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Volumn 560, Issue 2, 2004, Pages 101-118

Apoptosis may contribute to false-positive results in the in vitro micronucleus test performed in extreme osmolality, ionic strength and pH conditions

Author keywords

Apoptosis; Bcl2; CTLL 2; Extreme culture conditions; False positive results; Micronucleus test

Indexed keywords

APOPTOSIS INHIBITOR; CLASTOGEN; FLUORESCEIN ISOTHIOCYANATE; INTERLEUKIN 2; LIPOCORTIN 5; PROTEIN BCL 2;

EID: 2442447465     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2004.02.003     Document Type: Article
Times cited : (22)

References (56)
  • 1
    • 0030805031 scopus 로고    scopus 로고
    • The in vitro micronucleus test: A multi-endpoint assay to detect simultaneously mitotic delay, apoptosis, chromosome breakage, chromosome loss and non-disjunction
    • Kirsch-Volders M., Elhajouji A., Cundari E., Van Hummelen P. The in vitro micronucleus test: a multi-endpoint assay to detect simultaneously mitotic delay, apoptosis, chromosome breakage, chromosome loss and non-disjunction. Mutat. Res. 392:1997;19-30
    • (1997) Mutat. Res. , vol.392 , pp. 19-30
    • Kirsch-Volders, M.1    Elhajouji, A.2    Cundari, E.3    Van Hummelen, P.4
  • 2
  • 3
    • 0030982652 scopus 로고    scopus 로고
    • Appearance of 1-2 Mbp giant DNA fragments as an early common response leading to cell death induced by various substances that cause oxidative stress
    • Higuchi Y., Matsukawa S. Appearance of 1-2 Mbp giant DNA fragments as an early common response leading to cell death induced by various substances that cause oxidative stress. Free Radic. Biol. Med. 23:1997;90-99
    • (1997) Free Radic. Biol. Med. , vol.23 , pp. 90-99
    • Higuchi, Y.1    Matsukawa, S.2
  • 5
    • 0027276494 scopus 로고
    • The protein kinase inhibitor staurosporine induces morphological changes typical of apoptosis in MOLT-4 cells without concomitant DNA fragmentation
    • Falcieri E., Martelli A.M., Bareggi R., Cataldi A., Cocco L. The protein kinase inhibitor staurosporine induces morphological changes typical of apoptosis in MOLT-4 cells without concomitant DNA fragmentation. Biochem. Biophys. Res. Commun. 193:1993;19-25
    • (1993) Biochem. Biophys. Res. Commun. , vol.193 , pp. 19-25
    • Falcieri, E.1    Martelli, A.M.2    Bareggi, R.3    Cataldi, A.4    Cocco, L.5
  • 6
    • 0027217084 scopus 로고
    • Apoptotic death in epithelial cells: Cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation
    • Oberhammer F., Wilson J.W., Dive C., Morris I.D., Hickman J.A., Wakeling A.E., Walker P.R., Sikorska M. Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation. Embo J. 12:1993;3679-3684
    • (1993) Embo J. , vol.12 , pp. 3679-3684
    • Oberhammer, F.1    Wilson, J.W.2    Dive, C.3    Morris, I.D.4    Hickman, J.A.5    Wakeling, A.E.6    Walker, P.R.7    Sikorska, M.8
  • 7
    • 0026508561 scopus 로고
    • Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages
    • Fadok V.A., Voelker D.R., Campbell P.A., Cohen J.J., Bratton D.L., Henson P.M. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J. Immunol. 148:1992;2207-2216
    • (1992) J. Immunol. , vol.148 , pp. 2207-2216
