메뉴 건너뛰기




Volumn 20, Issue 9, 2005, Pages 2653-2660

Levonorgestrel intrauterine system (LNG-IUS) with conjugated oral equine estrogen: A successful regimen for HRT in perimenopausal women

Author keywords

Bleeding; Endometrium; Hyperplasia; LNG IUS; Perimenopause

Indexed keywords

CONJUGATED ESTROGEN; LEVONORGESTREL;

EID: 24044442911     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/dei085     Document Type: Article
Times cited : (56)

References (50)
  • 1
    • 0025076634 scopus 로고
    • Levonorgestrel-releasing intrauterine device in the treatment of menorrhagia
    • Andersson K and Rybo G (1990) Levonorgestrel-releasing intrauterine device in the treatment of menorrhagia. Br J Obstet Gynaecol 97, 690-694.
    • (1990) Br. J. Obstet. Gynaecol. , vol.97 , pp. 690-694
    • Andersson, K.1    Rybo, G.2
  • 2
    • 0026654966 scopus 로고
    • Intrauterine release of levonorgestrel - A new way of adding progestogen in hormone replacement therapy
    • Andersson K, Mattsson LA, Rybo G and Stadberg E (1992) Intrauterine release of levonorgestrel - a new way of adding progestogen in hormone replacement therapy. Obstet Gynecol 79,963-967.
    • (1992) Obstet. Gynecol. , vol.79 , pp. 963-967
    • Andersson, K.1    Mattsson, L.A.2    Rybo, G.3    Stadberg, E.4
  • 3
    • 0028258807 scopus 로고
    • Levonorgestrel-releasing and copper-releasing (Nova T) IUDs during five years of use: A randomised comparative trial
    • Andersson K, Odlind V and Rybo G (1994) Levonorgestrel-releasing and copper-releasing (Nova T) IUDs during five years of use: A randomised comparative trial. Contraception 49,56-72.
    • (1994) Contraception , vol.49 , pp. 56-72
    • Andersson, K.1    Odlind, V.2    Rybo, G.3
  • 4
    • 0004034228 scopus 로고    scopus 로고
    • Points to consider on hormone replacement therapy
    • EMEA CPMP/EWP/021/97. Committee for Proprietary Medicinal Products, London. November 1997
    • EMEA (1997) Points to consider on hormone replacement therapy. CPMP/EWP/ 021/97. Committee for Proprietary Medicinal Products, London. November 1997.
    • (1997)
  • 7
    • 0024831713 scopus 로고
    • Compliance considerations with estrogen replacement withdrawal bleeding and other factors
    • Hahn RG (1989) Compliance considerations with estrogen replacement withdrawal bleeding and other factors. Am J Obstet Gynecol 161,1854-1858.
    • (1989) Am. J. Obstet. Gynecol. , vol.161 , pp. 1854-1858
    • Hahn, R.G.1
  • 10
    • 84921431140 scopus 로고    scopus 로고
    • Progesterone/progestogen releasing intrauterine systems versus either placebo or any other medication for heavy menstrual bleeding
    • (Cochrane Review) Update Software, Oxford
    • Lethaby AE, Cooke I and Rees M (2001) Progesterone/progestogen releasing intrauterine systems versus either placebo or any other medication for heavy menstrual bleeding (Cochrane Review). In the Cochrane Library. Update Software, Oxford.
    • (2001) In the Cochrane Library
    • Lethaby, A.E.1    Cooke, I.2    Rees, M.3
  • 11
    • 0026706414 scopus 로고
    • Endometrial effects of transdermal estradiol/norethisterone acetate
    • Lindgren R, Risberg B, Hammar M, Berg G and Pryse-Davies J (1992) Endometrial effects of transdermal estradiol/norethisterone acetate. Maturitas 15,71-78.
    • (1992) Maturitas , vol.15 , pp. 71-78
    • Lindgren, R.1    Risberg, B.2    Hammar, M.3    Berg, G.4    Pryse-Davies, J.5
  • 13
    • 0021949588 scopus 로고
    • Amenorrhea and endometrial atrophy with continuous oral estrogen and progestogen therapy in postmenopausal women
    • Magos AL, Brincat M, Studd JWW, Wardle P, Schlesinger P and O'Dowd T (1985) Amenorrhea and endometrial atrophy with continuous oral estrogen and progestogen therapy in postmenopausal women. Obstet Gynecol 65,496-499.
