Thiourea-based non-nucleoside inhibitors of HIV reverse transcriptase as bifunctional organocatalysts in the asymmetric Strecker synthesis

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 19, 2005, Pages 5680-5685

  Tsogoeva, Svetlana B ^a   Hateley, Martin J ^b   Yalalov, Denis A ^a   Meindl, Kathrin ^a   Weckbecker, Christoph ^b   Huthmacher, Klaus ^b  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b EVONIK INDUSTRIES AG   (Germany)

Author keywords

Bifunctional organocatalyst; Inhibitor; NNI; Strecker synthesis; Thiourea derivative

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BIOTIN; IMIDAZOLE; IMIDAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; PYRROLIDINE DERIVATIVE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; THIOUREA DERIVATIVE;

ARTICLE; ASYMMETRIC SYNTHESIS; CATALYSIS; CATALYST; CRYSTAL STRUCTURE; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN IMMUNODEFICIENCY VIRUS; NONHUMAN; STRECKER SYNTHESIS; STRUCTURE ANALYSIS;

CATALYSIS; CRYSTALLOGRAPHY, X-RAY; HIV; HIV-1 REVERSE TRANSCRIPTASE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; REVERSE TRANSCRIPTASE INHIBITORS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIOUREA;

EID: 23944488828     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.05.014     Document Type: Article

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