Thyrotropin-releasing hormone (protirelin) inhibits potassium-stimulated glutamate and aspartate release from hippocampal slices in vitro

Brain Research

Volumn 1054, Issue 1, 2005, Pages 45-54

  Nie, Y ^a,d   Schoepp, D D ^c   Klaunig, J E ^b   Yard, M ^b   Lahiri, D K ^b   Kubek, M J ^a,b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY   (United States)

^c ELI LILLY AND COMPANY   (United States)

^d LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Brain slice; Glutamate; Glutamate antagonist; Hippocampus; Metabotropic receptor; Neurodegeneration; Neuroprotection; Protirelin; Thyrotropin releasing hormone; TRH

Indexed keywords

ASPARTIC ACID; EXCITATORY AMINO ACID; GLUTAMIC ACID; POTASSIUM; PROTIRELIN;

AMINO ACID SYNTHESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CELL MEMBRANE DEPOLARIZATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; HORMONE ACTION; HORMONE INHIBITION; MALE; NEUROMODULATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PULSATILE HORMONE RELEASE; RAT; THYROTROPIN RELEASE;

ANIMALS; ASPARTIC ACID; CALCIUM; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG INTERACTIONS; GLUTAMIC ACID; HIPPOCAMPUS; L-LACTATE DEHYDROGENASE; MALE; POTASSIUM; RATS; RATS, SPRAGUE-DAWLEY; THYROTROPIN-RELEASING HORMONE; TIME FACTORS;

EID: 23944489345     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2005.06.077     Document Type: Article

References (70)