    • Fadok, V.A.1    Voelker, D.R.2    Campbell, P.A.3    Cohen, J.J.4    Bratton, D.L.5    Henson, P.M.6
  • 8
    • 0028820202 scopus 로고
    • Mechanisms of phosphatidylserine exposure, a phagocyte recognition signal, on apoptotic T lymphocytes
    • Verhoven B., Schlegel R.A., Williamson P. Mechanisms of phosphatidylserine exposure, a phagocyte recognition signal, on apoptotic T lymphocytes. J. Exp. Med. 182:1995;1597-1601
    • (1995) J. Exp. Med. , vol.182 , pp. 1597-1601
    • Verhoven, B.1    Schlegel, R.A.2    Williamson, P.3
  • 9
    • 45949118213 scopus 로고
    • Effects of high osmotic strength on chromosome aberrations, sister-chromatid exchanges and DNA strand breaks, and the relation to toxicity
    • Galloway S.M., Deasy D.A., Bean C.L., Kraynak A.R., Armstrong M.J., Bradley M.O. Effects of high osmotic strength on chromosome aberrations, sister-chromatid exchanges and DNA strand breaks, and the relation to toxicity. Mutat. Res. 189:1987;15-25
    • (1987) Mutat. Res. , vol.189 , pp. 15-25
    • Galloway, S.M.1    Deasy, D.A.2    Bean, C.L.3    Kraynak, A.R.4    Armstrong, M.J.5    Bradley, M.O.6
  • 10
    • 45949118273 scopus 로고
    • Implications of treatment-condition-induced genotoxicity for chemical screening and data interpretation
    • Brusick D.J. Implications of treatment-condition-induced genotoxicity for chemical screening and data interpretation. Mutat. Res. 189:1987;1-6
    • (1987) Mutat. Res. , vol.189 , pp. 1-6
    • Brusick, D.J.1
  • 11
    • 0024545881 scopus 로고
    • Effects of pH in the in vitro chromosomal aberration test
    • Morita T., Watanabe Y., Takeda K., Okumura K. Effects of pH in the in vitro chromosomal aberration test. Mutat. Res. 225:1989;55-60
    • (1989) Mutat. Res. , vol.225 , pp. 55-60
    • Morita, T.1    Watanabe, Y.2    Takeda, K.3    Okumura, K.4
  • 12
    • 0026062312 scopus 로고
    • International Commission for Protection Against Environmental Mutagens and Carcinogens. Genotoxicity under extreme culture conditions. A report from ICPEMC Task Group 9
    • Scott D., Galloway S.M., Marshall R.R., Ishidate M. Jr., Brusick D., Ashby J., Myhr B.C. International Commission for Protection Against Environmental Mutagens and Carcinogens. Genotoxicity under extreme culture conditions. A report from ICPEMC Task Group 9. Mutat. Res. 257:1991;147-205
    • (1991) Mutat. Res. , vol.257 , pp. 147-205
    • Scott, D.1    Galloway, S.M.2    Marshall, R.R.3    Ishidate Jr., M.4    Brusick, D.5    Ashby, J.6    Myhr, B.C.7
  • 13
    • 0034744170 scopus 로고    scopus 로고
    • Apoptosis can be a confusing factor in in vitro clastogenic assays
    • Meintières S., Biola A., Pallardy M., Marzin D. Apoptosis can be a confusing factor in in vitro clastogenic assays. Mutagenesis. 16:2001;243-250
    • (2001) Mutagenesis , vol.16 , pp. 243-250
    • Meintières, S.1    Biola, A.2    Pallardy, M.3    Marzin, D.4
  • 14
    • 0037261354 scopus 로고    scopus 로고
    • Using CTLL-2 and CTLL-2 Bcl2 cells to avoid interference by apoptosis in the in vitro micronucleus test
    • S. Meintières, A. Biola, M. Pallardy, D. Marzin, Using CTLL-2 and CTLL-2 Bcl2 cells to avoid interference by apoptosis in the in vitro micronucleus test, Environ. Mol. Mutagen 41 (2003) 14-27.
