Characteristics of porcine circovirus-2 replication in lymphoid organs of pigs inoculated in late gestation or postnatally and possible relation to clinical and pathological outcome of infection

Journal of Veterinary Diagnostic Investigation

Volumn 16, Issue 3, 2004, Pages 175-185

  Sanchez Jr , Romeo E ^a   Meerts, Peter ^a   Nauwynck, Hans J ^a   Ellis, John A ^b   Pensaert, Maurice B ^a  

^a GHENT UNIVERSITY   (Belgium)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; CIRCOVIRIDAE; CIRCOVIRUS; PORCINE CIRCOVIRUS; PORCINE CIRCOVIRUS 2; SUIDAE; SUS SCROFA;

EID: 2442581146     PISSN: 10406387     EISSN: None     Source Type: Journal    
DOI: 10.1177/104063870401600301     Document Type: Article

References (48)

1. Allan G, Ellis J: 2000, Porcine circoviruses: a review. J Vet Diagn Invest 12:3-14.
2. Allan GM, Kennedy S, McNeilly F, et al.: 1999, Experimental reproduction of severe wasting disease by co-infection of pigs with porcine circovirus and porcine parvovirus. J Comp Pathol 121:1-11.
3. Allan GM, McNeilly F, Ellis J, et al.: 2000, Experimental infection of colostrum deprived piglets with porcine circovirus 2 (PCV2) and porcine reproductive and respiratory syndrome virus (PRRSV) potentiates PCV2 replication. Arch Virol 145:2421-2429.
4. Allan GM, McNeilly F, Meehan B, et al.: 2002, Reproduction of PMWS with a 1993 Swedish isolate of PCV-2. Vet Rec 150:255-256.
5. Andersen JK, Takamatsu H, Oura CA, et al.: 1999, Systematic characterization of porcine ileal Peyer's patch, I. apoptosis-sensitive immature B cells are the predominant cell type. Immunology 98:612-621.
6. Ardavin C, Martinez G, Martin P, et al.: 2001, Origin and differentiation of dendritic cells. Trends Immunol 22:691-700.
7. Bolin SR, Stoffregen WC, Nayar GP, Hamel AL: 2001, Post-weaning multisystemic wasting syndrome induced after experimental inoculation of cesarean-derived, colostrum-deprived piglets with type 2 porcine circovirus. J Vet Diagn Invest 13:185-194.
8. Carrasco CP, Rigden RC, Schaffner R, et al.: 2001, Porcine dendritic cells generated in vitro: morphological, phenotypic and functional properties. Immunology 104:175-184.
9. Charley B, Lavenant L: 1990, Characterization of blood mononuclear cells producing IFN alpha following induction by coronavirus-infected cells (porcine transmissible gastroenteritis virus). Res Immunol 141:141-151.
10. Cutlip RC, Mengeling WL: 1975, Experimentally induced infection of neonatal swine with porcine parvovirus. Am J Vet Res 36:1179-1182.
11. Duan X, Nauwynck H, Favoreel H, Pensaert M: 1998, Identification of a putative receptor for porcine reproductive and respiratory syndrome virus on porcine alveolar macrophages. J Virol 72:4520-4523.
12. Duan X, Nauwynck HJ, Pensaert MB: 1997, Virus quantification and identification of cellular targets in the lungs and lymphoid tissues of pigs at different time intervals after inoculation with porcine reproductive and respiratory syndrome virus (PRRSV). Vet Microbiol 56:9-19.
13. Harms PA, Sorden SD, Halbur PG, et al.: 2001, Experimental reproduction of severe disease in CD/CD pigs concurrently infected with type 2 porcine circovirus and porcine reproductive and respiratory syndrome virus. Vet Pathol 38:528-539.
14. Haverson K, Bailey M, Higgins V, et al.: 1994, Characterization of monoclonal antibodies specific for monocytes, macrophages and granulocytes from porcine peripheral blood and mucosal tissues. J Immunol Methods 170:233-245.
15. Johnson C, Joo HS, Direksin K, et al.: 2002, Experimental in utero inoculation of late-term swine fetuses with porcine circovirus type 2. J Vet Diagn Invest 14:507-512.
16. Joo HS, Donaldson-Wood CR, Johnson RH: 1976, A standardised haemagglutination inhibition test for porcine parvovirus antibody. Aust Vet J 52:422-424.
17. Kennedy S, Moffett D, McNeilly F, et al.: 2000, Reproduction of lesions of postweaning multisystemic wasting syndrome by infection of conventional pigs with porcine circovirus type 2 alone or in combination with porcine parvovirus. J Comp Pathol 122:9-24.
18. Kiupel M, Stevenson GW, Kanitz CL, et al.: 1999, Cellular localization of porcine circovirus in postweaning pigs with chronic wasting disease. Eur J Vet Pathol 5:77-82.
19. Krakowka S, Ellis JA, McNeilly F, et al.: 2001, Activation of the immune system is the pivotal event in the production of wasting disease in pigs infected with porcine circovirus-2 (PCV-2). Vet Pathol 38:31-42.
20. Krakowka S, Ellis JA, McNeilly F, et al.: 2002, Immunologic features of porcine circovirus type 2 infection. Viral Immunol 15:567-582.
21. Krakowka S, Ellis JA, Meehan B, et al.: 2000, Viral wasting syndrome of swine: experimental reproduction of postweaning multisystemic wasting syndrome in gnotobiotic swine by coinfection with porcine circovirus 2 and porcine parvovirus. Vet Pathol 37:254-263.
