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Volumn 132, Issue 15, 2005, Pages 3515-3524

Tec29 controls actin remodelling and endoreplication during invagination of the Drosophila embryonic salivary glands

Author keywords

Actin; Btk29A; Endocycle; Tec kinase

Indexed keywords

ACTIN; CELL DNA; CELL PROTEIN; F ACTIN; G ACTIN; MUTANT PROTEIN; PROTEIN TEC29; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

EID: 24344501818     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: 10.1242/dev.01926     Document Type: Article
Times cited : (22)

References (51)
  • 1
    • 0037725015 scopus 로고    scopus 로고
    • Constructing an organ: The Drosophila salivary gland as a model for tube formation
    • Abrams, E. W., Vining, M. S. and Andrew, D. J. (2003). Constructing an organ: the Drosophila salivary gland as a model for tube formation. Trends Cell Biol. 13, 247-254.
    • (2003) Trends Cell Biol. , vol.13 , pp. 247-254
    • Abrams, E.W.1    Vining, M.S.2    Andrew, D.J.3
  • 2
    • 0031036933 scopus 로고    scopus 로고
    • The Drosophila dCREB-A gene is required for dorsal/ventral patterning of the larval cuticle
    • Andrew, D. J., Baig, A., Bhanot, P., Smolik, S. M. and Henderson, K. D. (1997). The Drosophila dCREB-A gene is required for dorsal/ventral patterning of the larval cuticle. Development 12, 181-193.
    • (1997) Development , vol.12 , pp. 181-193
    • Andrew, D.J.1    Baig, A.2    Bhanot, P.3    Smolik, S.M.4    Henderson, K.D.5
  • 3
    • 0033012909 scopus 로고    scopus 로고
    • The Drosophila Bruton's tyrosine kinase (Btk) homolog is required for adult survival and male genital formation
    • Baba, K., Takeshita, A., Majima, K., Ueda, R., Kondo, S., Juni, N. and Yamamoto, D. (1999a). The Drosophila Bruton's tyrosine kinase (Btk) homolog is required for adult survival and male genital formation. Mol. Cell. Biol. 19, 4405-4413.
    • (1999) Mol. Cell Biol. , vol.19 , pp. 4405-4413
    • Baba, K.1    Takeshita, A.2    Majima, K.3    Ueda, R.4    Kondo, S.5    Juni, N.6    Yamamoto, D.7
  • 5
    • 0034628471 scopus 로고    scopus 로고
    • Localization of apical epithelial determinants by the basolateral PDZ protein Scribble
    • Bilder, D. and Perrimon, N. (2000). Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Nature 403, 676-680.
    • (2000) Nature , vol.403 , pp. 676-680
    • Bilder, D.1    Perrimon, N.2
  • 7
    • 0142106031 scopus 로고    scopus 로고
    • Senseless is necessary for the survival of embryonic salivary glands in Drosophila
    • Chandrasekaran, V. and Beckendorf, S. K. (2003). senseless is necessary for the survival of embryonic salivary glands in Drosophila. Development 130, 4719-4728.
    • (2003) Development , vol.130 , pp. 4719-4728
    • Chandrasekaran, V.1    Beckendorf, S.K.2
  • 8
    • 0026747879 scopus 로고
    • Chickadee encodes a profilin required for intercellular cytoplasm transport during Drosophila oogenesis
    • Cooley, L., Verheyen, E. and Ayers, K. (1992). chickadee encodes a profilin required for intercellular cytoplasm transport during Drosophila oogenesis. Cell 69, 173-184.
    • (1992) Cell , vol.69 , pp. 173-184
    • Cooley, L.1    Verheyen, E.2    Ayers, K.3
  • 9
    • 33645612579 scopus 로고    scopus 로고
    • Src64 is involved in fusome development, cytokinesis and in karyosome formation during Drosophila oogenesis
    • (in press)
    • Djagaeva, I., Doronkin, S. and Beckendorf, S. K. (2005). Src64 is involved in fusome development, cytokinesis and in karyosome formation during Drosophila oogenesis (in press).
