메뉴 건너뛰기




Volumn 50, Issue 3, 2003, Pages 725-734

Inhibitors of benzamidine type influence the virulence properties of Porphyromonas gingivalis strains

Author keywords

Adhesion to KB cells; Growth inhibition; Inhibitors of benzamidine type; Phagocytosis and intracellular killing; Porphyromonas gingivalis strains

Indexed keywords

BENZAMIDINE; BENZAMIDINE DERIVATIVE; CYSTEINE PROTEINASE INHIBITOR; PENTAMIDINE; VIRULENCE FACTOR;

EID: 2442442352     PISSN: 0001527X     EISSN: None     Source Type: Journal    
DOI: 10.18388/abp.2003_3663     Document Type: Conference Paper
Times cited : (7)

References (37)
  • 1
    • 0031887213 scopus 로고    scopus 로고
    • Biochemical and functional properties of lysine-specific cysteine proteinase (Lys-gingipain) as a virulence factor of Porphyromonas gingivalis in periodontal disease
    • Abe N, Kadowaki T, Okamoto K, Nakayama K, Ohishi M, Yamamoto K. (1998) Biochemical and functional properties of lysine-specific cysteine proteinase (Lys-gingipain) as a virulence factor of Porphyromonas gingivalis in periodontal disease. J Biochem.; 123: 305-12.
    • (1998) J Biochem , vol.123 , pp. 305-312
    • Abe, N.1    Kadowaki, T.2    Okamoto, K.3    Nakayama, K.4    Ohishi, M.5    Yamamoto, K.6
  • 2
    • 0032036421 scopus 로고    scopus 로고
    • Maturation of the arginine-specific proteases of Porphyromonas gingivalis W 50 is dependent on a functional prR2-gene
    • Aduse-Opoku J, Rangarajan M, Young KA, Curtis MA. (1998) Maturation of the arginine-specific proteases of Porphyromonas gingivalis W 50 is dependent on a functional prR2-gene. Infect Immun.; 66: 1594-600.
    • (1998) Infect Immun , vol.66 , pp. 1594-1600
    • Aduse-Opoku, J.1    Rangarajan, M.2    Young, K.A.3    Curtis, M.A.4
  • 3
    • 0035061098 scopus 로고    scopus 로고
    • Porphyromonas gingivalis gingipains and adhesion to epithelial cells
    • Chen T, Nakayama K, Belliveau L, Duncan MJ. (2001) Porphyromonas gingivalis gingipains and adhesion to epithelial cells. Infect Immun.; 69: 3048-56.
    • (2001) Infect Immun , vol.69 , pp. 3048-3056
    • Chen, T.1    Nakayama, K.2    Belliveau, L.3    Duncan, M.J.4
  • 4
    • 0036480669 scopus 로고    scopus 로고
    • Distribution of erm(F) and tet(Q) genes in 4 oral bacterial species and genotypic variation between resistant and susceptible isolates
    • Chung WO, Gabany J, Persson GR, Roberts MC. (2002) Distribution of erm(F) and tet(Q) genes in 4 oral bacterial species and genotypic variation between resistant and susceptible isolates. J Clin Periodontol.; 29: 152-8.
    • (2002) J Clin Periodontol , vol.29 , pp. 152-158
    • Chung, W.O.1    Gabany, J.2    Persson, G.R.3    Roberts, M.C.4
  • 6
    • 0027135337 scopus 로고
    • Inhibition of C3 and IgG proteolysis enhances phagocytosis of Porphyromonas gingivalis
    • Cutler CW, Arnold RR, Schenkein HA. (1993) Inhibition of C3 and IgG proteolysis enhances phagocytosis of Porphyromonas gingivalis. J Immunol.; 151: 7016-29.
