Effect of ldhA gene deletion on the metabolism of Escherichia coli based on gene expression, enzyme activities, intracellular metabolite concentrations, and metabolic flux distribution

Biochemical Engineering Journal

Volumn 26, Issue 1, 2005, Pages 1-11

  Kabir, Md Mohiuddin ^a,c   Pei, Yee Ho ^a   Shimizu, Kazuyuki ^a,b  

^a KYUSHU INSTITUTE OF TECHNOLOGY   (Japan)

^b KEIO UNIVERSITY   (Japan)

^c LAWRENCE LIVERMORE NATIONAL LABORATORY   (United States)

Author keywords

Anaerobic processes; Bioreactors; Enzyme activity; Gene expression; ldhA mutant E. coli; Metabolic flux distribution; Microbial growth

Indexed keywords

ALCOHOLS; BIOREACTORS; CONCENTRATION (PROCESS); ENZYMES; GENES; METABOLISM; METABOLITES;

ANEROBIC PROCESSES; ENZYME ACTIVITY; GENE EXPRESSION; IDHA MUTANT E. COLI; METABOLIC FLUX DISTRIBUTION; MICROBIAL GROWTH;

ESCHERICHIA COLI;

ACETIC ACID; ALCOHOL; FORMIC ACID; LACTATE DEHYDROGENASE; MALIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PHOSPHOENOLPYRUVATE CARBOXYLASE; PYRUVIC ACID; SUCCINIC ACID;

ARTICLE; BACTERIAL STRAIN; CATALYSIS; CELL METABOLISM; DOWN REGULATION; ENZYME ACTIVITY; ENZYME SPECIFICITY; ESCHERICHIA COLI; GENE CONTROL; GENE DELETION; GENE EXPRESSION; GLUCOSE INTAKE; HEAT SHOCK RESPONSE; METABOLISM; NONHUMAN; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; STRESS; UPREGULATION;

ESCHERICHIA COLI;

EID: 24044469045     PISSN: 1369703X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bej.2005.05.010     Document Type: Article

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