    • (2005)
    • Djagaeva, I.1    Doronkin, S.2    Beckendorf, S.K.3
  • 10
    • 0031704474 scopus 로고    scopus 로고
    • Src64 is required for ovarian ring canal morphogenesis during Drosophila oogenesis
    • Dodson, G. S., Guarnieri, D. J. and Simon, M. A. (1998). Src64 is required for ovarian ring canal morphogenesis during Drosophila oogenesis. Development 125, 2883-2892.
    • (1998) Development , vol.125 , pp. 2883-2892
    • Dodson, G.S.1    Guarnieri, D.J.2    Simon, M.A.3
  • 11
    • 0035805201 scopus 로고    scopus 로고
    • Endoreplication cell cycles: More for less
    • Edgar, B. A. and Orr-Weaver, T. L. (2001). Endoreplication cell cycles: more for less. Cell 105, 297-306.
    • (2001) Cell , vol.105 , pp. 297-306
    • Edgar, B.A.1    Orr-Weaver, T.L.2
  • 12
    • 4143074805 scopus 로고    scopus 로고
    • Tec kinases: Shaping T-cell activation through actin
    • Finkelstein, L. D. and Schwartzberg, P. L. (2004). Tec kinases: shaping T-cell activation through actin. Trends Cell Biol. 14, 443-451.
    • (2004) Trends Cell Biol. , vol.14 , pp. 443-451
    • Finkelstein, L.D.1    Schwartzberg, P.L.2
  • 13
    • 0023356605 scopus 로고
    • Primary sequence and developmental expression of a novel Drosophila melanogaster src gene
    • Gregory, R. J., Kammermeyer, K. L., Vincent, W. S., 3rd and Wadsworth, S. G. (1987). Primary sequence and developmental expression of a novel Drosophila melanogaster src gene. Mol. Cell. Biol. 7, 2119-2127.
    • (1987) Mol. Cell Biol. , vol.7 , pp. 2119-2127
    • Gregory, R.J.1    Kammermeyer, K.L.2    Vincent III, W.S.3    Wadsworth, S.G.4
  • 14
    • 0034716888 scopus 로고    scopus 로고
    • A genetic link between morphogenesis and cell division during formation of the ventral furrow in Drosophila
    • Grosshans, J. and Wieschaus, E. (2000). A genetic link between morphogenesis and cell division during formation of the ventral furrow in Drosophila. Cell 101, 523-531.
    • (2000) Cell , vol.101 , pp. 523-531
    • Grosshans, J.1    Wieschaus, E.2
  • 15
    • 0032059734 scopus 로고    scopus 로고
    • SRC64 regulates the localization of a Tec-family kinase required for Drosophila ring canal growth
    • Guarnieri, D. J., Dodson, G. S. and Simon, M. A. (1998). SRC64 regulates the localization of a Tec-family kinase required for Drosophila ring canal growth. Mol. Cell. 1, 831-840.
    • (1998) Mol. Cell , vol.1 , pp. 831-840
    • Guarnieri, D.J.1    Dodson, G.S.2    Simon, M.A.3
  • 16
    • 0032422123 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of the Wiskott-Aldrich Syndrome protein by Lyn and Btk is regulated by CDC42
    • Guinamarda, R., Aspenströmb, P., Fougereaua, M., Chavriera, P. and Guillemota, J. (1998). Tyrosine phosphorylation of the Wiskott-Aldrich Syndrome protein by Lyn and Btk is regulated by CDC42. FEBS Lett. 434, 431-436.
    • (1998) FEBS Lett. , vol.434 , pp. 431-436
    • Guinamarda, R.1    Aspenströmb, P.2    Fougereaua, M.3    Chavriera, P.4    Guillemota, J.5
  • 17
    • 0028799957 scopus 로고
    • Mutations in twinstar, a Drosophila gene encoding a cofilin/ADF homologue, result in defects in centrosome migration and cytokinesis
    • Gunsalus, K. C., Bonaccorsi, S., Williams, E., Verni, F., Gatti, M. and Goldberg, M. L. (1995). Mutations in twinstar, a Drosophila gene encoding a cofilin/ADF homologue, result in defects in centrosome migration and cytokinesis. J. Cell Biol. 131, 1243-1259.
