Mycotoxins and mycotoxicosis in Tunisia: What do we know and what do we need to know?

Journal of Toxicology - Toxin Reviews

Volumn 18, Issue 3-4, 1999, Pages 245-262

  Bacha, H ^a   Maaroufi, K ^a   Ghedira Chekir, L ^a   Abid, S ^a   Cherif, A ^a   Achour, A ^b   Creppy, E E ^c  

^a UNIVERSITY OF MONASTIR   (Tunisia)

^b FATTOUMA BOURGUIBA UNIVERSITY HOSPITAL   (Tunisia)

^c UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; MYCOTOXIN; OCHRATOXIN; ZERANOL;

CONFERENCE PAPER; FOOD CONTAMINATION; HUMAN; INTERSTITIAL NEPHRITIS; LIVER FUNCTION; MYCOTOXICOSIS; NONHUMAN; REPRODUCTION; TUNISIA;

ANIMALIA; FUNGI;

EID: 0032752531     PISSN: 07313837     EISSN: None     Source Type: Journal    
DOI: 10.3109/15569549909009256     Document Type: Conference Paper

References (89)

1. Sarkisov, A., in Doklad na Komissi Posepticheskoï Angine Ychenogo Meditsins Kikh Soveta Narkonsdrawa, S.S.R., 1946.
2. Mironov, S.G., Joffe, A.Z., Bakbardina, M.K., Fok, R.A. and Davidowa, V.L., Phytopathological analysis of toxic samples of overwintered millet in alimentary toxic aleukaemia, Orenburg Inst. Epidemiol. Microbiol., 2: 11, 1947.
3. Bilai, V.I., in Izdatel'stuo Akad Nauk, p. 93, Ukrain S.S.R., 1953.
4. Uraguchi, K., Tatsumo, M., Tsukioka, M., Sakai, F., Kobayashi, Y., Saito, M., Enomoto, M. and Miyake, M., Toxicological approach to the metabolites of Pénicillium islandicum Spp growing on the yellowed rice, Jpn J. Exp. Med., 31: 1, 1961.
5. Reye, R.D.K., Morgan, G. and Baral, J., Encephalopathy and fatty degeneration of the viscera, a disease entity in childhood, Lancet, ii: 749, 1963.
6. Senti, F.R., in mycotoxins in Human and Animal Health, edited by J.V. Rodricks, C.W. Hesseltine and M.A. Mehlman, p. 779, Pathotox Publishers, Park Forest South, Illinois, 1977.
7. First International Symposium of Monastir "Pollution, Bioconversion, Toxicology" (April 19-21, 1993), Biologia de Tunisie, H. Bacha (volume 1, February 1993).
8. Colloque INSERM "Human ochratoxicosis and its pathologies" (Bordeaux, July 4-6, 1993), INSERM/John Libbey EUROTEXT, E.E. Creppy, M. Castegnaro and G. Dirheimer, (volume 231, 1993).
9. Mycotox 98 "Mycotoxins in food chain, processing and toxicological aspects" (Toulouse, July 2-4, 1998), Revue de Médecine Vétérinaire, J. Le Bars and P. Galtier (volume: June 1998).
10. Moreau, C., in Moisissures Toxiques dans l'alimentation, edited by MASSON ET Cie, p. 471, Paris, 1974.
11. Le Bars, J., Ecologie des Moisissures Toxinogènes, Cah. Nutr. Diet. (Mycotoxines), 2: 23, 1976.
12. Golumbic, C. and Kulik, M.M., in Aflatoxin, edited by L.A. Goldblatt, p. 307, Academic Press, New York, 1969.
13. Landers, K.E., Davis, N.D. and Diener, U.L., Influence of atmospheric gas on aflatoxin production by Aspergillus flavus in peanuts, Phytopathology, 57: 1086, 1967.
14. WHO, Word Heath Organisation, IPCS Environmental Health Criteria Document 11, Mycotoxins, WHO/IPCS, Geneve, 1979.
15. WHO, Word Heath Organisation, IPCS Environmental Health Criteria Document 105, Selected Mycotoxins, Ochratoxin, Trichothenes, Ergot, WHO/IPCS, Geneve, 1990.
16. Chelkowski, J., Golinski, P. and Wiewiorowska, M., Mycotoxins in cereal grain. Part 12. Contamination with ochratoxin A and penicillic acid as indicator of improper storage of cereal grain, Nhrung, 31: 81, 1987.
17. Ciegler, A., Bioproduction of ochratoxin and penicillic acid by members of the Aspergillus ochraceus group, Canad. J. Microbiol., 18: 631, 1972.