    • (1993) J Immunol , vol.151 , pp. 7016-7029
    • Cutler, C.W.1    Arnold, R.R.2    Schenkein, H.A.3
  • 7
    • 0036057243 scopus 로고    scopus 로고
    • Interaction of Porphyromonas gingivalis with KB cells: Comparison of different clinical isolates
    • Eick S, Rödel J, Einax JW, Pfister W (2002). Interaction of Porphyromonas gingivalis with KB cells: comparison of different clinical isolates. Oral Microbiol Immunol.; 17: 201-8.
    • (2002) Oral Microbiol Immunol , vol.17 , pp. 201-208
    • Eick, S.1    Rödel, J.2    Einax, J.W.3    Pfister, W.4
  • 8
    • 0026724045 scopus 로고
    • Inactivation of human serum bactericidal activity by a trypsinlike protease isolated from Porphyromonas gingivalis
    • Grenier D. (1992) Inactivation of human serum bactericidal activity by a trypsinlike protease isolated from Porphyromonas gingivalis. Infect Immun.; 60: 1854-7.
    • (1992) Infect Immun , vol.60 , pp. 1854-1857
    • Grenier, D.1
  • 9
    • 0028509197 scopus 로고
    • Occurence and identity of proteolytic bacteria in adult periodontitis
    • Grenier D, Turgeon J. (1994) Occurence and identity of proteolytic bacteria in adult periodontitis. J Periodont Res.; 29: 365-70.
    • (1994) J Periodont Res , vol.29 , pp. 365-370
    • Grenier, D.1    Turgeon, J.2
  • 10
    • 0034916392 scopus 로고    scopus 로고
    • Role of gingipains in growth of Porphyromonas gingivalis in the presence of human serum albumin
    • Grenier D, Imbeault S, Plamondon P, Grenier G, Nakayama K, Mayrand D. (2001) Role of gingipains in growth of Porphyromonas gingivalis in the presence of human serum albumin. Infect Immun.; 69: 5166-72.
    • (2001) Infect Immun , vol.69 , pp. 5166-5172
    • Grenier, D.1    Imbeault, S.2    Plamondon, P.3    Grenier, G.4    Nakayama, K.5    Mayrand, D.6
  • 11
    • 0037261991 scopus 로고    scopus 로고
    • The role of gingipains in the pathogenesis of periodontal disease
    • Imamura T. (2003) The role of gingipains in the pathogenesis of periodontal disease. J Periodontol.; 74: 111-8.
    • (2003) J Periodontol , vol.74 , pp. 111-118
    • Imamura, T.1
  • 12
    • 0034806954 scopus 로고    scopus 로고
    • Inhibition of trypsin-like cysteine proteinases (gingipains) from Porphyromonas gingivalis by tetracycline and its analogues
    • Imamura T, Matsushita K, Travis J, Potempa J. (2001) Inhibition of trypsin-like cysteine proteinases (gingipains) from Porphyromonas gingivalis by tetracycline and its analogues. Antimicrob Agents Chemother.; 45: 2871-6.
    • (2001) Antimicrob Agents Chemother , vol.45 , pp. 2871-2876
    • Imamura, T.1    Matsushita, K.2    Travis, J.3    Potempa, J.4
  • 14
    • 0032582491 scopus 로고    scopus 로고
    • Arg-gingipain acts as a major processing enzyme for various cell surface proteins in Porphyromonas gingivalis
    • Kadowaki T, Nakayama K, Yoshimura F, Okamoto K, Abe N, Yamamoto K. (1998) Arg-gingipain acts as a major processing enzyme for various cell surface proteins in Porphyromonas gingivalis. J Biol Chem.; 273: 29072-6.
    • (1998) J Biol Chem , vol.273 , pp. 29072-29076
    • Kadowaki, T.1    Nakayama, K.2    Yoshimura, F.3    Okamoto, K.4    Abe, N.5    Yamamoto, K.6
  • 16
    • 0032803762 scopus 로고    scopus 로고
    • Inhibitory effects of protamines on proteolytic and adhesive activities of Porphyromonas gingivalis
    • Kontani M, Amano A, Nakamura T, Nakagawa I, Kawabata S, Hamada S. (1999) Inhibitory effects of protamines on proteolytic and adhesive activities of Porphyromonas gingivalis. Infection Immun.; 67: 4917-20.
