Analysis of gene network regulating yeast multidrug resistance by artificial activation of transcription factors: Involvement of Pdr3 in salt tolerance

Gene

Volumn 332, Issue 1-2, 2004, Pages 51-59

  Onda, Miyuki ^a,b   Ota, Kazuhisa ^a,c   Chiba, Tomoko ^a   Sakaki, Yoshiyuki ^b,d   Ito, Takashi ^a,b,c  

^a KANAZAWA UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d RIKEN YOKOHAMA INSTITUTE   (Japan)

Author keywords

DNA microarray; gene ontology; GO; open reading frame; ORF; PCR; Pdr1; Pdr1 response element; PDRE; Pleiotropic drug resistance; polymerase chain reaction; Transcriptome; Yrr1

Indexed keywords

GENE PRODUCT; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PDR1; TRANSCRIPTION FACTOR PDR3; TRANSCRIPTION FACTOR YRR1; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; GENE CONTROL; GENE FUNCTION; GENE INDUCTION; GENE TARGETING; GENETIC ANALYSIS; MULTIDRUG RESISTANCE; NONHUMAN; PHYLOGENY; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; SALT TOLERANCE; TRANSACTIVATION; TRANSCRIPTION INITIATION; YEAST;

ATP-BINDING CASSETTE TRANSPORTERS; CALCIUM; DNA-BINDING PROTEINS; DRUG RESISTANCE, MULTIPLE, FUNGAL; GENE EXPRESSION REGULATION, FUNGAL; MUTATION; PHYLOGENY; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SODIUM; SODIUM CHLORIDE; TIME FACTORS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSFORMATION, GENETIC;

EID: 2442495304     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gene.2004.02.003     Document Type: Article

References (22)

1. Aburatani S., et al. Discovery of novel transcription control relationships with gene regulatory networks generated from multiple-disruption full genome expression libraries. DNA Res. 10:2003;1-8
2. Balzi E., Goffeau A. Yeast multidrug resistance: the PDR network. J. Bioenerg. Biomembranes. 27:1995;71-76
3. Carey M., Kakidani H., Leatherwood J., Mostashari F., Ptashne M. An amino-terminal fragment of GAL4 binds DNA as a dimer. J. Mol. Biol. 209:1989;4223-4232
4. Carvajal E., van den Hazel H.B., Cybularz-Kolaczkowska A., Balzi E., Goffeau A. Molecular and phenotypic characterization of yeast PDR1 mutants that show hyperactive transcription of various ABC multidrug transporter genes. Mol. Gen. Genet. 256:1997;406-441
5. Cui Z., Shiraki T., Hirata D., Miyakawa T. Yeast gene YRR1, which is required for resistance to 4-nitroquinoline N-oxide, mediates transcriptional activation of the multidrug resistance transporter gene SNQ2. Mol. Microbiol. 29:1998;1307-1315
6. Delaveau T., Delahodde A., Carvajal E., Subik J., Jacq C. PDR3, a new yeast regulatory gene, is homologous to PDR1 and controls the multidrug resistance phenomenon. Mol. Gen. Genet. 244:1994;501-511
7. DeRisi J., van der Henzel B., Marc P., Balzi E., Brown P., Jacq C., Goffeau A. Genome microarray analysis of transcriptional activation in multidrug resistance yeast mutants. FEBS Lett. 470:2000;156-160
8. Devaux F., Marc P., Bouchoux C., Delaveau T., Hikkel I., Potier M.-C., Jacq C. An artificial transcription activator mimics the genome-wide properties of the yeast Pdr1 transcription factor. EMBO Rep. 2:2001;493-498
9. Devaux F., Carvajal E., Moye-Rowley S., Jacq C. Genome-wide studies on the nuclear PDR3-controlled response to mitochondrial dysfunction in yeast. FEBS Lett. 515:2002;25-28
10. Giaever G., et al. Functional profiling of the Saccharomyces cerevisiae genome. Nature. 418:2002;387-391
11. Hikkel I., Lucau-Danila A., Delaveau T., Marc P., Devaux F., Jacq C. A general strategy to uncover transcription factor properties identifies a new regulator of drug resistance in yeast. J. Biol. Chem. 278:2003;11427-11432
12. Ito T., Tashiro K., Muta S., Ozawa R., Chiba T., Nishizawa M., Yamamoto K., Kuhara S., Sakaki Y. Toward a protein-protein interaction map of the budding yeast: a comprehensive system to examine two-hybrid interactions in all possible combinations between the yeast proteins. Proc. Natl. Acad. Sci. U. S. A. 97:2000;1143-1147
13. Jia Y., Rothermal B., Thornton J., Butow R.A. A basic helix-loop-helix-leucine zipper transcription complex in yeast functions in a signaling pathway from mitochondria to the nucleus. Mol. Cell. Biol. 17:1997;1110-1117
14. Keeven J., Ko D., Shallom J., Uccelini B., Golin J. PDR2 Gain-of-function mutations eliminate the need for Pdr1 and require the UBP6 product for resistance to translational inhibitors. Curr. Genet. 41:2002;11-19
15. Kubota H., Ota K., Sakaki Y., Ito T. Budding yeast GCN1 binds the GI domain to activate the eIF2alpha kinase GCN2. J. Biol. Chem. 256:2001;17591-17596
16. Le Crom S., Devaux F., Marc P., Zhang X., Moye-Rowley W.S., Jacq C. New insights into the pleiotropic drug resistance network from genome-wide characterization of the YRR1 transcription factor regulation system. Mol. Cell. Biol. 22:2002;2642-2649
17. Miura F., Yada T., Nakai K., Sakaki Y., Ito T. Differential display analysis of mutants for the transcription factor Pdr1p regulating multidrug resistance in the budding yeast. FEBS Lett. 505:2001;103-108
18. Posas F., Chambers J.R., Heyman J.A., Hoeffler J.P., deNadal E., Arino J. The transcriptional response of yeast to saline stress. J. Biol. Chem. 275:2000;17249-17255
19. Shan D., Press O.W., Tsu T.T., Hayden M.S., Ledbetter J.A. Characterization of scFv-Ig constructs generated from the anti-CD20 mAb 1F5 using linker peptides of varying lengths. J. Immunol. 162:1999;6589-6595
20. Yale J., Bohnert H.J. Transcript expression in Saccharomyces cerevisiae at high salinity. J. Biol. Chem. 276:2001;15996-16007
21. Yoshimoto H., Saltsman K., Gasch A.P., Li H.X., Ogawa N., Botstein D., Brown P.O., Cyert M.S. Genome-wide analysis of gene expression regulated by the calcineurin/Crz1p signaling pathway in Saccharomyces cerevisiae. J. Biol. Chem. 277:2002;31079-31088
22. Zhang X., Cui Z., Miyakawa T., Moye-Rowley W.S. Cross-talk between transcriptional regulators of multidrug resistance in Saccharomyces cerevisiae. J. Biol. Chem. 276:2001;8812-8819