Porphyromonas gingivalis gingipains and adhesion to epithelial cells

Infection and Immunity

Volumn 69, Issue 5, 2001, Pages 3048-3056

  Chen, T ^a   Nakayama, K ^a   Belliveau, L ^a   Duncan, M J ^a  

^a FORSYTH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESIN; GINGIPAIN R;

ARTICLE; BACTERIAL COLONIZATION; BACTERIAL GENETICS; BACTERIUM ADHERENCE; BACTERIUM MUTANT; CONTROLLED STUDY; EPITHELIUM CELL; HUMAN; HUMAN CELL; NONHUMAN; PATHOGENESIS; PERIODONTITIS; PORPHYROMONAS GINGIVALIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING;

ADHESINS, BACTERIAL; AMINO ACID SEQUENCE; ANIMALS; BACTERIAL ADHESION; CATALYSIS; CYSTEINE ENDOPEPTIDASES; HEMAGGLUTININS; HUMANS; KB CELLS; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; PORPHYROMONAS GINGIVALIS; SHEEP;

EID: 0035061098     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.5.3048-3056.2001     Document Type: Article

References (42)

1. A cell-associated protein complex of Porphyromonas gingivalis W50 composed of Arg- and Lys-specific cysteine proteinases and adhesins
2. Pleiotropic pigmentation mutants of Porphyromonas gingivalis
3. Molecular genetics and nomenclature of proteases of Porphyromonas gingivalis
4. Porphyrin-mediated binding to hemoglobin by the HA2 domain of cysteine proteinases (gingipains) and hemagglutinins from the periodontal pathogen Porphyromonas gingivalis
5. Genomic loci of the Porphyromonas gingivalis insertion element IS1126
6. Porphyromonas gingivalis genes isolated by screening for epithelial cell attachment
7. Interactions of Porphyromonas gingivalis with epithelial cells
8. Functional characterization of extracellular vesicles produced by Bacteroides gingivalis
9. The great escape: Structure and function of the autotransporter proteins
10. Arg-gingipain acts as a major processing enzyme for various cell surface proteins in Porphyromonas gingivalis
11. Characterization of Porphyromonas gingivalis-induced degradation of epithelial cell junctional complexes
12. The relationship between colonization and haemagglutination inhibiting and B cell epitopes of Porphyromonas gingivalis
13. Adherence of Porphyromonas gingivalis to matrix proteins via a fimbrial cryptic receptor exposed by its own arginine-specific protease
14. Cysteine protease of Porphyromonas gingivalis 381 enhances binding of fimbriae to cultured human fibroblasts and matrix proteins
15. The number of direct repeats in hagA is variable among Porphyromonas gingivalis strains
16. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
17. Identification of Porphyromonas gingivalis components that mediate its interactions with fibronectin
18. Binding of cultured mammalian cells to immobilized bacteria
19. A novel family of channel-forming, autotransporting, bacterial virulence factors
20. Inactivation of the Porphyromonas gingivalis fimA gene blocks periodontal damage in gnotobiotic rats
21. Clonal diversity of the taxon Porphyromonas gingivalis assessed by random amplified polymorphic DNA fingerprinting
22. Construction and characterization of arginine-specific cysteine proteinase (Arg-gingipain)-deficient mutants of Porphyromonas gingivalis. Evidence for significant contribution of Arg-gingipain to virulence
23. Involvement of arginine-specific cysteine proteinase (Arg-gingipain) in fimbriation of Porphyromonas gingivalis
24. A role for fimbriae in Porphyromonas gingivalis invasion of oral epithelial cells
25. RgpA-Kgp peptide-based immunogens provide protection against Porphyromonas gingivalis challenge in a murine lesion model
26. Cloning and sequencing of the gene encoding a novel lysine-specific cysteine proteinase (Lys-gingipain) in Porphyromonas gingivalis: Structural relationship with the arginine-specific cysteine proteinase (Arg-gingipain)
27. Structural characterization of argingipain, a novel arginine-specific cysteine proteinase as a major periodontal pathogenic factor from Porphyromonas gingivalis
28. Molecular cloning and characterization of Porphyromonas gingivalis lysine-specific gingipain. A new member of an emerging family of pathogenic bacterial cysteine proteinases
29. Molecular cloning and structural characterization of the Arg-gingipain proteinase of Porphyromonas gingivalis. Biosynthesis as a proteinase-adhesin polyprotein
30. Lysine- and arginine-specific proteinases from Porphyromonas gingivalis. Isolation, characterization, and evidence for the existence of complexes with hemagglutinins
31. Characterization of the binding activities of proteinase-adhesin complexes from Porphyromonas gingivalis
32. Gene structure and extracellular secretion of Neisseria gonorrhoeae IgA protease
33. Targeted disruption of fibronectin-integrin interactions in human gingival fibroblasts by the RI protease of Porphyromonas gingivalis W50
34. Determination and characterization of the hemagglutinin-associated short motifs found in Porphyromonas gingivalis multiple gene products
35. Role of the amino-terminal region of Porphyromonas gingivalis fimbriae in adherence to epithelial cells
36. Role of Porphyromonas gingivalis protease activity in colonization of oral surfaces
37. Role of Arg-gingipain A in virulence of Porphyromonas gingivalis
38. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
39. Bacterial proteinases as targets for the development of second-generation antibiotics
40. Role of fimbriae in Porphyromonas gingivalis invasion of gingival epithelial cells
41. IL-8 degradation by Porphyromonas gingivalis proteases