The structure of an enzyme-product complex reveals the critical role of a terminal hydroxide nucleophile in the bacterial phosphotriesterase mechanism

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1752, Issue 1, 2005, Pages 56-64

  Jackson, Colin ^a   Kim, Hye Kyung ^a   Carr, Paul D ^a   Liu, Jian Wei ^a   Ollis, David L ^a  

^a AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

Binuclear; Mechanism; Metalloenzyme; Nucleophile; Phosphotriesterase

Indexed keywords

BACTERIAL ENZYME; ETHYLENE GLYCOL; HYDROXIDE; ORGANOPHOSPHATE; PESTICIDE; PHOSPHATASE; PHOSPHOROTHIOIC ACID; PHOSPHOTRIESTERASE;

ARTICLE; BINDING AFFINITY; CATALYSIS; CHEMICAL STRUCTURE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DETOXIFICATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SUBSTRATE; NONHUMAN; PRIORITY JOURNAL; RHIZOBIUM RADIOBACTER; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; MODELS, MOLECULAR; PHOSPHORIC TRIESTER HYDROLASES; PLASMIDS; PSEUDOMONAS; RECOMBINANT PROTEINS; RHIZOBIUM; SUBSTRATE SPECIFICITY;

AGROBACTERIUM TUMEFACIENS;

EID: 23944485399     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbapap.2005.06.008     Document Type: Article

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