ReN-1869 [(R)-1-(3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-propyl) -3-piperidine carboxylic acid], a novel histamine H1 receptor antagonist, produces potent and selective antinociceptive effects on dorsal horn neurons after inflammation and neuropathy

Journal of Pharmacology and Experimental Therapeutics

Volumn 309, Issue 3, 2004, Pages 1230-1238

  Suzuki, Rie ^a   Edwards, M ^b   Dickenson, A H ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b RENEURON LTD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 [3 (10,11 DIHYDRO 5H DIBENZO[A,D]CYCLOHEPTEN 5 YLIDENE)PROPYL] 3 PIPERIDINECARBOXYLIC ACID; CARRAGEENAN; HISTAMINE H1 RECEPTOR ANTAGONIST; MEPYRAMINE; UNCLASSIFIED DRUG;

ALLODYNIA; ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ELECTROSTIMULATION; EVOKED RESPONSE; INFLAMMATION; MALE; MECHANICAL STIMULATION; NERVE FIBER C; NERVE LIGATION; NEUROPATHY; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD DORSAL HORN; THERMAL STIMULATION; TISSUE INJURY;

ANALGESICS; ANIMALS; DISEASE MODELS, ANIMAL; ELECTROPHYSIOLOGY; HISTAMINE H1 ANTAGONISTS; INFLAMMATION; MALE; NEURONS; PAIN; PERIPHERAL NERVOUS SYSTEM DISEASES; PIPERIDINES; POSTERIOR HORN CELLS; PYRILAMINE; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD;

EID: 2442680274     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.063511     Document Type: Article

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