    • (2003) Environ. Mol. Mutagen , vol.41 , pp. 14-27
    • Meintières, S.1    Biola, A.2    Pallardy, M.3    Marzin, D.4
  • 15
    • 0022996750 scopus 로고
    • IL-2 addiction: Withdrawal of growth factor activates a suicide program in dependent T cells
    • Duke R.C., Cohen J.J. IL-2 addiction: withdrawal of growth factor activates a suicide program in dependent T cells. Lymphokine Res. 5:1986;289-299
    • (1986) Lymphokine Res. , vol.5 , pp. 289-299
    • Duke, R.C.1    Cohen, J.J.2
  • 16
    • 0027537118 scopus 로고
    • Suppression of apoptosis in a cytotoxic T-cell line by interleukin 2-mediated gene transcription and deregulated expression of the protooncogene bcl-2
    • Deng G., Podack E.R. Suppression of apoptosis in a cytotoxic T-cell line by interleukin 2-mediated gene transcription and deregulated expression of the protooncogene bcl-2. Proc. Natl. Acad. Sci. U.S.A. 90:1993;2189-2193
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 2189-2193
    • Deng, G.1    Podack, E.R.2
  • 17
    • 0028813378 scopus 로고
    • Apoptosis in an interleukin-2-dependent cytotoxic T lymphocyte cell line is associated with intracellular acidification. Role of the Na(+)/H(+)-antiport
    • Li J., Eastman A. Apoptosis in an interleukin-2-dependent cytotoxic T lymphocyte cell line is associated with intracellular acidification. Role of the Na(+)/H(+)-antiport. J. Biol. Chem. 270:1995;3203-3211
    • (1995) J. Biol. Chem. , vol.270 , pp. 3203-3211
    • Li, J.1    Eastman, A.2
  • 18
    • 0029036047 scopus 로고
    • Deoxyribonuclease induction in apoptotic cytotoxic T lymphocytes
    • Deng G., Podack E.R. Deoxyribonuclease induction in apoptotic cytotoxic T lymphocytes. Faseb J. 9:1995;665-669
    • (1995) Faseb J. , vol.9 , pp. 665-669
    • Deng, G.1    Podack, E.R.2
  • 19
    • 0025204548 scopus 로고
    • Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
    • Hockenbery D., Nunez G., Milliman C., Schreiber R.D., Korsmeyer S.J. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature. 348:1990;334-336
    • (1990) Nature , vol.348 , pp. 334-336
    • Hockenbery, D.1    Nunez, G.2    Milliman, C.3    Schreiber, R.D.4    Korsmeyer, S.J.5
  • 20
    • 0030757751 scopus 로고    scopus 로고
    • Morphological and biochemical characterization and analysis of apoptosis
    • Allen R.T., Hunter W.J., Agrawal D.K. III Morphological and biochemical characterization and analysis of apoptosis. J. Pharmacol. Toxicol. Meth. 37:1997;215-228
    • (1997) J. Pharmacol. Toxicol. Meth. , vol.37 , pp. 215-228
    • Allen, R.T.1    Hunter, W.J.2    Agrawal III, D.K.3
  • 21
    • 0028180560 scopus 로고
    • In vitro and in vivo genotoxicity evaluation of hormonal drugs. II. Dexamethasone
    • Singh H., Singh J.R., Dhillon V.S., Bali D., Paul H. In vitro and in vivo genotoxicity evaluation of hormonal drugs. II. Dexamethasone. Mutat. Res. 308:1994;89-97
    • (1994) Mutat. Res. , vol.308 , pp. 89-97
    • Singh, H.1    Singh, J.R.2    Dhillon, V.S.3    Bali, D.4    Paul, H.5
  • 22
    • 0028863401 scopus 로고
    • Evaluation of the micronucleus test in vitro using Chinese hamster cells: Results of four chemicals weakly positive in the in vivo micronucleus test