18. Hayes, A.W., Cain, J.A. and Moore, B.G., Effect of aflatoxin B1, ochratoxin A and rubratoxin B on infant rats. Foot Cosmet. Toxicol., 15: 23, 1977.
19. Huff, W.E., Kubena, L.F., Harvey, R.B., Hagler, W.M., Swanson, S.P., Phillips, T.D. and Creger, C.R., Individual and combined effects of aflatoxin and deoxynivalenol (DON, Vomitoxin) in broiler chickens, Poult. Sci., 65: 1291, 1986.
20. Huff, W.E., Kubena, L.F., Harvey, R.B. and Doerr, J.A., Mycotoxin interactions in poultry and swine, J. Animal. Sci., 66: 2351, 1988a.
21. Huff, W.E., Harvey, R.B., Kubena, L.F. and Rottinghaus, G.E., Toxic synergism between aflatoxin and T-2 toxin in broiler chickens, Poult. Sci., 67: 1418, 1988b.
22. Jelinek, C.F., Pohland, A.E. and Wood, G.E., Worldwide occurence of mycotoxins in food and feeds, an update. J. Assoc. Off. Anal. Chem., 72: 223, 1989.
23. Jonsyn, F.E., Seedborne fungi of sesame (Sesamum indicum L) in Sierra Leone and their potential aflatoxin/mycotoxin production, Mycopathologia, 104:123, 1988.
24. Krogh, P., Hald, B. and Pederson, E.J., Occurrence of ochratoxin A and citrinin in cereals associated with mycotoxic porcine nephropathy, Acta Pathol. Microbiol. Scand. B, 81:689, 1973.
25. Lillehoj, E.B. and Ciegler, A., in Microbiology, edited by D. Schlessinger, p. 344, American Society for Microbiology, Washington DC, 1975.
26. Pathre, S.V. and Mirocha, C.J., in Mycotoxins in Human and Animal Health, edited by J.V. Rodricks, C.W. Hesseltine and M.A. Mehlman, p. 229, Pathotox Publishers, Park Forest South, Illinois, 1977.
27. Scott, P.M., van Walbeek, W., Kennedy, B. and Anyeti, D., Mycotoxins (ochratoxin A, citrinin and sterigmatocystin) and toxigenic fungi in grains and other agricultural products, J. Agric. Food Chem., 20: 1103, 1972.
28. Scott, P.M., Mycotoxins in feeds and ingredients and their origin, J. Food Protect., 41: 385, 1978.
29. Soares, L.M. and Rodriguez-Amaya, D.B., Survey of aflatoxins, ochratoxin A, zearalenone and sterigmatocystin in some Brazilian foods by using multi-toxin thin-layer chromathographic method, J.A.O.A.C., 72: 22, 1989.
30. Ueno, Y., in Mycotoxins in Food, edited by P. Krogh, p. 123, Academic Press, Cambridge, 1987.
31. Watson, D.H., Toxic fungal metabolites in foods, CRC Critical Reviews in Food Science and Nutrition, 22: 177, 1985.
32. Hadidane, R., Roger-Regnault, C., Bouattour, H., Ellouz, F., Bacha, H., Creppy, E.E. and Dirheimer, G., Correlation between alimentary mycotoxin contamination and specific diseases, Hum. Toxicol., 4: 491, 1985.
33. Bacha, H., Hadidane, R., Regnault, C.R., Ellouz, F., Creppy, E.E. and Dirheimer, G., Mycotoxines et Mycotoxicoses en Tunisie, Cahiers Médicaux de Tunisie-Nutrition et santé, 49: 34, 1986.
34. Bacha, H., Hadidane, R., Creppy, E.E., Regnault, C.R., Ellouz, F. and Dirheimer, G., Monitoring and identification of fungal toxins in food products, animal feed and cereals in Tunisia, J. Stored Prod. Res., 24: 199, 1988.
35. Pier, A.C., Richard, J.L. and Cysewski, S.J., Implications of mycotoxins in animal diseases, J. Am. Vet. Med. Assoc., 176: 719, 1980.
36. Huff, W.E. and Doerr, J.A., Synergism between aflatoxin and ochratoxin A in broiler chikens, Poutl. Sci., 60: 550, 1981.
37. Blaude, M.N., Goethals, F.M., Ansay, M.A. and Roberfroid, M.B., Interaction between aflatoxin B1 and oxytetracycline in isolated rat hepatocytes, Cell Biol. Toxicol., 6: 339, 1990.