    • (1985) Obstet. Gynecol. , vol.65 , pp. 496-499
    • Magos, A.L.1    Brincat, M.2    Studd, J.W.W.3    Wardle, P.4    Schlesinger, P.5    O'Dowd, T.6
  • 14
    • 0020318181 scopus 로고
    • Evaluation of a continuous oestrogen-progestogen regimen for climacteric complaints
    • Mattsson LA, Cullberg G and Samsioe G (1982) Evaluation of a continuous oestrogen-progestogen regimen for climacteric complaints. Maturitas 4,95-102.
    • (1982) Maturitas , vol.4 , pp. 95-102
    • Mattsson, L.A.1    Cullberg, G.2    Samsioe, G.3
  • 15
    • 0242657312 scopus 로고    scopus 로고
    • Low dose hormone replacement therapy: Clinical efficacy
    • Mattsson LA and Sporrong T (2003) Low dose hormone replacement therapy: clinical efficacy. Minerva Ginecol 55,201-207.
    • (2003) Minerva Ginecol. , vol.55 , pp. 201-207
    • Mattsson, L.A.1    Sporrong, T.2
  • 16
    • 1642318709 scopus 로고    scopus 로고
    • A low-dose start in hormone replacement therapy provides a beneficial bleeding profile and few side-effects: Randomized comparison with a conventional-dose regimen
    • Mattsson LA, Skouby SO, Heikkinen J, Vaheri R, Maenpaa J and Timonen U (2004) A low-dose start in hormone replacement therapy provides a beneficial bleeding profile and few side-effects: Randomized comparison with a conventional-dose regimen. Climacteric 7,59-69.
    • (2004) Climacteric , vol.7 , pp. 59-69
    • Mattsson, L.A.1    Skouby, S.O.2    Heikkinen, J.3    Vaheri, R.4    Maenpaa, J.5    Timonen, U.6
  • 17
    • 0017344407 scopus 로고
    • Comparative quantification of menstrual blood loss of a d-norgestrel-releasing IUD and a Nova-T-copper device
    • Nilsson CG (1977) Comparative quantification of menstrual blood loss of a d-norgestrel-releasing IUD and a Nova-T-copper device. Contraception 15,379-387.
    • (1977) Contraception , vol.15 , pp. 379-387
    • Nilsson, C.G.1
  • 18
    • 0026668930 scopus 로고
    • Intrauterine progestin induces continuous insulin-like growth factor-binding protein-1 production in the human endometrium
    • Pekonen F, Nyman T, Lahteenamaki P et al. (1992) Intrauterine progestin induces continuous insulin-like growth factor-binding protein-1 production in the human endometrium. J Clin Endocrinol Metab 75,660-664.
    • (1992) J. Clin. Endocrinol. Metab. , vol.75 , pp. 660-664
    • Pekonen, F.1    Nyman, T.2    Lahteenamaki, P.3
  • 19
    • 0023221609 scopus 로고
    • Treatment of endometrial hyperplasia with levonorgestrel releasing intrauterine devices
    • Perino A, Quartararo P, Catinella E et al. (1987) Treatment of endometrial hyperplasia with levonorgestrel releasing intrauterine devices. Acta Eur Fertil 18,137-140.
    • (1987) Acta Eur. Fertil. , vol.18 , pp. 137-140
    • Perino, A.1    Quartararo, P.2    Catinella, E.3
  • 20
    • 0242661467 scopus 로고    scopus 로고
    • Endometrial effects of lower doses of conjugated equine estrogens and medroxyprogesterone acetate: Two-year substudy results
    • Pickar JH, Yeh IT, Wheeler JE, Cunnane MF and Speroff L (2003) Endometrial effects of lower doses of conjugated equine estrogens and medroxyprogesterone acetate: Two-year substudy results. Fertil Steril 80,1234-1240.
    • (2003) Fertil. Steril. , vol.80 , pp. 1234-1240
    • Pickar, J.H.1    Yeh, I.T.2    Wheeler, J.E.3    Cunnane, M.F.4    Speroff, L.5
  • 22
    • 0035170386 scopus 로고    scopus 로고
    • Estrogen replacement therapy: Determinants of persistence with treatment
    • Pilon D, Castilloux A-M and Lelorier J (2001) Estrogen replacement therapy: Determinants of persistence with treatment. Obstet Gynecol 197,97-100.
    • (2001) Obstet. Gynecol. , vol.197 , pp. 97-100
    • Pilon, D.1    Castilloux, A.-M.2    Lelorier, J.3
  • 23
    • 0023688286 scopus 로고
    • A microcomputer software for the analysis of menstrual diaries: The menstrual diary system
    • Pinol A and Machin D (1988) A microcomputer software for the analysis of menstrual diaries: The menstrual diary system. Contraception 38,157-163.