    • Miller B.M., Pujadas E., Gocke E. Evaluation of the micronucleus test in vitro using Chinese hamster cells: results of four chemicals weakly positive in the in vivo micronucleus test. Environ. Mol. Mutagen. 26:1995;240-247
    • (1995) Environ. Mol. Mutagen , vol.26 , pp. 240-247
    • Miller, B.M.1    Pujadas, E.2    Gocke, E.3
  • 23
    • 0034693730 scopus 로고    scopus 로고
    • The in vitro micronucleus technique
    • Fenech M. The in vitro micronucleus technique. Mutat. Res. 455:2000;81-95
    • (2000) Mutat. Res. , vol.455 , pp. 81-95
    • Fenech, M.1
  • 24
    • 0026445710 scopus 로고
    • Evaluation of the micronucleus test using a Chinese hamster cell line as an alternative to the conventional in vitro chromosomal aberration test
    • Matsuoka A., Yamazaki N., Suzuki T., Hayashi M., Sofuni T. Evaluation of the micronucleus test using a Chinese hamster cell line as an alternative to the conventional in vitro chromosomal aberration test. Mutat. Res. 272:1992;223-236
    • (1992) Mutat. Res. , vol.272 , pp. 223-236
    • Matsuoka, A.1    Yamazaki, N.2    Suzuki, T.3    Hayashi, M.4    Sofuni, T.5
  • 28
    • 0026623304 scopus 로고
    • Clastogenicity of low pH to various cultured mammalian cells
    • Morita T., Nagaki T., Fukuda I., Okumura K. Clastogenicity of low pH to various cultured mammalian cells. Mutat. Res. 268:1992;297-305
    • (1992) Mutat. Res. , vol.268 , pp. 297-305
    • Morita, T.1    Nagaki, T.2    Fukuda, I.3    Okumura, K.4
  • 29
    • 0023010822 scopus 로고
    • Genotoxic effects in cultured mammalian cells produced by low pH treatment conditions and increased ion concentrations
    • Brusick D. Genotoxic effects in cultured mammalian cells produced by low pH treatment conditions and increased ion concentrations. Environ. Mutagen. 8:1986;879-886
    • (1986) Environ. Mutagen , vol.8 , pp. 879-886
    • Brusick, D.1
  • 30
    • 0022885846 scopus 로고
    • Clastogenicity in vitro of the Na, K, Ca and Mg salts of saccharin and of magnesium chloride; Consideration of significance
    • Ashby J., Ishidate M. Jr. Clastogenicity in vitro of the Na, K, Ca and Mg salts of saccharin and of magnesium chloride; consideration of significance. Mutat. Res. 163:1986;63-73
    • (1986) Mutat. Res. , vol.163 , pp. 63-73
    • Ashby, J.1    Ishidate Jr., M.2
  • 31
    • 0030892234 scopus 로고    scopus 로고
    • Apoptosis by death factor
    • Nagata S. Apoptosis by death factor. Cell. 88:1997;355-365
    • (1997) Cell , vol.88 , pp. 355-365
    • Nagata, S.1
  • 32
    • 0032575705 scopus 로고    scopus 로고
    • A matter of life and cell death
    • Evan G., Littlewood T. A matter of life and cell death. Science. 281:1998;1317-1322
    • (1998) Science , vol.281 , pp. 1317-1322
    • Evan, G.1    Littlewood, T.2
  • 33
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • Green D.R., Reed J.C. Mitochondria and apoptosis. Science. 281:1998;1309-1312
    • (1998) Science , vol.281 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 34
    • 0032575714 scopus 로고    scopus 로고
    • Death receptors: Signaling and modulation
    • Ashkenazi A., Dixit V.M. Death receptors: signaling and modulation. Science. 281:1998;1305-1308
    • (1998) Science , vol.281 , pp. 1305-1308
    • Ashkenazi, A.1    Dixit, V.M.2
