Human Fibroblasts with Mutations in COL5A1 and COL3A1 Genes Do Not Organize Collagens and Fibronectin in the Extracellular Matrix, Down-regulate α2β1 Integrin, and Recruit α vβ3 Instead of α5β1 Integrin

Journal of Biological Chemistry

Volumn 279, Issue 18, 2004, Pages 18157-18168

  Zoppi, Nicoletta ^a   Gardella, Rita ^a   De Paepe, Anne ^b   Barlati, Sergio ^a   Colombi, Marina ^a  

^a UNIVERSITY OF BRESCIA   (Italy)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; COLLAGEN; MUTAGENESIS; SYNTHESIS (CHEMICAL);

EXTRACELLULAR MATRICES (ECM); HUMAN FIBROBLASTS;

GENETIC ENGINEERING;

COLLAGEN; FIBRONECTIN; INTEGRIN RECEPTOR; LIGAND; VERY LATE ACTIVATION ANTIGEN 2; VERY LATE ACTIVATION ANTIGEN 5; VITRONECTIN RECEPTOR;

ARTICLE; COL3A1 GENE; COL5A1 GENE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FIBROBLAST; GENE; GENE MUTATION; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN PURIFICATION;

ADOLESCENT; CELLS, CULTURED; COLLAGEN; COLLAGEN TYPE III; COLLAGEN TYPE V; DOWN-REGULATION; EHLERS-DANLOS SYNDROME; EXTRACELLULAR MATRIX; FIBROBLASTS; FIBRONECTINS; HUMANS; INTEGRIN ALPHA2BETA1; INTEGRIN ALPHA5BETA1; INTEGRIN ALPHAVBETA3; INTEGRINS; MUTATION;

EID: 2442626736     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M312609200     Document Type: Article

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