HRT and Vit D in prevention of non-vertebral fractures in postmenopausal women; A 5 year randomized trial

Maturitas

Volumn 31, Issue 1, 1998, Pages 45-54

  Komulainen, Marja H ^a   Kröger, Heikki ^a   Tuppurainen, Marjo T ^a   Heikkinen, Anna Mari ^a   Alhava, Esko ^a   Honkanen, Risto ^b,c   Saarikoski, Seppo ^a  

^a KUOPIO UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF TROMSØ   (Norway)

^c UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Fracture risk; Hormone replacement therapy; Menopause; Osteoporosis; Vitamin D3

Indexed keywords

CALCIUM; CALCIUM LACTATE; COLECALCIFEROL; CYPROTERONE ACETATE; CYPROTERONE ACETATE PLUS ESTRADIOL VALERATE; D CALSOR; ESTRADIOL; PLACEBO; UNCLASSIFIED DRUG; VITAMIN D;

ADULT; ARTICLE; BONE MINERAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DOUBLE BLIND PROCEDURE; DUAL ENERGY X RAY ABSORPTIOMETRY; ESTROGEN THERAPY; FEMALE; FEMUR NECK; FRACTURE; HEADACHE; HUMAN; MAJOR CLINICAL STUDY; MENSTRUATION DISORDER; MULTICENTER STUDY; ORAL DRUG ADMINISTRATION; OSTEOPOROSIS; POSTMENOPAUSE; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT;

BONE DENSITY; FEMALE; FRACTURES, BONE; HORMONE REPLACEMENT THERAPY; HUMANS; MIDDLE AGED; OSTEOPOROSIS, POSTMENOPAUSAL; PROSPECTIVE STUDIES; TREATMENT OUTCOME; VITAMIN D;

EID: 0344718436     PISSN: 03785122     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5122(98)00085-1     Document Type: Article

References (18)

1. Cauley JA, Seeley DG, Ensrud KE, Ettinger B, Black D, Cummings S. Estrogen replacement therapy and fractures in older women. Ann Intern Med 1995;122:9-16.
2. Tuppurainen M, Kröger H, Honkanen R, et al. Risks for perimenopausal fractures - a population-based study over 2.4 years follow-up. Acta Obstet Gynecol Scand 1995;74:624-8.
3. Consensus Development Conference. Diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med 1993;94:646-50.
4. Kanis JA, Johnell O, Gullberg B, et al. Evidence for efficacy of drugs affecting bone metabolism in preventing hip fracture. BMJ 1992;305:1124-8.
5. Naessen T, Persson I, Adami HO, Bergström R, Bergkvist. Hormone replacement therapy and the risk for first hip fracture. A prospective, population-based cohort study. Ann Intern Med 1990;113:95-103.
6. Kiel DP, Felson DT, Anderson JJ, Wilson PWF, Moskowitz MA. Hip fracture and the use of estrogens in postmenopausal women. New Engl J Med 1987;317:1169-74.
7. Ooms ME, Roos JC, Bezemer PD, et al. Prevention of bone loss by vitamin D supplementation in elderly women: a randomized double-blind trial. J Clin Endocrinol Metab 1995;80:1052-8.
8. 3 and calcium to prevent hip fractures in elderly women. New Engl J Med 1992;327:1637-42.
9. Lips P, Graafmans WC, Ooms ME, Bezemer PD, Bouter LM. Vitamin D supplementation and fracture incidence in elderly persons. Ann Intern Med 1996;124:400-6.
10. 3. Maturitas 1995;22:55-61.
11. Kröger H, Heikkinen J, Laitinen K, Kotaniemi A. Dual-energy X-ray absorptiometry in normal women: a cross-sectional study of 717 Finnish volunteers. Osteoporos Int 1992;2:135-40.
12. Lindstedt K. Validity of a short questionnaire on calcium intake. M.Sc. thesis. Deptartment of Clinical Nutrition, University of Kuopio, 1993. (In Finnish).
13. Komulainen M, Tuppurainen MT, Kröger H, et al. Vitamin D and HRT-no benefit additional to that of HRT alone in prevention of bone loss in early postmenopausal women; a 2.5-year randomized placebo-controlled study. Osteoporos Int 1997;7:126-32.
14. Lufkin EG, Wahner HW, O'Fallon WM, et al. Treatment of postmenopausal osteoporosis with transdermal estrogen. Ann Intern Med 1992;117:1-9.
15. 3 on circulating levels of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin. D. Calcif Tissue Int 1998;62:26-30.
16. Cummings SR, Black DM, Nevitt MC, et al. Bone density at various sites for prediction of hip fractures. Lancet 1993;341:72-5.
17. Kröger H, Huopio J, Honkanen R, et al. Prediction of fracture risk using axial bone mineral density in a perimenopausal population: a prospective study. J Bone Miner Res 1995;10:302-6.
18. Sanders KM, Pasco JA, Ugoni AM. Low trauma fractures underestimate the incidence of osteoporosis (abstract). J Bone Miner Res 1997;12 Suppl 1:S173.