Role of conformational heterogeneity in domain swapping and adapter function of the Cks Proteins

Journal of Biological Chemistry

Volumn 280, Issue 34, 2005, Pages 30448-30459

  Seeliger, Markus A ^a,b   Spichty, Martin ^c   Kelly, Sadie E ^e   Bycroft, Mark ^a,b   Freund, Stefan M V ^a,b   Karplus, Martin ^c,d   Itzhaki, Laura S ^e  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b Harvard University ^*  (United Kingdom)

^c HARVARD UNIVERSITY   (United States)

^d UNIVERSITÉ LOUIS PASTEUR   (France)

^e HUTCHISON MRC RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEXATION; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE; PHOSPHORUS; PROTEINS; SPECTROSCOPIC ANALYSIS;

LIGANDS; MOLECULAR DYNAMIC SIMULATIONS; MULTIPROTEIN COMPLEXES; PHOSPHOPROTEIN BINDING;

CONFORMATIONS;

ADAPTOR PROTEIN; CYCLIN DEPENDENT KINASE 2; PROTEIN CKS; UNCLASSIFIED DRUG;

ARTICLE; BETA SHEET; BINDING AFFINITY; BINDING SITE; ENTROPY; GENETIC HETEROGENEITY; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HYDROGEN BOND; LIGAND BINDING; MATHEMATICAL ANALYSIS; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN MODIFICATION;

ALLOSTERIC SITE; BINDING SITES; CARRIER PROTEINS; CDC2-CDC28 KINASES; CELL CYCLE PROTEINS; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASES; DIMERIZATION; ESCHERICHIA COLI; HUMANS; HYDROGEN BONDING; LIGANDS; LYSINE; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MODELS, STATISTICAL; MULTIPROTEIN COMPLEXES; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN KINASES; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SOFTWARE; SOLVENTS; TIME FACTORS; WATER;

EID: 24044443897     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M501450200     Document Type: Article

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