    • (1995) J. Cell Biol. , vol.131 , pp. 1243-1259
    • Gunsalus, K.C.1    Bonaccorsi, S.2    Williams, E.3    Verni, F.4    Gatti, M.5    Goldberg, M.L.6
  • 18
    • 0031965218 scopus 로고    scopus 로고
    • DRhoGEF2 encodes a member of the Dbl family of oncogenes and controls cell shape chages during gastrulation in Drosophila
    • Hacker, U. and Perrimon, N. (1998). DRhoGEF2 encodes a member of the Dbl family of oncogenes and controls cell shape chages during gastrulation in Drosophila. Genes Dev. 12, 274-284.
    • (1998) Genes Dev. , vol.12 , pp. 274-284
    • Hacker, U.1    Perrimon, N.2
  • 19
    • 0026285616 scopus 로고
    • In situ hybridization: An improved whole-mount method for Xenopus embryos
    • Harland, R. M. (1991). In situ hybridization: an improved whole-mount method for Xenopus embryos. Methods Cell Biol. 36, 685-695.
    • (1991) Methods Cell Biol. , vol.36 , pp. 685-695
    • Harland, R.M.1
  • 20
    • 0034650505 scopus 로고    scopus 로고
    • Regulation and function of Scr, exd, and hth in the Drosophila salivary gland
    • Henderson, K. D. and Andrew, D. J. (2000). Regulation and function of Scr, exd, and hth in the Drosophila salivary gland. Dev. Biol. 217, 362-374.
    • (2000) Dev. Biol. , vol.217 , pp. 362-374
    • Henderson, K.D.1    Andrew, D.J.2
  • 21
    • 0025633043 scopus 로고
    • Diverse expression of dsrc29A, a gene related to src, during the life cycle of Drosophila melanogaster
    • Katzen, A. L., Kornberg, T. and Bishop, J. M. (1990). Diverse expression of dsrc29A, a gene related to src, during the life cycle of Drosophila melanogaster. Development 110, 1169-1183.
    • (1990) Development , vol.110 , pp. 1169-1183
    • Katzen, A.L.1    Kornberg, T.2    Bishop, J.M.3
  • 22
    • 0037128203 scopus 로고    scopus 로고
    • Drosophila Kelch regulates actin organization via Src64-dependent tyrosine phosphorylation
    • Kelso, R. J., Hudson, A. M. and Cooley, L. (2002). Drosophila Kelch regulates actin organization via Src64-dependent tyrosine phosphorylation. J. Cell Biol. 156, 703-713.
    • (2002) J. Cell Biol. , vol.156 , pp. 703-713
    • Kelso, R.J.1    Hudson, A.M.2    Cooley, L.3
  • 23
    • 0028358931 scopus 로고
    • Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation
    • Knoblich, J. A., Sauer, K., Jones, L., Richardson, H., Saint, R. and Lehner, C. F. (1994). Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation. Cell 77, 107-120.
    • (1994) Cell , vol.77 , pp. 107-120
    • Knoblich, J.A.1    Sauer, K.2    Jones, L.3    Richardson, H.4    Saint, R.5    Lehner, C.F.6
  • 25
    • 1642304551 scopus 로고    scopus 로고
    • Inhibition of the cell cycle is required for convergent extension of the paraxial mesoderm during Xenopus neurulation
    • Leise, W. F., 3rd and Mueller, P. R. (2004). Inhibition of the cell cycle is required for convergent extension of the paraxial mesoderm during Xenopus neurulation. Development 131, 1703-1715.
    • (2004) Development , vol.131 , pp. 1703-1715
    • Leise III, W.F.1    Mueller, P.R.2
  • 26
    • 0025080165 scopus 로고
    • Cell shape changes during gastrulation in Drosophila
    • Leptin, M. and Grunewald, B. (1990). Cell shape changes during gastrulation in Drosophila. Development 110, 73-84.
