Association between type 1 diabetes age of onset and HLA among sibling pairs

Diabetes

Volumn 48, Issue 8, 1999, Pages 1658-1661

  Valdes, Ana M ^a,d   Thomson, Glenys ^a   Erlich, Henry A ^b,c   Noble, Janelle A ^b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Roche Molecular Systems   (United States)

^c CHILDREN S HOSPITAL OAKLAND   (United States)

^d GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; HLA DP ANTIGEN; HLA DQ ANTIGEN; HLA DR ANTIGEN;

ADOLESCENT; ADULT; ARTICLE; CONTROLLED STUDY; GENE LOCUS; GENOTYPE; HAPLOTYPE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; ONSET AGE; PRIORITY JOURNAL; SCHOOL CHILD; SIBLING;

ADOLESCENT; ADULT; AGE OF ONSET; ALLELES; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; HAPLOTYPES; HISTOCOMPATIBILITY ANTIGENS CLASS I; HISTOCOMPATIBILITY ANTIGENS CLASS II; HLA ANTIGENS; HLA-DQ ANTIGENS; HLA-DR ANTIGENS; HUMANS; INFANT; INFANT, NEWBORN;

EID: 0032806186     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.48.8.1658     Document Type: Article

References (19)

1. Atkinson MA, Maclaren NJ: The pathogenesis of insulin-dependent diabetes mellitus. N Engl J Med 331:1428-1436, 1994
2. Noble J, Valdes AM, Cook M, Klitz W, Thomson G, Erlich HA: The role of HLA class II genes in insulin-dependent diabetes mellitus: molecular analysis of 180 Caucasian, multiplex families. Am J Hum Genet 59:1134-1148, 1996
3. Todd J: Genetic analysis of type I diabetes using whole genome approaches. Proc Natl Acad Sci U S A 92:8560-8565, 1995
4. Thomson G: Strategies involved in mapping diabetes genes: an overview. Diabetes Rev 5:106-115, 1997
5. Cucca F, Muntoni F, Lampis R, Frau F, Argiolas J, Silvetti M, Angius E, Cao A, De Virgiliis S, Congia M: Combinations of specific DRB1, DQA1, DQB1 haplotypes are associated with insulin-dependent diabetes mellitus in Sardinia. Hum Immunol 37:85-94, 1993
6. Erlich HA, Zeidler A, Chang J, Shaw S, Raffel LJ, Klitz W, Beshkov Y, Costin G, Pressman S, Bigawan T, Rotter JI: HLA class II alleles and susceptibility and resistance to insulin dependent diabetes mellitus in Mexican American families. Nature Genet 3:358-364, 1993
7. Ghabanbasani MZ, Spaepen M, Buyse I, Marynen P, Bex M, Bouillon R, Cassiman JJ: Improved risk assessment for insulin-dependent diabetes mellitus by analysis of amino acids in HLA-DQ and DRB1 loci. Eur J Hum Genet 2:177-184, 1994
8. She JX: Susceptibility to type 1 diabetes HLA-DQ and DR revisited. Immunol Today 17:323-329, 1996
9. Valdes AM, McWeeney SK, Thomson G: HLA class II DR-DQ amino acids and insulin-dependent diabetes mellitus: application of the haplotype method. Am J Hum Genet 60:717-728, 1997
10. Caillat-Zucman S, Garchon H-J, Timsit J, Assan R, Boitard C, Djilali-Saiah I, Bougneres P, Bach J-B: Age dependent HLA genetic heterogeneity of type 1 insulin-dependent diabetes mellitus. J Clin Invest 90:2242-2250, 1992
11. Tait BD, Harrison LC, Drummond BP, Steward V, Varney MD, Honeyman MC: HLA antigens and age at diagnosis of insulin-dependent diabetes mellitus. Hum Immunol 42:116-122, 1995
12. Fava D, Gardner S, Pyke D, Leslie RDG: Evidence that the age at diagnosis of IDDM is genetically determined. Diabetes Care 21:925-929, 1998
13. Nakanishi K, Kobayashi T, Murase T, Nakatsuji T, Inoko H, Tsuji K, Kosaka K: Association of HLA-A24 with complete beta-cell destruction in IDDM. Diabetes 42:1086-1093, 1993
14. Svejgaard A, Jakobsen BK, Platz P, Ryder LP, Nerup J, Christy M, Borch-Johnsen K, Parving H-H, Decker T, Mølsted-Pedersen L, Kühl C, Buschard K, Green A: HLA associations in insulin-dependent diabetes: search for heterogeneity in different groups of patients from a homogeneous population. Tissue Antigens 28:237-244, 1986
15. Ludvigsson J, Samuelsson U, Beauforte C, Deschamps I, Dorchy H, Drash A, Francois R, Herz G, New M, Schober E: DR3 is associated with a more slowly progressive form of type 1 (insulin dependent) diabetes. Diabetologia 29: 207-210, 1986
16. Chan SH, Thai AC, Lin YN, Liu KF, Wee GB: Influence of gender and age of onset on the HLA associations in Chinese with insulin-dependent diabetes mellitus. Hum Immunol 44:175-180, 1995
17. Agresti A: Categorical Data Analysis. New York, Wiley and Sons, 1990, p. 101
18. Demaine AG, Hibberd ML, Mangels D, Millward BA: A new marker in the HLA class I region is associated with the age at onset of IDDM. Diabetologia 38:623-628, 1995
19. Fujisawa T, Ikegami H, Kawagushi Y, Yamato E, Takekawa K, Nakagawa Y, Hamada Y, Ueda H, Shima K, Ogihara T: Class I HLA is associated with age-at-onset of IDDM, while class II HLA confers susceptibility to IDDM. Diabetologia 38:1493-1495, 1995