Identification of virulence determinants for endocarditis in Streptococcus sanguinis by signature-tagged mutagenesis

Infection and Immunity

Volumn 73, Issue 9, 2005, Pages 6064-6074

  Paik, Sehmi ^a,b   Senty, Lauren ^a   Das, Sankar ^a   Noe, Jody C ^a,c   Munro, Cindy L ^a   Kitten, Todd ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

^c 859 MDTS/MTLLM ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLOSUCCINATE LYASE; RIBONUCLEOTIDE REDUCTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL ENDOCARDITIS; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM IDENTIFICATION; CONTROLLED STUDY; GENE DELETION; GENE INSERTION; MOUTH CAVITY; MUTAGENESIS; NONHUMAN; NUCLEIC ACID SYNTHESIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; SCREENING; SIGNATURE TAGGED MUTAGENESIS; STRAIN DIFFERENCE; STREPTOCOCCUS SANGUINIS; TRANSPOSON;

ANIMALS; BACTERIAL PROTEINS; DISEASE MODELS, ANIMAL; ENDOCARDITIS, BACTERIAL; MUTAGENESIS; RABBITS; RATS; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS SANGUIS; VIRULENCE;

EID: 23944431509     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.73.9.6064-6074.2005     Document Type: Article

References (67)

1. Altschul, S. F., W. Gish, W. Miller, E. W. Myers, and D. J. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol. 215:403-410.
2. Andersen, R. G., H. Hussey, and J. Baddiley, 1972. The mechanism of wall synthesis in bacteria. The organization of enzymes and isoprenoid phosphates in the membrane. Biochem. J. 127:11-25.
3. Baddour, L. M., C. Lowrance, A. Albus, J. H. Lowrance, S. K. Anderson, and J. C. Lee. 1992. Staphylococcus aureus microcapsule expression attenuates bacterial virulence in a rat model of experimental endocarditis. J. Infect. Dis. 165:749-753.
4. Bareich, D., K. Koteva, I. Nazi, and G. D. Wright. 2004. Small molecule functional discrimination of the kinases required for the microbial synthesis of threonine and isoleucine. Bioorg. Med. Chem. 12:807-815.
5. Behbehani, M. J., H. V. Jordan, and D. L. Santoro. 1982. Simple and convenient method for culturing anaerobic bacteria. Appl. Environ. Microbiol. 43:255-256.
6. Bensing, B. A., J. A. López, and P. M. Sullam. 2004. The Streptococcus gordonii surface proteins GspB and Hsa mediate binding to sialylated carbohydrate epitopes on the platelet membrane glycoprotein Ibα. Infect. Immun. 72:6528-6537.
7. Brendel, V., and E. N. Trifonov. 1984. A computer algorithm for testing potential prokaryotic terminators. Nucleic Acids Res. 12:4411-4427.
8. Burall, L. S., J. M. Harro, X. Li, C. V. Lockatell, S. D. Himpsl, J. R. Hebel, D. E. Johnson, and H. L. Mobley. 2004. Proteus mirabilis genes that contribute to pathogenesis of urinary tract infection: identification of 25 signature-tagged mutants attenuated at least 100-fold. Infect. Immun. 72:2922-2938.
9. Burnette-Curley, D., V. Wells, H. Viscount, C. L. Munro, JF. C. Fenno, P. Fives-Taylor, and F. L. Macrina. 1995. FimA, a major virulence factor associated with Streptococcus parasanguis endocarditis. Infect. Immun. 63:4669-4674.
10. Cain, B. D., P. J. Norton, W. Eubanks, H. S. Nick, and C. M. Allen. 1993. Amplification of the bacA gene confers bacitracin resistance to Escherichia coli. J. Bacteriol. 175:3784-3789.
11. Chalker, A. F., K. A. Ingraham, R. D. Lunsford, A. P. Bryant, J. Bryant, N. G. Wallis, J. P. Broskey, S. C. Pearson, and D. J. Holmes. 2000. The bacA gene, which determines bacitracin susceptibility in Streptococcus pneumoniae and Staphylococcus aureus, is also required for virulence. Microbiology 146:1547-1553.
