Efficient production of complement (C3d)3 fusion proteins using the baculovirus expression vector system

Journal of Immunological Methods

Volumn 304, Issue 1-2, 2005, Pages 158-173

  Barrault, Denise V ^a,b   Steward, Michael ^c   Cox, Vivienne F ^d   Smith, Richard A G ^e   Knight, Andrew M ^a,f  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b IMEX Business Centre   (United Kingdom)

^c Domantis Limited   (United Kingdom)

^d ROYAL VETERINARY COLLEGE   (United Kingdom)

^e Inflazyme Pharmaceuticals Ltd   (Canada)

^f NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Adjuvant; B cells; Complement; Immunogenicity; Protein expression; Tetanus toxin

Indexed keywords

ANTIBODY; ANTIGEN; COMPLEMENT COMPONENT C3D; HYBRID PROTEIN; RECOMBINANT PROTEIN;

ANIMAL CELL; ANION EXCHANGE CHROMATOGRAPHY; ARTICLE; BACULOVIRUS EXPRESSION SYSTEM; BINDING AFFINITY; CELL ASSAY; CONTROLLED STUDY; GENE CONSTRUCT; GENE FUSION; IMMUNOREACTIVITY; IN VIVO STUDY; INFECTION; INSECT CELL; MOLECULAR BIOLOGY; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN PURIFICATION; SUPERNATANT;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; BACULOVIRIDAE; CELL LINE; CLONE CELLS; CLONING, MOLECULAR; CLOSTRIDIUM TETANI; COMPLEMENT C3D; FEMALE; GENETIC VECTORS; MICE; MICE, INBRED C57BL; MOTHS; PEPTIDE FRAGMENTS; RECOMBINANT FUSION PROTEINS; SPODOPTERA; TETANUS TOXIN;

INSECTA;

EID: 24344445276     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jim.2005.07.013     Document Type: Article

References (30)

