A multicellular systems biology model predicts epidermal morphology, kinetics and Ca2+ flow

Bioinformatics

Volumn 21, Issue 17, 2005, Pages 3541-3547

  Grabe, Niels ^a   Neuber, Karsten ^b  

^a UNIVERSITY OF HAMBURG   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION;

ALGORITHM; ARTICLE; BIOLOGICAL MODEL; CALCIUM TRANSPORT; CELL DIFFERENTIATION; EPIDERMIS; HOMEOSTASIS; HUMAN; KINETICS; MORPHOLOGY; PREDICTION; PRIORITY JOURNAL; SIMULATION; SQUAMOUS EPITHELIUM;

EID: 24144487070     PISSN: 13674803     EISSN: 13674811     Source Type: Journal    
DOI: 10.1093/bioinformatics/bti585     Document Type: Article

References (25)

1. Bartels,P.H. et al. (1976) Modeling of histologic images by computer. Acta Cytol., 20, 62-67.
2. Bauer,J. et al. (2001) A strikingly constant ratio exists between Langerhans cells and other epidermal cells in human skin. A stereologic study using the optical disector method and the confocal laser scanning microscope. J. Invest. Dermatol., 116, 313-318.
3. Castelijns,F.A. et al. (1998) Epidermal cell kinetics by combining in situ hybridization and immunohistochemistry. Histochem. J. 30, 869-877.
4. Clem,C.J. et al. (1997) A three-dimensional dynamic simulation model of epithelial tissue renewal. Anal. Quant. Cytol. Histol., 19, 174-184.
5. Elias,P. et al. (2002a) Origin of the epidermal calcium gradient: regulation by barrier status and role of active vs passive mechanisms. J. Invest. Dermatol., 119, 1269-1274.
6. Elias,P.M. et al. (2002b) Modulations in epidermal calcium regulate the expression of differentiation-specific markers. J. Invest. Dermatol., 119, 1128-1136.
7. Galle,J. et al. (2005) Modeling the effect of deregulated proliferation and apoptosis on the growth dynamics of epithelial cell populations in vitro. Biophys. J., 88, 62-75.
8. Grubauer,G. et al. (1989) Transepidermal water loss: The signal for recovery of barrier structure and function. J. Lipid Res., 30, 323-333.
9. Heenen,M. et al. (1998) Ki-67 immunostaining of normal human epidermis: Comparison with 3H-thymidine labelling and PCNA immunostaining. Dermatology, 197, 123-126.
10. Hoath,S. and Leahy,D. (2003) The organization of human epidermis: functional epidermal units and phi proportionality. J. Invest. Dermatol., 121, 1440-1446.
11. Hodgkin,A.L. and Huxley,A.F. (1952) A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol., 117, 500-544.
12. Honda,H. and Oshibe,S. (1984) A computer simulation of cell stacking for even thickness in mammalian epidermis. J. Theor. Biol., 111, 625-633.
13. Honda,H. et al. (1979) Establishment of epidermal cell columns in mammalian skin: Computer simulation. J. Theor. Biol., 81, 745-759.
14. Iizuka,H. et al. (1996) Epidermal remodelling in psoriasis. Br. J. Dermatol., 135, 433-438.
15. Luke,S. et al. (2003) MASON: A new multi-agent simulation toolkit. In Proceedings of the 2004 Swarmfest Workshop.
16. + gradients in routine epidermis: Quantitative measurement using PIXE. J. Invest. Dermatol., 111, 1198-1201.
17. Meineke,F.A. et al. (2001) Cell migration and organization in the intestinal crypt using a lattice free model. Cell Prolif., 34 253-266.
18. Mitrani,E. (1983) Is upward basal cell movement independent of mitosis in the normal epidermis? Br. J. Dermatol., 109, 635-642.
19. Morel,D. et al. (2001) A proliferation control network model: The simulation of two-dimensional epithelial homeostasis. Acta Biotheor. 49, 219-234.
20. Noble,D. (1962) A modification of the Hodgkin-Huxley equations applicable to Purkinje fibre action and pace-maker potentials. J. Physiol., 160, 317-352.
21. Noble,D. (2004) Modeling the heart. Physiology (Bethesda), 19 191-197.
22. Odland,G.F. and Holbrook,K. (1981) The lamellar granules of epidermis. Curr. Probl. Dermatol., 9, 29-49.
23. Rashbass,J. (1996) Modelling tissues on the computer. Trends Cell Biol., 6, 280-281.
24. Walker,D. et al. (2004) Agent-based computational modeling of epithelial cell monolayers: Predicting the effect of exogenous calcium concentration on the rate of wound closure. IEEE/ACM Trans. Nanobiosci., 3, 153-163.
25. Webb,A. et al. (2004) Location and phenotype of human adult keratinocyte stem cells of the skin. Differentiation, 72, 387-395.