The 4N cell cycle delay in Fanconi anemia reflects growth arrest in late S phase

Molecular Genetics and Metabolism

Volumn 74, Issue 4, 2001, Pages 403-412

  Akkari, Yassmine M N ^a   Bateman, Raynard L ^a   Reifsteck, Carol A ^a   D'Andrea, Alan D ^b   Olson, Susan B ^a   Grompe, Markus ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Fanconi anemia; Fanconi anemia group A; Fanconi anemia group C; Interstrand DNA crosslink

Indexed keywords

ARTICLE; CELL CYCLE S PHASE; CHROMOSOME BREAKAGE; CONTROLLED STUDY; DNA CONTENT; DNA CROSS LINKING; DNA REPLICATION; FANCONI ANEMIA; HUMAN; HUMAN CELL; MITOSIS INHIBITION; PRIORITY JOURNAL;

EID: 0035691754     PISSN: 10967192     EISSN: None     Source Type: Journal    
DOI: 10.1006/mgme.2001.3259     Document Type: Article

References (54)

1. Familial constitutional panmyelocytopathy, Fanconi's anemia (F.A.) I. Clinical aspects
2. The emerging genetic and molecular basis of Fanconi anaemia
3. Complementation analysis in Fanconi anemia: Assignment of the reference FA-H patient to group A
4. Evidence for at least eight Fanconi anemia genes
5. Positional cloning of a novel Fanconi anemia gene, FANCD2
6. Isolation of a cDNA representing the Fanconi anemia complementation group E gene
7. The Fanconi anaemia group G gene FANCG is identical with XRCC9
8. Expression cloning of a cDNA for the major Fanconi anaemia gene, FAA
9. The Fanconi anaemia gene FANCF encodes a novel protein with homology to ROM
10. Positional cloning of the Fanconi anaemia group A gene
11. Repair analysis of mitomycin C-induced DNA crosslinking in ribosomal RNA genes in lymphoblastoid cells from Fanconi's anemia patients
12. Mutational response of Fanconi anaemia cells to shuttle vector site-specific psoralen cross-links
13. Defective repair of mitomycin C crosslinks in Fanconi's anemia and loss in confluent normal human and xeroderma pigmentosum cells
14. Cross-link repair in human cells and its possible defect in Fanconi's anemia cells
15. Endogenous blockage and delay of the chromosome cycle despite normal recruitment and growth phase explain poor proliferation and frequent edomitosis in Fanconi anemia cells
16. Modulation of the spontaneous G2 phase blockage in Fanconi anemia cells by caffeine: Differences from cells arrested by X-irradiation
17. Comparative evaluation of diepoxybutane sensitivity and cellcycle blockage in the diagnosis of Fanconi anemia
18. Is Fanconi's anaemia defective in a process essential to the repair of DNA cross links?
19. The Fanconi anaemia proteins, FAA and FAC, interact to form a nuclear complex
20. Fanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complex
21. A physical complex of the Fanconi anemia proteins FANCG/XRCC9 and FANCA
22. Elevated homologous recombination activity in Fanconi anemia fibroblasts
23. Fanconi anemia C gene product plays a role in the fidelity of blunt DNA end-joining
24. Human alpha spectrin II and the FANCA, FANCC and FANCG proteins bind to DNA containing psoralen interstrand cross-links
25. Fanconi anemia, complementation group A, cells are defective in ability to produce incisions at sites of psoralen interstrand cross-links
26. Damage-resistant DNA synthesis in fanconi anemia cells treated with a DNA cross-linking agent
27. Arrest of S-phase progression is impaired in fanconi anemia cells
28. Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway
29. Fanconi anemia mutation causes cellular susceptibility to ambient oxygen
30. Fanconi anemia group C protein prevents apoptosis in hematopoietic cells through redox regulation of GSTP1
31. Apoptosis in the haemopoietic system
32. Fanconi anemia C protein acts at a switch between apoptosis and necrosis in mitomycin C-induced cell death
33. Multiple inhibitory cytokines induce deregulated progenitor growth and apoptosis in hematopoietic cells from Fac-/- mice
34. The Fanconi anemia group C gene product modulates apoptotic responses to tumor necrosis factor-alpha and Fas ligand but does not suppress expression of receptors of the tumor necrosis factor receptor superfamily
35. Tumor necrosis factor-alpha and CD95 ligation suppress erythropoiesis in Fanconi anemia C gene knockout mice
36. Effect of stem cell factor on colony growth from acquired and constitutional (Fanconi) aplastic anemia
37. DNA replication is required to elicit cellular responses to psoralen-induced DNA interstrand cross-links
38. G2 phase cell cycle disturbance as a manifestation of genetic cell damage
39. Subtyping analysis of Fanconi anemia by immunoblotting and retroviral gene transfer
40. Synchronization of human diploid fibroblasts at multiple stages of the cell cycle
41. Cellular pharmacology of quinone bioreductive alkylating agents
42. Diepoxybutane cross-links DNA at 5′-GNC sequences
43. Mutagenic and carcinogenic properties of platinum-based anticancer drugs
44. DNA semi-conservative synthesis in normal and Fanconi anemia fibroblasts following treatment with 8-methoxypsoralen and near ultraviolet light or with X-rays
45. Two complementation groups of Fanconi's anemia differ in their phenotypic response to a DNA-crosslinking treatment
46. Generation of reactive oxygen radicals through bioactivation of mitomycin antibiotics
47. The sensitivity of Fanconi anaemia group C cells to apoptosis induced by mitomycin C is due to oxygen radical generation, not DNA crosslinking
48. The fate of 8-methoxypsoralen-photoinduced DNA interstrand crosslinks in Fanconi's anemia cells of defined genetic complementation groups
49. The reaction of the psoralens with deoxyribonucleic acid
50. Angelicins, angular analogs of psoralens: Chemistry, photochemical, photobiological and phototherapeutic properties
51. Repair of psoralen adducts in human DNA: Differences among xeroderma pigmentosum complementation groups
52. Repair of psoralen-induced crosslinks and monoadducts in normal and repair-deficient human fibroblasts
53. Fanconi anemia