Inhibition of high voltage-activated calcium channels by spider toxin PnTx3-6

Journal of Pharmacology and Experimental Therapeutics

Volumn 314, Issue 3, 2005, Pages 1370-1377

  Vieira, Luciene B ^a,b   Kushmerick, Christopher ^b   Hildebrand, Michael E ^a   Garcia, Esperanza ^a   Stea, Antony ^a,d   Cordeiro, Marta N ^c   Richardson, Michael ^c   Gomez, Marcus Vinicius ^b   Snutch, Terrance P ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^c FUNDAÇÃO EZEQUIEL DIAS   (Brazil)

^d UNIVERSITY OF THE FRASER VALLEY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL; CALCIUM CHANNEL N TYPE; CALCIUM CHANNEL P TYPE; CALCIUM CHANNEL Q TYPE; CALCIUM CHANNEL R TYPE; CONOTOXIN; NEUROTOXIN; SPIDER TOXIN PNTX3 6; SPIDER VENOM; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL;

ARTICLE; CELL CLONE; CELL STRAIN HEK293; DRUG EFFECT; DRUG POTENCY; HUMAN; HUMAN CELL; IC 50; KIDNEY CELL; NEUROBLASTOMA CELL; PATCH CLAMP; PRIORITY JOURNAL; PURIFICATION; WHOLE CELL;

AMINO ACID SEQUENCE; ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, N-TYPE; CELL LINE; HUMANS; MOLECULAR SEQUENCE DATA; NEUROPEPTIDES; NEUROTOXINS; SPIDER VENOMS;

EID: 23944493407     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.105.087023     Document Type: Article

References (40)

