-
1
-
-
0024509701
-
-
Q.-L. Choo, G. Kuo, A.J. Weiner, L.R. Overby, D.W. Bradley, and M. Houghton Science 244 1989 359
-
(1989)
Science
, vol.244
, pp. 359
-
-
Choo, Q.-L.1
Kuo, G.2
Weiner, A.J.3
Overby, L.R.4
Bradley, D.W.5
Houghton, M.6
-
2
-
-
0024511734
-
-
G. Kuo, Q.-L. Choo, H.J. Alter, G.L. Gitnik, A.G. Redeker, R.H. Purcell, T. Miyamuza, J.L. Dienstag, M.J. Alter, C.E. Stevens, G.E. Tegtmeier, F. Bonino, M. Colombo, W.-S. Lee, C. Kuo, K. Berger, J.R. Shuster, L.R. Overby, D.W. Bradley, and M. Houghton Science 244 1989 362
-
(1989)
Science
, vol.244
, pp. 362
-
-
Kuo, G.1
Choo, Q.-L.2
Alter, H.J.3
Gitnik, G.L.4
Redeker, A.G.5
Purcell, R.H.6
Miyamuza, T.7
Dienstag, J.L.8
Alter, M.J.9
Stevens, C.E.10
Tegtmeier, G.E.11
Bonino, F.12
Colombo, M.13
Lee, W.-S.14
Kuo, C.15
Berger, K.16
Shuster, J.R.17
Overby, L.R.18
Bradley, D.W.19
Houghton, M.20
more..
-
3
-
-
0025107484
-
-
M.J. Alter, S.C. Hadler, F.N. Judson, A. Mares, W.J. Alexander, P.J. Hu, J.K. Miller, L.A. Moyer, H.A. Fields, D.W. Bradley, and H.S.J. Margolis J. Am. Med. Assoc. 264 1990 2231
-
(1990)
J. Am. Med. Assoc.
, vol.264
, pp. 2231
-
-
Alter, M.J.1
Hadler, S.C.2
Judson, F.N.3
Mares, A.4
Alexander, W.J.5
Hu, P.J.6
Miller, J.K.7
Moyer, L.A.8
Fields, H.A.9
Bradley, D.W.10
Margolis, H.S.J.11
-
5
-
-
0000648439
-
Hepatitis C Treatment
-
H.W. Reesink Karger Basel
-
D. Bresters Hepatitis C Treatment H.W. Reesink Hepatitis C Virus 1994 Karger Basel 121
-
(1994)
Hepatitis C Virus
, pp. 121
-
-
Bresters, D.1
-
6
-
-
0000361013
-
Hepatitis C Virus
-
3rd ed. B.N. Fields D.M. Knipe D.M. Howley Raven Press New York
-
M. Houghton Hepatitis C Virus 3rd ed. B.N. Fields D.M. Knipe D.M. Howley Virology Vol. 1 1995 Raven Press New York 1035 1058
-
(1995)
Virology
, vol.1
, pp. 1035-1058
-
-
Houghton, M.1
-
7
-
-
0001424128
-
Flaviviridae: The Viruses and Their Replication
-
3rd ed. B.N. Fields D.M. Knipe D.M. Howley Raven Press New York
-
C.M. Rice Flaviviridae: The Viruses and Their Replication 3rd ed. B.N. Fields D.M. Knipe D.M. Howley Virology Vol. 1 1995 Raven Press New York 931 960
-
(1995)
Virology
, vol.1
, pp. 931-960
-
-
Rice, C.M.1
-
10
-
-
33645398623
-
-
note
-
35S- labeled translated substrate in a 20 μl volume containing 10 mM Tris, pH 7.5, 120 mM NaCl, 5 mM DTT, 0.5% EDTA, 0.1% Tween 20, and 12% glycerol followed by incubation at 30°C for 30 min. Inhibitors were added to assay mixtures prior to incubation. In-house standards of HCV protease inhibitor molecules served as positive controls. Cleavage reactions were terminated by addition of an equal volume of 2x Laemmli sample buffer and boiling for 3 min. Cleavage products were analyzed by SDS/15% PAGE gel electrophoresis and autoradiography.