  • 35
    • 0033957359 scopus 로고    scopus 로고
    • Morphologic and biochemical hallmarks of apoptosis
    • Saraste A., Pulkki K. Morphologic and biochemical hallmarks of apoptosis. Cardiovasc. Res. 45:2000;528-537
    • (2000) Cardiovasc. Res. , vol.45 , pp. 528-537
    • Saraste, A.1    Pulkki, K.2
  • 38
    • 0023897099 scopus 로고
    • High-dose-level effects in mutagenicity assays utilizing mammalian cells in culture
    • Seeberg A.H., Mosesso P., Forster R. High-dose-level effects in mutagenicity assays utilizing mammalian cells in culture. Mutagenesis. 3:1988;213-218
    • (1988) Mutagenesis , vol.3 , pp. 213-218
    • Seeberg, A.H.1    Mosesso, P.2    Forster, R.3
  • 39
    • 0019493303 scopus 로고
    • Transformation parameters induced in chick cells by incubation in media of altered NaCl concentration
    • Garry R.F., Moyer M.P., Bishop J.M., Moyer R.C., Waite M.R. Transformation parameters induced in chick cells by incubation in media of altered NaCl concentration. Virology. 111:1981;427-439
    • (1981) Virology , vol.111 , pp. 427-439
    • Garry, R.F.1    Moyer, M.P.2    Bishop, J.M.3    Moyer, R.C.4    Waite, M.R.5
  • 40
    • 0021680539 scopus 로고
    • Solute concentration effects on the expression of cellular heterogeneity of anchorage-independent growth among spontaneously transformed BALB/c3T3 cells
    • Rubin H., Chu B.M. Solute concentration effects on the expression of cellular heterogeneity of anchorage-independent growth among spontaneously transformed BALB/c3T3 cells. In Vitro. 20:1984;585-596
    • (1984) In Vitro , vol.20 , pp. 585-596
    • Rubin, H.1    Chu, B.M.2
  • 41
    • 0020659374 scopus 로고
    • Endoreduplication in Chinese hamster cells during alpha-radiation induced G2 arrest
    • Lucke-Huhle C. Endoreduplication in Chinese hamster cells during alpha-radiation induced G2 arrest. Mutat. Res. 119:1983;407-413
    • (1983) Mutat. Res. , vol.119 , pp. 407-413
    • Lucke-Huhle, C.1
  • 44
    • 0033988721 scopus 로고    scopus 로고
    • Hypoosmolarity influences the activity of transcription factor NF-kappaB in rat H4IIE hepatoma cells
    • Michalke M., Cariers A., Schliess F., Aussinger D.H. Hypoosmolarity influences the activity of transcription factor NF-kappaB in rat H4IIE hepatoma cells. FEBS Lett. 465:2000;64-68
    • (2000) FEBS Lett. , vol.465 , pp. 64-68
    • Michalke, M.1    Cariers, A.2    Schliess, F.3    Aussinger, D.H.4
  • 45
    • 0030747128 scopus 로고    scopus 로고
    • NF-kappa B as a frequent target for immunosuppressive and anti-inflammatory molecules
    • Baeuerle P.A., Baichwal V.R. NF-kappa B as a frequent target for immunosuppressive and anti-inflammatory molecules. Adv. Immunol. 65:1997;111-137
    • (1997) Adv. Immunol. , vol.65 , pp. 111-137
    • Baeuerle, P.A.1    Baichwal, V.R.2
  • 46
    • 0033141406 scopus 로고    scopus 로고
    • NF-kappaB to the rescue: RELs, apoptosis and cellular transformation
    • Foo S.Y., Nolan G.P. NF-kappaB to the rescue: RELs, apoptosis and cellular transformation. Trends Genet. 15:1999;229-235
    • (1999) Trends Genet. , vol.15 , pp. 229-235
    • Foo, S.Y.1    Nolan, G.P.2
  • 47
    • 0031126554 scopus 로고    scopus 로고
    • Rel/NF-kappa B transcription factors and the control of apoptosis