1. G.W. Bennett, C.A. Marsden, K.C.F. Fone, J.V. Johnson, and D.J. Heal TRH-catecholamine interactions in brain and spinal cord Ann. N. Y. Acad. Sci. 553 1989 106 120
2. I. Blumcke, K. Behle, B. Malitschek, R. Kuhn, T. Knopfel, H.K. Wolf, and O.D. Wiestler Immunohistochemical distribution of metabotropic glutamate receptor subtypes mGluR1b, mGluR2/3, mGluR4a and mGluR5 in human hippocampus Brain Res. 736 1996 217 226
3. L. Calza, L. Giardino, S. Ceccatelli, M. Zanni, R. Elde, and T. Hokfelt Distribution of thyrotropin-releasing hormone receptor messenger RNA in the rat brain: an in situ hybridization study Neuroscience 51 1992 891 909
4. J. Cao, D. O'Donnell, H. Vu, K. Payza, C. Pou, C. Godbout, A. Jakob, M. Pelletier, P. Lembo, S. Ahmad, and P. Walker Cloning and characterization of a cDNA encoding a novel subtype of rat thyrotropin-releasing hormone receptor J. Biol. Chem. 273 1998 32281 32287
5. D. Choi Glutamate neurotoxicity in cortical cell culture is calcium dependent Neurosci. Lett. 58 1985 293 297
6. D.W. Choi, M. Maulucci-Gedde, and A.R. Kriegstein Glutamate neurotoxicity in cortical cell culture J. Neurosci. 7 1987 357 368
7. L.B. Cook, C.C. Zhu, and P.M. Hinkle TRH receptor processing: role of ubiquitination and proteasomal degradation Mol. Endocrinol. 17 2003 1777 1791
8. L.B. Dale, M. Bhattacharya, P.H. Anborgh, B. Murdoch, M. Bhatia, S. Nakanishi, and S.S. Ferguson G protein-coupled receptor kinase-mediated desensitization of metabotropic glutamate receptor 1A protects against cell death J. Biol. Chem. 275 2000 38213 38220
9. A.I. Faden, T.P. Jacobs, and J.W. Holaday Thyrotropin-releasing hormone improves neurologic recovery after spinal trauma in cats N. Engl. J. Med. 305 1981 1063 1067
10. A.I. Faden, G.B. Fox, X. Di, S.M. Knoblach, I. Cernak, P. Mullins, M. Nikolaeva, and A.P. Kozikowski Neuroprotective and nootropic actions of a novel cyclized dipeptide after controlled cortical impact injury in mice J. Cereb. Blood Flow Metab. 23 2003 355 363
11. A.I. Faden, S.M. Knoblach, I. Cernak, L. Fan, R. Vink, G.L. Araldi, S.T. Fricke, B.L. Roth, and A.P. Kozikowski Novel diketopiperazine enhances motor and cognitive recovery after traumatic brain injury in rats and shows neuroprotection in vitro and in vivo J. Cereb. Blood Flow Metab. 23 2003 342 354
12. A. Francesconi, and R.M. Duvoisin Opposing effects of protein kinase C and protein kinase A on metabotropic glutamate receptor signaling: selective desensitization of the inositol trisphosphate/Ca2+ pathway by phosphorylation of the receptor-G protein-coupling domain Proc. Natl. Acad. Sci. U. S. A. 97 2000 6185 6190
13. K.A. Gary, K.A. Sevarino, G.G. Yarbrough, A.J. Prange Jr., and A. Winokur The thyrotropin-releasing hormone (TRH) hypothesis of homeostatic regulation: implications for TRH-based therapeutics J. Pharmacol. Exp. Ther. 305 2003 410 416
14. R.W. Gereau, and S.F. Heinemann Role of protein kinase C phosphorylation in rapid desensitization of metabotropic glutamate receptor 5 Neuron 20 1998 143 151
15. M.C. Gershengorn, and R. Osman Molecular and cellular biology of thyrotropin-releasing hormone receptors Physiol. Rev. 76 1996 175 191
16. S. Greber, C. Schwarzer, and G. Sperk Neuropeptide Y inhibits potassium-stimulated glutamate release through Y2 receptors in rat hippocampal slices in vitro Br. J. Pharmacol. 113 1994 737 740
17. I. Herrero, M.T. Miras-Portugal, and J. Sanchez-Prieto Rapid desensitization of the metabotropic glutamate receptor that facilitates glutamate release in rat cerebrocortical nerve terminals Eur. J. Neurosci. 6 1994 115 120
18. H. Heuer, M.K. Schafer, D. O'Donnell, P. Walker, and K. Bauer Expression of thyrotropin-releasing hormone receptor 2 (TRH-R2) in the central nervous system of rats J. Comp. Neurol. 428 2000 319 336
19. P.M. Hinkle Pituitary TRH receptors Ann. N. Y. Acad. Sci. 553 1989 176 187
20. T. Hokfelt, Y. Tsuruo, B. Ulfhake, S. Cullheim, U. Arvidsson, G.A. Foster, M. Schultzberg, M. Schalling, L. Arborelius, J. Freedman, C. Post, and T. Visser Distribution of TRH-like immunoreactivity with special reference to coexistence with other neuroactive compounds Ann. N. Y. Acad. Sci. 553 1989 76 105
21. E. Hrabovszky, G. Wittmann, G.F. Turi, Z. Liposits, and C. Fekete Hypophysiotropic thyrotropin-releasing hormone and corticotropin-releasing hormone neurons in the rat contain vesicular glutamate transporter-2 Endocrinology 146 2005 341 347
22. H. Itadani, T. Nakamura, J. Itoh, H. Iwaasa, A. Kanatani, J. Borkowski, M. Ihara, and M. Ohta Cloning and characterization of a new subtype of thyrotropin-releasing hormone receptors Biochem. Biophys. Res. Commun. 250 1998 68 71
