, Sereni D, et al. Once-daily combination therapy with emtricitabine, didanosine, and efavirenz in human immunodeficiency virus-infected patients. J Infect Dis 2000;182:599-602.
    • (2000) J Infect Dis , vol.182 , pp. 599-602
    • Molina, J.M.1    Ferchal, F.2    Rancinan, C.3    Raffi, F.4    Rozenbaum, W.5    Sereni, D.6
  • 50
    • 0012823616 scopus 로고    scopus 로고
    • Once-daily combination of emtricitabine, didanosine, and efavirenz vs continued PI-based HAART in HIV-infected adults with undetectable plasma HIV-RNA: 48-Week results of a prospective randomized multicenter trial (ALIZE-ANRS 99)
    • Boston, February 10-14
    • Molina JM, Ferchal F, Rancinan C, Yéni P, Rozenbaum W, Journot V, et al. Once-daily combination of emtricitabine, didanosine, and efavirenz vs continued PI-based HAART in HIV-infected adults with undetectable plasma HIV-RNA: 48-week results of a prospective randomized multicenter trial (ALIZE-ANRS 99) (poster). Presented at: 10th Conference on Retroviruses and Opportunistic Infections, Boston, February 10-14, 2003.
    • (2003) 10th Conference on Retroviruses and Opportunistic Infections
    • Molina, J.M.1    Ferchal, F.2    Rancinan, C.3    Yéni, P.4    Rozenbaum, W.5    Journot, V.6
  • 51
    • 0345099698 scopus 로고    scopus 로고
    • Emtricitabine, didanosine and efavirenz once-daily (OD) versus continued PI-based HAART (c) in HIV-infected adults with undetectable plasma HIV-RNA: 48-Week results of a prospective randomized multicenter trial (ALIZE-ANRS 99)
    • Paris, July 13-16
    • Molina JM, Ferchal F, Journot V, Yéni P, Rozenbaum W, Rancinan C, et al. Emtricitabine, didanosine and efavirenz once-daily (OD) versus continued PI-based HAART (c) in HIV-infected adults with undetectable plasma HIV-RNA: 48-week results of a prospective randomized multicenter trial (ALIZE-ANRS 99) (abstract). Presented at: 2nd IAS Conference on HIV Pathogenesis and Treatment, Paris, July 13-16, 2003.
    • (2003) 2nd IAS Conference on HIV Pathogenesis and Treatment
    • Molina, J.M.1    Ferchal, F.2    Journot, V.3    Yéni, P.4    Rozenbaum, W.5    Rancinan, C.6
  • 52
    • 0037879368 scopus 로고    scopus 로고
    • Once-a-day highly active antiretroviral therapy in treatment-naive HIV-1-infected adults in Senegal
    • Landman R, Schiemann R, Thiam S, Vray M, Canestri A, Mboup S, et al. Once-a-day highly active antiretroviral therapy in treatment-naive HIV-1-infected adults in Senegal. AIDS 2003;17:1017-22.
    • (2003) AIDS , vol.17 , pp. 1017-1022
    • Landman, R.1    Schiemann, R.2    Thiam, S.3    Vray, M.4    Canestri, A.5    Mboup, S.6
  • 53
    • 0035715574 scopus 로고    scopus 로고
    • Virological and immunological responses to a once-a-day antiretroviral regimen with didanosine, lamivudine and efavirenz
    • Maggiolo F, Migliorino M, Maserati R, Pan A, Rizzi M, Provettoni G, et al. Virological and immunological responses to a once-a-day antiretroviral regimen with didanosine, lamivudine and efavirenz. Antiviral Ther 2001;6:249-53.
    • (2001) Antiviral Ther , vol.6 , pp. 249-253
    • Maggiolo, F.1    Migliorino, M.2    Maserati, R.3    Pan, A.4    Rizzi, M.5    Provettoni, G.6
  • 55
    • 0003308615 scopus 로고    scopus 로고
    • Nevirapine (NVP) + efavirenz (EFV) + didanosine (ddI): A very simple, safe, and effective once-daily regimen
    • Durban, South Africa, July 9-14
    • Jordan W, Jefferson R, Yemofio F, Tolbert L, Conlan V, Carroll H, et al. Nevirapine (NVP) + efavirenz (EFV) + didanosine (ddI): a very simple, safe, and effective once-daily regimen (abstract). Presented at: XIII International AIDS Conference, Durban, South Africa, July 9-14, 2000.