    • (1999) Infection Immun , vol.67 , pp. 4917-4920
    • Kontani, M.1    Amano, A.2    Nakamura, T.3    Nakagawa, I.4    Kawabata, S.5    Hamada, S.6
  • 17
    • 0030054346 scopus 로고    scopus 로고
    • Porphyromonas gingivalis FDC381 multiplies and persists within human oral epithelial cells in vitro
    • Madianos PN, Papapanou PN, Nannmark U, Dahlen G, Sandros J. (1996) Porphyromonas gingivalis FDC381 multiplies and persists within human oral epithelial cells in vitro. Infect Immun.; 64: 660-4.
    • (1996) Infect Immun , vol.64 , pp. 660-664
    • Madianos, P.N.1    Papapanou, P.N.2    Nannmark, U.3    Dahlen, G.4    Sandros, J.5
  • 18
    • 0031951529 scopus 로고    scopus 로고
    • Genetic variations of Porphyromonas gingivalis genes encoding gingipains, cysteine proteinases with arginine or lysine specifity
    • Mikolajczyk-Pawlinska J, Kordula T, Pavloff N, Pemberton PA, Audrey Chen WC, Travis J, Potempa J. (1998) Genetic variations of Porphyromonas gingivalis genes encoding gingipains, cysteine proteinases with arginine or lysine specifity. Biol Chem.; 379: 205-11.
    • (1998) Biol Chem , vol.379 , pp. 205-211
    • Mikolajczyk-Pawlinska, J.1    Kordula, T.2    Pavloff, N.3    Pemberton, P.A.4    Audrey Chen, W.C.5    Travis, J.6    Potempa, J.7
  • 19
    • 0003945303 scopus 로고
    • New ideas about neutrophil antimicrobial mechanisms: Antibiotic peptides, postphagocytic protein processing, and cytosolic defense
    • Genco R, Hamada S, Lehner T, McGhee J, Mergenhagen S. eds, ASM Press, Washington DC
    • Miyasaki KT, Bodeau AL, Shafer WM, Pohl J, Murthy ARK, Lehrer RI. (1994) New ideas about neutrophil antimicrobial mechanisms: antibiotic peptides, postphagocytic protein processing, and cytosolic defense. In Molecular pathogenesis of periodontal disease. Genco R, Hamada S, Lehner T, McGhee J, Mergenhagen S. eds, pp 321-36. ASM Press, Washington DC.
    • (1994) Molecular Pathogenesis of Periodontal Disease , pp. 321-336
    • Miyasaki, K.T.1    Bodeau, A.L.2    Shafer, W.M.3    Pohl, J.4    Murthy, A.R.K.5    Lehrer, R.I.6
  • 20
    • 0036676042 scopus 로고    scopus 로고
    • Local antibiotic therapy guided by microbiological diagnosis
    • Mombelli A, Schmid B, Rutar A, Lang NP (2002) Local antibiotic therapy guided by microbiological diagnosis. J Clin Periodontol.; 29: 743-9.
    • (2002) J Clin Periodontol , vol.29 , pp. 743-749
    • Mombelli, A.1    Schmid, B.2    Rutar, A.3    Lang, N.P.4
  • 21
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • Mosmann T. (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods.; 65: 55-63.
    • (1983) J Immunol Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 22
    • 0029917103 scopus 로고    scopus 로고
    • Involvement of arginine-specific cysteine proteinase (Arg-gingipain) in fimbriation of Porphyromonas gingivalis
    • Nakayama K, Yoshimura F, Kadowaki T, Yamamoto K. (1996) Involvement of arginine-specific cysteine proteinase (Arg-gingipain) in fimbriation of Porphyromonas gingivalis. J Bacteriol.; 178: 2818-24.