12. Chenna, R., H. Sugawara, T. Koike, R. Lopez, T. J. Gibson, D. G. Higgins, and J. D. Thompson. 2003. Multiple sequence alignment with the Clustal series of programs. Nucleic Acids Res. 31:3497-3500.
13. Chiang, S. L., J. J. Mekalanos, and D. W. Holden. 1999. In vivo genetic analysis of bacterial virulence. Annu. Rev. Microbiol. 53:129-154.
14. Coulter, S. N., W. R. Schwan, E. Y. Ng, M. H. Langhorne, H. D. Ritchie, S. Westbrock-Wadman, W. O. Hufnagle, K. R. Folger, A. S. Bayer, and C. K. Stover. 1998. Staphylococcus aureus genetic loci impacting growth and survival in multiple infection environments. Mol. Microbiol. 30:393-404.
15. Dankert, J., J. Krijgsveld, J. van Der Werff, W. Joldersma, and S. A. Zaat. 2001. Platelet microbicidal activity is an important defense factor against viridans streptococcal endocarditis. J. Infect, Dis. 184:597-605.
16. Das, S., J. C. Noe, S. Paik, and T. Kitten. An improved arbitrary primed PCR method for rapid characterization of transposon insertion sites. J. Microbiol. Methods, in press.
17. Douglas, C. W., J. Heath, K. K. Hampton, and F. E. Preston. 1993. Identity of viridans streptococci isolated from cases of infective endocarditis. J. Med. Microbiol. 39:179-182.
18. Durack, D. T., P. B. Beeson, and R. G. Petersdorf. 1973. Experimental bacterial endocarditis. 3. Production and progress of the disease in rabbits. Br. J. Exp. Pathol. 54:142-151.
19. Folmsbee, M. J., M. J. McInerney, and D. P. Nagle. 2004. Anaerobic growth of Bacillus mojavensis and Bacillus subtilis requires deoxyribonucleosides or DNA. Appl. Environ. Microbiol. 70:5252-5257.
20. Ganeshkumar, N., P. M. Hannam, P. E. Kolenbrander, and B. C. McBride. 1991. Nucleotide sequence of a gene coding for a saliva-binding protein (SsaB) from Streptococcus sanguis 12 and possible role of the protein in coaggregation with actinomyces. Infect. Immun. 59:1093-1099.
21. Gaustad, P., and L. S. Havardstein. 1997. Competence-pheromone in Streptococcus sanguis. Identification of the competence gene comC and the competence pheromone. Adv. Exp. Med. Biol. 418:1019-1021.
22. Hava, D. L., and A. Camilli. 2002. Large-scale identification of serotype 4 Streptococcus pneumoniae virulence factors. Mol. Microbiol. 45:1389-1406.
23. He, B., J. M. Smith, and H. Zalkin. 1992. Escherichia coli purB gene: cloning, nucleotide sequence, and regulation by purR. J. Bacteriol. 174:130-136.
24. Hensel, M., J. E. Shea, C. Gleeson, M. D. Jones, E. Dalton, and D. W. Holden. 1995. Simultaneous identification of bacterial virulence genes by negative selection. Science 269:400-403.
25. Herzberg, M. C. 1996. Platelet-streptococcal interactions in endocarditis. Crit. Rev. Oral Biol. Med. 7:222-236.
26. Herzberg, M. C., G. D. MacFarlane, K. Gong, N. N. Armstrong, A. R. Witt, P. R. Erickson, and M. W. Meyer. 1992. The platelet interactivity phenotype of Streptococcus sanguis influences the course of experimental endocarditis. Infect. Immun. 60:4809-4818.
27. Hoen, B. 2002. Platelets and platelet inhibitors in infective endocarditis. Curr. Infect. Dis. Rep. 4:299-303.
28. Horton, R. M. 1995. PCR-mediated recombination and mutagenesis. SOE-ing together tailor-made genes. Mol. Biotechnol. 3:93-99.
29. Jones, A. L., K. M. Knoll, and C. E. Rubens. 2000. Identification of Streptococcus agalactiae virulence genes in the neonatal rat sepsis model using signature-tagged mutagenesis. Mol. Microbiol. 37:1444-1455.
30. Jordan, A., and P. Reichard. 1998. Ribonucleotide reductases. Annu. Rev. Biochem. 67:71-98.
