Gestational and lactational exposure to heptachlor does not alter reproductive system development in rats

Veterinary and Human Toxicology

Volumn 46, Issue 3, 2004, Pages 113-118

  Lawson, Gregory ^a   Luderer, Ulrike ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORDANE; ESTRADIOL; HEPTACHLOR; ORGANOCHLORINE INSECTICIDE; PROGESTERONE; SEX HORMONE; TESTOSTERONE;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIRTH WEIGHT; CONTROLLED STUDY; DELAYED PUBERTY; ESTRADIOL BLOOD LEVEL; ESTRUS CYCLE; FEMALE; FEMALE INFERTILITY; GENITAL SYSTEM; LACTATION; LIPOPHILICITY; MALE INFERTILITY; NEWBORN; NEWBORN PERIOD; NIPPLE; NONHUMAN; ONSET AGE; OVARY; PREGNANCY; PRENATAL EXPOSURE; PROGESTERONE BLOOD LEVEL; RADIOIMMUNOASSAY; RAT; TESTIS WEIGHT; TESTOSTERONE BLOOD LEVEL; WEANING; WEIGHT GAIN;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEPTACHLOR; INSECTICIDES; LACTATION; MALE; ORGAN SIZE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCTION;

ANIMALIA; ZEA MAYS;

EID: 2442593712     PISSN: 01456296     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. UNECE: Protocol on persistent organic pollutants to the Convention on Long-range Transboundary Air Pollution. United Nations Economic Commission For Europe: Geneva, 1998.
2. ATSDR: Toxicological Profile for Chlordane (Update). ATSDR/TP-93/03 ed. US Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry. Atlanta, GA: 1994.
3. ATSDR: Toxicological Profile for Heptachlor/Heptachlor Epoxide (Update). ATSDR/TP-92/11 ed. US Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry. Atlanta, GA: 1998.
4. Gray LE Jr, Ostby J, Ferrell J, et al: A dose-response analysis of methoxychlor-induced alterations of reproductive development and function in the rat. Fund Appl Toxicol 12: 92-108, 1989.
5. Kelce, WR, Stone, CR, Laws, SC, et al: Persistent DDT Metabolite p, p'-DDE is a Potent Androgen Receptor Antagonist. Nature 375: 581-585, 1995.
6. Green VA: Effects of Pesticides on Rat and Chick Embryo. In Hemphill DD, editor: Trace Substances in Environmental Health, III, University of Missouri: Columbia, MO: 183-209, 1970.
7. Smialowicz J, Williams WC, Copeland CB et al: The Effects of perinatal/juvenile heptachlor exposure on adult immune and reproductive system function in rats. Toxicol Sci 61: 164-175, 2001.
8. Talamantes F, Jang H: Effects of chlordane isomer administered to female mice during the neonatal period. J Toxicol Environ Health 3: 713-720, 1977.
9. Narotsky MG, Kavlock RJ: A multidisciplinary approach to toxicological screening: II. Developmental toxicity. J Toxicol Environ Health 45: 145-171, 1995.
10. Baker DB: Estimation of human exposure to heptachlor epoxide in Hawaii - A report to the Hawaii heptachlor research and education foundation. Mount Sinai School of Medicine: New York, 1993.
11. Le Marchand L, Kolonel LN, Siegel BZ, et al: Trends in birth defects for a Hawaiian population exposed to heptachlor and for the United States. Arch Environ Health 41: 145-148, 1986.
12. NRC: Guide for the Care and Use of Laboratory Animals. National Research Council, National Academy of Sciences, Washington DC, 1996.
13. Oduma JA, Wango EO, Makawiti DW et al: Effects of graded doses of the pesticide heptachlor on body weight, mating success, oestrous cycle, gestation length, and litter size in laboratory rats. Comp Biochem Physiol 110C: 221-227, 1995.
14. Oduma JA, Wango EO, Oduor-Okelo D, et al: In vivo and In vitro effects of graded doses of the pesticide heptachlor on female sex steroid hormone production in rats. Comp Biochem Physiol 111C: 191-196, 1995.
15. Wango EO, Onyango DW, Odongo H, et al: In vitro production of testosterone and plasma levels of luteinising hormone, testosterone, and cortisol in male rats treated with heptachlor. Comp Biochem Physiol 118C: 381-386, 1997.
16. Narotsky MG, Weller EA, Chinchilli VM et al: Nonadditive developmental toxicity in mixtures of trichloroethylene, di(2-ethylhexyl) phthalate, and heptachlor in a 5 × 5 × 5 design. Fund Appl Toxicol 27: 203-216, 1995.
17. Moser VC, Shafer TJ, Ward TR et al: Neurotoxicological outcomes of perinatal heptachlor exposure in the rat. Toxicol sci 60: 315-326, 2001.
18. Purkerson-Parker S, McDaniel KL, Moser VC: Dopamine transporter binding in the rat striatum is increased by gestational, perinatal, and adolescent exposure to heptachlor. Toxicol Sci 64: 216-223, 2001.
19. Krinke GJ ed: The Laboratory Rat. Academic Press, San Diego: 2000.
20. Mestitzova M: On reproduction studies and the occurrence of cataracts in rats after long-term feeding of the insecticide heptachlor. Experientia 23: 42-43, 1967.
21. Burch TA: An investigation of the possible effect of heptachlor contamination of milk on pregnancy outcome of Oahu women residents. Research and Statistics Office, Hawaii State Department of Health, Honolulu, 1983.
22. Hoffman JS: The effects of prenatal heptachlor exposure on infant development. University of Hawaii, Honolulu, 1985.