Effects of intrathecal injections of melatonin analogs on capsaicin-induced secondary mechanical allodynia and hyperalgesia in rats

Pain

Volumn 109, Issue 3, 2004, Pages 340-350

  Tu, Yijun ^a   Sun, Rui Qing ^a   Willis, William D ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Analgesia; Behavior; Central sensitization; Nociception; Pain; Spinal cord

Indexed keywords

6 CHLOROMELATONIN; CAPSAICIN; MELATONIN;

ALLODYNIA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; HYPERALGESIA; LOCOMOTION; LUMBAR SPINAL CORD; MALE; MOTOR PERFORMANCE; NONHUMAN; PRIORITY JOURNAL; RAT; THORACIC SPINAL CORD;

ADMINISTRATION, TOPICAL; AFFERENT PATHWAYS; ANIMALS; CAPSAICIN; DISEASE MODELS, ANIMAL; DRUG INTERACTIONS; HYPERALGESIA; INJECTIONS, INTRAMUSCULAR; INJECTIONS, SPINAL; MALE; MELATONIN; NEURAL INHIBITION; PAIN; PHYSICAL STIMULATION; RATS; RATS, SPRAGUE-DAWLEY; REFLEX; SKIN; SPINAL CORD; SPINAL CORD INJURIES; TETRAHYDRONAPHTHALENES; TRYPTAMINES;

EID: 2442428681     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2004.01.027     Document Type: Article

References (65)