    • (2000) XIII International AIDS Conference
    • Jordan, W.1    Jefferson, R.2    Yemofio, F.3    Tolbert, L.4    Conlan, V.5    Carroll, H.6
  • 56
    • 0035393638 scopus 로고    scopus 로고
    • A pilot trial of indinavir, ritonavir, didanosine, and lamivudine in a once-daily four-drug regimen for HIV infection
    • Mole L, Schmidgall D, Holodniy M. A pilot trial of indinavir, ritonavir, didanosine, and lamivudine in a once-daily four-drug regimen for HIV infection. J Acquir Immune Defic Syndr 2001;27:260-5.
    • (2001) J Acquir Immune Defic Syndr , vol.27 , pp. 260-265
    • Mole, L.1    Schmidgall, D.2    Holodniy, M.3
  • 57
    • 2442712773 scopus 로고    scopus 로고
    • Early virologic failure in a pilot study evaluating the efficacy of abacavir, lamivudine and tenofovir in the treatment naive HIV-infected patients
    • Paris, July 13-16
    • Farthing C, Khanlou H, Yeh V. Early virologic failure in a pilot study evaluating the efficacy of abacavir, lamivudine and tenofovir in the treatment naive HIV-infected patients (abstract). Presented at: 2nd International AIDS Society Conference on HIV Pathogenesis and Treatment, Paris, July 13-16, 2003.
    • (2003) 2nd International AIDS Society Conference on HIV Pathogenesis and Treatment
    • Farthing, C.1    Khanlou, H.2    Yeh, V.3
  • 59
    • 0035873751 scopus 로고    scopus 로고
    • Once-daily regimen may increase drug holidays
    • Parienti JJ, Verdon R, Bazin C. Once-daily regimen may increase drug holidays. J Infect Dis 2001;183:1539-40.
    • (2001) J Infect Dis , vol.183 , pp. 1539-1540
    • Parienti, J.J.1    Verdon, R.2    Bazin, C.3
  • 60
    • 27744446978 scopus 로고    scopus 로고
    • Once-daily combination therapy with emtricitabine (FTC), didanosine (ddI) and efavirenz (EFV) in treatment naive HIV-infected adults: 3-Year follow-up of the Montana (ANRS 091) trial
    • Paris, July 13-16
    • Molina JM, Noé E, Raffi F, Rozenbaum W, Morlat P, Rancinan C, et al. Once-daily combination therapy with emtricitabine (FTC), didanosine (ddI) and efavirenz (EFV) in treatment naive HIV-infected adults: 3-year follow-up of the Montana (ANRS 091) trial (poster). Presented at: 2nd IAS Conference on HIV Pathogenesis and Treatment, Paris, July 13-16, 2003.
    • (2003) 2nd IAS Conference on HIV Pathogenesis and Treatment
    • Molina, J.M.1    Noé, E.2    Raffi, F.3    Rozenbaum, W.4    Morlat, P.5    Rancinan, C.6
  • 62
    • 0034654880 scopus 로고    scopus 로고
    • South Africa to tighten control on drug trials after five deaths
    • Sidley P. South Africa to tighten control on drug trials after five deaths. BMJ 2000;320:1028.
    • (2000) BMJ , vol.320 , pp. 1028
    • Sidley, P.1
  • 64
    • 0003196141 scopus 로고    scopus 로고
    • Severe liver toxicity in patients receiving two nucleoside analogues and a non-nucleoside reverse transcriptase inhibitor
    • Chicago, February 4-8
    • Bartlett J. Severe liver toxicity in patients receiving two nucleoside analogues and a non-nucleoside reverse transcriptase inhibitor (abstract). Presented at: 8th Conference on Retroviruses and Opportunistic Infections, Chicago, February 4-8, 2001.
    • (2001) 8th Conference on Retroviruses and Opportunistic Infections
    • Bartlett, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.