    • Sonenshein G.E. Rel/NF-kappa B transcription factors and the control of apoptosis. Semin. Cancer Biol. 8:1997;113-119
    • (1997) Semin. Cancer Biol. , vol.8 , pp. 113-119
    • Sonenshein, G.E.1
  • 49
    • 0029999656 scopus 로고    scopus 로고
    • Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis
    • Grimm S., Bauer M.K., Baeuerle P.A., Schulze-Osthoff K. Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis. J. Cell Biol. 134:1996;13-23
    • (1996) J. Cell Biol. , vol.134 , pp. 13-23
    • Grimm, S.1    Bauer, M.K.2    Baeuerle, P.A.3    Schulze-Osthoff, K.4
  • 51
    • 0025019463 scopus 로고
    • Evaluation of clastogenicity of formic acid, acetic acid and lactic acid on cultured mammalian cells
    • Morita T., Takeda K., Okumura K. Evaluation of clastogenicity of formic acid, acetic acid and lactic acid on cultured mammalian cells. Mutat. Res. 240:1990;195-202
    • (1990) Mutat. Res. , vol.240 , pp. 195-202
    • Morita, T.1    Takeda, K.2    Okumura, K.3
  • 52
    • 0026028980 scopus 로고
    • Effect of pH on the activity and stability of clastogens in the in vitro chromosomal aberration test with Chinese hamster ovary K1 cells
    • Morita T., Nagaki T., Fukuda I., Okumura K. Effect of pH on the activity and stability of clastogens in the in vitro chromosomal aberration test with Chinese hamster ovary K1 cells. Mutat. Res. 262:1991;159-166
    • (1991) Mutat. Res. , vol.262 , pp. 159-166
    • Morita, T.1    Nagaki, T.2    Fukuda, I.3    Okumura, K.4
  • 53
    • 0024539856 scopus 로고
    • Utilization of rat lymphocytes for the in vitro chromosomal aberration assay
    • Sinha A.K., Gollapudi B.B., Linscombe V.A., McClintock M.L. Utilization of rat lymphocytes for the in vitro chromosomal aberration assay. Mutagenesis. 4:1989;147-153
    • (1989) Mutagenesis , vol.4 , pp. 147-153
    • Sinha, A.K.1    Gollapudi, B.B.2    Linscombe, V.A.3    McClintock, M.L.4
  • 54
    • 0025102827 scopus 로고
    • Hypotonic treatment leads to chromosomal aberrations but not to sister-chromatid exchanges in human lymphocytes
    • Kalweit S., Nowak C., Obe G. Hypotonic treatment leads to chromosomal aberrations but not to sister-chromatid exchanges in human lymphocytes. Mutat. Res. 245:1990;5-9
    • (1990) Mutat. Res. , vol.245 , pp. 5-9
    • Kalweit, S.1    Nowak, C.2    Obe, G.3
  • 55
    • 0022481384 scopus 로고
    • Intracellular pH controls growth factor-induced ribosomal protein S6 phosphorylation and protein synthesis in the G0-G1 transition of fibroblasts
    • Chambard J.C., Pouyssegur J. Intracellular pH controls growth factor-induced ribosomal protein S6 phosphorylation and protein synthesis in the G0-G1 transition of fibroblasts. Exp. Cell Res. 164:1986;282-294
    • (1986) Exp. Cell Res. , vol.164 , pp. 282-294
    • Chambard, J.C.1    Pouyssegur, J.2
  • 56
    • 0025323951 scopus 로고
    • Chromosomal aberrations in V79 hamster cells induced by hyperosmotic solutions of NaCl
    • Nowak C. Chromosomal aberrations in V79 hamster cells induced by hyperosmotic solutions of NaCl. Mutat. Res. 230:1990;227-234
    • (1990) Mutat. Res. , vol.230 , pp. 227-234
    • Nowak, C.1


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