23. L. Jaworska-Feil, J. Turchan, B. Przewlocka, B. Budziszewska, M. Leskiewicz, and W. Lason Effects of pilocarpine- and kainate-induced seizures on thyrotropin-releasing hormone biosynthesis and receptors in the rat brain J. Neural Transm. 106 1999 395 407
24. L. Jaworska-Feil, M. Kajta, B. Budziszewska, M. Leskiewicz, and W. Lason Protective effects of TRH and its stable analogue, RGH-2202, on kainate-induced seizures and neurotoxicity in rodents Epilepsy Res. 43 2001 67 73
25. Y. Kanai, C.P. Smith, and M.A. Hediger A new family of neurotransmitter transporters: the high-affinity glutamate transporters FASEB J. 8 1994 1450 1459
26. H.H. Keller, G. Bartholini, and A. Pletscher Enhancement of cerebral noradrenaline turnover by thyrotropin-releasing hormone Nature 248 1974 528 529
27. S.M. Knoblach, and M.J. Kubek Thyrotropin-releasing hormone release is enhanced in hippocampal slices after electroconvulsive shock J. Neurochem. 62 1994 119 125
28. S.M. Knoblach, and M.J. Kubek Changes in Thyrotropin-releasing hormone levels in hippocampal subregions induced by a model of human temporal lobe epilepsy: effect of partial and complete kindling Neuroscience 76 1997 97 104
29. S.M. Knoblach, and M.J. Kubek Increases in thyrotropin-releasing hormone mRNA expression induced by a model of human temporal lobe epilepsy: effect of partial and complete kindling Neuroscience 76 1997 85 95
30. M.L. Koenig, D.L. Yourick, and J.L. Meyerhoff Thyrotropin-releasing hormone (TRH) attenuates glutamate-stimulated increases in calcium in primary neuronal cultures Brain Res. 730 1996 143 149
31. M.L. Koenig, C.M. Sgarlat, D.L. Yourick, J.B. Long, and J.L. Meyerhoff In vitro neuroprotection against glutamate-induced toxicity by pGlu-Glu-Pro-NH(2) (EEP) Peptides 22 2001 2091 2097
32. J.-Y. Koh, and D.W. Choi Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay J. Neurosci. Methods 20 1987 83 89
33. J.-Y. Koh, M.P. Goldberg, D.M. Hartley, and D.W. Choi Non-NMDA receptor-mediated neurotoxicity in cortical culture J. Neurosci. 10 1990 693 705
34. M.J. Kubek, and B.P. Garg Thyrotropin-releasing hormone (TRH) in the treatment of intractable epilepsy Pediatr. Neurol. 26 2002 9 17
35. M.J. Kubek, M.A. Lorincz, and J.F. Wilber The identification of thyrotropin releasing hormone (TRH) in hypothalamic and extrahypothalamic loci of the human nervous system Brain Res. 126 1977 196 200
36. M.J. Kubek, S.M. Knoblach, N.A. Sharif, D.R. Burt, G.G. Buterbaugh, and K.S. Fuson Thyrotropin-releasing hormone gene expression and receptors are differentially modified in limbic foci by seizures Ann. Neurol. 33 1993 70 76
37. W.C. Low, S.D. Farber, T.G. Hill, A. Sattin, and M.J. Kubek Evidence for extrinsic and intrinsic sources of thyrotropin-releasing hormone (TRH) in the hippocampal formation as determined by radioimmunoassay and immunocytochemistry Ann. N. Y. Acad. Sci. 553 1989 574 578
38. S. Manaker, A. Winokur, W.H. Rostene, and T.C. Rainbow Autoradiographic localization of thyrotropin-releasing hormone receptors in the rat central nervous system J. Neurosci. 5 1985 167 174
39. S. Manaker, A. Eichen, A. Winokur, C.H. Rhodes, and T.C. Rainbow Autoradiographic localization of thyrotropin releasing hormone receptors in human brain Neurology 36 1986 641 646
40. S. Manaker, T.C. Rainbow, and A. Winokur Thyrotropin-releasing hormone (TRH) receptors: localization in rat and human central nervous system C. Boast E. Snowhill C.A. Altar Quantitative Receptor Autoradiography 1986 Alan R. Liss Inc. 103 135
41. C.A. Marsden, G.W. Bennett, K.C.F. Fone, and J.V. Johnson Functional interactions between TRH and 5-hydroxytryptamine (5-HT) and proctolin in rat brain and spinal cord Ann. N. Y. Acad. Sci. 553 1989 121 134
42. B.S. Meldrum Glutamate as a neurotransmitter in the brain: review of physiology and pathology J. Nutr. 130 Suppl. 4 2000 1007S 1015S
43. D. Mouginot, P. Feltz, and R. Schlichter Modulation of GABA-gated chloride currents by intracellular Ca2+ in cultured porcine melanotrophs J. Physiol. 437 1991 109 132
44. S.J. Mundell, G. Pula, R.A. McIlhinney, P.J. Roberts, and E. Kelly Desensitization and internalization of metabotropic glutamate receptor 1a following activation of heterologous Gq/11-coupled receptors Biochemistry 43 2004 7541 7551
45. S. Narumi, Y. Nagai, M. Miyamoto, and Y. Nagawa Thyrotropin-releasing hormone (TRH) and its analog (DN-1417): interaction with pentobarbital in choline uptake and acetylcholine synthesis of rat brain slices Life Sci. 32 1983 1637 1645
46. E.A. Nillni, and K.A. Sevarino The biology of pro-thyrotropin-releasing hormone-derived peptides Endocr. Rev. 20 1999 599 648
