Proteolytic processing of the peanut allergen Ara h 3

Molecular Nutrition and Food Research

Volumn 49, Issue 8, 2005, Pages 744-755

  Piersma, Sander R ^a   Gaspari, Marco ^b   Hefle, Susan L ^c   Koppelman, Stef J ^b,d,e,f  

^a FOM INSTITUTE AMOLF   (Netherlands)

^b TNO   (Netherlands)

^c UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^e HAL Allergy BV   (Netherlands)

^f AllerTeQ   (Netherlands)

Author keywords

Allergen; Ara h 3; Mass spectrometry; Peanut; Proteolytic processing

Indexed keywords

ALLERGEN; ALLERGEN ARA H3; PEPTIDE FRAGMENT; PROTEIN SUBUNIT; TRYPSIN; VEGETABLE PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CHEMISTRY; MASS SPECTROMETRY; METABOLISM; MOLECULAR GENETICS; MOLECULAR WEIGHT; POLYACRYLAMIDE GEL ELECTROPHORESIS; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS;

ALLERGENS; AMINO ACID SEQUENCE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; PEPTIDE FRAGMENTS; PLANT PROTEINS; PROTEIN SUBUNITS; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, PROTEIN; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TRYPSIN;

ARA; ARACHIS HYPOGAEA;

EID: 23944434895     PISSN: 16134125     EISSN: None     Source Type: Journal    
DOI: 10.1002/mnfr.200500020     Document Type: Article

References (29)

