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note
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Bromination of 2-methyl-2-cyclohexenone provided a single dibromide (e.g., trans-2,3-dibromo-2-methyl cyclohexanone).
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27
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0038676290
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The vinyl iodide (-)-3 can be prepared from (R)-(-)-Roche's ester via the route in eq 2 in eight steps with 30% overall yield. Also see: Organ, M. G.; Wang, J. J. Org. Chem. 2003, 68, 5568.
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23944491981
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Prepared from δ-valerolactone (55%, 2 steps); see: Slouggi, N.; Rousseau, G. Tetrahedron 1985, 41, 2643. Both 38 and 39 are also available via the RCM or aldol route used for (-)-35 in Scheme 7.
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