    • (1990) Development , vol.110 , pp. 73-84
    • Leptin, M.1    Grunewald, B.2
  • 27
    • 0035660786 scopus 로고    scopus 로고
    • Role of Bruton's tyrosine kinase in B cell development
    • Maas, A. and Hendriks, R. W. (2001). Role of Bruton's tyrosine kinase in B cell development. Dev. Immunol. 8, 171-181.
    • (2001) Dev. Immunol. , vol.8 , pp. 171-181
    • Maas, A.1    Hendriks, R.W.2
  • 28
    • 0033190523 scopus 로고    scopus 로고
    • Tec family of protein-tyrosine kinases: An overview of their structure and function
    • Mano, H. (1999). Tec family of protein-tyrosine kinases: an overview of their structure and function. Cytokine Growth Factor Rev. 10, 267-280.
    • (1999) Cytokine Growth Factor Rev. , vol.10 , pp. 267-280
    • Mano, H.1
  • 29
    • 0034716905 scopus 로고    scopus 로고
    • Tribbles coordinates mitosis and morphogenesis in Drosophila by regulating string/CDC25 proteolysis
    • Mata, J., Curado, S., Ephrussi, A. and Rorth, P. (2000). Tribbles coordinates mitosis and morphogenesis in Drosophila by regulating string/CDC25 proteolysis. Cell 101, 511-522.
    • (2000) Cell , vol.101 , pp. 511-522
    • Mata, J.1    Curado, S.2    Ephrussi, A.3    Rorth, P.4
  • 30
    • 0034010981 scopus 로고    scopus 로고
    • Organ shape in the Drosophila salivary gland is controlled by regulated, sequential internalization of the primordia
    • Myat, M. M. and Andrew, D. J. (2000a). Organ shape in the Drosophila salivary gland is controlled by regulated, sequential internalization of the primordia. Development 127, 679-691.
    • (2000) Development , vol.127 , pp. 679-691
    • Myat, M.M.1    Andrew, D.J.2
  • 31
    • 0033763271 scopus 로고    scopus 로고
    • Fork head prevents apoptosis and promotes cell shape change during formation of the Drosophila salivary glands
    • Myat, M. M. and Andrew, D. J. (2000b). Fork head prevents apoptosis and promotes cell shape change during formation of the Drosophila salivary glands. Development 127, 4217-4226.
    • (2000) Development , vol.127 , pp. 4217-4226
    • Myat, M.M.1    Andrew, D.J.2
  • 32
    • 6944220167 scopus 로고    scopus 로고
    • A Rho GTPase signaling pathway is used reiteratively in epithelial folding and potentially selects the outcome of Rho activation
    • Nikolaidou, K. K. and Barrett, K. (2004). A Rho GTPase signaling pathway is used reiteratively in epithelial folding and potentially selects the outcome of Rho activation. Curr. Biol. 14, 1822-1826.
    • (2004) Curr. Biol. , vol.14 , pp. 1822-1826
    • Nikolaidou, K.K.1    Barrett, K.2
  • 33
    • 0026572990 scopus 로고
    • Organogenesis in Drosophila melanogaster: Embryonic salivary gland determination is controlled by homeotic and dorsoventral patterning genes
    • Panzer, S., Weigel, D. and Beckendorf, S. K. (1992). Organogenesis in Drosophila melanogaster: embryonic salivary gland determination is controlled by homeotic and dorsoventral patterning genes. Development 114, 49-57.
    • (1992) Development , vol.114 , pp. 49-57
    • Panzer, S.1    Weigel, D.2    Beckendorf, S.K.3
  • 34
    • 0032062412 scopus 로고    scopus 로고
    • The Tec29 tyrosine kinase is required during Drosophila embryogenesis and interacts with Src64 in ring canal development
    • Roulier, E. M., Panzer, S. and Beckendorf, S. K. (1998). The Tec29 tyrosine kinase is required during Drosophila embryogenesis and interacts with Src64 in ring canal development. Mol. Cell 1, 819-829.
    • (1998) Mol. Cell , vol.1 , pp. 819-829
    • Roulier, E.M.1    Panzer, S.2    Beckendorf, S.K.3
  • 35
    • 0033945186 scopus 로고    scopus 로고
    • The role of Bruton's tyrosine kinase in B-cell development and function: A genetic perspective
    • Satterthwaite, A. B. and Witte, O. N. (2000). The role of Bruton's tyrosine kinase in B-cell development and function: a genetic perspective. Immunol. Rev. 175, 120-127.
