Probing the Active Site Loop Motif of Murine Ferrochelatase by Random Mutagenesis

Journal of Biological Chemistry

Volumn 279, Issue 19, 2004, Pages 19977-19986

  Shi, Zhen ^a   Ferreira, Gloria C ^a,b  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; ENZYMES; ESCHERICHIA COLI; GENETIC ENGINEERING; IRON; MOLECULAR DYNAMICS; MUTAGENESIS; PLASTICITY; PORPHYRINS; REACTION KINETICS; STRUCTURAL ANALYSIS;

MUTANTS; SPATIAL POSITIONING;

BIOCHEMISTRY;

FERROCHELATASE; FERROUS ION; GLUTAMINE; GLYCINE; LEUCINE; PORPHYRIN; PROLINE; PROTOPORPHYRIN; TRYPTOPHAN; VALINE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BACTERIAL STRAIN; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; ESCHERICHIA COLI; HEME SYNTHESIS; MOLECULAR DYNAMICS; MOLECULAR MODEL; MOUSE; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL MEMBRANE; CONSERVED SEQUENCE; ESCHERICHIA COLI; FERROCHELATASE; GENE LIBRARY; GENETIC COMPLEMENTATION TEST; GENETIC VECTORS; KINETICS; LIPIDS; LIPOSOMES; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTATION; PLASMIDS; PORPHYRINS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTOPORPHYRINS; SPECTROPHOTOMETRY; ULTRAVIOLET RAYS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; MURINAE;

EID: 2442452562     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M313821200     Document Type: Article

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