In vitro production of testosterone and plasma levels of luteinising hormone, testosterone and cortisol in male rats treated with heptachlor

Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology

Volumn 118, Issue 3, 1997, Pages 381-386

  Wango, E O ^a   Onyango, D W ^a   Odongo, H ^a   Okindo, E ^a   Mugweru, J ^a  

^a UNIVERSITY OF NAIROBI   (Kenya)

Author keywords

Cortisol; Heptachlor; Luteinizing hormone; Male rats; Reproduction; Testis; Testosterone

Indexed keywords

HEPTACHLOR; HYDROCORTISONE; LUTEINIZING HORMONE; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HISTOPATHOLOGY; HORMONE DETERMINATION; HYDROCORTISONE BLOOD LEVEL; LUTEINIZING HORMONE BLOOD LEVEL; MALE; NONHUMAN; POLLUTANT; PRIORITY JOURNAL; RAT; TESTIS INJURY; TESTOSTERONE BLOOD LEVEL;

ANIMALS; BODY WEIGHT; CELL SURVIVAL; HEPTACHLOR; HYDROCORTISONE; INSECTICIDES; LEYDIG CELLS; LINEAR MODELS; LUTEINIZING HORMONE; MALE; RATS; RATS, SPRAGUE-DAWLEY; TESTIS; TESTOSTERONE;

EID: 0031450591     PISSN: 07428413     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0742-8413(97)00104-7     Document Type: Article

References (32)