31. Kerrigan, S. W., I. Douglas, A. Wray, J. Heath, M. F. Byrne, D. Fitzgerald, and D. Cox. 2002. A role for glycoprotein Ib in Streptococcus sanguis-induced platelet aggregation. Blood 100:509-516.
32. Kilian, M., L. Mikkelsen, and J. Henrichsen. 1989. Taxonomic study of viridans streptococci: description of Streptococcus gordonii sp. nov. and emended descriptions of Streptococcus sanguis (White and Niven 1946), Streptococcus oralis (Bridge and Sneath 1982), and Streptococcus mitis (Andrewes and Horder 1906). Int. J. Syst. Bacteriol. 39:471-484.
33. Kiliç, A. O., M. C. Herzberg, M. W. Meyer, X. Zhao, and L. Tao. 1999. Streptococcal reporter gene-fusion vector for identification of in vivo expressed genes. Plasmid 42:67-72.
34. Kitten, T., C. L. Munro, S. M. Michalek, and F. L. Macrina. 2000. Genetic characterization of a Streptococcus mutans LraI family operon and role in virulence. Infect. Immun. 68:4441-4451.
35. Komano, T., R. Utsumi, and M. Kawamukai. 1991. Functional analysis of the fic gene involved in regulation of cell division. Res. Microbiol. 142:269-277.
36. Lampe, D. J., B. J. Akerley, E. J. Rubin, J. J. Mekalanos, and H. M. Robertson. 1999. Hyperactive transposase mutants of the Himar1 mariner transposon. Proc. Natl. Acad. Sci. USA 96:11428-11433.
37. Lampe, D. J., M. E. Churchill, and H. M. Robertson. 1996. A purified mariner transposase is sufficient to mediate transposition in vitro. EMBO J. 15:5470-5479.
38. Lau, G. W., S. Haataja, M. Lonetto, S. E. Kensit, A. Marra, A. P. Bryant, D. McDevitt, D. A. Morrison, and D. W. Holden. 2001. A functional genomic analysis of type 3 Streptococcus pneumoniae virulence. Mol. Microbiol. 40:555-571.
39. Li, Y.-H., P. C. Y. Lau, J. H. Lee, R. P. Ellen, and D. G. Cvitkovitch. 2001. Natural genetic transformation of Streptococcus mutans growing in biofilms. J. Bacteriol. 183:897-908.
40. Loo, C. Y., D. A. Corliss, and N. Ganeshkumar. 2000. Streptococcus gordonii bofilm formation: identification of genes that code for biofilm phenotypes. J. Bacteriol. 182:1374-1382.
41. Macrina, F. L., J. A. Tobian, K. R. Jones, R. P. Evans, and D. B. Clewell. 1982. A cloning vector able to replicate in Escherichia coli and Streptococcus sanguis. Gene 19:345-353.
42. Martin, B., M. Prudhomme, G. Alloing, C. Granadel, and J. P. Claverys. 2000. Cross-regulation of competence pheromone production and export in the early control of transformation in Streptococcus pneumoniae. Mol. Microbiol. 38:867-878.
43. Masalha, M., I. Borovok, R. Schreiber, Y. Aharonowitz, and G. Cohen. 2001. Analysis of transcription of the Staphylococcus aureits aerobic class Ib and anaerobic class III ribonucleotide reductase genes in response to oxygen. J. Bacteriol. 183:7260-7272.
44. Mecsas, J. 2002. Use of signature-tagged mutagenesis in pathogenesis studies. Curr. Opin. Microbiol. 5:33-37.
45. Mei, J. M., F. Nourbakhsh, C. W. Ford, and D. W. Holden. 1997. Identification of Staphylococcus aureus virulence genes in a murine model of bacteraemia using signature-tagged mutagenesis. Mol. Microbiol. 26:399-407.
46. Miller, J. D., and M. N. Neely. 2005. Large-scale screen highlights the importance of capsule for virulence in the zoonotic pathogen Streptococcus iniae. Infect. Immun. 73:921-934.
47. Moreillon, P., J. M. Entenza, P. Francioli, D. McDevitt, T. J. Foster, P. Francois, and P. Vaudaux. 1995. Role of Staphylococcus aureus coagulase and clumping factor in pathogenesis of experimental endocarditis. Infect. Immun. 63:4738-4743.
