Design, synthesis, and AMPA receptor antagonistic activity of a novel 6-nitro-3-oxoquinoxaline-2-carboxylic acid with a substituted phenyl group at the 7 position

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 20, 2005, Pages 5841-5863

  Takano, Yasuo ^a   Shiga, Futoshi ^a   Asano, Jun ^a   Ando, Naoki ^a   Uchiki, Hideharu ^a   Fukuchi, Kazunori ^a   Anraku, Tsuyosi ^a  

^a KYORIN PHARMACEUTICAL CO LTD   (Japan)

Author keywords

3 Oxoquinoxaline 2 carboxylic acid; Cerebral ischemia; Competitive AMPA R antagonist; Excitatory amino acid

Indexed keywords

3,4 DIHYDRO 6 NITRO 3 OXO 7 (4 PYRIDON 1 YL)QUINOXALINE 2 CARBOXYLIC ACID; 3,4 DIHYDRO 6 NITRO 3 OXO 7 (PYRROL 1 YL)QUINOXALINE 2 CARBOXYLIC ACID; 3,4 DIHYDRO 6 NITRO 3 OXO 7 [4 [(PHENYLAMINO)CARBONYLOXYMETHYL]IMIDAZOL 1 YL]OXOQUINOXALINE 2 CARBOXYLIC ACID; 3,4 DIHYDRO 6 NITRO 3 OXO 7 [4 [[(2 PHENYLETHYL)AMINO]CARBONYLOXYMETHYL] IMIDAZOL 1 YL]OXOQUINOXALINE 2 CARBOXYLIC ACID; 3,4 DIHYDRO 6 NITRO 3 OXO 7 PIPERIDINOQUINOXALINE 2 CARBOXYLIC ACID; 3,4 DIHYDRO 6 NITRO 3 OXOQUINOXALINE 2 CARBOXYLIC ACID; 3,4 DIHYDRO 7 (2 METHYLIMIDAZOL 1 YL) 6 NITRO 3 OXOQUINOXALINE 2 CARBOXYLIC ACID; 3,4 DIHYDRO 7 (4 HYDROXYPIPERIDINO) 6 NITRO 3 OXOQUINOXALINE 2 CARBOXYLIC ACID; 3,4 DIHYDRO 7 (4 METHYLIMIDAZOL 1 YL) 6 NITRO 3 OXOQUINOXALINE 2 CARBOXYLIC ACID; 3,4 DIHYDRO 7 (IMIDAZOL 1 YL) 6 NITRO 3 OXOQUINOXALINE 2 CARBOXYLIC ACID; 3,4 DIHYDRO 7 [4 (4 FLUOROPHENYL)PIPERAZIN 1 YL] 6 NITRO 3 OXOQUINOXALINE 2 CARBOXYLIC ACID; 3,4 DIHYDRO 7 [4 (HYDROXYMETHYL)IMIDAZOL 1 YL] 6 NITRO 3 OXOQUINOXALINE 2 CARBOXYLIC ACID; 3,4 DIHYDRO 7 [4 [(ISOPROPYLAMINO)CARBONYLOXYMETHYL]IMIDAZOL 1 YL] 6 NITRO 3 OXOQUINOXALINE 2 CARBOXYLIC ACID; 3,4 DIHYDRO 7 DIMETHYLAMINO 6 NITRO 3 OXOQUINOXALINE 2 CARBOXYLIC ACID; 3,4 DIHYDRO 7 MORPHOLINO 6 NITRO 3 OXOQUINOXALINE 2 CARBOXYLIC ACID; 6 (1 IMIDAZOLYL) 7 NITRO 2,3 QUINOXALINEDIONE; 7 (4 ACETYLPIPERAZIN 1 YL) 3,4 DIHYDRO 6 NITRO 3 OXOQUINOXALINE 2 CARBOXYLIC ACID; 7 [4 (CARBOXYMETHYL)IMIDAZOL 1 YL] 3,4 DIHYDRO 6 NITRO 3 OXOQUINOXALINE 2 CARBOXYLIC ACID; 7 [4 [(3 CARBOXYPHENYLAMINO)CARBONYLOXYMETHYL]IMIDAZOL 1 YL] 3,4 DIHYDRO 6 NITRO 3 OXOQUINOXALINE 2 CARBOXYLIC ACID; 7 [4 [(4 CARBOXYPHENYLAMINO)CARBONYLOXYMETHYL]IMIDAZOL 1 YL] 3,4 DIHYDRO 6 NITRO 3 OXOQUINOXALINE 2 CARBOXYLIC ACID; 7 [4 [(BENYLAMINO)CARBONYLOXYMETHYL]IMIDAZOL 1 YL] 3,4 DIHYDRO 6 NITRO 3 OXOQUINOXALINE 2 CARBOXYLIC ACID; 7 [4 [(CYCLOHEXYLAMINO)CARBONYLOXYMETHYL]IMIDAZOL 1 YL] 3,4 DIHYDRO 6 NITRO 3 OXOQUINOXALINE 2 CARBOXYLIC ACID; 7 [4 [(N BUTYLAMINO)CARBONYLOXYMETHYL]IMIDAZOL 1 YL] 3,4 DIHYDRO 6 NITRO 3 OXOQUINOXALINE 2 CARBOXYLIC ACID; 7 AMINO 3,4 DIHYDRO 6 NITRO 3 OXOQUINOXALINE 2 CARBOXYLIC ACID; [1,2,3,4 TETRAHYDRO 7 (1H IMIDAZOL 1 YL) 6 NITRO 2,3 DIOXO 1 QUINOXALINYL]ACETIC ACID; AMPA RECEPTOR ANTAGONIST; CARBOXYLIC ACID DERIVATIVE; ETHYL 3 ETHOXY 6 NITRO 7 [4 [[(2 PHENYLETHYL)AMINO]CARBONYLOXYMETHYL] IMIDAZOL 1 YL]OXOQUINOXALINE 2 CARBOXYLIC ACID; ETHYL 3 ETHOXY 7 (4 METHOXYBENZYL)AMINO 6 NITROQUINOXALINE 2 CARBOXYLIC ACID; ETHYL 3 ETHOXY 7 [4 (HYDROXYETHYL)IMIDAZOLYL] 6 NITROQUINOXALINE 2 CARBOXYLIC ACID; GRA 293; PHENYL GROUP; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AQUEOUS SOLUTION; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFICACY; DRUG SOLUBILITY; DRUG SYNTHESIS; NEUROPROTECTION; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; BRAIN ISCHEMIA; EXCITATORY AMINO ACID ANTAGONISTS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MODELS, MOLECULAR; NEUROPROTECTIVE AGENTS; NITRO COMPOUNDS; QUINOXALINES; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, AMPA;

EID: 24344503747     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.05.030     Document Type: Article

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