1. Aulerich R.J., Bursian S.J., Napolitano A.C. Subacute toxicity of dietary heptachlor to mink (Mustela vision.). Arch Environ. Contam. Toxicol. 19:1990;913-916.
2. ATSDR Toxicological Profile for Toxaphene. 1990;Agency for Toxic Substances and Disease Registry, Atlanta, GA.
3. ATSDR Toxicological Profile for Endosulfan. 1991;Agency for Toxic Substances and Disease Registry, Atlanta, GA.
4. Campbell M.A., Gyorkos J., Leece B., Homonko K., Safe S. The effect of twenty two organochlorine pesticides as inducers of the hepatic drug-metabolising enzymes. Gen. Pharmacol. 14:1983;445-454.
5. Chahoud I., Krowke R., Schimmel A., Merker H.-J., Neubert D. Reproductive toxicity and pharmacokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Arch. Toxicol. 63:1989;432-439.
6. Colborn T., vom Saal F.S., Soto A.M. Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environ. Health Pespect. 101:1993;378-384.
7. Crum J.A., Bursian S.J., Aulerich R.J., Polin D., Braselton W.E. The reproductive effects of dietary heptachlor in mink (Mustela vision.). Arch. Environ. Contam. Toxicol. 24:1993;154-164.
8. Enzyme immunoassays for LH, FSH and prolactin. Protocol Version 1.0, London. Published by Programme for Provision of Matched Assay Reagents for Immunoassay of Hormones. Hammersmith Hospital; July 1994.
9. Environmental Health Criteria 38. Heptachlor, Published by World Health Organization, Geneva, Switzerland; 1984.
10. Fendick E.A., Mather-Mihaich E., Houck K.A., St. Clair M.B., Faust J.B., Rockwell C.H., Owens M. Ecological toxicology and human health effects of heptachlor. Rev. Environ. Contam. Toxicol. 111:1990;61-142.
11. Gupta P.K., Gupta R.C. Pharmacology, toxicology and degradation of endosulfan. A review. Toxicology. 13:1979;115-130.
12. Guzelian P.S. Comparative toxicology of chlordecone (kepone) in humans and experimental animals. Annu. Rev. Pharmacol. Toxicol. 22:1982;89-113.
13. Haake J., Kelley M., Keys B., Safe S. The effect of organochlorine pesticides as inducers of testosterone and benzo [a] pyrene hydroxylases. Gen. Pharmacol. 18:1987;165-169.
14. IRDC. Heptachlor epoxide:two generation reproduction and teratology study in beagle dogs. Nattawan, Michigan, International Research and Development Corporation (Report No. 163-048) (sponsored by the Velsical Chemical Corporation); 1973.
15. Izushi F., Ogata M. Hepatic and muscle injuries in mice treated with heptachlor. Toxicol. Lett. 54:1990;47-54.
16. Jarrell J.F., McMahon A., Villeneuve D., Franklin C., Singh A., Valli V.E., Burtlett S. Hexachlorobenzene toxicity in monkey primordial germ cell without induced porphyria. Reprod. Toxicol. 7:1993;41-47.
17. Kimmel C.A. Approaches to evaluating reproductive hazards and risks. Environ. Health Perspect. Suppls. 101(Suppl. 2):1993;137-143.
18. Lummis S.C., Buckingham S.D., Rauh J.J., Satelle D.B. Blocking actions of heptachlor at an insect central nervous system GABA receptor. Proc. R. Soc. Lond. Biol. 240:1990;97-106.
19. Lyon M.F. Sensitivity of various germ-cell stages to environmental mutagens. Mutat. Res. 87:1981;323-345.
20. Marcus M., Silbergeld E., Mattison D. Research Needs Working Group. A reproductive hazards research agenda for 1990s. Environ. Health Perspect. Suppls. 101(Suppl. 2):1993;175-180.
21. Narahashi, T.; Frey, J.M.; Ginsburg, K.S.; Roy, M.L. Sodium and GABA- activated channels as the targets for pyrethroids and cyclodienes. Toxicol. Lett. 64-65 Spe. No. 429-436;1992.
22. NCI Bioassay of endosulfan for possible carcinogenicity. National Cancer Institute technical report series NCI-CG-TR-62. 1978;National Cancer Institute, Bethesda, MD. 18-54;
23. Oduma J.A., Wango E.O., Makawiti D.W., Einer-Jensen N., Oduor-Okelo D. Effects of graded doses of the pesticide heptachlor on body weight, mating success, oestrous cycle, gestation length and litter size in laboratory rats. Comp. Biochem. Physiol. 110C:1995;221-227.
24. Oduma J.A., Wango E.O., Oduor-Okelo D., Makawiti D.W., Odongo H. In vivo and in vitro effects of graded doses of the pesticide heptachlor on female sex steroid hormone production in rats. Comp. Biochem. Physiol. 111C:1995;191-196.
25. Ogata M., Izushi F., Etok K., Sakai R., Inuoe B., Noguchi N. Effects of chlordane on hepatic mitochondrial respiration. Toxicol. Lett. 48:1984;67-74.
26. Paasivirta J., Rantio T. Chloroterpenes and other organochlorines in Baltic, Finnish and Arctic wildlife. Chemosphere. 22:1991;47-55.
27. Singh S.K., Pandey R.S. Effect of sub-chronic endosulfan exposures on plasma gonadotropins, testosterone, testicular testosterone and enzymes of androgen biosynthesis in rat. Ind. J. Exp. Biol. 28:1990;953-956.
28. Soto A.M., Chung K.L., Sonnenschein C. The pesticides endosulfan, toxaphene, and dieldrin have estrogenic effects on human estrogen-sensitive cells. Environ. Health Perspect. 102:1994;380-383.
29. Sufi, S.B.; Donaldson, A.; Jeffcoate, S.L. WHO Matched Reagent Programme Method Manual. London;1993.
30. Szymczynski G.A., Waliszewski S.M. Chlorinated pesticide residues in testicular tissue samples. Pesticides in human testicles. Andrologia. 15:1983;696-698.
31. Van Damme M.P., Robertson D.M., Diczfalusy E. An improved in vitro bioassay method for measuring luteinising hormone (LH) activity using mouse Leydig cell preparations. Acta Endocrinol. 77:1974;655-671.
32. Whorton M.D., Krauss R.M., Marshall S., Milby T.H. Infertility in male pesticide workers. Lancet. ii:1977;1259-1261.