22. Labarque G, Nauwynck H, Mesu A, Pensaert M: 2001, Seroprevalence of porcine circovirus types 1 and 2 in the Belgian pig population. Vet Q 22:234-236.
23. Labarque GG, Nauwynck HJ, Van Reeth K, Pensaert MB: 2000, Effect of cellular changes and onset of humoral immunity on the replication of porcine reproductive and respiratory syndrome virus in the lungs of pigs. J Gen Virol 81:1327-1334.
24. Ladekjær-Mikkelsen AS, Nielsen J, Stadejek T, et al.: 2002, Reproduction of postweaning multisystemic wasting syndrome (PMWS) in immunostimulated and non-immunostimulated 3-week-old piglets experimentally infected with porcine circovirus type 2 (PCV2). Vet Microbiol 89:97-114.
25. Liu Q, Tikoo SK, Babiuk LA: 2001, Nuclear localization of the ORF2 protein encoded by porcine circovirus type 2. Virology 285:91-99.
26. Magar R, Larochelle R, Thibault S, Lamontagne L: 2000, Experimental transmission of porcine circovirus type 2 (PCV2) in weaned pigs: a sequential study. J Comp Pathol 123:258-269.
27. McCullough KC, Schaffner R, Natale V, et al.: 1997, Phenotype of porcine monocytic cells: modulation of surface molecule expression upon monocyte differentiation into macrophages. Vet Immunol Immunopathol 58:265-275.
28. McNeilly F, McNair I, Mackie DP, et al.: 2000, Production, characterization and application of monoclonal antibodies to porcine circovirus 2. Arch Virol 146:909-922.
29. Nielsen J, Vincent IE, Botner A, et al.: 2003, Association of lymphopenia with porcine circovirus type 2 induced postweaning multisystemic wasting syndrome (PMWS). Vet Immunol Immunopathol 92:97-111.
30. Paillot R, Laval F, Audonnet JC, et al.: 2001, Functional and phenotypic characterization of distinct porcine dendritic cells derived from peripheral blood monocytes. Immunology 102:396-404.
31. Pensaert M, Sanchez RE, Ladekjær-Mikkelsen AS, et al.: 2004, Viremia and effect of fetal infection with porcine viruses with special reference to porcine circovirus 2 infection. Vet Microbiol (in press).
32. Pescovitz M, Lunney J, Sachs D: 1984, Preparation and characterization of monoclonal antibodies reactive with porcine PBL. J Immunol 133:368-375.
33. Pescovitz MD, Aasted B, Canals A, et al.: 1994, Analysis of monoclonal antibodies reactive with the porcine CD4 antigen. Vet Immunol Immunopathol 43:233-236.
34. Pogranichnyy RM, Yoon KJ, Harms PA, et al.: 2000, Characterization of immune response of young pigs to porcine circovirus type 2 infection. Viral Immunol 13:143-153.
35. Rosell C, Segales J, Plana-Duran J, et al.: 1999, Pathological, immunohistochemical, and in-situ hybridization studies of natural cases of postweaning multisystemic wasting syndrome (PMWS) in pigs. J Comp Pathol 120:59-78.
36. Rovira A, Balasch M, Segales J, et al.: 2002, Experimental inoculation of conventional pigs with porcine reproductive and respiratory syndrome virus and porcine circovirus 2. J Virol 76:3232-3239.
37. Saalmuller A, Hirt W, Reddehase MJ: 1989, Phenotypic discrimination between thymic and extrathymic CD4-CD8- and CD4+CD8+ porcine T lymphocytes. Eur J Immunol 19:2011-2016.
38. Sanchez RE, Meerts P, Nauwynck H, Pensaert M: 2003, Change of porcine circovirus 2 target cells during development in pigs from fetal to early postnatal life. Vet Microbiol 95:15-25.
39. Sanchez RE, Nauwynck H, McNeilly F, et al.: 2001, Porcine circovirus 2 infection in swine foetuses inoculated at different stages of gestation. Vet Microbiol 83:169-176.
40. Segales J, Domingo M: 2002, Postweaning multisystemic wasting syndrome (PMWS) in pigs. A review. Vet Q 24:109-124.
41. Shibahara T, Sato K, Ishikawa Y, Kadota K: 2000, Porcine circovirus induces B lymphocyte depletion in pigs with wasting disease syndrome. J Vet Med Sci 62:1125-1131.
42. Summerfield A, Rziha HJ, Saalmuller A: 1996, Functional characterization of porcine CD4+CD8+ extrathymic T lymphocytes. Cell Immunol 168:291-296.
43. Terai C, Wasson D, Carrera C, Carson D: 1991, Dependence of cell survival on DNA repair in human mononuclear phagocytes. J Immunol 147:4302-4306.
44. Tischer I, Peters D, Rasch R, Pociuli S: 1987, Replication of porcine circovirus: induction by glucosamine and cell cycle dependence. Arch Virol 96:39-57.
45. Vanderheijden N, Delputte P, Favoreel H, et al.: 2003, Involvement of sialoadhesin in the entry of porcine reproductive and respiratory syndrome virus into porcine alveolar macrophages. J Virol 77:8207-8215.
46. Van Zaane D, Hulst M: 1987, Monoclonal antibodies against porcine immunoglobulin isotypes. Vet Immunol Immunopathol 16:23-36.
47. West H, Bystrom JM, Wojnarowicz C, et al.: 1999, Myocarditis and abortion associated with intrauterine infection of sows with porcine circovirus 2. J Vet Diagn Invest 11:530-532.
48. Zuckermann FA, Pescovitz MD, Aasted B, et al.: 1998, Report on the analyses of MAb reactive with porcine CD8 for the second international swine CD workshop. Vet Immunol Immunopathol 60:291-303.