38. Blaude, M.N., Goethals, F.M., Ansay, M.A. and Roberfroid, M.B., Synergism between aflatoxin Bl and oxytetracycline on fatty acid esterification in isolated rat hepatocytes, Toxicol. Lett., 61: 159, 1992.
39. Brownie, C.F. and Brownie, C., Preliminary study on serum enzyme changes in Long Evans rats given parenteral ochratoxin A, aflatoxin B1 and their combination. Vet. Human Toxicol., 30: 211, 1988.
40. Campbell, M.L., May, J.D., Huff, W.E. and Doerr, J.A., Evaluation of immunity of young broiler chickens during simultaneous aflatoxicosis and ochratoxicosis, Poult. Sci., 62: 2138, 1983.
41. Harvey, R.B., Huff, W.E., Kubena, L.F. and Phillips, T.D., Evaluation of diets cocontaminated with aflatoxin and ochratoxin fed to growing pigs, Am. J. Vet. Res., 50: 1400, 1989.
42. Huff, W.E., Doerr, J.A., Wabeck, C.J., Chaloupka, G.W., May, J.D. and Merkley, J.W., Individual and combined effects on aflatoxin and ochratoxin A on bruising in broiler chickens, Poult. Sci., 62: 1764, 1983.
43. Micco, C., Miraglia, M., Benelli, L., Onori, R., Ioppolo, A. and Mantovani, A.L., Long term administration of low doses of mycotoxins in poultry. 2. Residues of ochratoxin A and aflatoxin in broilers and laying hens after combined administration of ochratoxin A and aflatoxin B1, Food Add. Contam., 5: 309, 1988.
44. Tapia, M.O. and Seawright, A.A., Experimental combined aflatoxin B1 and ochratoxin A intoxication in pigs, Australian Veterinary Journal, 62: 33, 1985.
45. Creppy, E.E., Lorkowski, G., Beck, G., Röschenthaler, R. and Dirheimer, G., Combined action of citrinin and ochratoxin A on hepatoma tissue culture cells, Toxicol. Lett., 5: 375, 1980.
46. Kanisawa, M., Synergistic effect of citrinin on hepatorenal carcinogenesis of ochratoxin A in mice, Devel. Food Sci., 7: 245, 1984.
47. Manning, R.O., Brown, T.P., Wyatt, R.D. and Fletcher, O.J., The individual and combined effects of citrinin and ochratoxin A in broiler chicks, Avian. Dis., 29: 986, 1985.
48. Sandor, G., Busch, A., Watzke, H., Reek, J. and Vanyi, A., Subacute toxicity testing of ochratoxin A and citrinin in swine, Acta Vet. Hung., 39: 149, 1991.
49. Kubena, L.F., Huff, W.E., Harvey, R.B., Corrier, D.E., Phillips, T.D. and Creger, C.R., Influence of ochratoxin A and deoxynivalenol on growing broiler chicks, Poult. Sci., 67: 253, 1988.
50. Kubena, L.F., Phillips, T.D., Witzel, D.A. and Heidelbaugh, N.D., Toxicity of ochratoxin A and penicillic acid to chicks, Bull. Environ. Contam. Toxicol., 32: 717, 1984.
51. Kubena, L.F., Harvey, R.B., Huff, W.E., Corrier, D.E., Phillips, T.D. and Rottinghaus, G.E., Influence of ochratoxin A and T-2 Toxin sinsly and in combination on broiler chickens, Poult. Sci., 68: 867, 1989.
52. Smith, E.E., Kubena, L.F., Braithwaite, C.E., Harvey, R.B., Phillips, T.D. and Reine, A.H., Toxicological evaluation of aflatoxin and cyclopiazonic acid in broiler chickens, Poult. Sci., 71: 1136, 1992.
53. Giroir, L.E., Huff, W.E., Kubena, L.F., Harvey, R.B., Elissalde, M.H., Witzel, D.A., Yersin, A.G. and Ivie, G.W., The individual and combined toxicity of kojic acid and aflatoxin in broiler chickens, Poult. Sci., 70: 1351, 1991.
54. Pier, A.C., Varman, M.J., Dahlgren, R.R., Belden, E.L. and Maki, L.R., in Mycotoxins and Phycotoxins, edited by P.S. Steyn and R. Vleggaar, p. 423, Elsevier Science Publishers, Amsterdam, 1986.