    • (1988) Contraception , vol.38 , pp. 157-163
    • Pinol, A.1    Machin, D.2
  • 24
    • 0007618820 scopus 로고
    • Transdermal estrogen with a levonorgestrel-releasing intrauterine device for climacteric complaints: Clinical and endometrial responses
    • Raudaskoski TH, Lahti EI, Kauppila A, Apaja-Sarkkinen MA and Laatikainen TJ (1995) Transdermal estrogen with a levonorgestrel-releasing intrauterine device for climacteric complaints: Clinical and endometrial responses. Am J Obstet Gynecol 156,1332-1334.
    • (1995) Am. J. Obstet. Gynecol. , vol.156 , pp. 1332-1334
    • Raudaskoski, T.H.1    Lahti, E.I.2    Kauppila, A.3    Apaja-Sarkkinen, M.A.4    Laatikainen, T.J.5
  • 25
    • 0027380655 scopus 로고
    • Comparison of transdermal and oral sequential gestagen in combination with transdermal estradiol: Effects on bleeding patterns and endometrial histology
    • Ross AH, Boyd ME, Colgan TJ, Ferenczy A, Fugere P and Lorrain P (1993) Comparison of transdermal and oral sequential gestagen in combination with transdermal estradiol: Effects on bleeding patterns and endometrial histology. Obstet Gynecol 82,773-779.
    • (1993) Obstet. Gynecol. , vol.82 , pp. 773-779
    • Ross, A.H.1    Boyd, M.E.2    Colgan, T.J.3    Ferenczy, A.4    Fugere, P.5    Lorrain, P.6
  • 26
    • 0031226055 scopus 로고    scopus 로고
    • mRNA expression of insulin-like growth factor-I (IGF-I) is suppressed and those of IGF-II and IGF-binding protein-1 are constantly expressed in the endometrium during use of an intrauterine levonorgestrel system
    • Rutanen EM, Salmi A and Nyman T (1997) mRNA expression of insulin-like growth factor-I (IGF-I) is suppressed and those of IGF-II and IGF-binding protein-1 are constantly expressed in the endometrium during use of an intrauterine levonorgestrel system. Mol Hum Reprod 3,749-754.
    • (1997) Mol. Hum. Reprod. , vol.3 , pp. 749-754
    • Rutanen, E.M.1    Salmi, A.2    Nyman, T.3
  • 27
    • 0034676775 scopus 로고    scopus 로고
    • Extracts from "clinical evidence" menopausal symptoms
    • Rymer J and Morris EP (2000) Extracts from "clinical evidence" menopausal symptoms. BMJ 321(7275),1516-1519.
    • (2000) BMJ , vol.321 , Issue.7275 , pp. 1516-1519
    • Rymer, J.1    Morris, E.P.2
  • 28
    • 0031744092 scopus 로고    scopus 로고
    • The effect of intrauterine levonorgestrel use on the expression of c-JUN, oestrogen receptors, progesterone receptors and Ki-67 in human endometrium
    • Salmi A, Pakarinen P, Peltola AM and Rutanen EM (1998) The effect of intrauterine levonorgestrel use on the expression of c-JUN, oestrogen receptors, progesterone receptors and Ki-67 in human endometrium. Mol Hum Reprod 4,1110-1115.
    • (1998) Mol. Hum. Reprod. , vol.4 , pp. 1110-1115
    • Salmi, A.1    Pakarinen, P.2    Peltola, A.M.3    Rutanen, E.M.4
  • 32
    • 0019795849 scopus 로고
    • Continuous treatment with natural oestrogens and progestogens. A method to avoid endometrial stimulation
    • Staland B (1981) Continuous treatment with natural oestrogens and progestogens. A method to avoid endometrial stimulation. Maturitas 3,145-156.
    • (1981) Maturitas , vol.3 , pp. 145-156
    • Staland, B.1
  • 34
    • 0028894697 scopus 로고
    • Intrauterine and subdermal progestin administration in postmenopausal hormone therapy
    • Suhonen SP, Holmstrom T, Allonen H and Lahteenmaki P (1995a) Intrauterine and subdermal progestin administration in postmenopausal hormone therapy. Fertil Steril 63,336-342.
