-
2
-
-
0023652701
-
Chekhov MD and Coley's toxin
-
Gresser IA. Chekhov MD and Coley's toxin. N Engl J Med 1987; 317: 457.
-
(1987)
N Engl J Med
, vol.317
, pp. 457
-
-
Gresser, I.A.1
-
3
-
-
0001836474
-
A review of the influence of bacterial infection and of bacterial products (Coley's toxins) on malignant tumors in man
-
Nauts HC, Fowler GAA, Bogato FH. A review of the influence of bacterial infection and of bacterial products (Coley's toxins) on malignant tumors in man. Acta Med Scand 1953; 145 (Suppl. 276): 5-103.
-
(1953)
Acta Med Scand
, vol.145
, Issue.SUPPL. 276
, pp. 5-103
-
-
Nauts, H.C.1
Fowler, G.A.A.2
Bogato, F.H.3
-
4
-
-
36249006186
-
A synopsis of the history of medical bacteriology
-
Dubos, RJ, ed. Philadelphia (PA): Lippincott
-
Murray EGD. A synopsis of the history of medical bacteriology. In: Dubos, RJ, ed. Bacterial and Mycotic Infections of Man, 3rd edn. Philadelphia (PA): Lippincott, 1958: 1-13.
-
(1958)
Bacterial and Mycotic Infections of Man, 3rd Edn.
, pp. 1-13
-
-
Murray, E.G.D.1
-
5
-
-
27744489008
-
The history of immunological ideas Chapter 1
-
Cambridge: Cambridge University Press
-
Burnet M. The history of immunological ideas. Chapter 1. In: Cellular Immunology Bacterial and Mycotic Infections of Man, Cambridge: Cambridge University Press, 1969; 3-20.
-
(1969)
Cellular Immunology Bacterial and Mycotic Infections of Man
, pp. 3-20
-
-
Burnet, M.1
-
6
-
-
0001252242
-
Principles of cancer management: Biologic therapy
-
DeVita, VT Jr, Hellman, S, Rosenberg, SA, eds. Philadelphia (PA): Lippincott Williams & Wilkins
-
Rosenberg SA. Principles of cancer management: biologic therapy. In: DeVita, VT Jr, Hellman, S, Rosenberg, SA, eds. Cancer. Principles and Practice of Oncology, 6th edn. Philadelphia (PA): Lippincott Williams & Wilkins, 2001; 307-33.
-
(2001)
Cancer. Principles and Practice of Oncology, 6th Edn.
, pp. 307-333
-
-
Rosenberg, S.A.1
-
8
-
-
0004027213
-
-
Hamilton, Ont.: BC Becker Inc.
-
Kufe DW, Pollock RE, Weichselbaum RR, Bast RC Jr, Gansler TS, Holland JF, Frei E III. eds. Cancer Medicine. Hamilton, Ont.: BC Becker Inc., 2003.
-
(2003)
Cancer Medicine
-
-
Kufe, D.W.1
Pollock, R.E.2
Weichselbaum, R.R.3
Bast Jr., R.C.4
Gansler, T.S.5
Holland, J.F.6
Frei III, E.7
-
11
-
-
0032722442
-
The plasminogen (fibrinolytic) system
-
Collen D. The plasminogen (fibrinolytic) system. Thromb Haemost 1999; 82: 298-304.
-
(1999)
Thromb Haemost
, vol.82
, pp. 298-304
-
-
Collen, D.1
-
12
-
-
0024551905
-
Heterogeneity of the streptokinase gene in Group A streptococci
-
Huang T-T, Malke H, Ferretti JJ. Heterogeneity of the streptokinase gene in Group A streptococci. Infect Immun 1989; 57: 502-6.
-
(1989)
Infect Immun
, vol.57
, pp. 502-506
-
-
Huang, T.-T.1
Malke, H.2
Ferretti, J.J.3
-
13
-
-
0026623072
-
Streptokinase-producing streptococci grown in human plasma acquire unregulated cell-associated plasmin activity
-
Lottenberg R, DesJardin LE, Wang H, Boyle MDP. Streptokinase-producing streptococci grown in human plasma acquire unregulated cell-associated plasmin activity. J Infect Dis 1992; 166: 436-40.