1. Sampson, H. A., McCaskill, C. C., Food hypersensitivity and atopic dermatitis: Evaluation of 113 patients. J. Pediatr. 1985, 107, 669-675.
2. Sachs, M. I., Jones, R. T., Yunginger, J. W., Isolation and partial characterization of a major peanut allergen. J. Allergy Clin. Immunol. 1981, 67, 27-34.
3. Barnett, D., Howden, M. E., Partial characterization of an allergenic glycoprotein from peanut (Arachis hypogaea I.). Biochim. Biophys. Acta 1986, 882, 97-105.
4. Burks, W., Sampson, H. A., Bannon, G. A., Peanut allergens. Allergy 1998, 53, 725-730.
5. Buschmann, L., Petersen, A., Schlaak, M., Becker, W. M., Reinvestigation of the major peanut allergen Ara h 1 on molecular level. Monogr. Allergy 1996, 32, 92-98.
6. Burks, A. W., Williams, L. W., Helm, R. M., Connaughton, C., et al., Identification of a maj or peanut allergen, Ara h 1, in patients with atopic dermatitis and positive peanut challenges. J. Allergy Clin. Immunol. 1991, 88, 172-179.
7. Koppelman, S. J., Bruijnzeel-Koomen, C. A., Hessing, M., de Jongh, H. H., Heat-induced conformational changes of Ara h l, a major peanut allergen, do not affect its allergenic properties. J. Biol. Chem. 1999, 274, 4770-4777.
8. Burks, A. W., Shin, D., Cockrell, G., Stanley, J. S., et al., Mapping and mutational analysis of the IgE-binding epitopes on Ara h 1, a legume vicilin protein and a major allergen in peanut hypersensitivity. Eur. J. Biochem. 1997, 245, 334-339.
9. Shin, D. S., Compadre, C. M., Maleki, S. J., Kopper, R. A., et al., Biochemical and structural analysis of the IgE binding sites on Ara h 1, an abundant and highly allergenic peanut protein. J. Biol. Chem. 1998, 273, 13753-13759.
10. van der Veen, M. J., van Ree, R., Aalberse, R. C., Akkerdaas, J., et al., Poor biologic activity of cross-reactive IgE directed to carbohydrate determinants of glycoproteins. J. Allergy Clin. Immunol. 1997, 100, 327-334.
11. de Jong, E. C., Van Zijverden, M., Spanhaak, S., Koppelman, S. J., et al., Identification and partial characterization of multiple major allergens in peanut proteins. Clin. Exp. Allergy 1998, 28, 743-751.
12. Burks, A. W., Williams, L. W., Connaughton, C., Cockrell, G., et al., Identification and characterization of a second major peanut allergen, Ara h 2, with use of the sera of patients with atopic dermatitis and positive peanut challenge. J. Allergy Clin. Immunol. 1992, 90, 962-969.
13. Kleber-Janke, T., Crameri, R., Appenzeller, U., Schlaak, M., Becker, W. M., Selective cloning of peanut allergens, including profilin and 2s albumins, by phage display technology. Int. Arch. Allergy Immunol. 1999, 119, 265-274.
14. Eigenmann, P. A., Burks, A. W., Bannon, G. A., Sampson, H. A., Identification of unique peanut and soy allergens in sera adsorbed with cross-reacting antibodies. J. Allergy Clin. Immunol. 1996, 98, 969-978.
15. Rabjohn, P., Helm, E. M., Stanley, J. S., West, C. M., et al., Molecular cloning and epitope analysis of the peanut allergen Ara h 3. J. Clin. Invest. 1999, 103, 535-542.
16. Koppelman, S. J., Knol, E. F., Vlooswijk, R. A., Wensing, M., et al., Peanut allergen Ara h 3: Isolation from peanut and biochemical characterization. Allergy 2003, 58, 1144-1151.
17. Scott, M. P., Jung, R., Muntz, K., Nielsen, N. C., A protease responsible for post-translational cleavage of a conserved asn-gly linkage in glycinin, the major seed storage protein of soybean. Proc. Natl. Acad. Sci. USA 1992, 89, 658-662.
18. Jung, R., Scott, M. P., Nam, Y. W., Beaman, T. W., et al., The role of proteolysis in the processing and assembly of 11s seed globulins. Plant Cell 1998, 10, 343-357.
19. Dickinson, C. D., Hussein, E. H., Nielsen, N. C., Role of post-translational cleavage in glycinin assembly. Plant Cell 1989, 1, 459-469.
20. Staswick, P. E., Hermodson, M. A., Nielsen, N. C., Identification of the cystines which link the acidic and basic components of the glycinin subunits. J. Biol. Chem. 1984, 259, 13431-13435.
21. Adachi, M., Kanamori, J., Masuda, T., Yagasaki, K., et al., Crystal structure of soybean 11s globulin: Glycinin A3B4 homohexamer. Proc. Natl. Acad. Sci. USA 2003, 100, 7395-7400.
22. Koppelman, S. J., Vlooswijk, R. A., Knippels, L. M., Hessing, M., et al., Quantification of major peanut allergens Ara h 1 and Ara h 2 in the peanut varieties runner, Spanish, Virginia, and valencia, bred in different parts of the world. Allergy 2001, 56, 132-137.
23. Boldt, A., Fortunato, D., Conti, A., Petersen, A., et al., Analysis of the composition of an immunoglobulin E reactive high molecular weight protein complex of peanut extract containing Ara h 1 and Ara h 3/4. Proteomics 2005, 5, 675-686.
24. Laemmli, U. K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227, 680-685.
25. Shevchenko, A., Wilm, M., Vorm, O., Mann, M., Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal. Chem. 1996, 68, 850-858.
26. Beyer, K., Ellman-Grunther, L., Jarvinen, K. M., Wood, R. A., et al., Measurement of peptide-specific IgE as an additional tool in identifying patients with clinical reactivity to peanuts. J. Allergy Clin. Immunol. 2003, 112, 202-207.
27. Pedersen, H. S., Djurtoft, R., Antigenic and allergenic properties of acidic and basic peptide chains from glycinin. Food Agric. Immunol. 1989, 1, 101-109.
28. Herian, A. M., Taylor, S. L., Bush, R. K., Identification of soybean allergens by immunoblotting with sera from soy-allergic adults. Int. Arch. Allergy Appl. Immunol. 1990, 92, 193-198.
29. Helm, R. M., Cockrell, G., Connaughton, C., Sampson, H. A., et al., A soybean G2 glycinin allergen. 2. Epitope mapping and three-dimensional modeling. Int. Arch. Allergy Immunol. 2000, 123, 213-219.