Enhancement of the stability of BCNU using self-emulsifying drug delivery systems (SEDDS) and in vitro antitumor activity of self-emulsified BCNU-loaded PLGA wafer

International Journal of Pharmaceutics

Volumn 301, Issue 1-2, 2005, Pages 6-14

  Gang, Soo Chae ^a   Jin, Soo Lee ^a   Seon, Hwa Kim ^a   Kwang, Su Seo ^a   Moon, Suk Kim ^b   Hai, Bang Lee ^b   Khang, Gilson ^a,b  

^a Chonbuk National University   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

1,3 Bis(2 chloroethyl) 1 nitrosourea (BCNU); Brain tumor; Self emulsifying drug delivery system (SEDDS)

Indexed keywords

CARMUSTINE; CREMOPHOR; LABRAFIL 1944; PHOSPHATE BUFFERED SALINE; RESOMER; SURFACTANT; TRIBUTYRIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BRAIN TISSUE; CANCER CELL; COMPRESSION; CYTOTOXICITY; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; DRUG PENETRATION; DRUG RELEASE; DRUG STABILITY; EMULSION; GLIOSARCOMA; HYDROLYSIS; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS, ALKYLATING; BRAIN NEOPLASMS; CARMUSTINE; CELL LINE, TUMOR; CELL SURVIVAL; DRUG DELIVERY SYSTEMS; DRUG STABILITY; DRUG STORAGE; EMULSIONS; EXCIPIENTS; GLIOSARCOMA; HUMANS; LACTIC ACID; PARTICLE SIZE; POLYGLYCOLIC ACID; POLYMERS;

EID: 23944475628     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2005.03.034     Document Type: Article

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