-
(1992)
J Infect Dis
, vol.166
, pp. 436-440
-
-
Lottenberg, R.1
DesJardin, L.E.2
Wang, H.3
Boyle, M.D.P.4
-
14
-
-
0029039458
-
Analysis of the interaction of group A streptococci with fibrinogen, streptokinase and plasminogen
-
Wang H, Lottenberg R, Boyle MD. Analysis of the interaction of group A streptococci with fibrinogen, streptokinase and plasminogen. Microb Pathog 1995; 18: 153-66.
-
(1995)
Microb Pathog
, vol.18
, pp. 153-166
-
-
Wang, H.1
Lottenberg, R.2
Boyle, M.D.3
-
15
-
-
0019471560
-
Blood coagulation and fibrinolytic systems in patients with erysipelas and necrotizing fasciitis
-
Sverdrup B, Blomback M, Borglund E, Hammer H. Blood coagulation and fibrinolytic systems in patients with erysipelas and necrotizing fasciitis. Scand J Infect Dis 1981; 13: 29-36.
-
(1981)
Scand J Infect Dis
, vol.13
, pp. 29-36
-
-
Sverdrup, B.1
Blomback, M.2
Borglund, E.3
Hammer, H.4
-
16
-
-
0018905955
-
An improved quantitative method for the study of fibrinolysis in the skin as exemplified in patients with leukocytoclastic vasculitis and erysipelas
-
Hammer H, Blomback M, Sverdrup B, Borglund E. An improved quantitative method for the study of fibrinolysis in the skin as exemplified in patients with leukocytoclastic vasculitis and erysipelas. Acta Derm Venereol 1980; 60: 287-93.
-
(1980)
Acta Derm Venereol
, vol.60
, pp. 287-293
-
-
Hammer, H.1
Blomback, M.2
Sverdrup, B.3
Borglund, E.4
-
17
-
-
0033018951
-
Severe pulmonary hemorrhage in patients with serious Group A streptococcal infections: Report of two cases
-
Ooe K, Nakada H, Udagawa H, Shimizu Y. Severe pulmonary hemorrhage in patients with serious Group A streptococcal infections: report of two cases. Clin Infect Dis 1999; 28: 1317-19.
-
(1999)
Clin Infect Dis
, vol.28
, pp. 1317-1319
-
-
Ooe, K.1
Nakada, H.2
Udagawa, H.3
Shimizu, Y.4
-
18
-
-
0025988405
-
Streptokinases produced by pathogenic group C streptococci demonstrate species-specific plasminogen activation
-
McCoy HE, Broder CC, Lottenberg R. Streptokinases produced by pathogenic group C streptococci demonstrate species-specific plasminogen activation. J Infect Dis 1991; 164: 515-21.
-
(1991)
J Infect Dis
, vol.164
, pp. 515-521
-
-
McCoy, H.E.1
Broder, C.C.2
Lottenberg, R.3
-
19
-
-
84965191589
-
Effect of human plasmin on the toxic effects and growth of blood-borne metastasis of the Brown-Pearce carcinoma and the V2 carcinoma of rabbits
-
Cliffton EE, Grossi CE. Effect of human plasmin on the toxic effects and growth of blood-borne metastasis of the Brown-Pearce carcinoma and the V2 carcinoma of rabbits. Cancer 1956; 9: 1147-52.
-
(1956)
Cancer
, vol.9
, pp. 1147-1152
-
-
Cliffton, E.E.1
Grossi, C.E.2
-
20
-
-
27744536307
-
Historical developments in fibrinolysis
-
Sawaya R, eds. Philadelphia (PA): Hanley Belfus, Inc.
-
Sherry S. Historical developments in fibrinolysis. In: Sawaya R, eds. Fibrinolysis and the Central Nervous System. Philadelphia (PA): Hanley & Belfus, Inc., 1990; 3-13.
-
(1990)
Fibrinolysis and the Central Nervous System
, pp. 3-13
-
-
Sherry, S.1
-
21
-
-
0141834741
-
Characterization of group B streptococcal glyceraldehyde-3-phosphate dehydrogenase. Surface localization, enzymatic activity, and protein-protein interactions
-
Seifert KN, McArthur WP, Bleiweis AS, Brady LJ. Characterization of group B streptococcal glyceraldehyde-3-phosphate dehydrogenase. surface localization, enzymatic activity, and protein-protein interactions. Can J Microbiol 2003; 49: 350-6.