-
-
-
-
12
-
-
16044365570
-
-
M. Chu, R. Mierzwa, I. Truumees, A. King, M. Patel, R. Berrie, A. Hart, N. Butkiewicz, B. DasMahapatra, T.-M. Chan, and M.S. Puar Tetrahedron Lett. 37 1996 7229
-
(1996)
Tetrahedron Lett.
, vol.37
, pp. 7229
-
-
Chu, M.1
Mierzwa, R.2
Truumees, I.3
King, A.4
Patel, M.5
Berrie, R.6
Hart, A.7
Butkiewicz, N.8
Dasmahapatra, B.9
Chan, T.-M.10
Puar, M.S.11
-
14
-
-
0034700964
-
-
F. Narjes, M. Brunetti, S. Colarusso, B. Gerlach, U. Koch, G. Bisasiol, D. Fattori, R. DeFrancesco, V.G. Matassa, and C. Steinkuhler Biochemistry 39 2000 1849
-
(2000)
Biochemistry
, vol.39
, pp. 1849
-
-
Narjes, F.1
Brunetti, M.2
Colarusso, S.3
Gerlach, B.4
Koch, U.5
Bisasiol, G.6
Fattori, D.7
Defrancesco, R.8
Matassa, V.G.9
Steinkuhler, C.10
-
15
-
-
0035847669
-
-
J.M. Bennett, A.D. Campbell, A.J. Campbell, M.G. Carr, R.M. Dunsdon, J.R. Greening, D.N. Hurst, N.S. Jennings, P.S. Jones, S. Jordan, P.B. Kay, M.A. O'Brien, J. King-Underwood, T.M. Raynham, C.S. Wilkinson, T.C. Wilkinson, and F.X. Wilson Bioorg. Med. Chem. Lett. 11 2001 355
-
(2001)
Bioorg. Med. Chem. Lett.
, vol.11
, pp. 355
-
-
Bennett, J.M.1
Campbell, A.D.2
Campbell, A.J.3
Carr, M.G.4
Dunsdon, R.M.5
Greening, J.R.6
Hurst, D.N.7
Jennings, N.S.8
Jones, P.S.9
Jordan, S.10
Kay, P.B.11
O'Brien, M.A.12
King-Underwood, J.13
Raynham, T.M.14
Wilkinson, C.S.15
Wilkinson, T.C.16
Wilson, F.X.17
-
16
-
-
18744381560
-
-
D.M. Andrews, H. Chaignot, B.A. Coomber, A.C. Good, M.R. Hind Johnson, P.S. Jones, G. Mills, J.E. Robinson, T. Skarzynski, M.J. Slater, and D. O'NSomers Org. Lett. 4 2002 4479
-
(2002)
Org. Lett.
, vol.4
, pp. 4479
-
-
Andrews, D.M.1
Chaignot, H.2
Coomber, B.A.3
Good, A.C.4
Hind Johnson, M.R.5
Jones, P.S.6
Mills, G.7
Robinson, J.E.8
Skarzynski, T.9
Slater, M.J.10
O'Nsomers, D.11
-
17
-
-
0037463788
-
-
W. Han, Z. Hu, X. Jiang, Z.R. Wasserman, and C.P. Decicco Bioorg. Med. Chem. Lett. 13 2003 1111
-
(2003)
Bioorg. Med. Chem. Lett.