1. J.M. Ahearn, M.B. Fischer, D. Croix, S. Goerg, M. Ma, J. Xia, X. Zhou, R.G. Howard, T.L. Rothstein, and M.C. Carroll Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen Immunity 4 1996 251
2. A.N. Antoniou, and C. Watts Antibody modulation of antigen presentation: positive and negative effects on presentation of the tetanus toxin antigen via the murine B cell isoform of FcgammaRII Eur. J. Immunol. 32 2002 530
3. D.V. Barrault, and A.M. Knight Distinct sequences in the cytoplasmic domain of complement receptor 2 are involved in antigen internalization and presentation J. Immunol. 172 2004 3509
4. R.A. Barrington, O. Pozdnyakova, M.R. Zafari, C.D. Benjamin, and M.C. Carroll B lymphocyte memory: role of stromal cell complement and Fc{gamma}RIIB receptors J. Exp. Med. 196 2002 1189
5. S.A. Boackle, V.M. Holers, and D.R. Karp CD21 augments antigen presentation in immune individuals Eur. J. Immunol. 27 1997 122
6. R.H. Carter, M.O. Spycher, Y.C. Ng, R. Hoffman, and D.T. Fearon Synergistic interaction between complement receptor type 2 and membrane IgM on B lymphocytes J. Immunol. 141 1988 457
7. A. Cherukuri, P.C. Cheng, and S.K. Pierce The role of the CD19/CD21 complex in B cell processing and presentation of complement-tagged antigens J. Immunol. 167 2001 163
8. A. Cherukuri, P.C. Cheng, H.W. Sohn, and S.K. Pierce The CD19/CD21 complex functions to prolong B cell antigen receptor signaling from lipid rafts Immunity 14 2001 169
9. P.W. Dempsey, M.E. Allison, S. Akkaraju, C.C. Goodnow, and D.T. Fearon C3d of complement as a molecular adjuvant: bridging innate and acquired immunity Science 271 1996 348
10. A. Eden, G.W. Miller, and V. Nussenzweig Human lymphocytes bear membrane receptors for C3b and C3d J. Clin. Invest. 52 1973 3239
11. Y. Fang, C. Xu, Y.X. Fu, V.M. Holers, and H. Molina Expression of complement receptors 1 and 2 on follicular dendritic cells is necessary for the generation of a strong antigen-specific IgG response J. Immunol. 160 1998 5273
12. T.D. Green, D.C. Montefiori, and T.M. Ross Enhancement of antibodies to the human immunodeficiency virus type 1 envelope by using the molecular adjuvant C3d J. Virol. 77 2003 2046
13. T. Hebell, J.M. Ahearn, and D.T. Fearon Suppression of the immune response by a soluble complement receptor of B lymphocytes Science 254 1991 102
14. E.W. Hewitt, A. Treumann, N. Morrice, P.J. Tatnell, J. Kay, and C. Watts Natural processing sites for human cathepsin E and cathepsin D in tetanus toxin: implications for T cell epitope generation J. Immunol. 159 1997 4693
15. M.R. Jacquier-Sarlin, F.M. Gabert, M.B. Villiers, and M.G. Colomb Modulation of antigen processing and presentation by covalently linked complement C3b fragment Immunology 84 1995 164
16. G.G. Klaus, and J.H. Humphrey The generation of memory cells. I. The role of C3 in the generation of B memory cells Immunology 33 1977 31
17. G.G. Klaus, J.H. Humphrey, A. Kunkl, and D.W. Dongworth The follicular dendritic cell: its role in antigen presentation in the generation of immunological memory Immunol. Rev. 53 1980 3
18. M.H. Kosco-Vilbois Are follicular dendritic cells really good for nothing? Nat. Rev. Immunol. 3 2003 764
19. M.H. Kosco-Vilbois, D. Gray, D. Scheidegger, and M. Julius Follicular dendritic cells help resting B cells to become effective antigen-presenting cells: induction of B7/BB1 and upregulation of major histocompatibility complex class II molecules J. Exp. Med. 178 1993 2055
20. W.H. Lay, and V. Nussenzweig Receptors for complement of leukocytes J. Exp. Med. 128 1968 991
21. H. Molina, V.M. Holers, B. Li, Y. Fung, S. Mariathasan, J. Goellner, J. Strauss-Schoenberger, R.W. Karr, and D.D. Chaplin Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2 Proceedings of the National Academy of Sciences of the United States of America vol. 93 1996 3357
22. D.R. O' Reilly, L.K. Miller, and V.A. Lucklow Baculovirus Expression Vectors: A Laboratory Manual 1992 W.H. Freeman and Co. NY
23. A.F. Ochsenbein, D.D. Pinschewer, B. Odermatt, M.C. Carroll, H. Hengartner, and R.M. Zinkernagel Protective T cell-independent antiviral antibody responses are dependent on complement J. Exp. Med. 190 1999 1165
24. M.B. Pepys Role of complement in induction of the allergic response Nat. New Biol. 237 1972 157
25. T.M. Ross, Y. Xu, R.A. Bright, and H.L. Robinson C3d enhancement of antibodies to hemagglutinin accelerates protection against influenza virus challenge Nat. Immunol. 1 2000 127
26. T.M. Ross, Y. Xu, T.D. Green, D.C. Montefiori, and H.L. Robinson Enhanced avidity maturation of antibody to human immunodeficiency virus envelope: DNA vaccination with gp120-C3d fusion proteins AIDS Res. Hum. Retrovir. 17 2001 829
27. F.K. Stevenson DNA vaccines and adjuvants Immunol. Rev. 199 2004 5
28. B.P. Thornton, V. Vetvicka, and G.D. Ross Natural antibody and complement-mediated antigen processing and presentation by B lymphocytes J. Immunol. 152 1994 1727
29. M.B. Villiers, C.L. Villiers, M.R. Jacquier-Sarlin, F.M. Gabert, A.M. Journet, and M.G. Colomb Covalent binding of C3b to tetanus toxin: influence on uptake/internalization of antigen by antigen-specific and non-specific B cells Immunology 89 1996 348
30. M.R. Wessels, P. Butko, M. Ma, H.B. Warren, A.L. Lage, and M.C. Carroll Studies of group B streptococcal infection in mice deficient in complement component C3 or C4 demonstrate an essential role for complement in both innate and acquired immunity Proc. Natl. Acad. Sci. U. S. A. 92 1995 11490