    • (1996) J Bacteriol , vol.178 , pp. 2818-2824
    • Nakayama, K.1    Yoshimura, F.2    Kadowaki, T.3    Yamamoto, K.4
  • 23
    • 0030938896 scopus 로고    scopus 로고
    • A role of fimbriae in Porphyromonas gingivalis invasion of oral epithelial cells
    • Njoroge T, Genco RJ, Sojar HT, Hamada N, Genco CA. (1997) A role of fimbriae in Porphyromonas gingivalis invasion of oral epithelial cells. Infect Immun.; 65: 1980-84.
    • (1997) Infect Immun , vol.65 , pp. 1980-1984
    • Njoroge, T.1    Genco, R.J.2    Sojar, H.T.3    Hamada, N.4    Genco, C.A.5
  • 24
    • 0018648791 scopus 로고
    • Assessment of blood leukocyte microbial killing by using a new fluorochrome microassay
    • Pantazis CG, Kniker WT. (1979) Assessment of blood leukocyte microbial killing by using a new fluorochrome microassay. J Reticuloendothel Soc.; 26: 155-70.
    • (1979) J Reticuloendothel Soc , vol.26 , pp. 155-170
    • Pantazis, C.G.1    Kniker, W.T.2
  • 25
    • 0031691925 scopus 로고    scopus 로고
    • Contact-dependent protein secretion in Porphyromonas gingivalis
    • Park Y, Lamont RJ. (1998) Contact-dependent protein secretion in Porphyromonas gingivalis. Infect Immun.; 66: 4777-82.
    • (1998) Infect Immun , vol.66 , pp. 4777-4782
    • Park, Y.1    Lamont, R.J.2
  • 26
    • 0031008093 scopus 로고    scopus 로고
    • Titration and mapping of the active site of cysteine proteinases from Porphyromonas gingivalis (gingipains) using peptidyl chloromethanes
    • Potempa J, Pike R, Travis J. (1997) Titration and mapping of the active site of cysteine proteinases from Porphyromonas gingivalis (gingipains) using peptidyl chloromethanes. Biol Chem.; 378: 223-30.
    • (1997) Biol Chem , vol.378 , pp. 223-230
    • Potempa, J.1    Pike, R.2    Travis, J.3
  • 27
    • 0035143619 scopus 로고    scopus 로고
    • Mechanisms mediating Porphyromonas gingivalis gingipain RgpA-induced oral mucosa inflammation in vivo
    • Rubinstein I, Potempa J, Travis J, Gao XP. (2001) Mechanisms mediating Porphyromonas gingivalis gingipain RgpA-induced oral mucosa inflammation in vivo. Infect Immun.; 69: 1199-201.
    • (2001) Infect Immun , vol.69 , pp. 1199-1201
    • Rubinstein, I.1    Potempa, J.2    Travis, J.3    Gao, X.P.4
  • 28
    • 0029013679 scopus 로고
    • Increased opsonization of a prH-defective mutant of Porphyromonas gingivalis W83 is caused by degradation of complement-derived opsonins
    • Schenkein HA, Fletcher HM, Bodnar M, Macrina FL. (1995) Increased opsonization of a prH-defective mutant of Porphyromonas gingivalis W83 is caused by degradation of complement-derived opsonins. J Immunol.; 154: 5331-7.
    • (1995) J Immunol , vol.154 , pp. 5331-5337
    • Schenkein, H.A.1    Fletcher, H.M.2    Bodnar, M.3    Macrina, F.L.4
  • 29
    • 0033580821 scopus 로고    scopus 로고
    • Genetic analyses of proteolysis, hemoglobin binding, and hemagglutination of Porphyromonas gingivalis. Construction of mutants with a combination of rgpA, rgpB, kgp and hag1
    • Shi Y, Ratnayake DB, Okamoto K, Abe N, Yamamoto K, Nakayama K. (1999) Genetic analyses of proteolysis, hemoglobin binding, and hemagglutination of Porphyromonas gingivalis. Construction of mutants with a combination of rgpA, rgpB, kgp and hag1. J Biol Chem.; 274: 17955-60.
