Altered mitochondrial RNA production in adipocytes from HIV-infected individuals with lipodystrophy

Antiviral Therapy

Volumn 10, Issue SUPPL. 2, 2005, Pages

  Galluzzi, Lorenzo ^a   Pinti, Marcello ^a   Guaraldi, Giovanni ^b   Mussini, Cristina ^b   Troiano, Leonarda ^a   Roat, Erika ^a   Giovenzana, Chiara ^a   Nemes, Elisa ^a   Nasi, Milena ^a   Orlando, Gabriella ^b   Salomoni, Paolo ^c   Cossarizza, Andrea ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL RNA; RNA DIRECTED DNA POLYMERASE INHIBITOR;

ADIPOCYTE; ADULT; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HIV ASSOCIATED LIPODYSTROPHY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; MALE; MITOCHONDRIAL TOXICITY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RNA ANALYSIS; RNA DEGRADATION; SEX DIFFERENCE; STATISTICAL SIGNIFICANCE;

ADIPOCYTES; ADULT; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; BASE SEQUENCE; DNA, MITOCHONDRIAL; FEMALE; HIV INFECTIONS; HIV-ASSOCIATED LIPODYSTROPHY SYNDROME; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; REVERSE TRANSCRIPTASE INHIBITORS; RNA; TRANSCRIPTION, GENETIC;

EID: 24044437217     PISSN: 13596535     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (41)