    • (1995) Fertil. Steril. , vol.63 , pp. 336-342
    • Suhonen, S.P.1    Holmstrom, T.2    Allonen, H.3    Lahteenmaki, P.4
  • 35
    • 0028959666 scopus 로고
    • Sustained release estradiol implants and a levonorgestrel-releasing intrauterine device in hormone replacement therapy
    • Suhonen SP, Allonen H and Lahteenmaki P (1995b) Sustained release estradiol implants and a levonorgestrel-releasing intrauterine device in hormone replacement therapy. Am J Obstet Gynecol 172,562-567.
    • (1995) Am. J. Obstet. Gynecol. , vol.172 , pp. 562-567
    • Suhonen, S.P.1    Allonen, H.2    Lahteenmaki, P.3
  • 36
    • 0029871353 scopus 로고    scopus 로고
    • Endometrial response to hormone replacement therapy as assessed by expression of insulin-like growth factor-binding protein-1 in the endometrium
    • Suhonen S, Haukkamaa M, Holmstrom T, Lahteenmaki P and Rutanen EM (1996) Endometrial response to hormone replacement therapy as assessed by expression of insulin-like growth factor-binding protein-1 in the endometrium. Fertil Steril 65,776-782.
    • (1996) Fertil. Steril. , vol.65 , pp. 776-782
    • Suhonen, S.1    Haukkamaa, M.2    Holmstrom, T.3    Lahteenmaki, P.4    Rutanen, E.M.5
  • 37
    • 0031059743 scopus 로고    scopus 로고
    • Three year follow-up of the use of a levonorgestrel-releasing system in hormone replacement therapy
    • Suhonen SP, Holmstrom T and Lahteenmaki P (1997) Three year follow-up of the use of a levonorgestrel-releasing system in hormone replacement therapy. Acta Obstet Gynecol Scand 76,145-150.
    • (1997) Acta Obstet. Gynecol. Scand. , vol.76 , pp. 145-150
    • Suhonen, S.P.1    Holmstrom, T.2    Lahteenmaki, P.3
  • 38
    • 0033168317 scopus 로고    scopus 로고
    • The levonorgestrel intrauterine system in menopausal hormone replacement therapy: Five year experience
    • Suvanto-Luukkonen E and Kauppila A (1999) The levonorgestrel intrauterine system in menopausal hormone replacement therapy: Five year experience. Fertil Steril 72,161-163.
    • (1999) Fertil. Steril. , vol.72 , pp. 161-163
    • Suvanto-Luukkonen, E.1    Kauppila, A.2
  • 39
    • 0028828174 scopus 로고
    • Insulin-like growth factor-binding protein-1: A biochemical marker of endometrial response to progestin during hormone replacement therapy
    • Suvanto-Luukkonen E, Sundstrom H, Penttinen J, Kauppila A and Rutanen EM (1995) Insulin-like growth factor-binding protein-1: A biochemical marker of endometrial response to progestin during hormone replacement therapy. Maturitas 22,255-262.
    • (1995) Maturitas , vol.22 , pp. 255-262
    • Suvanto-Luukkonen, E.1    Sundstrom, H.2    Penttinen, J.3    Kauppila, A.4    Rutanen, E.M.5
  • 40
    • 0030963160 scopus 로고    scopus 로고
    • Percutaneous estradiol gel with an intrauterine levonorgestrel releasing device or natural progesterone in hormone replacement therapy
    • Suvanto-Luukkonen E, Sundstrom H, Penttinen J, Laara E, Pramila S and Kauppila A (1997) Percutaneous estradiol gel with an intrauterine levonorgestrel releasing device or natural progesterone in hormone replacement therapy. Maturitas 26,211-217.
    • (1997) Maturitas , vol.26 , pp. 211-217
    • Suvanto-Luukkonen, E.1    Sundstrom, H.2    Penttinen, J.3    Laara, E.4    Pramila, S.5    Kauppila, A.6
  • 41
    • 0035854025 scopus 로고    scopus 로고
    • Hormone replacement therapy and prevention of nonvertebral fractures. A meta-analysis of randomized trials
    • Torgerson DJ and Bell-Syer SEM (2001) Hormone replacement therapy and prevention of nonvertebral fractures. A meta-analysis of randomized trials. J Am Med Assoc 285,2891-2897.
    • (2001) J. Am. Med. Assoc. , vol.285 , pp. 2891-2897
    • Torgerson, D.J.1    Bell-Syer, S.E.M.2
  • 42
    • 0023889465 scopus 로고
    • Clinicopathologic findings in endometrial polyps
    • Van Bogaert LJ (1988) Clinicopathologic findings in endometrial polyps. Obstet Gynecol 5,771-773.