    • (1999) J Biol Chem , vol.274 , pp. 17955-17960
    • Shi, Y.1    Ratnayake, D.B.2    Okamoto, K.3    Abe, N.4    Yamamoto, K.5    Nakayama, K.6
  • 30
    • 0033173625 scopus 로고    scopus 로고
    • Arg-gingipain inhibition and anti-bacterial activity selective for Porphyromonas gingivalis by malabaricone C
    • Shinohara C, Mori S, Ando T, Tsuji T. (1999) Arg-gingipain inhibition and anti-bacterial activity selective for Porphyromonas gingivalis by malabaricone C. Biosci Biotechnol Biochem.; 63: 1475-7.
    • (1999) Biosci Biotechnol Biochem , vol.63 , pp. 1475-1477
    • Shinohara, C.1    Mori, S.2    Ando, T.3    Tsuji, T.4
  • 31
    • 0017666675 scopus 로고
    • A rapid micro method for the simultaneous determination of phagocytic microbiocidal-activity of human peripheral blood leukocytes in vitro
    • Smith D, Rommel F. (1977) A rapid micro method for the simultaneous determination of phagocytic microbiocidal-activity of human peripheral blood leukocytes in vitro. J Immunol Methods.; 17: 241-7.
    • (1977) J Immunol Methods , vol.17 , pp. 241-247
    • Smith, D.1    Rommel, F.2
  • 32
    • 0027198962 scopus 로고
    • Changes in complement and immunoglobulin G receptor expression on neutrophils associated with Porphyromonas gingivalis-induced inhibition of phagocytosis
    • Tai H, Kobayashi T, Hara K. (1993) Changes in complement and immunoglobulin G receptor expression on neutrophils associated with Porphyromonas gingivalis-induced inhibition of phagocytosis. Infect Immun.; 61: 3533-5.
    • (1993) Infect Immun , vol.61 , pp. 3533-3535
    • Tai, H.1    Kobayashi, T.2    Hara, K.3
  • 33
    • 0029847260 scopus 로고    scopus 로고
    • Role of Porphyromonas gingivalis protease activity in colonization of oral surfaces
    • Tokuda M, Duncan M, Cho MI, Kuramitsu HK. (1996) Role of Porphyromonas gingivalis protease activity in colonization of oral surfaces. Infect Immun.; 64: 4067-73.
    • (1996) Infect Immun , vol.64 , pp. 4067-4073
    • Tokuda, M.1    Duncan, M.2    Cho, M.I.3    Kuramitsu, H.K.4
  • 35
    • 0034615573 scopus 로고    scopus 로고
    • Bacterial proteinases as targets for the development of second-generation antibiotics
    • Travis J, Potempa J. (2000) Bacterial proteinases as targets for the development of second-generation antibiotics. Biochim Biophys Acta.; 1477: 35-50.
    • (2000) Biochim Biophys Acta , vol.1477 , pp. 35-50
    • Travis, J.1    Potempa, J.2
  • 36
    • 0030631850 scopus 로고    scopus 로고
    • Porphyromonas gingivalis proteinases as virulence factors in the development of periodontitis
    • Travis J, Pike R, Imamura T, Potempa J. (1997) Porphyromonas gingivalis proteinases as virulence factors in the development of periodontitis J Periodontol Res.; 32: 120-5.
    • (1997) J Periodontol Res , vol.32 , pp. 120-125
    • Travis, J.1    Pike, R.2    Imamura, T.3    Potempa, J.4
  • 37
    • 0031014527 scopus 로고    scopus 로고
    • Role of fimbriae in Porphyromonas gingivalis invasion of gingival epithelial cells
    • Weinberg A, Belton CM, Park Y, Lamont RJ. (1997) Role of fimbriae in Porphyromonas gingivalis invasion of gingival epithelial cells. Infect Immun.; 65: 313-316.
    • (1997) Infect Immun , vol.65 , pp. 313-316
    • Weinberg, A.1    Belton, C.M.2    Park, Y.3    Lamont, R.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.