48. Moreillon, P., and Y. A. Que. 2004. Infective endocarditis. Lancet 363:139-149.
49. Munro, C. L. 1998. The rat model of endocarditis. Methods Cell Sci. 20:203-207.
50. Munro, C. L., and F. L. Macrina. 1993. Sucrose-derived exopolysaccharides of Streptococcus mutans V403 contribute to infectivity in endocarditis. Mol. Microbiol. 8:133-142.
51. Noe, J. 2003. Characterization of Streptococcus sanguis mutants generated by signature-tagged mutagenesis. M.S. thesis. Virginia Commonwealth University, Richmond.
52. +-responsive metal transporter and pepO encoding a zinc metallopeptidase are not co-ordinately regulated. Infect. Immun. 70:5706-5714.
53. Paik, S., A. Brown, C. L. Munro, C. N. Cornelissen, and T. Kitten. 2003. The sloABCR operon of Streptococcus mutans encodes an Mn and Fe transport system required for endocarditis virulence and its Mn-dependent repressor. J. Bacteriol. 185:5967-5975.
54. Parsek, M. R., and P. K. Singh. 2003. Bacterial biofilms: an emerging link to disease pathogenesis. Annu. Rev. Microbiol. 57:677-701.
55. Plummer, C., H. Wu, S. W. Kerrigan, G. Meade, D. Cox, and C. W. I. Douglas. 2005. A serine-rich glycoprotein of Streptococcus sanguis mediates adhesion to platelets via GPIb. Br. J. Haematol. 129:101-109.
56. Polissi, A., A. Pontiggia, G. Feger, M. Altieri, H. Mottl, L. Ferrari, and D. Simon. 1998. Large-scale identification of virulence genes from Streptococcus pneumoniae. Infect. Immun. 66:5620-5629.
57. Rice, P., I. Longden, and A. Bleasby. 2000. EMBOSS: the European Molecular Biology Open Software Suite. Trends Genet. 16:276-277.
58. Roberts, R. B., A. G. Krieger, N. L. Schiller, and K. C. Gross. 1979. Viridans streptococcal endocarditis: the role of various species, including pyridoxal-dependent streptococci. Rev. Infect. Dis. 1:955-966.
59. Strom, B. L., E. Abrutyn, J. A. Berlin, J. L. Kinman, R. S. Feldman, P. D. Stolley, M. E. Levison, O. M. Korzeniowski, and D. Kaye. 1998. Dental and cardiac risk factors for infective endocarditis. A population-based, case-control study. Ann. Intern. Med. 129:761-769.
60. Sullam, P. M., U. Frank, M. R. Yeaman, M. G. Tauber, A. S. Bayer, and H. F. Chambers. 1993. Effect of thrombocytopenia on the early course of streptococcal endocarditis. J. Infect. Dis. 168:910-914.
61. Sztukowska, M., M. Bugno, J. Potempa, J. Travis, and D. M. Kurtz, Jr. 2002. Role of rubrerythrin in the oxidative stress response of Porphyromonas gingivalis. Mol. Microbiol. 44:479-488.
62. Tart, R. C., and I. van de Rijn. 1991. Analysis of adherence of Streptococcus defectivus and endocarditis-associated streptococci to extracellular matrix. Infect. Immun. 59:857-862.
63. Tartof, K. D., and C. A. Hobbs. 1987. Improved media for growing plasmid and cosmid clones. Focus 9:12.
64. Viola, R. E. 2001. The central enzymes of the aspartate family of amino acid biosynthesis. Acc. Chem. Res. 34:339-349.
65. Voskuil, M. I., and G. H. Chambliss. 1998. The -16 region of Bacillus subtilis and other gram-positive bacterial promoters. Nucleic Acids Res. 26:3584-3590.
66. Wells, V. D., C. L. Munro, M. C. Sulavik, D. B. Clewell, and F. L. Macrina. 1993. Infectivity of a glucan synthesis-defective mutant of Streptococcus gordonii (Challis) in a rat endocarditis model. FEMS Microbiol. Lett. 112:301-305.
67. Zhou, T., M. Daugherty, N. V. Grishin, A. L. Osterman, and H. Zhang. 2000. Structure and mechanism of homoserine kinase: prototype for the GHMP kinase superfamily. Struct. Fold Des. 8:1247-1257.