-
(2003)
Can J Microbiol
, vol.49
, pp. 350-356
-
-
Seifert, K.N.1
McArthur, W.P.2
Bleiweis, A.S.3
Brady, L.J.4
-
22
-
-
0036546758
-
Mapping the fibrinogen-binding domain of serum opacity factor of group a streptococci
-
Courtney HS, Dale JB, Hasty DL. Mapping the fibrinogen-binding domain of serum opacity factor of group a streptococci. Curr Microbiol 2002; 44: 236-40.
-
(2002)
Curr Microbiol
, vol.44
, pp. 236-240
-
-
Courtney, H.S.1
Dale, J.B.2
Hasty, D.L.3
-
23
-
-
0034430849
-
Interaction of group A streptococci with human plasmin(ogen) under physiological conditions
-
D'Costa SS, Boyle MD. Interaction of group A streptococci with human plasmin(ogen) under physiological conditions. Methods 2000; 21: 165-77.
-
(2000)
Methods
, vol.21
, pp. 165-177
-
-
D'Costa, S.S.1
Boyle, M.D.2
-
24
-
-
0030754785
-
Identification and characterization of a new protein from Streptococcus pyogenes having homology with fibronectin and fibrinogen binding proteins
-
Rocha CL, Fischetti VA. Identification and characterization of a new protein from Streptococcus pyogenes having homology with fibronectin and fibrinogen binding proteins. Adv Exp Med Biol 1997; 418: 737-9.
-
(1997)
Adv Exp Med Biol
, vol.418
, pp. 737-739
-
-
Rocha, C.L.1
Fischetti, V.A.2
-
25
-
-
0026034135
-
Fibrinogen deposition without thrombin generation in primary human breast cancer tissue
-
Costantini V, Zacharski LR, Memoli VA, Kisiel W, Kudryk BJ, Hunt J, Rousseau SM, Stump DC. Fibrinogen deposition without thrombin generation in primary human breast cancer tissue. Cancer Res 1991; 51: 349-53.
-
(1991)
Cancer Res
, vol.51
, pp. 349-353
-
-
Costantini, V.1
Zacharski, L.R.2
Memoli, V.A.3
Kisiel, W.4
Kudryk, B.J.5
Hunt, J.6
Rousseau, S.M.7
Stump, D.C.8
-
27
-
-
0025797786
-
Thrombolytic therapy with streptokinase stimulates collagen breakdown
-
Peuhkurinen KJ, Risteli L, Melkko JT, Linnaluoto M, Jounela A, Risteli J. Thrombolytic therapy with streptokinase stimulates collagen breakdown. Circulation 1991; 83: 1969-75.
-
(1991)
Circulation
, vol.83
, pp. 1969-1975
-
-
Peuhkurinen, K.J.1
Risteli, L.2
Melkko, J.T.3
Linnaluoto, M.4
Jounela, A.5
Risteli, J.6
-
28
-
-
84959808645
-
The fibrinolytic activity of hemolytic streptococci
-
Tillett WS, Garner RL. The fibrinolytic activity of hemolytic streptococci. J Exp Med 1933; 68: 485-502.
-
(1933)
J Exp Med
, vol.68
, pp. 485-502
-
-
Tillett, W.S.1
Garner, R.L.2
-
29
-
-
27744451776
-
Thromboangiitis: Significant findings and theory of etiology (non-specific protein therapy with Coley's erysipelas and prodigiosus toxins)
-
Gray HJ. Thromboangiitis: significant findings and theory of etiology (non-specific protein therapy with Coley's erysipelas and prodigiosus toxins). Med Bull Vet Admin 1935; 11: 16-23.
-
(1935)
Med Bull Vet Admin
, vol.11
, pp. 16-23
-
-
Gray, H.J.1
-
30
-
-
0027456468
-
Intra-arterial streptokinase as adjuvant therapy for complicated Buerger's disease: Early trials
-
Hussein EA, el Dorri A. Intra-arterial streptokinase as adjuvant therapy for complicated Buerger's disease: early trials. Int Surg 1993; 78: 54-8.