1. Carr A, Samaras K, Burton S, Law M, Freund J, Chisholm DJ & Cooper DA. A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors. AIDS 1998; 12:F51-F58.
2. Carr A. HIV lipodystrophy: risk factors, pathogenesis, diagnosis and management. AIDS 2003; 17(Suppl 1):S141-S148.
3. Brinkman K, Smeitink JA, Romijn JA & Reiss P. Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy-related lipodystrophy. Lancet 1999; 354:1112-1115.
4. Carr A, Samaras K, Thorisdottir A, Kaufmann GR, Chisholm DJ & Cooper DA. Diagnosis, prediction, and natural course of HIV-1 protease-inhibitor- associated lipodystrophy, hyperlipidaemia, and diabetes mellitus: a cohort study. Lancet 1999; 353:2093-2099.
5. Carr A, Miller J, Law M & Cooper DA. A syndrome of lipoatrophy, lactic acidaemia and liver dysfunction associated with HIV nucleoside analogue therapy: contribution to protease inhibitor-related lipodystrophy syndrome. AIDS 2000; 14:F25-F32.
6. Côté HC, Brumme ZL, Craib KJ, Alexander CS, Wynhoven B, Ting L, Wong H, Harris M, Harrigan PR, O'Shaughnessy MV & Montaner JS. Changes in mitochondrial DNA as a marker of nucleoside toxicity in HIV-infected patients. New England Journal of Medicine 2002; 346:811-820.
7. Cossarizza A, Troiano L & Mussini C. Mitochondria and HIV infection: the first decade. Journal of Biological Regulators & Homeostatic Agents 2002; 16:18-24.
8. Cossarizza A, Pinti M, Moretti L, Bricalli D, Bianchi R, Troiano L, Fernandez MG, Balli F, Brambilla P, Mussini C & Vigano A. Mitochondrial functionality and mitochondrial DNA content in lymphocytes of vertically infected human immunodeficiency virus-positive children with highly active antiretroviral therapy-related lipodystrophy. Journal of Infectious Diseases 2002; 185:299-305.
9. Cossarizza A, Riva A, Pinti M, Ammannato S, Fedeli P, Mussini C, Esposito R & Galli M. Increased mitochondrial DNA content in peripheral blood lymphocytes from HIV-infected patients with lipodystrophy. Antiviral Therapy 2003; 8:315-321.
10. Hoy JF, Gahan ME, Carr A, Smith D, Lewin SR, Wesselingh S & Cooper DA. Changes in mitochondrial DNA in peripheral blood mononuclear cells from HIV-infected patients with lipoatrophy randomized to receive abacavir. Journal of Infectious Diseases 2004; 190:688-692.
11. Shikuma CM, Hu N, Milne C, Yost F, Waslien C, Shimizu S & Shiramizu B. Mitochondrial DNA decrease in subcutaneous adipose tissue of HIV-infected individuals with peripheral lipoatrophy. AIDS 2001; 15:1801-1809.
12. Shiramizu B, Shikuma KM, Kamemoto L, Gerschenson M, Erdem G, Pinti M, Cossarizza A & Shikuma C. Placenta and cord blood mitochondrial DNA toxicity in HIV-infected women receiving nucleoside reverse transcriptase inhibitors during pregnancy. Journal of Acquired Immune Deficiency Syndromes 2003; 32:370-374.
13. Cossarizza A & Moyle G. Antiretroviral nucleoside and nucleotide analogues and mitochondria. AIDS 2004; 18:137-151.
14. Galluzzi L, Pinti M, Troiano L, Prada N, Nasi M, Ferraresi R, Salomoni P, Mussini C & Cossarizza A. Changes in mitochondrial RNA production in cells treated with nucleoside analogues. Antiviral Therapy 2005; 10:191-195.
15. Anderson S, Bankier AT, Barrell BG, de Bruijn MH, Coulson AR, Drouin J, Eperon IC, Nierlich DP, Roe BA, Sanger F, Schreier PH, Smith AJ, Staden R & Young IG. Sequence and organization of the human mitochondrial genome. Nature 1981; 290:457-465.
16. Bonen L. The mitochondrial genome: so simple yet so complex. Current Opinion in Genetics & Development 1991; 1:515-522.
17. Shuey DJ & Attardi G. Characterization of an RNA polymerase activity from HeLa cell mitochondria, which initiates transcription at the heavy strand rRNA promoter and the light strand promoter in human mitochondrial DNA. Journal of Biological Chemistry 1985; 260:1952-1958.
18. Clayton DA. Transcription of the mammalian mitochondrial genome. Annual Reviews of Biochemistry 1984; 53:573-594.
19. Clayton DA. Transcription and replication of mitochondrial DNA. Human Reproduction 2000; 15(Suppl 2):11-17.
20. Sambrook J & Russell DW. Molecular Cloning: a Laboratory Manual. 3rd edn 2001. New York: Cold Spring Harbor Laboratory Press.
21. Pinti M, Troiano L, Nasi M, Monterastelli E, Moretti L, Bellodi C, Mazzacani A, Mussi C, Salvioli G & Cossarizza A. Development of real time PCR assays for the quantification of Fas and FasL mRNA levels in lymphocytes: studies on centenarians. Mechanisms of Ageing & Development 2003; 124:511-516.
22. Fu X, Menke JG, Chen Y, Zhou G, MacNaul KL, Wright SD, Sparrow CP & Lund EG. 27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. Journal of Biological Chemistry 2001; 276:38378-38387.
23. Cherry CL, Gahan ME, McArthur JC, Lewin SR, Hoy JF & Wesselingh SL. Exposure to dideoxynucleosides is reflected in lowered mitochondrial DNA in subcutaneous fat. Journal of Acquired Immune Deficiency Syndromes 2002; 30:271-277.
