NMDA receptor antagonism blocks the cardiovascular responses to microinjection of trans-ACPD into the NTS of awake rats

Experimental Physiology

Volumn 89, Issue 3, 2004, Pages 279-286

  Antunes, Vagner R ^a   Bonagamba, Leni G H ^a   Machado, Benedito H ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

1 AMINO 1,3 CYCLOPENTANEDICARBOXYLIC ACID; 2 AMINO 5 PHOSPHONOVALERIC ACID; ALPHA METHYL 4 CARBOXYPHENYLGLYCINE; METABOTROPIC RECEPTOR AGONIST; METHYLATROPINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR STIMULATING AGENT;

ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ARTERIAL PRESSURE; ARTICLE; BRADYCARDIA; CARDIOVASCULAR RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; HEART RATE VARIABILITY; HYPOTENSION; MALE; MEAN ARTERIAL PRESSURE; MICROINJECTION; NONHUMAN; PULSATILE FLOW; RAT; SOLITARY TRACT NUCLEUS; WAKEFULNESS;

EID: 2442660399     PISSN: 09580670     EISSN: None     Source Type: Journal    
DOI: 10.1113/expphysiol.2003.026666     Document Type: Article

References (28)

1. Aniksztejn L, Bregestovski P & Ben-Ari Y (1991). Selective activation of quisqualate metabotropic receptor potentiates NMDA but not AMPA responses. Eur J Pharmacol 205, 327-328.
2. Antunes VR & Machado BH (2003). Antagonism of glutamatergic metabotropic receptors in the NTS of awake rats does not affect the gain of the baroreflex. Autonomic Neurosc: Basic Clin 103, 65-71.
3. Bleakman D, Rusin KI, Chard PS, Glaum SR & Miller RJ (1992). Metabotropic glutamate receptors potentiate ionotropic glutamate responses in the rat dorsal horn. Mol Pharmacol 42, 192-196.
4. Chianca DA Jr & Machado BH (1996). Microinjection of NMDA antagonist into the NTS of conscious rats blocks the Bezold-Jarish reflex. Brain Res 718, 185-188.
5. Ciriello J & Calaresu FR (1981). Projections from buffer nerves to the nucleus of the solitary tract: an anatomical and electrophysiological study in cat. J Auton Nerv Syst 3, 299-310.
6. Colombari E, Bonagamba LGH & Machado BH (1994). Mechanisms of pressor and bradycardic responses to 1-glutamate microinjected into the NTS of conscious rats. Am J Physiol 266, R730-R738.
7. Colombari E, Bonagamba LGH & Machado BH (1997). NMDA receptor antagonist blocks the bradycardic but not the pressor response to 1-glutamate microinjected into the nucleus tractus solitarius (NTS) of unanesthetized rats. Brain Res 749, 209-213.
8. Foley CM, Vogl HW, Mueller PJ, Hay M & Hasser EM (1999). Cardiovascular response to group I metabotropic glutamate receptors activation in NTS. Am J Physiol 276, R1469-R1478.
9. Frigero M, Bonagamba LGH & Machado BH (2000). The gain of the baroreflex bradycardia is reduced by microinjection of NMDA receptor antagonist into the nucleus tractus solitarii of awake rats. J Auton Nerv Syst 79, 28-33.
10. Glaum SR & Miller RJ (1992). Metabotropic glutamate receptors mediate excitatory transmission in the nucleus of the solitary tract. J Neurosc 12, 2251-2258.
11. Glaum SR & Miller RJ (1993). Activation of metabotropic glutamate receptors produces reciprocal regulation of ionotropic glutamate and GABA responses in the nucleus of the tractus solitarius of the rat. J Neurosc 13, 1636-1641.
12. Gordon FJ & Talman WT (1992). Role of excitatory amino acids and their receptors in bulbospinal control of cardiovascular function. In Central Neural Mechanisms in Cardiovascular Regulation, ed. Kunos G & Ciriello J, pp. 209-228. Birkhauser, Boston, MA, USA.
13. Haibara AS, Bonagamba LGH & Machado BH (1999). Sympathoexcitatory neurotransmission of the chemoreflex in the NTS of awake rats. Am J Physiol 276, R69-R80.
14. Haibara AS, Colombari E, Chianca DA Jr, Bonagamba LGH & Machado BH (1995). NMDA receptors in NTS are involved in bradycardic but not in pressor response of chemoreflex. Am J Physiol 269, H1421-H1427.
15. Hay M & Hasser EM (1998). Measurement of synaptic vesicle exocytosis in aortic baroreceptor neurons. Am J Physiol 275, H710-H716.
16. Kubo T & Kihara M (1988). Evidence of N-methyl-d-aspartate receptor-mediated modulation of the aortic baroreceptor reflex in the rat nucleus tractus solitarii. Neurosc Lett 87, 69-74.
17. Leone C & Gordon FJ (1989). Is 1-glutamate a neurotransmitter of baroreceptor information in the nucleus of the tractus solitarius? J Pharmacol Exp Therap 250, 953-962.
18. Machado BH (2001). Neurotransmission of the cardiovascular reflex in the nucleus tractus solitarii of awake rats. Ann New York Acad Sc 940, 179-196.
19. Machado BH & Bonagamba LGH (1992). Microinjection of 1-glutamate into the nucleus tractus solitarii increases arterial pressure in conscious rats. Brain Res 576, 131-138.
20. Machado BH & Bonagamba LGH (1998). Cardiovascular responses to microinjection of trans-(±)-ACPD into the NTS were similar in conscious and chloralose-anesthetized rats. Braz J Med Biol Res 31, 573-579.
21. Michelini LC & Bonagamba LGH (1988). Baroreceptor reflex modulation by vasopressin microinjected into the nucleus tractus solitarii of conscious rats. Hypertension 11 (suppl. 1), 75-79.
22. Pawloski-Dahm C & Gordon FJ (1992). Evidence for a kynurenate-insensitive glutamate receptor in nucleus tractus solitarii. Am J Physiol 262, H1611-H1615.
23. Paxinos G & Watson C (1986). The Rat Brain in Stereotaxic Coordinates. Academic Press, New York.
24. Spyer KM (1981). Neural organization and control of the baroreceptor reflex. Rev Physiol, Biochem Pharmacol 88, 23-124.
25. Sved AF & Gordon FJ (1994). Amino acids as central neurotransmitters in the baroreceptor pathway. News Physiol Sc 9, 243-246.
26. Talman WT (1989). Kynurenic acid microinjected into the nucleus tractus solitarius of rat blocks the arterial baroreflex but not responses to glutamate. Neurosc Lett 102, 247-252.
27. Talman WT, Perrone MH & Reis DJ (1980). Evidence for 1-glutamate as the neurotransmitter of baroreceptor afferent nerve fibers. Science 209, 813-815.
28. Viard E & Sapru HN (2002). Cardiovascular responses to activation of metabotropic glutamate receptors in the nTS of the rat. Brain Res 952, 308-321.