1. Bean BP (1984) Nitrendipine block of cardiac calcium channels: high-affinity binding to the inactivated state. Proc Natl Acad Sci USA 81:6388-6392.
2. Berjukow S, Doring F, Froschmayr M, Grabner M, Glossmann H, and Hering S (1996) Endogenous calcium channels in human embryonic kidney (HEK293) cells. Br J Pharmacol 118:748-754.
3. Bourinet E, Charnet P, Tomlinson WJ, Stea A, Snutch TP, and Nargeot J (1994) Voltage-dependent facilitation of a neuronal alpha 1C L-type calcium channel. EMBO (Eur Mol Biol Organ) J 13:5032-5039.
4. Carlson RO, Masco D, Brooker G, and Spiegel S (1994) Endogenous ganglioside GM1 modulates L-type calcium channel activity in N18 neuroblastoma cells. J Neurosci 14:2272-2281.
5. Cassola AC, Jaffe H, Fales HM, Castro Afeche S, Magnoli F, and Cipolla-Neto J (1998) Omega-phonetoxin-IIA: a calcium channel blocker from the spider Phoneutria nigriventer. Pflugers Arch 436:545-552.
6. Catterall WA (1995) Structure and function of voltage-gated ion channels. Annu Rev Biochem 64:493-531.
7. Chuang RS, Jaffe H, Cribbs L, Perez-Reyes E, and Swartz KJ (1998) Inhibition of T-type voltage-gated calcium channels by a new scorpion toxin. Nat Neurosci 1:668-674.
8. Cordeiro MN, Figueiredo SG, Valentim AC, Diniz CR, Eicksted RD, Goroy J, and Richardson M (1993) Purification and amino acid sequences of six TX3 type neurotoxins from the venom of the Brazilian "armed" spider Phoneutria nigriventer. Toxicon 31:35-42.
9. Doering CJ and Zamponi GW (2003) Molecular pharmacology of high voltage-activated calcium channels. J Bioenerg Biomembr 35:491-505.
10. Dos Santos RG, Van Renterghem C, Martin-Moutot N, Mansuelle P, Cordeiro MN, Diniz CR, Mori Y, De Lima ME, and Seagar M (2002) Phoneutria nigriventer omega-phonetoxin IIA blocks the Cav2 family of calcium channels and interacts with omega-conotoxin-binding sites. J Biol Chem 277:13856-13862.
11. Dubel SJ, Starr TV, Hell J, Ahlijanian MK, Enyeart JJ, Catterall WA, and Snutch TP (1992) Molecular cloning of the alpha-1 subunit of an omega-conotoxin-sensitive calcium channel. Proc Natl Acad Sci USA 89:5058-5062.
12. Dunlap K, Luebke JI, and Turner TJ (1995) Exocytotic Ca2+ channels in mammalian central neurons. Trends Neurosci 18:89-98.
13. Dworakowska B and Dolowy K (2000) Ion channels-related diseases. Acta Biochim Pol 47:685-703.
14. Feng ZP, Doering CJ, Winkfein RJ, Beedle AM, Spafford JD, and Zamponi GW (2003) Determinants of inhibition of transiently expressed voltage-gated calcium channels by omega-conotoxins GVIA and MVIIA. J Biol Chem 278:20171-20178.
15. Gomez MV, Kalapothakis E, Guatimosin C, and Prado MA (2002) Phoneutria nigriventer venom: a cocktail of toxins that affect ion channels. Cell Mol Neurobiol 22:579-588.
16. Hamill OP, Marty A, Neher E, Sakmann B, and Sigworth FJ (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 391:85-100.
17. Hildebrand ME, McRory JE, Snutch TP, and Stea A (2004) Mammalian voltage-gated calcium channels are potently blocked by the pyrethroid insecticide allethrin. J Pharmacol Exp Ther 308:805-813.
18. Jen J (1999) Calcium channelopathies in the central nervous system. Curr Opin Neurobiol 9:274-280.
19. Kobayashi T and Mori Y (1998) Ca2+ channel antagonists and neuroprotection from cerebral ischemia. Eur J Pharmacol 363:1-15.
20. Kokubun S, Prodhom B, Becker C, Porzig H, and Reuter H (1986) Studies on Ca channels in intact cardiac cells: voltage-dependent effects and cooperative interactions of dihydropyridine enantiomers. Mol Pharmacol 30:571-584.
21. Leão RM, Cruz JS, Diniz CR, Cordeiro MN, and Beirao PS (2000) Inhibition of neuronal high-voltage activated calcium channels by the omega-Phoneutria nigriventer Tx3-3 peptide toxin. Neuropharmacology 39:1756-1767.
22. Mackie K, Devane WA, and Hille B (1993) Anandamide, an endogenous cannabinoid, inhibits calcium currents as a partial agonist in N18 neuroblastoma cells. Mol Pharmacol 44:498-503.
23. McDonough SI, Boland LM, Mintz IM, and Bean BP (2002) Interactions among toxins that inhibit N-type and P-type calcium channels. J Gen Physiol 119:313-328.
24. McDonough SI, Swartz KJ, Mintz IM, Boland LM, and Bean BP (1996) Inhibition of calcium channels in rat central and peripheral neurons by omega-conotoxin MVIIC. J Neurosci 16:2612-2623.
25. McRory JE, Santi CM, Hammning KS, Mezeyova J, Sutton KG, Baillie DL, Stea A, and Snutch TP (2001) Molecular and functional characterization of a family of rat brain T-type calcium channels. J Biol Chem 276:3999-4011.
26. Mintz IM (1994) Block of Ca channels in rat central neurons by the spider toxin omega-Aga-IIIA. J Neurosci 14:2844-2853.
27. Newcomb R, Szoke B, Palma A, Wang G, Chen X, Hopkins W, Cong R, Miller J, Urge L, Tarczy-Hornoch K, et al. (1998) Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas. Biochemistry 37:15353-15362.
28. Olivera BM, Gray WR, Zeikus R, McIntosh JM, Varga J, Rivier J, de Santos V, and Cruz LJ (1985) Peptide neurotoxins from fish-hunting cone snails. Science (Wash DC) 230:1338-1343.
29. Randall A and Tsien RW (1995) Pharmacological dissection of multiple types of Ca2+ channel currents in rat cerebellar granule neurons. J Neurosci 15:2995-3012.
30. Rezende LJ, Cordeiro MN, Oliveira EB, and Diniz CR (1991) Isolation of neurotoxic peptides from the venom of the 'armed' spider Phoneutria nigriventer. Toxicon 29:1225-1233.
31. Schroeder CI, Smythe ML, and Lewis RJ (2004) Development of small molecules that mimic the binding of omega-conotoxins at the N-type voltage-gated calcium channel. Mol Divers 8:127-134.
32. Sidach SS and Mintz IM (2002) Kurtoxin, a gating modifier of neuronal high- and low-threshold Ca channels. J Neurosci 22:2023-2034.
33. Soong TW, Stea A, Hodson CD, Dubel SJ, Vincet SR, and Snutch TP (1993) Structure and functional expression of a member of the low voltage-activated calcium channel family. Science (Wash DC) 260:1133-1136.
34. Starr TV, Prystay W, and Snutch TP (1991) Primary structure of a calcium channel that is highly expressed in the rat cerebellum. Proc Natl Acad Sci USA 88:5621-5625.
35. Stea A, Dubel SJ, Pragnell M, Leonard JP, Campbell KP, and Snutch TP (1993) A beta-subunit normalizes the electrophysiological properties of a cloned N-type Ca2+ channel alpha 1-subunit. Neuropharmacology 32:1103-1116.
36. Vieira LB, Kushmerick C, Reis HJ, Diniz CR, Cordeiro MN, Prado MA, Kalapothakis E, Romano-Silva MA, and Gomez MV (2003) PnTx3-6 a spider neurotoxin inhibits K-evoked increase in [Ca2+] (i) and Ca2+-dependent glutamate release in synaptosomes. Neurochem Int 42:277-282.
37. Wang YX, Gao D, Pettus M, Phillips C, and Bowersox SS (2000) Interactions of intrathecally administered ziconotide, a selective blocker of neuronal N-type voltage-sensitive calcium channels, with morphine on nociception in rats. Pain 84:271-281.
38. Williams ME, Brust PF, Feldman DH, Patthi S, Simerson S, Maroufi A, McCue AF, Velicelebi G, Ellis SB, and Harpold MM (1992) Structure and functional expression of an omega-conotoxin-sensitive human N-type calcium channel. Science (Wash DC) 257:389-395.
39. Yan L and Adams ME (2000) The spider toxin omega-Aga IIIA defines a high affinity site on neuronal high voltage-activated calcium channels. J Biol Chem 14:21309-21316.
40. Zamponi GW, Bourinet E, Nelson D, Nargeot J, and Snutch TP (1997) Crosstalk between G proteins and protein kinase C mediated by the calcium channel alpha1 subunit. Nature (Lond) 385:442-446.