-
(1993)
Int Surg
, vol.78
, pp. 54-58
-
-
Hussein, E.A.1
El Dorri, A.2
-
31
-
-
0036191983
-
Treatment of malignancy by activation of the plasminogen system
-
Zacharski LR, Ornstein DL, Gabazza EC, D'Alessandro-Gabazza CN, Brugarolas A, Schneider J. Treatment of malignancy by activation of the plasminogen system. Semin Thrombos Hemostas 2002; 28: 5-17.
-
(2002)
Semin Thrombos Hemostas
, vol.28
, pp. 5-17
-
-
Zacharski, L.R.1
Ornstein, D.L.2
Gabazza, E.C.3
D'Alessandro-Gabazza, C.N.4
Brugarolas, A.5
Schneider, J.6
-
32
-
-
0030788411
-
The urokinase-type plasminogen activator system in cancer metastasis: A review
-
Andreasen PA, Kjoller L, Christensen L, Duffy MJ. The urokinase-type plasminogen activator system in cancer metastasis: a review. Int J Cancer 1997; 72: 1-22.
-
(1997)
Int J Cancer
, vol.72
, pp. 1-22
-
-
Andreasen, P.A.1
Kjoller, L.2
Christensen, L.3
Duffy, M.J.4
-
33
-
-
0026562588
-
Pathways of coagulation/fibrinolysis activation in malignancy
-
Zacharski LR, Wojtukiewicz MZ, Costantini V, Ornstein DL, Memoli VA. Pathways of coagulation/fibrinolysis activation in malignancy. Semin Thromb Hemost 1992; 18: 104-16.
-
(1992)
Semin Thromb Hemost
, vol.18
, pp. 104-116
-
-
Zacharski, L.R.1
Wojtukiewicz, M.Z.2
Costantini, V.3
Ornstein, D.L.4
Memoli, V.A.5
-
35
-
-
0033850076
-
Cancer treatment with inhibitors of urokinase-type plasminogen activator and plasmin
-
Dunbar SD, Ornstein DL, Zacharski LR. Cancer treatment with inhibitors of urokinase-type plasminogen activator and plasmin. Exp Opin Invest Drugs 2000; 9: 2085-92.
-
(2000)
Exp Opin Invest Drugs
, vol.9
, pp. 2085-2092
-
-
Dunbar, S.D.1
Ornstein, D.L.2
Zacharski, L.R.3
-
36
-
-
0032953135
-
Prognostic value of tissue-type plasminogen activator (tPA) and its complex with the type-1 inhibitor (PAI-1) in breast cancer
-
de Witte JH, Sweep CG, Klijn JG, Grebenschikov N, Peters HA, Look MP, van Tiemoven TH, Heuvel JJ, Bolt-De Vries J, Benraad TJ, Foekens JA. Prognostic value of tissue-type plasminogen activator (tPA) and its complex with the type-1 inhibitor (PAI-1) in breast cancer. Br J Cancer 1999; 80: 286-94.
-
(1999)
Br J Cancer
, vol.80
, pp. 286-294
-
-
De Witte, J.H.1
Sweep, C.G.2
Klijn, J.G.3
Grebenschikov, N.4
Peters, H.A.5
Look, M.P.6
Van Tiemoven, T.H.7
Heuvel, J.J.8
Bolt-De Vries, J.9
Benraad, T.J.10
Foekens, J.A.11
-
37
-
-
0033016406
-
Prognostic impact of urokinase-type plasminogen activator (uPA) and its inhibitor (PAI-1) in cytosols and pellet extracts derived from 892 breast cancer patients
-
de Witte JH, Sweep CG, Klijn JG, Grebenschikov N, Peters HA, Look MP, van Tiemoven TH, Heuvel JJ, van Putten WL, Benraad TJ, Foekens JA. Prognostic impact of urokinase-type plasminogen activator (uPA) and its inhibitor (PAI-1) in cytosols and pellet extracts derived from 892 breast cancer patients. Br J Cancer 1999; 79: 1190-8.