24. Walker UA, Bickel M, Lutke Volksbeck SI, Ketelsen UP, Schofer H, Setzer B, Venhoff N, Rickerts V & Staszewski S. Evidence of nucleoside analogue reverse transcriptase inhibitor - associated genetic and structural defects of mitochondria in adipose tissue of HIV-infected patients. Journal of Acquired Immune Deficiency Syndromes 2002; 29:117-121.
25. Nolan D, Hammond E, Martin A, Taylor L, Herrmann S, McKinnon E, Metcalf C, Latham B & Mallal S. Mitochondrial DNA depletion and morphologic changes in adipocytes associated with nucleoside reverse transcriptase inhibitor therapy. AIDS 2003; 17:1329-1338.
26. van der Valk M, Casula M, Weverlingz GJ, van Kuijk K, van Eck-Smit B, Hulsebosch HJ, Nieuwkerk P, van Eeden A, Brinkman K, Lange J, de Ronde A & Reiss P. Prevalence of lipoatrophy and mitochondrial DNA content of blood and subcutaneous fat in HIV-1-infected patients randomly allocated to zidovudine- or stavudine-based therapy. Antiviral Therapy 2004; 9:385-393.
27. Mallal SA, John M, Moore CB, James IR & McKinnon EJ. Contribution of nucleoside analogue reverse transcriptase inhibitors to subcutaneous fat wasting in patients with HIV infection. AIDS 2000; 14:309-1316.
28. Zaera MG, Mirò O, Pedrol E, Soler A, Picon M, Cardellach F, Casademont J & Nunes V. Mitochondrial involvement in antiretroviral therapy-related lipodystrophy. AIDS 2001; 15:1643-1651.
29. Pace CS, Martin AM, Hammond EL, Mamotte CD, Nolan DA & Mallal SA. Mitochondrial proliferation, DNA depletion and adipocyte differentiation in subcutaneous adipose tissue of HIV-positive HAART recipients. Antiviral Therapy 2003; 8:323-331.
30. Carr A, Workman C, Smith DE, Hoy J, Hudson J, Doong N, Martin A, Amin J, Freund J, Law M & Cooper DA; for the Mitochondrial Toxicity (MITOX) Study Group. Abacavir substitution for nucleoside analogs in patients with HIV lipoatrophy: a randomized trial. Journal of the American Medical Association 2002; 288:207-215.
31. Martin A, Smith DE, Carr A, Ringland C, Amin J, Emery S, Hoy J, Workman C, Doong N, Freund J & Cooper DA; for the Mitochondrial Toxicity (MITOX) Study Group. Reversibility of lipoatrophy in HIV-infected patients 2 years after switching from a thymidine analogue to abacavir: the MITOX Extension Study. AIDS 2004; 18:1029-1036.
32. McComsey GA, Paulsen DM, Lonergan JT, Hessenthaler SM, Hoppel CL, Williams VC, Fisher RL, Cherry CL, White-Owen C, Thompson KA, Ross ST, Hernandez JE & Ross LL. Improvements in lipoatrophy, mitochondrial DNA levels and fat apoptosis after replacing stavudine with abacavir or zidovudine. AIDS 2005; 19:15-24.
33. Negredo E, Paredes R, Peraire J, Pedrol E, Côté H, Gel S, Fumoz CR, Ruiz L, Abril V, Rodriguez de Castro E, Ochoa C, Martinez-Picado J, Montaner J, Rey-Joly C & Clotet B (Swatch Study Team). Alternation of antiretroviral drug regimens for HIV infection. Efficacy, safety and tolerability at week 96 of the Swatch Study. Antiviral Therapy 2004; 9:889-893.
34. Hammond E, Nolan D, James I, Metcalf C & Mallal S. Reduction of mitochondrial DNA content and respiratory chain activity occurs in adipocytes within 6-12 months of commencing nucleoside reverse transcriptase inhibitor therapy. AIDS 2004; 18:815-817.
35. Seidel-Rogol BL & Shadel GS. Modulation of mitochondrial transcription in response to mtDNA depletion and repletion in HeLa cells. Nucleic Acids Research 2002; 30:1929-1934.
36. Mirò O, Lopez S, Rodriguez de la Concepcion M, Martinez E, Pedrol E, Garrabou G, Giralt M, Cardellach F, Gatell JM, Vilarroya F & Casademont J. Upregulatory mechanisms compensate for mitochondrial DNA depletion in asymptomatic individuals receiving stavudine plus didanosine. Journal of Acquired Immune Deficiency Syndromes 2004; 37:1550-1555.
37. d'Amati G & Lewis W. Zidovudine causes early increases in mitochondrial ribonucleic acid abundance and induces ultrastructural changes in cultured mouse muscle cells. Laboratory Investigations 1994; 71:879-884.
38. Mallon P, Unemori P, Bowen M, Miller J, Winterbotham M, Kelleher A, Williams K, Cooper D & Carr A. Nucleoside reverse transcriptase inhibitors decrease mitochondrial and PPARgamma gene expression in adipose tissue after only 2 weeks in HIV-uninfected healthy adults. 11th Conference on Retroviruses & Opportunistic Infections. 11-14 February 2004, San Francisco, CA, USA. Abstract 76.
39. Suomalainen A, Majander A, Pihko H, Peltonen L & Syvanen AC. Quantification of tRNA3243(Leu) point mutation of mitochondrial DNA in MELAS patients and its effects on mitochondrial transcription. Human Molecular Genetics 1993; 2:525-534.
40. Bonod-Bidaud C, Giraud S, Mandon G, Mousson B & Stepien G. Quantification of OXPHOS gene transcripts during muscle cell differentiation in patients with mitochondrial myopathies. Experimental Cell Research 1999; 246:91-97.
41. Lopez S, Mirò O, Martinez E, Pedrol E, Rodriguez-Santiago B, Milinkovic A, Soler A, Garcia-Viejo MA, Nunes V, Casademont J, Gatell JM & Cardellach F. Mitochondrial effects of antiretroviral therapies in asymptomatic patients. Antiviral Therapy 2004; 9:47-55.