1. Behrens U.D., Douglas R.H., Sugden D., Davies D.J., Wagner H.J. Effect of melatonin agonists and antagonists on horizontal cell spinule formation and dopamine release in a fish retina. Cell Tissue Res. 299:2000;299-306
2. Benitez-King G., Hernandez M.E., Tovar R., Ramirez G. Melatonin activates PKC-alpha but not PKC-epsilon in N1E-115 cells. Neurochem Int. 39:2001;95-102
3. Bozon B., Kelly A., Josselyn S.A., Silva A.J., Davis S., Laroche S. MAPK, CREB and zif268 are all required for the consolidation of recognition memory. Philos Trans R Soc London Ser B: Biol Sci. 358:2003;805-814
4. Dubocovich M.L., Masana M.I., Iacob S., Sauri D.M. Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor. NS Arch Pharmacol. 355:1997;365-375
5. Dziema H., Oatis B., Butcher G.Q., Yates R., Hoyt K.R., Obrietan K. The ERK/MAP kinase pathway couples light to immediate-early gene expression in the suprachiasmatic nucleus. Eur J Neurosci. 17:2003;1617-1627
6. El-Shenawy S.M., Abdel-Salam O.M., Baiuomy A.R., El-Batran S., Arbid M.S. Studies on the anti-inflammatory and anti-nociceptive effects of melatonin in the rat. Pharmacol Res. 46:2002;235-243
7. Fang L., Wu J., Lin Q., Willis W.D. Calcium-calmodulin-dependent protein kinase II contributes to spinal cord central sensitization. J Neurosci. 22:2002;4196-4204
8. Fukunaga K., Horikawa K., Shibata S., Takeuchi Y., Miyamoto E. Ca2+/calmodulin-dependent protein kinase II-dependent long-term potentiation in the rat suprachiasmatic nucleus and its inhibition by melatonin. J Neurosci Res. 70:2002;799-807
9. von Gall C., Weaver D.R., Kock M., Korf H.W., Stehle J.H. Melatonin limits transcriptional impact of phosphoCREB in the mouse SCN via the Mel1a receptor. NeuroReport. 11:2000;1803-1807
10. von Gall C., Stehle J.H., Weaver D.R. Mammalian melatonin receptors: molecular biology and signal transduction. Cell Tissue Res. 309:2002;151-162
11. Garcia-Perganeda A., Guerrero J.M., Rafii-El-Idrissi M., Romero P., Pozo D., Calvo J.R. Characterization of membrane melatonin receptor in mouse peritoneal macrophages: inhibition of adenylyl cyclase by a pertussis toxin-sensitive G protein. J Neuroimmunol. 95:1999;85-94
12. Gilchrist H.D., Allard B.L., Simone D.A. Enhanced withdrawal responses to heat and mechanical stimuli following intraplantar injection of capsaicin in rats. Pain. 67:1996;179-188
13. Juszczak M., Stempniak B. Melatonin inhibits the substance P-induced secretion of vasopressin and oxytocin from the rat hypothalamo-neurohypophysial system: in vitro studies. Brain Res Bull. 59:2003;393-397
14. Khasabov S.G., Rogers S.D., Ghilardi J.R., Peters C.M., Mantyh P.W., Simone D.A. Spinal neurons that possess the substance P receptor are required for the development of central sensitization. J Neurosci. 22:2002;9086-9098
15. LaMotte R.H., Shain C.N., Simone D.A., Tsai E.F.P. Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms. J Neurophysiol. 66:1991;190-211
16. Laurido C., Pelissie T., Soto-Moyano R., Valladares L., Flores F., Hernandez A. Effect of melatonin on rat spinal cord nociceptive transmission. NeuroReport. 13:2002;89-91
17. Leem J.W., Willis W.D., Chung J.M. Cutaneous sensory receptors in the rat foot. J Neurophysiol. 69:1993;1684-1699
18. Lin Q., Palecek J., Paleckova V., Peng Y.B., Wu J., Cui M., Willis W.D. Nitric oxide mediates the central sensitization of primate spinothalamic tract neurons. J Neurophysiol. 81:1999;1075-1085
19. Liu X.G., Sandkühler J. Characterization of long-term potentiation of C-fiber-evoked potentials in spinal cord dorsal horn of adult rat: essential role of NK1 and NK2 receptors. J Neurophysiol. 78:1997;1973-1982
20. Mantovani M., Pertile R., Calixto J.B., Santos A.R., Rodrigues A.L. Melatonin exerts an antidepressant-like effect in the tail suspension test in mice: evidence for involvement of N-methyl-D-aspartate receptors and the L-arginine-nitric oxide pathway. Neurosci Lett. 343:2003;1-4
21. McNulty S., Ross A.W., Barrett P., Hastings M.H., Morgan P.J. Melatonin regulates the phosphorylation of CREB in ovine pars tuberalis. J Neuroendocrinol. 6:1994;523-532
22. Morgan P.J., Barrett P., Howell E., Helliwell R. Melatonin receptors: localization, molecular pharmacology and physiological significance. Neurochem Int. 24:1994;101-146
23. Nelsen F.A., Farr L.A., Ebadi M. Salivary melatonin response to acute pain stimuli. J Pineal Res. 30:2001;206-212
24. Neugebauer V., Chen P.-S., Willis W.D. Role of metabotropic glutamate receptor subtype mGluR1 in brief nociception and central sensitization of primate STT cells. J Neurophysiol. 82:1999;272-282
25. Neugebauer V., Chen P.-S., Willis W.D. Groups II and III metabotropic glutamate receptors differentially modulate brief and prolonged nociception in primate STT cells. J Neurophysiol. 84:2000;2998-3009
26. Palecek J., Paleckova V., Willis W.D. The roles of pathways in the spinal cord lateral and dorsal funiculi in signaling nociceptive somatic and visceral stimuli in rats. Pain. 96:2002;297-307
27. Palecek J., Paleckova V., Willis W.D. Postsynaptic dorsal column neurons express NK1 receptors following colon inflammation. Neuroscience. 116:2003;565-572
28. Pang S.F., Wan Q., Brown G.M. Melatonin receptors in the spinal cord. Biol Signals. 6:1997;272-283
29. Poon A.M., Kravtsov G.M., Pang S.F. Receptor-mediated modulation of avian caecal muscle contraction by melatonin: role of tyrosine protein kinase. J Pineal Res. 32:2002;199-208
30. Raghavendra V., Agrewala J.N., Kulkarni S.K. Melatonin reversal of lipopolysacharides-induced thermal and behavioral hyperalgesia in mice. Eur J Pharmacol. 395:2000;15-21
31. Shiu S.Y., Li L., Siu S.W., Xi S.C., Fong S.W., Pang S.F. Biological basis and possible physiological implications of melatonin receptor-mediated signaling in the rat epididymis. Biol Signals Recept. 9:2000;172-187