-
(1999)
Br J Cancer
, vol.79
, pp. 1190-1198
-
-
De Witte, J.H.1
Sweep, C.G.2
Klijn, J.G.3
Grebenschikov, N.4
Peters, H.A.5
Look, M.P.6
Van Tiemoven, T.H.7
Heuvel, J.J.8
Van Putten, W.L.9
Benraad, T.J.10
Foekens, J.A.11
-
38
-
-
0035873886
-
Functional evaluation of plasmin formation in primary breast cancer
-
Chappuis PO, Dieterich B, Sciretta V, Lohse C, Bonnefoi H, Remadi S, Sappino AP. Functional evaluation of plasmin formation in primary breast cancer. J Clin Oncol 2001; 19: 2731-8.
-
(2001)
J Clin Oncol
, vol.19
, pp. 2731-2738
-
-
Chappuis, P.O.1
Dieterich, B.2
Sciretta, V.3
Lohse, C.4
Bonnefoi, H.5
Remadi, S.6
Sappino, A.P.7
-
40
-
-
0029943568
-
Plasminogen activators and matrix metalloproteinases in angiogenesis
-
Mignatti P, Rifkin DB. Plasminogen activators and matrix metalloproteinases in angiogenesis. Enzyme Protein 1996; 49: 117-37.
-
(1996)
Enzyme Protein
, vol.49
, pp. 117-137
-
-
Mignatti, P.1
Rifkin, D.B.2
-
41
-
-
0032542528
-
Gene therapy strategies for tumor antiangiogenesis
-
Kong HL, Crystal RG. Gene therapy strategies for tumor antiangiogenesis. J Natl Cancer Inst 1998; 90: 273-86.
-
(1998)
J Natl Cancer Inst
, vol.90
, pp. 273-286
-
-
Kong, H.L.1
Crystal, R.G.2
-
42
-
-
0030576517
-
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
-
Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996; 86: 353-64.
-
(1996)
Cell
, vol.86
, pp. 353-364
-
-
Hanahan, D.1
Folkman, J.2
-
43
-
-
0031454617
-
Endostatin: An endogenous inhibitor of angiogenesis and tumor growth
-
O'Reilly MS, Boehm T, Shing Y, Fukai N, Vasios G, Lane WS, Flynn E, Birkhead JR, Olsen BR, Folkman J. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 1997; 88: 277-85.
-
(1997)
Cell
, vol.88
, pp. 277-285
-
-
O'Reilly, M.S.1
Boehm, T.2
Shing, Y.3
Fukai, N.4
Vasios, G.5
Lane, W.S.6
Flynn, E.7
Birkhead, J.R.8
Olsen, B.R.9
Folkman, J.10
-
44
-
-
0034695685
-
The hemostatic system as a regulator of angiogenesis
-
Browder T, Folkman J, Pirie-Shepherd S. The hemostatic system as a regulator of angiogenesis. J Biol Chem 2000; 275: 1521-4.
-
(2000)
J Biol Chem
, vol.275
, pp. 1521-1524
-
-
Browder, T.1
Folkman, J.2
Pirie-Shepherd, S.3
-
45
-
-
0024230465
-
Human tissue-type plasminogen activator releases fibrinopeptides A and B from fibrinogen
-
Weitz JI, Cruickshank MK, Thong B, Leslie B, Levine MN, Ginsberg J, Eckhardt T. Human tissue-type plasminogen activator releases fibrinopeptides A and B from fibrinogen. J Clin Invest 1988; 82: 1700-7.
-
(1988)
J Clin Invest
, vol.82
, pp. 1700-1707
-
-
Weitz, J.I.1
Cruickshank, M.K.2
Thong, B.3
Leslie, B.4
Levine, M.N.5
Ginsberg, J.6
Eckhardt, T.7
-
46
-
-
0034528886
-
Angiostatin and angiostatin-related proteins
-
Soff GA. Angiostatin and angiostatin-related proteins. Cancer Metastasis Rev 2000; 19: 97-107.