55. Harvey, R.B., Kubena, L.F., Huff, W.E., Corrier, D.E., Rottinghaus, G.E. and Phillips, T.D., Effects of treatment of growing swine with aflatoxin and T-2 toxin, Am. J. Vet. Res., 51: 1688, 1990.
56. Wogan, G.N., Edwards, G.S. and Newberne, P.M., Acute and chronic toxicology of rubratoxin B, Toxicol. Appl. Pharmacol., 19: 712, 1971.
57. Boutrif, E., Jemmali, M., Campbell, A.D. and Pohland, A.E., Aflatoxin in Tunisian food and foodstuffs, Ann. Nutr. Alim., 31: 431, 1977.
58. Hadidane, R., Bacha, H., Creppy, E.E., Hammami, M., Ellouz, F. and Dirheimer, G., Isolation and structure determination of natural analogues of the mycotoxin ochratoxin A produced by Aspergillus Ochraceus, Toxicology, 76: 233, 1992.
59. Krogh, P., Hald, B., Plestina, R. and Ceovic, S., Balkan Endemic Nephropathy and foodborn ochratoxin A: preliminary results of survey of foodstuffs, Acta Pathol. Microbiol. Scand., Sect. B, 85: 238, 1977.
60. Krogh, P., Elling, F., Friss, C.H.R., Hald, B., Larsen, A.E., Lillehoj, E.B., Madsen, A., Mortensen, H.P., Rasmussen, F. and Ravoskov, V.. Porcine nephropathy induced by long term ingestion of ochratoxin A, Vet. Pathol., 16: 466, 1979.
61. Castegnaro, M. and Chernozemsky, I.N., Endemic nephropathy and urinary tract tumors in the Balkans, Cancer Res., 47: 3608, 1987.
62. Bacha, H., Maaroufi, K., Achour, A., Hammami, M., Ellouz, F. and Creppy, E.E, in Human ochratoxicosis and its pathologies, edited by E.E. Creppy, M. Castegnaro and G. Dirheimer, p. 111, INSERM/John Libbey EUROTEXT, 1993.
63. Maaroufi, K., Achour, A., Hammami, M., El May, M., Betbeder, A.M., Ellouz, F., Creppy, E.E. and Bacha, H., Ochratoxins in human blood and nephropathy in Tunisia, Human Exp. Toxicol., 14: 609, 1995.
64. Maaroufi, K., Achour, A., Zakhama, A., Ellouz, F., EL May, M., Creppy, E.E. and Bacha, H., Human nephropathy related to ochratoxin A in Tunisia, J. Toxicol.-Toxin Reviews, 15 (3): 223, 1996.
65. Chernozemsky, I.N., Stoyanov, I.S., Petkova-Bocharova, T.K., Nocolov, I.G., Draganov, I.G., Stoichev, I., Tanchev, Y., Naidenov, D. and Kalcheva, N.D., Geographic correlation between the occurence of endemic nephropathy and urinary tract tumours in Vratza district, Bulgaria, J. Cancer., 19: 1, 1977.
66. Maaroufi, K., Achour, A., Betbeder, A.M., Hammami, M., Ellouz, F., Creppy. E.E. and Bacha, H., Foodstuffs and human blood contamination by the mycotoxin ochratoxin A: correlation with chronic interstitial nephropathy in Tunisia, Archives of Toxicology, 69: 552, 1995.
67. Hagelberg, S., Hult, K. and Fuchs, R., Toxicokinetics of Ochratoxin A in several species and its plasma-binding properties, J. Appl. Toxicol., 9: 91, 1989.
68. Klaassen C.D., in: The basic science of poisons, Casarett and Doull's Toxicology, edited by C.D. Klaassen and J. Doull, p. 33, New-York, MacMillan, 1986.
69. Maaroufi, K., Pfohl-Leszkowicz, A., Achour, A., El May, M., Grosse, Y., Hammami, M., Ellouz, F., Creppy, E.E. and Bacha, H., Génotoxicité de l'ochratoxine A, relation avec la tumeur rénale, Archs. Inst. Pasteur Tunis, 71: 21, 1994.
70. Godin, M., Rancois, A., Le Roy, F., Morin, J.P., Creppy, E.E., Hemet, J. and Fillastre, J.P., Karyomegalic interstitial nephritis, American Journal of Kidney Diseases, 27: 166, 1996.
71. Maaroufi, K., Abid, S., Cherif, A., Zakhama, A., Achour, A., Creppy, E.E. and Bacha, H., Human ochratoxicosis in Tunisia, Molecular aspects, Journal of Toxicology-Toxin Reviews, 1999 (this volume).