    • (2000) Immunol. Rev. , vol.175 , pp. 120-127
    • Satterthwaite, A.B.1    Witte, O.N.2
  • 36
    • 0036439238 scopus 로고    scopus 로고
    • Molecular mechanisms of epithelial morphogenesis
    • Schöck, F. and Perrimon, N. (2002). Molecular mechanisms of epithelial morphogenesis. Annu. Rev. Cell Dev Biol. 18, 463-493.
    • (2002) Annu. Rev. Cell Dev. Biol. , vol.18 , pp. 463-493
    • Schöck, F.1    Perrimon, N.2
  • 37
    • 0034213302 scopus 로고    scopus 로고
    • Tribbles, a cell-cycle brake that coordinates proliferation and morphogenesis during Drosophila gastrulation
    • Seher, T. C. and Leptin, M. (2000). Tribbles, a cell-cycle brake that coordinates proliferation and morphogenesis during Drosophila gastrulation. Curr. Biol. 10, 623-629.
    • (2000) Curr. Biol. , vol.10 , pp. 623-629
    • Seher, T.C.1    Leptin, M.2
  • 38
    • 0002726419 scopus 로고    scopus 로고
    • BrdU labeling of chromosomes
    • (ed. W. Sullivan, M. Ashburner and R. S. Hawley), New York: Cold Spring Harbor Press
    • Shermoen, A. W. (2000). BrdU labeling of chromosomes. In Drosophila Protocols (ed. W. Sullivan, M. Ashburner and R. S. Hawley), pp. 57-65. New York: Cold Spring Harbor Press.
    • (2000) Drosophila Protocols , pp. 57-65
    • Shermoen, A.W.1
  • 39
    • 0025874499 scopus 로고
    • The regulation of the cell cycle during Drosophila embryogenesis: The transition to polyteny
    • Smith, A. V. and Orr-Weaver, T. L. (1991). The regulation of the cell cycle during Drosophila embryogenesis: the transition to polyteny. Development 112, 997-1008.
    • (1991) Development , vol.112 , pp. 997-1008
    • Smith, A.V.1    Orr-Weaver, T.L.2
  • 40
    • 0036676540 scopus 로고    scopus 로고
    • Beyond calcium: New signaling pathways for Tec family kinases
    • Takesono, A., Finkelstein, L. D. and Schwartzberg, P. L. (2002). Beyond calcium: new signaling pathways for Tec family kinases. J. Cell Sci. 115, 3039-3048.
    • (2002) J. Cell Sci. , vol.115 , pp. 3039-3048
    • Takesono, A.1    Finkelstein, L.D.2    Schwartzberg, P.L.3
  • 41
    • 0033979243 scopus 로고    scopus 로고
    • Regulation of JNK by Src during Drosophila development
    • Tateno, M., Nishida, Y. and Adachi-Yamada, T. (2000). Regulation of JNK by Src during Drosophila development. Science 287, 324-327.
    • (2000) Science , vol.287 , pp. 324-327
    • Tateno, M.1    Nishida, Y.2    Adachi-Yamada, T.3
  • 42
    • 0024319520 scopus 로고
    • A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback
    • Tautz, D. and Pfeifle, C. (1989). A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. Chromosoma 98, 81-85.
    • (1989) Chromosoma , vol.98 , pp. 81-85
    • Tautz, D.1    Pfeifle, C.2
  • 43
    • 0025285657 scopus 로고
    • Crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia
    • Tepass, U., Theres, C. and Knust, E. (1990). crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia. Cell. 61, 787-799.
    • (1990) Cell , vol.61 , pp. 787-799
    • Tepass, U.1    Theres, C.2    Knust, E.3
  • 44
    • 0028180297 scopus 로고
    • Beta heavy-spectrin has a restricted tissue and subcellular distribution during Drosophila embryogenesis
    • Thomas, G. H. and Kiehart, D. P. (1994). Beta heavy-spectrin has a restricted tissue and subcellular distribution during Drosophila embryogenesis. Development 120, 2039-2050.