47. B.F. O'Dowd, D.K. Lee, W. Huang, T. Nguyen, R. Cheng, Y. Liu, B. Wang, M.C. Gershengorn, and S.R. George TRH-R2 exhibits similar binding and acute signaling but distinct regulation and anatomic distribution compared with TRH-R1 Mol. Endocrinol. 14 2000 183 193
48. J.W. Olney, R.C. Collins, and R.S. Sloviter Excitotoxic mechanisms of epileptic brain damage Adv. Neurol. 44 1986 857 877
49. M. Pizzi, F. Boroni, M. Benarese, C. Moraitis, M. Memo, and P. Spano Neuroprotective effect of thyrotropin-releasing hormone against excitatory amino acid-induced cell death in hippocampal slices Eur. J. Pharmacol. 370 1999 133 137
50. R.B. Rastogi, R.L. Singhal, and Y.D. Lapierre Effects of MK-771, a novel TRH analogue, on dopaminergic and serotonergic systems Eur. J. Pharmacol. 73 1981 307 312
51. L.P. Renaud, and J.B. Martin Thyrotropin releasing hormone (TRH): depressant action on central neuronal activity Brain Res. 86 1975 150 154
52. L.P. Renaud, H.W. Blume, Q.J. Pittman, Y. Lamour, and A.T. Tan Thyrotropin-releasing hormone selectively depresses glutamate excitation of cerebral cortical neurons Science 205 1979 1275 1277
53. J.B. Rosen, S.R.B. Weiss, and R.M. Post Contingent tolerance to carbamazepine: alterations in TRH mRNA and TRH receptor binding in limbic structures Brain Res. 651 1994 252 260
54. P.A. Salin, M.G. Weisskopf, and R.A. Nicoll A comparison of the role of dynorphin in the hippocampal mossy fiber pathway in guinea pig and rat J. Neurosci. 15 1995 6939 6945
55. A. Sattin, M.J. Kubek, W.C. Low, C.J. Staley, and J.R. Simon Some regional anatomical relationships of TRH to 5-HT in rat limbic forebrain Neurochem. Res. 17 1992 469 474
56. D.D. Schoepp, A.Y. Gamble, C.R. Salhoff, B.G. Johnson, and P.L. Ornstein Excitatory amino acid-induced convulsions in neonatal rats mediated by distinct receptor subtypes Eur. J. Pharmacol. 182 1990 421 427
57. D.D. Schoepp, D.E. Jane, and J.A. Monn Pharmacological agents acting at subtypes of metabotropic glutamate receptors Neuropharmacology 38 1999 1431 1476
58. N.A. Sharif Quantitative autoradiography of TRH receptors in discrete brain regions of different mammalian species Ann. N. Y. Acad. Sci. 553 1989 147 175
59. N.A. Sharif, Z.P. To, and R.L. Whiting Analogs of thyrotropin-releasing hormone (TRH): receptor affinities in brains, spinal cords and pituitaries of different species Neurochem. Res. 16 1991 95 103
60. G. Stocca, and A. Nistri Enhancement of NMDA receptor mediated synaptic potentials of rat hippocampal neurones in vitro by thyrotropin releasing hormone Neurosci. Lett. 184 1995 9 12
61. J. Storm-Matheson Glutamate in hippocampal pathways G. DiChiara G. Gessa Glutamate as a Neurotransmitter 1981 Raven Press New York 43 55
62. Y. Sun, X. Lu, and M.C. Gershengorn Thyrotropin-releasing hormone receptors-Similarities and differences J. Mol. Endocrinol. 30 2003 87 97
63. Y. Takeuchi, T. Takano, J. Abe, S. Takikita, and M. Ohno Thyrotropin-releasing hormone: role in the treatment of West syndrome and related epileptic encephalopathies Brain Dev. 23 2001 662 667
64. K. Toide, M. Shinoda, M. Takase, K. Iwata, and H. Yoshida Effects of a noval thyrotropin-releasing hormone analogue, JTP-2942, on extracellular acetylcholine and choline levels in the rat frontal cortex and hippocampus Eur. J. Clin. Pharmacol. 233 1993 21 28
65. A. Urayama, S. Yamada, R. Kimura, J. Zhang, and Y. Watanabe Neuroprotective effect and brain receptor binding of taltirelin, a novel thyrotropin-releasing hormone (TRH) analogue, in transient forebrain ischemia of C57BL/6J mice Life Sci. 72 2002 601 607
66. M. Veronesi, M. Yard, J. Jackson, D.K. Lahiri, M.R. Vasko, and M.J. Kubek Thyrotropin-releasing hormone (TRH) protects primary fetal rat (E17) cultured neurons against glutamate-induced toxicity Endocr. Soc. Abs. 85 2003 148
67. M.G. Weisskopf, R.A. Zalutsky, and R.A. Nicoll The opioid peptide dynorphin mediates heterosynaptic depression of hippocampal mossy fibre synapses and modulates long-term potentiation Nature 362 1993 423 427
68. M. Yard, D.K. Lahiri, and M.J. Kubek Protective effect of thyrotropin-releasing hormone (TRH) against glutamate-induced toxicity in cell culture Endocrine Soc. Abs. 83 2001 552
69. M. Yard, D.K. Lahiri, and M.J. Kubek Effect of thyrotropin-releasing hormone (TRH) and its analogs on G-Alpha in superfused hippocampal dentate gyri Abstr.-Soc. Neurosci. 32 2002 17
70. R. Yu, and P.M. Hinkle Desensitization of thyrotropin-releasing hormone receptor-mediated responses involves multiple steps J. Biol. Chem. 272 1997 28301 28307