-
(2000)
Cancer Metastasis Rev
, vol.19
, pp. 97-107
-
-
Soff, G.A.1
-
47
-
-
12644251975
-
The mechanism of cancer-mediated conversion of plasminogen to the angiogenesis inhibitor angiostatin
-
Gately S, Twardowski P, Stack MS, Cundiff DL, Grella D, Castellino FJ, Enghild J, Kwaan HC, Lee F, Kramer RA, Volpert O, Bouck N, Soff GA. The mechanism of cancer-mediated conversion of plasminogen to the angiogenesis inhibitor angiostatin. Proc Natl Acad Sci USA 1997; 94: 10868-72.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 10868-10872
-
-
Gately, S.1
Twardowski, P.2
Stack, M.S.3
Cundiff, D.L.4
Grella, D.5
Castellino, F.J.6
Enghild, J.7
Kwaan, H.C.8
Lee, F.9
Kramer, R.A.10
Volpert, O.11
Bouck, N.12
Soff, G.A.13
-
48
-
-
0027970092
-
Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma
-
O'Reilly MS, Holmgren L, Shing Y, Chen C, Rosenthal RA, Moses M, Lane WS, Cao Y, Sage EH, Folkman J. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 1994; 79: 315-28.
-
(1994)
Cell
, vol.79
, pp. 315-328
-
-
O'Reilly, M.S.1
Holmgren, L.2
Shing, Y.3
Chen, C.4
Rosenthal, R.A.5
Moses, M.6
Lane, W.S.7
Cao, Y.8
Sage, E.H.9
Folkman, J.10
-
49
-
-
0037420209
-
In vitro and in vivo induction of antiangiogenic activity by plasminogen activators and captopril
-
Merchan JR, Chan B, Kale S, Schnipper LE, Sukhatme VP. In vitro and in vivo induction of antiangiogenic activity by plasminogen activators and captopril. J Natl Cancer Inst 2003; 95: 388-99.
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 388-399
-
-
Merchan, J.R.1
Chan, B.2
Kale, S.3
Schnipper, L.E.4
Sukhatme, V.P.5
-
50
-
-
0037417377
-
Images in clinical medicine. Effect of intrapleural streptokinase on a loculated malignant pleural effusion
-
Maskell NA, Gleeson FV. Images in clinical medicine. Effect of intrapleural streptokinase on a loculated malignant pleural effusion. N Engl J Med 2003; 1348: e4.
-
(2003)
N Engl J Med
, vol.1348
-
-
Maskell, N.A.1
Gleeson, F.V.2
-
51
-
-
15644365345
-
Intrapleural fibrinolysis with streptokinase as an adjunctive treatment in hemothorax and empyema: A multicenter trial
-
Jerjes-Sanchez C, Ramirez-Rivera A, Elizalde JJ, Delgado R, Cicero R, Ibarra-Perez C, Arroliga AC, Padua A, Portales A, Villareal A, Perez-Romo A. Intrapleural fibrinolysis with streptokinase as an adjunctive treatment in hemothorax and empyema: a multicenter trial. Chest 1996; 109: 1514-19.
-
(1996)
Chest
, vol.109
, pp. 1514-1519
-
-
Jerjes-Sanchez, C.1
Ramirez-Rivera, A.2
Elizalde, J.J.3
Delgado, R.4
Cicero, R.5
Ibarra-Perez, C.6
Arroliga, A.C.7
Padua, A.8
Portales, A.9
Villareal, A.10
Perez-Romo, A.11
-
52
-
-
0033028876
-
Intrapleural streptokinase in the management of malignant multiloculated pleural effusions
-
Davies CW, Traill ZC, Gleeson FV, Davies RJ. Intrapleural streptokinase in the management of malignant multiloculated pleural effusions. Chest 1999; 115: 729-33.
-
(1999)
Chest
, vol.115
, pp. 729-733
-
-
Davies, C.W.1
Traill, Z.C.2
Gleeson, F.V.3
Davies, R.J.4
-
53
-
-
0038772361
-
Malignancy as a solid phase coagulopathy. Implications for the etiology, pathogenesis and treatment of cancer
-
Zacharski LR. Malignancy as a solid phase coagulopathy. Implications for the etiology, pathogenesis and treatment of cancer. Semin Thrombos Hemostas 2003; 29: 239-46.
-
(2003)
Semin Thrombos Hemostas
, vol.29
, pp. 239-246
-
-
Zacharski, L.R.1
|