The delivery of BCNU to brain tumors

Journal of Controlled Release

Volumn 61, Issue 1-2, 1999, Pages 21-41

  Wang, Chi Hwa ^a   Li, Jian ^a   Teo, Chee Seng ^a   Lee, Timothy ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

1 3 Bis(2 chloroethyl) 1 nitrosourea; Polymeric delivery; Simulation; Systemic administration; Tumor

Indexed keywords

CARMUSTINE; ETHYLENE VINYL ACETATE COPOLYMER; POLYMER;

ARTICLE; BRAIN TUMOR; CONTROLLED STUDY; DRUG BRAIN LEVEL; DRUG DELIVERY SYSTEM; DRUG PENETRATION; HUMAN; MATHEMATICAL MODEL; PRIORITY JOURNAL; SIMULATION;

ANTINEOPLASTIC AGENTS, ALKYLATING; BRAIN NEOPLASMS; CAPILLARY PERMEABILITY; CARMUSTINE; DRUG DELIVERY SYSTEMS; HUMANS; MODELS, BIOLOGICAL;

EID: 0032856250     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(99)00098-X     Document Type: Article

References (28)

1. Taylor G.A., Goodman T.W., Rall A.S., Nies P. Goodman Gilman's The Pharmacological Basis of Therapeutics. 8th ed. 1990;1221 Macmillan, New York.
2. Blasberg R.G., Patlak C., Fenstermacher J.D. Intrathecal chemotherapy: brain tissue profiles after ventriculocisternal perfusion. J. Pharmacol. Exp. Ther. 195:1975;73-83.
3. Leong K.W., Brott B.C., Langer R. Bioerodible polyanhydrides as drug-carrier matrices. I. Characteristics, degradation, and release characteristics. J. Biomed. Mater. Res. 19:1985;941-955.
4. Leong K.W., D'amore P., Marletta M., Langer R. Bioerodible polyanhydrides as drug-carrier matrices. II. Biocompatibility and chemical reactivity. J. Biomed. Mater. Res. 20:1986;51-64.
5. Tamargo R.J., Epstein J.I., Reinhard C.S., Chasin M., Brem H. Brain, Biocompatibility of a biodegradable, controlled-release polymer in rats. J. Biomed. Mater. Res. 23:1989;253-266.
6. Tamargo R.J., Myseros J.S., Epstein J.I., Yang M.B., Chasin M., Brem H. Interstitial chemotherapy of the 9L Gliosarcoma: Controlled release polymers for drug delivery in the brain. Cancer Res. 53:1993;329-333.
7. Yang M.B., Tamargo R.J., Brem H. Controlled delivery of 1,3-bis(2-chloroethyl)-1-nitrosourea from ethylene-vinyl-acetate copolymer. Cancer Res. 49:1989;5103-5107.
8. Brem H., Piantadosi S.P., Burger C., Walker M., Selker R., Vick N.A., Black K., Sisti M., Brem S., Mohor G., Muller P., Morawetz R., Schold S.C. Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas. Lancet. 345:1995;1008-1012.
9. ® wafer summary (1995 and 1996).
10. Levin V.A., Stearns J., Byrd A., Finn A., Weinkam R.J. The effect of phenobarbital pre-treatment on the antitumor activity of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and 1-(2-chloroethyl)-3-(2,6-dioxo-3-piperidyl-1-nitrosourea (PCNU), and on the plasma pharmacokinetics and biotransformation of BCNU. J. Pharmacol. Exp. Ther. 208:1979;1-6.
11. Saltzman W.M., Radomsky M.L. Drugs released from polymers: diffusion and elimination in brain tissue. Chem. Eng. Sci. 46:1991;2429-2444.
12. Wang C.H., Li J. Three-dimensional simulation of IgG delivery to tumors. Chem. Eng. Sci. 53:(20):1998;3579-3600.
13. Fung L.K., Shin M., Tyler B., Brem H., Saltzman M. Chemotherapeutic drugs released from polymers: Distribution of 1,3-bis(2-chloroethyl)-1-nitrosourea in the rat brain. Pharm. Res. 13:(5):1996;671-682.
14. Fung L.K., Ewend M.G., Sills A., Sipos E.P., Thompson R., Watts M., Colvin M., Brem H., Saltzman M. Pharmacokinetics of interstitial delivery of carmustine, 4-hydroperoxycyclophosphamide, and paclitaxel from a biodegradable polymer implant in the monkey brain. Cancer Res. 58:1998;672-684.
15. Grossman S.A., Reinhard C., Colvin M., Chasin M., Brundrett R., Tamargo R.J., Brem H. The intracerebral distribution of BCNU delivered by surgically implanted biodegradable polymers. J. Neurosurg. 76:1992;640-647.
16. Ferszt R., Neu S., Cervos-avarro J., Sperner J. The spreading of focal brain edema induced by ultraviolet irradiation. Acta Neuropathol. 42:1978;223-239.
17. Groger U., Huber P., Reulen H.J. Formation and resolution of human peritumoral brain edema. Acta Neuropathol. Suppl. 60:1994;373-374.
18. Kalyanasundaram S., Calhoun V.D., Leong K.W. A finite element model for predicting the distribution of drugs delivered intracranially to the brain. Am. J. Physiol. 273:1997;R1810-1821.
19. Fluid Dynamics International, Inc. (1995) FIDAP User Manual.
20. Jain R.K., Baxter L.T. Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure. Cancer Res. 48:1988;7022-7032.
21. Baxter L.T., Jain R.K. Transport of fluid and macromolecules in tumors. I Role of interstitial pressure and convection. Microvasc. Res. 37:1989;77-104.
22. Baxter L.T., Jain R.K. Transport of fluid and macromolecules in tumors. II Role of heterogeneous perfusion and lymphatics. Microvasc. Res. 40:1990;246-263.
23. Kaviany M. Principles of Heat Transfer in Porous Media. 1991;62-64 Springer, New York.
24. 2 and Fab in tumors. Cancer Res. 49:1989;5656-5663.
25. Hori K., Suzuki M., Abe I., Saito S. Increased tumour tissue pressure in association with the growth of rat tumours. Jpn. J. Cancer Res. 77:1986;65-73.
26. Hilmas D., Gilette E.L. Morphometric analyses of the microvasculature of tumors during growth and after X-irradiation. Cancer. 33:1974;103-110.
27. Pappenheimer J.R., Renkin E.M., Borrero L.M. Filtration, diffusion and molecular sieving through peripheral capillary membranes: A contribution to the pore theory of capillary permeability. Am. J. Physiol. 82:1951;13-46.
28. Gerlowski L.E., Jain R.K. Microvascular permeability of normal and neoplastic tissues. Microvasc. Res. 31:1986;288-305.