Complement C3 is required for the progression of cutaneous lesions and neutrophil attraction in Leishmania major infection

Medical Microbiology and Immunology

Volumn 194, Issue 3, 2005, Pages 143-149

  Jacobs, Thomas ^a   Andrä, Jörg ^b,d   Gaworski, Iris ^a   Graefe, Sebastian ^a   Mellenthin, Katja ^a   Krömer, Manfred ^a   Halter, Roman ^c   Borlak, Jürgen ^c   Clos, Joachim ^a  

^a BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

^b UNIVERSITY OF HAMBURG   (Germany)

^c FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

^d RESEARCH CENTER BORSTEL   (Germany)

Author keywords

Cobra venom factor; Complement C3; Leishmania major; Neutrophil; Transgenic mice

Indexed keywords

ALPHA 1 ANTITRYPSIN; COBROTOXIN; COMPLEMENT COMPONENT C3;

ANIMAL CELL; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; DISEASE COURSE; INFECTION SENSITIVITY; LEISHMANIA MAJOR; MOUSE; NEUTROPHIL; NONHUMAN; PARASITE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTOZOAL INFECTION; SKIN DEFECT; T LYMPHOCYTE ACTIVATION;

ANIMALS; COBRA VENOMS; COMPLEMENT ACTIVATION; COMPLEMENT C3; DISEASE MODELS, ANIMAL; LEISHMANIA MAJOR; LEISHMANIASIS, CUTANEOUS; LEUKOCYTES; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; NEUTROPHIL INFILTRATION; T-LYMPHOCYTES;

EID: 23944489009     PISSN: 03008584     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00430-004-0229-y     Document Type: Article

References (26)

1. Titus RG, Theodosia CM, Shankar A, Hall LR (1993) Interactions between Leishmania major and macrophages. In: Zwilling T, Eisenstein T (eds) Macrophage-pathogen interactions. Marcel Dekker, New York, pp 437-459
2. Mosser DM, Brittingham A (1997). Leishmania, macrophages and complement: a tale of subversion and exploitation. Parasitology 115:S9-23
3. Mosser DM, Edelson PJ (1987). The third component of complement (C3) is responsible for the intracellular survival of Leishmania major. Nature 327:329-331
4. Da Silva RP, Hall BF, Joiner KA, Sacks DL ( 1989) CR1, the C3b receptor, mediates binding of infective Leishmania major metacyclic promastigotes to human macrophages. J Immunol 143:617-622
5. Guy RA, Belosevic M (1993) Comparison of receptors required for entry of Leishmania major amastigotes into macrophages. Infect Immun 61:1553-1558
6. Joshi PB, Kelly BL, Kamhawi S, Sacks DL, McMaster WR (2002) Targeted gene deletion in Leishmania major identifies leishmanolysin (GP63) as a virulence factor. Mol Biochem Parasitol 120:33-40
7. Joshi PB, Sacks DL, Modi G, McMaster WR (1998) Targeted gene deletion of Leishmania major genes encoding developmental stage-specific leishmanolysin (GP63). Mol Microbiol 27:519-530
8. Chaudhuri G, Chang KP (1988) Acid protease activity of a major surface membrane glycoprotein (gp63) from Leishmania mexicana promastigotes. Mol Biochem Parasitol 27:43-52
9. Brittingham A, Chen G, McGwire BS, Chang KP, Mosser DM (1999) Interaction of Leishmania gp63 with cellular receptors for fibronectin. Infect Immun 67:4477-4484
10. Russell DG, Wright SD (1988) Complement receptor type 3 (CR3) binds to an Arg-Gly-Asp-containing region of the major surface glycoprotein, gp63, of Leishmania promastigotes. J Exp Med 168:279-292
11. Dominguez M, Moreno I, Lopez-Trascasa M, Torano A. (2002) Complement interaction with trypanosomatid promastigotes in normal human serum. J Exp Med 195:451-459
12. Muller K, Zandbergen G van, Hansen B, Laufs H, Jahnke N, Solbach W, Laskay T (2001) Chemokines, natural killer cells and granulocytes in the early course of Leishmania major infection in mice. Med Microbiol Immunol 190:73-75
13. Beil WJ, Meinardus-Hager G, Neugebauer DC, Sorg C (1992) Differences in the onset of the inflammatory response to cutaneous leishmaniasis in resistant and susceptible mice. J Leukoc Biol 52:135-142
14. + Th2 response in BALB/c mice infected with Leishmania major. J Immunol 165:2628-2636
15. Laufs H, Muller K, Fleischer J, Reiling N, Jahnke N, Jensenius JC, Solbach W, Laskay T (2002) Intracellular survival of Leishmania major in neutrophil granulocytes after uptake in the absence of heat-labile serum factors. Infect Immun 70:826-835
16. Aga E, Katschinski DM, Zandbergen G van, Laufs H, Hansen B, Muller K, Solbach W, Laskay T (2002) Inhibition of the spontaneous apoptosis of neutrophil granulocytes by the intracellular parasite Leishmania major. J Immunol 169:898-905
17. Andrä J, Halter R, Kock M, Niemann H, Vogel CW, Paul D (2002) Generation and characterization of transgenic mice expressing cobra venom factor. Mol Immunol 39:357-365
18. Vogel CW, Bredehorst R, Fritzinger DC, Grunwald T, Ziegelmüller P, Kock MA (1996). Structure and function of cobra-venom factor, the complement-activating protein in cobra venom. In: Singh BR, Tu AT (eds) Natural toxins. Plenum Press, New York, pp 97-114
19. Vogel CW, Müller-Eberhard HJ (1984) Cobra venom factor: improved method for purification and biochemical characterization. J Immunol Methods 73:203-220
20. Brandau S, Dresel A, Clos J (1995) High constitutive levels of heat-shock proteins in human-pathogenic parasites of the genus Leishmania. Biochem J 310:225-232
21. Pahl A, Kuhlbrandt U, Brune K, Rollinghoff M, Gessner A (1999) Quantitative detection of Borrelia burgdorferi by real-time PCR. J Clin Microbiol 37:1958-1963
22. Van den Berg CW, Aerts PC, Dijk H van (1991) In vivo anti-complementary activities of the cobra venom factors from Naja naja and Naja haje. J Immunol Methods 136:287-294
23. Brittingham A, Morrison CJ, McMaster WR, McGwire BS, Chang KP, Mosser DM (1995) Role of the Leishmania surface protease gp63 in complement fixation, cell adhesion, and resistance to complement-mediated lysis. J Immunol 155:3102-3111
24. Cassatella MA, Bazzoni F, Ceska M, Ferro I, Baggiolini M, Berton G (1992) IL-8 production by human polymorphonuclear leukocytes. The chemoattractant formyl-methionyl-leucyl-phenylalanine induces the gene expression and release of IL-8 through a pertussis toxin-sensitive pathway. J Immunol 148:3216-3220
25. Ember JA, Sanderson SD, Hugli TE, Morgan EL (1994) Induction of interleukin-8 synthesis from monocytes by human C5a anaphylatoxin. Am J Pathol 144:393-403
26. Chen L, Watanabe T, Watanabe H, Sendo F (2001) Neutrophil depletion exacerbates experimental Chagas' disease in BALB/c, but protects C57BL/6 mice through modulating the Th1/Th2 dichotomy in different directions. Eur J Immunol 31:265-275