72. Bennet, G.A. and Shotwell, O.L., Zearalenone in cereal grains, J. Amer. Oil Chem. Soc., 56: 812, 1979.
73. Sutton, J.C., Balik, W. and Funnett, H.S., Relation of weather variables to incidence of zearalenone in corn in Southern Ontario, Can. J. Plant. Sci., 60: 149, 1980.
74. Trenholm, H.L., Thompson, B.K., Standish, J.F. and Seamen, W.L., in Mycotoxins: A Canadian Perspective, edited by P.M. Scott, H.L. Tranholm and M.D. Sutton, p. 43, National Research Council of Canada, Ottawa, Ontario, 22848, 1985.
75. Kim, J.C., Kang, H.J., Lee, D.H., Lee, Y.W. and Yoshizawa, T., Natural occurence of Fusarium mycotoxins (trichothecenes and zearalenone) in barley and corn in Korea, Appl. Environ. Microbiol., 59: 3798, 1993.
76. Yuwai, K.E., Rao, K.L., Singh, K., Tanaka, T. and Ueno, Y., Occurence of nivalenol, deoxynivalenol and zearalenone in imported cereals in Papua, New Guinea, Natural Toxins, 2: 19, 1994.
77. Etienne, M. and Jemmali, M., Effects of zearalenone (F2) on estrus activity and reproduction in gilts, J. Anim. Sci., 55: 1, 1982.
78. Bacha, H., Chekir, L., Ellouz, F. and Creppy, E.E., in Proceeding of a UK workshop held at Brunel, the University of West London, edited by K.A. Scudamore, p. 258, London, 1994.
79. Maaroufi, K., Chekir, L., Creppy, E.E., Ellouz, F. and Bacha, H., Zearalenone induces modifications of haematological and biochemical parameters in rats, Toxicon, 34: 535, 1996.
80. Ueno, Y. and Kubota, K., DNA-attacking ability of carcinogenic mycotoxins in recombination-deficient mutant cells of Bacillus subtilis, Cancer Res., 36: 445, 1976.
81. Pfohl-Leszkowicz, A., Chekir-Ghedira, L. and Bacha, H., Genotoxicity of zearalenone, an oestrogenic mycotoxin: DNA adduct formation in female mouse tissues, Carcinogenesis, 16: 2315, 1995.
82. Pfohl-Leszkowicz, A., Grosse, Y., Kane, A., Gharbi, A., Baudrimont, I., Obrecht, S., Creppy, E.E. and Dirheimer, G., in Human ochratoxicosis and its pathologies, edited by E.E. Creppy, M. Castegnaro and G. Dirheimer, p. 177, INSERM/John Libbey EUROTEXT, 1993.
83. Grosse, Y., Chekir-Ghedira, L., Hue, A., Obrecht-Pflumio, S., Dirheimer, G., Bacha, H. and Pfohl-Leszkowicz, A., Retinol, ascorbic acid and a-tocopherol prevent DNA adduct formation in mice treated with the mycotoxins ochratoxin A and zearalenone, Cancer Letters, 114: 225, 1997.
84. Miller, E.C. and Miller, J.A., Searches for ultimate chemical carcinogens and their reactions with cellular macromolecules, Cancer, 47: 2327, 1981.
85. Beland, F.A. and Kadhiban, F.F., Formation and persistence of arylamine DNA-adducts in vivo, Environ. Health Perspect., 62: 19, 1985.
86. Poirier, M.C. and Beland, F.A., DNA adducts measurements and tumor incidence during chronic carcinogen exposure in animal models: implications for DNA adduct-based human cancer risk assessment, Chem. Res. Toxicol., 5: 749, 1992.
87. Ghedira-Chekir, L., Maaroufi, K., Creppy, E.E. and Bacha, H., Cytotoxic and genotoxic effects of zearalenone: prevention by vitamin E, Journal of Toxicology-Toxin reviews, 1999 (this volume).
88. Ghedira-Chekir, L., Maaroufi, K., Zakhama, A., Ellouz, F., Dhouib, S., Creppy, E.E. and Bacha, H., Induction of a SOS repair system in lysogenic bacteria by zearalenone and its prevention by vitamin E, Chemico-Biol. Int., 113: 15, 1998.
89. Baudrimont, I., Variation de la néphrotoxicité de l'ochratoxine A sous l'effet de facteurs métaboliques et non métaboliques, PhD Thesis (N°2), Bordeaux 2 University, France, 1995.