, vol.13
, pp. 1111
-
-
Han, W.1
Hu, Z.2
Jiang, X.3
Wasserman, Z.R.4
Decicco, C.P.5
-
18
-
-
33645388694
-
VX-950: The Discovery of an Inhibitor of the Hepatitis C NS3-4A Protease and a Potential HCV Therapeutic
-
Boston, MA, October 24-28
-
Perni, R. B.; Chandorkar, G.; Chen, S. H.; Colacino, J.; Chaturvedi, P.; Courtney, L. F.; Decker, C.; Gates, C.; Harbeson, S. L.; Kwong, A. D.; Lin, C.; Lin, K.; Monroe, J. E.; Luong, Y.-P.; Murko, M. A.; Pitlik, J.; Rao, G.; Tebbe, M.; Tung, R. D.; Thomson, J. A. VX-950: The Discovery of an Inhibitor of the Hepatitis C NS3-4A Protease and a Potential HCV Therapeutic. AASLD Annual Meeting, Boston, MA, October 24-28, 2003.
-
(2003)
AASLD Annual Meeting
-
-
Perni, R.B.1
Chandorkar, G.2
Chen, S.H.3
Colacino, J.4
Chaturvedi, P.5
Courtney, L.F.6
Decker, C.7
Gates, C.8
Harbeson, S.L.9
Kwong, A.D.10
Lin, C.11
Lin, K.12
Monroe, J.E.13
Luong, Y.-P.14
Murko, M.A.15
Pitlik, J.16
Rao, G.17
Tebbe, M.18
Tung, R.D.19
Thomson, J.A.20
more..
-
19
-
-
12144290054
-
-
M. Llinas-Brunet, M.D. Bailey, G. Bolger, C. Brochu, A.-M. Faucher, J.M. Ferland, M. Garneau, E. Ghiro, V. Gorys, C. Grand-Maitre, T. Halmos, N. Lapeyre-Paquette, F. Liard, M. Poirer, M. Rheaume, Y.S. Tsantizos, and D. Lamarre J. Med. Chem. 47 2004 1605
-
(2004)
J. Med. Chem.
, vol.47
, pp. 1605
-
-
Llinas-Brunet, M.1
Bailey, M.D.2
Bolger, G.3
Brochu, C.4
Faucher, A.-M.5
Ferland, J.M.6
Garneau, M.7
Ghiro, E.8
Gorys, V.9
Grand-Maitre, C.10
Halmos, T.11
Lapeyre-Paquette, N.12
Liard, F.13
Poirer, M.14
Rheaume, M.15
Tsantizos, Y.S.16
Lamarre, D.17
-
20
-
-
20144370536
-
-
S.H. Chen, J. Lamar, Y. Yip, F. Victor, R.B. Johnson, Q.M. Wang, J.I. Glass, B. Heinz, J. Colacino, D. Guo, M. Tebbe, and J.E. Munroe Letters Drug Des. Discov. 2 2005 118
-
(2005)
Letters Drug Des. Discov.
, vol.2
, pp. 118
-
-
Chen, S.H.1
Lamar, J.2
Yip, Y.3
Victor, F.4
Johnson, R.B.5
Wang, Q.M.6
Glass, J.I.7
Heinz, B.8
Colacino, J.9
Guo, D.10
Tebbe, M.11
Munroe, J.E.12
-
21
-
-
33645409906
-
-
note
-
6 requires 457.1400.
-
-
-
-
24
-
-
33645404206
-
-
note
-
2 and in-house standards of HCV protease inhibitor molecules served as positive controls. After stopping the reaction, cleavage of the Cys-Ser bond was detected by the addition of streptavidin-coated SPA beads (Amersham), which can bind to the biotin-labeled peptide. Cleavage is indicated by reduction in signal caused by separation of the radiolabeled fragment from the bound biotinylated fragment (measured in CPM) which is proportional to proteolytic activity.
-
-
-
-
25
-
-
33645409526
-
-
note
-
3 requires 230.0817.
-
-
-
-
26
-
-
0033151691
-
-
R. Zhang, B.M. Beyer, J. Durkin, R. Ingram, F.G. Njoroge, W.T. Windsor, and B.A. Malcolm Anal. Biochem. 270 1999 268
-
(1999)
Anal. Biochem.
, vol.270
, pp. 268
-
-
Zhang, R.1
Beyer, B.M.2
Durkin, J.3
Ingram, R.4
Njoroge, F.G.5
Windsor, W.T.6
Malcolm, B.A.7
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