Substitutions in an Active Site Loop of Escherichia coli IscS Result in Specific Defects in Fe-S Cluster and Thionucleoside Biosynthesis in Vivo

Journal of Biological Chemistry

Volumn 279, Issue 19, 2004, Pages 19551-19558

  Lauhon, Charles T ^a   Skovran, Elizabeth ^a   Urbina, Hugo D ^b   Downs, Diana M ^a   Vickery, Larry E ^b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOSYNTHESIS; ENZYMES; ESCHERICHIA COLI; MUTAGENESIS; RNA; SULFUR;

MUTANT PROTEINS; MUTANT STRAINS;

BIOCHEMISTRY;

ALANINE; BACTERIAL PROTEIN; CYSTATHIONINE GAMMA LYASE; CYSTEINE; CYSTEINE PERSULFIDE; FERROUS ION; NUCLEOSIDE; PROTEIN ISCS; SULFIDE; SULFUR; TRANSFER RNA; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BACTERIAL STRAIN; CATALYSIS; CONTROLLED STUDY; DESULFURIZATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ESCHERICHIA COLI; IN VIVO STUDY; MUTATION; NONHUMAN; OPERON; PRIORITY JOURNAL;

ALANINE; AMINO ACID SEQUENCE; BINDING SITES; BLOTTING, WESTERN; CARBON-SULFUR LYASES; CELL DIVISION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYSTEINE; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HYDRO-LYASES; IRON-SULFUR PROTEINS; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; MUTATION; PHENOTYPE; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RNA, TRANSFER; SUBCELLULAR FRACTIONS; SUCCINATE DEHYDROGENASE; THIONUCLEOTIDES;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA;

EID: 2442538132     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M401261200     Document Type: Article

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