    • (1988) Obstet. Gynecol. , vol.5 , pp. 771-773
    • Van Bogaert, L.J.1
  • 43
    • 0034766176 scopus 로고    scopus 로고
    • A 5-year follow-up study on the use of a levonorgestrel intrauterine system in women receiving hormone replacement therapy
    • Varila E, Wahlstrom T and Rauramo I (2001) A 5-year follow-up study on the use of a levonorgestrel intrauterine system in women receiving hormone replacement therapy. Fertil Steril 76,969-973.
    • (2001) Fertil. Steril. , vol.76 , pp. 969-973
    • Varila, E.1    Wahlstrom, T.2    Rauramo, I.3
  • 45
    • 0025372654 scopus 로고
    • Evaluation of a continuous combined low-dose regimen of estrogen-progestin for treatment of the menopausal patient
    • Weinstein L, Belwtra C and Gallagher JC (1990) Evaluation of a continuous combined low-dose regimen of estrogen-progestin for treatment of the menopausal patient. Am J Obstet Gynecol 162,1534-1542.
    • (1990) Am. J. Obstet. Gynecol. , vol.162 , pp. 1534-1542
    • Weinstein, L.1    Belwtra, C.2    Gallagher, J.C.3
  • 46
    • 0037014937 scopus 로고    scopus 로고
    • Effect on endometrium of long term treatment with continuous combined oestrogen-progestogen replacement therapy: Follow-up study
    • Wells M, Sturdee DW, Barlow DH, Ulrich LG, O'Brien K, Campbell MJ, Vessey MP and Bragg AJ (2002) Effect on endometrium of long term treatment with continuous combined oestrogen-progestogen replacement therapy: Follow-up study. Br Med J 325(7358),231-232.
    • (2002) Br. Med. J. , vol.325 , Issue.7358 , pp. 231-232
    • Wells, M.1    Sturdee, D.W.2    Barlow, D.H.3    Ulrich, L.G.4    O'Brien, K.5    Campbell, M.J.6    Vessey, M.P.7    Bragg, A.J.8
  • 47
    • 0025190134 scopus 로고
    • A study of combined continuous ethinyloestradiol and norethindrone acetate for postmenopausal hormone replacement
    • Williams SR, Frenchek B, Speroff T and Speroff L (1990) A study of combined continuous ethinyloestradiol and norethindrone acetate for postmenopausal hormone replacement. Am J Obstet Gynecol 162,438-446.
    • (1990) Am. J. Obstet. Gynecol. , vol.162 , pp. 438-446
    • Williams, S.R.1    Frenchek, B.2    Speroff, T.3    Speroff, L.4
  • 48
    • 0001657785 scopus 로고    scopus 로고
    • Effects of hormone replacement therapy on endometrial histology in postmenopausal women. The postmenopausal estrogen/progestin interventions (PEPI) trial
    • Writing Group for the PEPI Trial
    • Writing Group for the PEPI Trial (1996) Effects of hormone replacement therapy on endometrial histology in postmenopausal women. The postmenopausal estrogen/progestin interventions (PEPI) trial. J Am Med Assoc 275,370-375.
    • (1996) J. Am. Med. Assoc. , vol.275 , pp. 370-375
  • 49
    • 0037125379 scopus 로고    scopus 로고
    • Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial
    • Writing Group for the Women's Health Initiative Investigators
    • Writing Group for the Women's Health Initiative Investigators (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial. J Am Med Assoc 288,321-333.
    • (2002) J. Am. Med. Assoc. , vol.288 , pp. 321-333
  • 50
    • 0024457367 scopus 로고
    • The effect of intrauterine devices, the stainless steel ring, the Copper T 220 and releasing levonorgestrel, on the bleeding profile and the morphological structure of the human endometrium - A comparative study of three IUDs. A morphometric study of 96 cases
    • Zhu P, Luo HZ, Xu RH, Cheng J, Wu SC, Chen JH, Wu MZ and Wang XP (1989) The effect of intrauterine devices, the stainless steel ring, the Copper T 220 and releasing levonorgestrel, on the bleeding profile and the morphological structure of the human endometrium - a comparative study of three IUDs. A morphometric study of 96 cases. Contraception 40, 425-438.
    • (1989) Contraception , vol.40 , pp. 425-438
    • Zhu, P.1    Luo, H.Z.2    Xu, R.H.3    Cheng, J.4    Wu, S.C.5    Chen, J.H.6    Wu, M.Z.7    Wang, X.P.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.