    • (1994) Development , vol.120 , pp. 2039-2050
    • Thomas, G.H.1    Kiehart, D.P.2
  • 45
    • 1342306010 scopus 로고    scopus 로고
    • Src64 and Tec29 are required for microfilament contraction during Drosophila cellularization
    • Thomas, J. H. and Wieschaus, E. (2004). Src64 and Tec29 are required for microfilament contraction during Drosophila cellularization. Development 131, 863-871.
    • (2004) Development , vol.131 , pp. 863-871
    • Thomas, J.H.1    Wieschaus, E.2
  • 46
    • 0024638404 scopus 로고
    • Embryonic expression of a Drosophila src gene: Alternate forms of the protein are expressed in segmental stripes and in the nervous system
    • Vincent, W. S., 3rd, Gregory, R. J. and Wadsworth, S. C. (1989). Embryonic expression of a Drosophila src gene: alternate forms of the protein are expressed in segmental stripes and in the nervous system. Genes Dev. 3, 334-347.
    • (1989) Genes Dev. , vol.3 , pp. 334-347
    • Vincent III, W.S.1    Gregory, R.J.2    Wadsworth, S.C.3
  • 47
    • 0025354989 scopus 로고
    • Differential expression of alternate forms of a Drosophila src protein during embryonic and larval tissue differentiation
    • Wadsworth, S. C., Muckenthaler, F. A. and Vincent, W. S., 3rd (1990). Differential expression of alternate forms of a Drosophila src protein during embryonic and larval tissue differentiation. Dev. Biol. 138, 296-312.
    • (1990) Dev. Biol. , vol.138 , pp. 296-312
    • Wadsworth, S.C.1    Muckenthaler, F.A.2    Vincent III, W.S.3
  • 48
    • 0024817008 scopus 로고
    • Primordium specific requirement of the homeotic gene fork head in the developing gut of the Drosophila embryo
    • Weigel, D., Bellen, H., Jürgens, G. and Jäckle, H. (1989). Primordium specific requirement of the homeotic gene fork head in the developing gut of the Drosophila embryo. Roux's Arch. Dev. Biol. 198, 201-210.
    • (1989) Roux's Arch. Dev. Biol. , vol.198 , pp. 201-210
    • Weigel, D.1    Bellen, H.2    Jürgens, G.3    Jäckle, H.4
  • 49
    • 0032510035 scopus 로고    scopus 로고
    • Continuous Cyclin E expression inhibits progression through endoreduplication cycles in Drosophila
    • Weiss, A., Herzig, A., Jacobs, H. and Lehner, C. F. (1998). Continuous Cyclin E expression inhibits progression through endoreduplication cycles in Drosophila. Curr. Biol. 8, 239-242.
    • (1998) Curr. Biol. , vol.8 , pp. 239-242
    • Weiss, A.1    Herzig, A.2    Jacobs, H.3    Lehner, C.F.4
  • 50
    • 0026032985 scopus 로고
    • Dynamic changes in the distribution of cytoplasmic myosin during Drosophila embryogenesis
    • Young, P. E., Pesacreta, T. C. and Kiehart, D. P. (1991). Dynamic changes in the distribution of cytoplasmic myosin during Drosophila embryogenesis. Development. 111, 1-14.
    • (1991) Development , vol.111 , pp. 1-14
    • Young, P.E.1    Pesacreta, T.C.2    Kiehart, D.P.3
  • 51
    • 0035448517 scopus 로고    scopus 로고
    • Salivary gland determination in Drosophila: A salivary-specific, fork head enhancer integrates spatial pattern and allows fork head autoregulation
    • Zhou, B., Bagri, A. and Beckendorf, S. K. (2001). Salivary gland determination in Drosophila: a salivary-specific, fork head enhancer integrates spatial pattern and allows fork head autoregulation. Dev. Biol. 237, 54-67.
    • (2001) Dev. Biol. , vol.237 , pp. 54-67
    • Zhou, B.1    Bagri, A.2    Beckendorf, S.K.3


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