32. Simone D.A., Baumann T.K., LaMotte R.H. Dose-dependent pain and mechanical hyperalgesia in humans after intradermal injection of capsaicin. Pain. 38:1989;99-107
33. Sluka K.A., Willis W.D. The effects of G-protein and protein kinase inhibitors on the behavioral responses of rats to intradermal injection of capsaicin. Pain. 71:1997;165-178
34. Stankov B., Cozzi B., Lucini V., Fumagalli P., Scaglione F., Fraschini F. Characterization and mapping of melatonin receptors in the brain of three mammalian species: rabbit, horse and sheep. A comparative in vitro binding study. Neuroendocrinology. 53:1991;214-221
35. Storkson R.V., Kjorsvik A., Tjolsen A., Hole K. Lumbar catheterization of the spinal subarachnoid space in the rat. J Neurosci Methods. 65:1996;167-172
36. Sugden D. Psychopharmacological effects of melatonin in mouse and rat. J Pharmacol Exp Ther. 227:1983;587-591
37. Sun R.Q., Lawand N.B., Willis W.D. The role of calcitonin gene-related peptide (CGRP) in the generation and maintenance of mechanical allodynia and hyperalgesia in rats after intradermal injection of capsaicin. Pain. 104:2003;201-208
38. Tu Y., Willis W.D. The role of spinal MAPK on rat exploratory activity and secondary mechanical hyperalgesia. Abs Soc Neurosci, 32nd Meeting, Orlando, FL. 2002
39. Tu Y., Willis W.D. Effects of intrathecal injections of melatonin analogs on capsaicin-evoked secondary mechanical hyperalgesia in rats. Abs Annu Am Pain Meeting, Chicago, IL. 2003
40. Vanecek J. Cellular mechanisms of melatonin action. Physiol Rev. 78:1998;687-721
41. Viswanathan M. Melatonin inhibits calcitonin gene-related peptide-induced vasodilation and increase in cAMP in rat middle cerebral arteries. Eur J Pharmacol. 415:2001;247-250
42. Waltereit R., Weller M. Signaling from cAMP/PKA to MAPK and synaptic plasticity. Mol Neurobiol. 27:2003;99-106
43. Wan Q., Pang S.F. [125I]Iodomelatonin binding sites in the chicken spinal cord: binding characteristics and diurnal variation. Neurosci Lett. 163:1993;101-104
44. Wan Q., Pang S.F. Segmental, coronal and subcellular distribution of 2-[125I]iodomelatonin binding sites in the chicken spinal cord. Neurosci Lett. 180:1994;253-256
45. Wan Q., Liao M., Brown G.M., Pang S.F. Localization and characterization of melatonin receptors in the rabbit spinal cord. Neurosci Lett. 204:1996;77-80
46. Wan Q., Liao M.X., Pang C.S., Pang S.F., Brown G.M. Guanosine 5′-O-(3-thiotriphosphate) and cations regulate melatonin receptors, and melatonin inhibits cyclic AMP production in the spinal cord. Biol Signals. 6:1997;67-76
47. Weber B., Schlicker E. Modulation of dopamine release in the guinea-pig retina by G(i)- but not by G(s)- or G(q)-protein-coupled receptors. Fundam Clin Pharmacol. 15:2001;393-400
48. Willis W.D. Hyperalgesia and allodynia. 2nd Bristol-Myers Squibb Symposium on Pain Research. 1992;Raven Press, New York
49. Willis W.D. Is central sensitization of nociceptive transmission in the spinal cord a variety of long-term potentiation? A commentary on the paper by Svendsen, Tjøsen and Hole. NeuroReport. 8:1997;16
50. Willis W.D. Role of neurotransmitters in sensitization of pain responses. Ann NY Acad Sci. 933:2001;142-156
51. Willis W.D. Mechanisms of central sensitization of nociceptive dorsal horn neurons. Patterson M.M., Grau J.W. Spinal cord plasticity: alterations in reflex function. 2001;127-161 Kluwer, Boston, MA
52. Willis W.D. Long-term potentiation in spinothalamic neurons. Brain Res Brain Res Rev. 40:2002;202-214
53. Willis W.D., Coggeshall R.E. Sensory mechanisms of the spinal cord. 2nd ed:1991;Plenum Press, New York
54. Willis W.D., Coggeshall R.E. Sensory mechanisms of the spinal cord. 3rd ed:2004;Kluwer, New York
55. Woolf C.J. Evidence for a central component of post-injury pain hypesensitivity. Nature. 306:1983;686-688
56. Wu J., Lin Q., McAdoo D.J., Willis W.D. Nitric oxide contributes to central sensitization following intradermal injection of capsaicin. NeuroReport. 9:1998;589-592
57. Wu F.S., Yang Y.C., Tsai J.J. Melatonin potentiates the GABA(A) receptor-mediated current in cultured chick spinal cord neurons. Neurosci Lett. 260:1999;177-180
58. Wu J., Fang L., Lin Q., Willis W.D. Nitric oxide synthase in spinal cord central sensitization following intradermal injection of capsaicin. Pain. 94:2001;47-58
59. Wu J., Fang L., Lin Q., Willis W.D. The role of nitric oxide in the phosphorylation of cyclic adenosine monophosphate-responsive element-binding protein in the spinal cord after intradermal injection of capsaicin. J Pain. 3:2002;190-198
60. Xia Z., Storm D.R. Calmodulin-regulated adenylyl cyclases and neuromodulation. Curr Opin Neurobiol. 7:1997;391-396
61. Yu C.X., Zhu C.B., Xu S.F., Cao X.D., Wu G.C. Selective MT(2) melatonin receptor antagonist blocks melatonin-induced antinociception in rats. Neurosci Lett. 282:2000;161-164
62. Yu C.X., Zhu B., Xu S.F., Cao X.D., Wu G.C. The analgesic effects of peripheral and central administration of melatonin in rats. Eur J Pharmacol. 403:2000;49-53
63. Zahn P.K., Lansmann T., Berger E., Speckmann E.J., Musshoff U. Gene expression and functional characterization of melatonin receptors in the spinal cord of the rat: implications for pain modulation. J Pineal Res. 35:2003;24-31
64. Zou X., Lin Q., Willis W.D. NMDA or non-NMDA receptor antagonists attenuate increased Fos expression in spinal dorsal horn GABAergic neurons after intradermal injection of capsaicin in rats. Neuroscience. 106:2001;171-182
65. Zou X., Lin Q., Willis W.D. Role of protein kinase A in phosphorylation of NMDA receptor 1 subunits in dorsal horn and spinothalamic tract neurons after intradermal injection of capsaicin in rats. Neuroscience. 115:2002;775-786