PKCα depletion in RAW264.7 macrophages following microbial/IFNγ stimulation is PC-PLC-mediated

Antioxidants and Redox Signaling

Volumn 7, Issue 9-10, 2005, Pages 1217-1222

  Von Knethen, Andreas ^a   Brüne, Bernhard ^a  

^a GOETHE UNIVERSITY MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; BACTERIUM LIPOPOLYSACCHARIDE; CALCIUM ION; DIACYLGLYCEROL; GAMMA INTERFERON; LIPOTEICHOIC ACID; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHATIDYLCHOLINE; PHOSPHOLIPASE C; PHOSPHOLIPASE C INHIBITOR; PROTEIN KINASE C ALPHA; REACTIVE OXYGEN METABOLITE; TRICYCLO[4.3.0.1]DECAN 9 YL XANTHOGENATE;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CHRONIC INFLAMMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DESENSITIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; INCUBATION TIME; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SEPSIS; TH1 CELL; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; BRIDGED COMPOUNDS; CALCIUM; DIGLYCERIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ESTRENES; FLOW CYTOMETRY; FREE RADICALS; INTERFERON TYPE II; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MONOCYTES; OXYGEN; PHOSPHOLIPASE C; PROTEIN KINASE C-ALPHA; PYRROLIDINONES; REACTIVE OXYGEN SPECIES; TEICHOIC ACIDS; THIONES;

NEGIBACTERIA; POSIBACTERIA;

EID: 24144434439     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/ars.2005.7.1217     Document Type: Article

References (28)

1. Aderem A. How to eat something bigger than your head. Cell 110: 5-8, 2002.
2. Andrei C, Margiocco P, Poggi A, Lotti LV, Torrisi MR, and Rubartelli A. Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: implications for inflammatory processes. Proc Natl Acad Sci U S A 101: 9745-9750, 2004.
3. Beutler B and Rietschel ET. Innate immune sensing and its roots: the story of endotoxin. Nat Rev Immunol 3: 169-176, 2003.
4. Chang YJ, Holtzman MJ, and Chen CC. Interferon-gamma-induced epithelial ICAM-1 expression and monocyte adhesion. Involvement of protein kinase C-dependent c-Src tyrosine kinase activation pathway. J Biol Chem 277: 7118-7126, 2002.
5. Chiang LL, Kuo CT, Wang CH, Chen TF, Ho YS, Kuo HP, and Lin CH. Involvement of nuclear factor-kappaB in lipoteichoic acid-induced cyclooxygenase-2 expression in RAW 264.7 macrophages. J Pharm Pharmacol 55: 115-123, 2003.
6. Cross AR and Segal AW. The NADPH oxidase of professional phagocytes-prototype of the NOX electron transport chain systems. Biochim Biophys Acta 1657: 1-22, 2004.
7. Docke WD, Randow F, Syrbe U, Krausch D, Asadullah K, Reinke P, Volk HD, and Kox W. Monocyte deactivation in septic patients: restoration by IFN-gamma treatment. Nat Med 3: 678-681, 1997.
8. Forman HJ and Torres M. Reactive oxygen species and cell signaling: respiratory burst in macrophage signaling. Am J Respir Crit Care Med 166: S4-S8, 2002.
9. Fukami K. Structure, regulation, and function of phospholipase C isozymes. J Biochem (Tokyo) 131: 293-299, 2002.
10. Giroux M, Schmidt M, and Descoteaux A. IFN-gamma-induced MHC class II expression: transactivation of class II transactivator promoter IV by IFN regulatory factor-1 is regulated by protein kinase C-alpha. J Immunol 171: 4187-4194, 2003.
11. Hotchkiss RS and Karl IE. The pathophysiology and treatment of sepsis. N Engl J Med 348: 138-150, 2003.
12. Iles KE and Forman HJ. Macrophage signaling and respiratory burst. Immunol Res 26: 95-105, 2002.
13. Kalechman Y, Gafter U, Gal R, Rushkin G, Yan D, Albeck M, and Sredni B. Anti-IL-10 therapeutic strategy using the immunomodulator AS101 in protecting mice from sepsis-induced death: dependence on timing of immunomodulating intervention. J Immunol 169: 384-392, 2002.
14. Kengatharan M, De Kimpe SJ, and Thiemermann C. Analysis of the signal transduction in the induction of nitric oxide synthase by lipoteichoic acid in macrophages. Br J Pharmacol 117: 1163-1170, 1996.
15. Lambeth JD. NOX enzymes and the biology of reactive oxygen. Nat Rev Immunol 4: 181-189, 2004.
16. Lee SC, Han JS, Seo JK, and Cha YN. Modulation of cyclooxygenase-2 expression by phosphatidylcholine specific phospholipase C and D in macrophages stimulated with lipopolysaccharide. Mol Cells 15: 320-326, 2003.
17. 2 production and low density lipoprotein lipid oxidation. J Biol Chem 274: 3764-3771, 1999.
18. Liu WS and Heckman CA. The sevenfold way of PKC regulation. Cell Signal 10: 529-542, 1998.
19. Ma J, Chen T, Mandelin J, Ceponis A, Miller NE, Hukkanen M, Ma GF, and Konttinen YT. Regulation of macrophage activation. Cell Mol Life Sci 60: 2334-2346, 2003.
20. i. FASEB J 14: 1653-1663, 2000.
21. Plo I, Lautier D, Levade T, Sekouri H, Jaffrezou JP, Laurent G, and Bettaieb A. Phosphatidylcholine-specific phospholipase C and phospholipase D are respectively implicated in mitogen-activated protein kinase and nuclear factor kappaB activation in tumour-necrosis-factor-alpha-treated immature acute-myeloid-leukaemia cells. Biochem J 351: 459-467, 2000.
22. Riedemann NC, Guo RF, and Ward PA. Novel strategies for the treatment of sepsis. Nat Med 9: 517-524, 2003.
23. Sands WA, Clark JS, and Liew FY. The role of a phosphatidylcholine- specific phospholipase C in the production of diacylglycerol for nitric oxide synthesis in macrophages activated by IFN-gamma and LPS. Biochem Biophys Res Commun 199: 461-466, 1994.
24. Tschaikowsky K, Schmidt J, and Meisner M. Modulation of mouse endotoxin shock by inhibition of phosphatidylcholine-specific phospholipase C. J Pharmacol Exp Ther 285: 800-804, 1998.
25. Wang JH, Doyle M, Manning BJ, Blankson S, Wu QD, Power C, Cahill R, and Redmond HP. Cutting edge: bacterial lipoprotein induces endotoxin-independent tolerance to septic shock. J Immunol 170: 14-18, 2003.
26. 2+. Biochem J 374: 281-296, 2003.
27. Yamauchi Y, Hayashi M, Abe-Dohmae S, and Yokoyama S. Apolipoprotein A-I activates protein kinase C alpha signaling to phosphorylate and stabilize ATP binding cassette transporter A1 for the high density lipoprotein assembly. J Biol Chem 278: 47890-47897, 2003.
28. Zhang F, Zhao G, and Dong Z. Phosphatidylcholine-specific phospholipase C and D in stimulation of RAW264.7 mouse macrophage-like cells by lipopolysaccharide. Int Immunopharmacol 1: 1375-1384, 2001.