Impaired sperm function after spinal cord injury in the rat is associated with altered cyclic adenosine monophosphate signaling

Journal of Andrology

Volumn 26, Issue 5, 2005, Pages 592-600

  Wang, Shulun ^a   Wang, Guichun ^a   Barton, Beverly E ^a   Murphy, Thomas F ^a   Huang, Hosea F S ^a,b  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

cAMP; JC 1; SYBR 14

Indexed keywords

CELL PROTEIN; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT MODULATOR; FOLLITROPIN; REGULATOR PROTEIN; SPERMATOZOON LIFESPAN; SPERMATOZOON PROTEIN; TESTOSTERONE; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL FUNCTION; CELL VIABILITY; CONTROLLED STUDY; CONTUSION; ELECTRIC POTENTIAL; GENE EXPRESSION; MALE; MITOCHONDRION; MITOCHONDRION POTENTIAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SPERMATOGENESIS; SPERMATOZOON ABNORMALITY; SPERMATOZOON FUNCTION; SPERMATOZOON MOTILITY; SPINAL CORD CONTUSION; SPINAL CORD INJURY; SPINAL CORD TRANSSECTION;

ANIMALS; BENZIMIDAZOLES; CARBOCYANINES; CELL SURVIVAL; CYCLIC AMP; FLUORESCENT DYES; FOLLICLE STIMULATING HORMONE; MALE; ORGANIC CHEMICALS; PHOSPHOPROTEINS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SPERM MOTILITY; SPERMATOGENESIS; SPERMATOZOA; SPINAL CORD INJURIES; TESTOSTERONE;

EID: 23844553714     PISSN: 01963635     EISSN: None     Source Type: Journal    
DOI: 10.2164/jandrol.04168     Document Type: Article

References (47)

1. Adeoya-Osiguwara SA, Fraser LA. Capacitation state-dependent changes in adenosine receptors and their regulation of adenylyl cyclase/cAMP. Mol Reprod Dev. 2002;63:245-255.
2. Beavo JA. Cyclic nucleotide phosphodiesterase: functional implications of multi-isoforms. Physiol Rev. 1995;75:725-748.
3. Bonny C, Cooker LA, Goldberg E. Deoxyribonucleic acid-protein interactions and expression of the human testis-specific lactate dehydrogenase promoter: transcription factor Sp1 plays a major role. Biol Reprod. 1998;58:754-759.
4. Bracho GE, Fritch JJ, Tash JS. Identification of flagellar proteins that initiate the activation of sperm motility in vivo. Biochem Biophy Res Comm. 1998;242:231-237.
5. Brackett NL, Lynne CM, Weizman MS, Bloch WE, Abae M. Endocrine profiles and semen quality of spinal cord injured men. J Urol. 1994;151:114-119.
6. Chow S-H, Giglio W, Anesetti R, Ottenseller JE, Pogach LM, Huang HFS. The effects of testicular denervation on spermatogenesis in the Sprague Dawley rat. Neuroendocrinology. 2000;72:37-45.
7. Collins S, Lohes MJ, O'Dowd B, Caron MG, Lefkowiz RJ. Structure and regulation of G protein-coupled receptors: the beta2-adrenergic receptor as a model. Vitam Horm. 1991;46:1-39.
8. Conti M, Nemoz G, Sette C, Vicini E. Recent progress in understanding the hormonal regulation of phosphodiesterases. Endocr Rev. 1995;16: 370-389.
9. Esposito G, Jaiswal BS, Xie F, Krajnc-Franken MAM, Robben TJ, Strik AM, Kuil C, Philipsen RLA, van Duin M, Conti M, Gossen JA. Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect. Proc Natl Acad Sci U S A. 2004;101:2993-2998.
10. Fisch JD, Behr B, Conti M. Enhancement of motility and acrosome reaction in human spermatozoa: differential activation by type-specific phosphodiesterase inhibitor. Hum Reprod. 1998;13:1248-1254.
11. Gadella BM, Harrison RAP. The capacitating agent bicarbonate induces protein kinase A-dependent changes in phospholipids transbilayer behavior in the sperm plasma membrane. Development. 2000;127:2407-2420.
12. Galantino-Homer HL, Visconti PE, Kopf GS. Regulation of protein tyrosine phosphorylation during bovine sperm capacitation by a cyclic adenosine 3′,5′-monophosphate-dependent pathway. Biol Reprod. 1997;56:707-719.
13. Graham JK, Kunze E, Hammerstedt RH. Analysis of sperm cell viability, acrosomal integrity, and mitochondrial function using flow cytometry. Biol Reprod. 1990;43:55-64.
14. Gravance CG, Garner DL, Miller MG, Berger T. Fluorescent probes and flow cytometry to assess rat sperm integrity and mitochondrial function. Reprod Toxicol. 2001;15:5-10.
15. Ha H, van Wijne AJ, Hecht NB. Tissue-specific protein-DNA interactions of the mouse protamine 2 gene promoter. J Cell Biochem. 1997;64: 94-105.
16. Hecht NB. Regulation of "haploid expressed genes" in male germ cells. J Reprod Fertil. 1990;88:679-693.
17. Hirsch IH, McCue P, Allen J, Lee J, Staas WE. Quantitative testicular biopsy in spinal cord injured men: comparison to fertile controls. J Urol. 1991;146:337-341.
18. Hoskins DD, Stephens DT, Hall ML. Cyclic adenosine 3′:5′- monophosphate and protein kinase levels in developing bovine spermatozoa. J Reprod Fertil. 1974;37:131-133.
19. Huang HFS, Li M-T Giglio W, Anesetti R, Ottenweller JE, Pogach P. The detrimental effects of spinal cord injury on spermatogenesis in the rat is partially reversed by testosterone, but enhanced by follicle-stimulating hormone. Endocrinology. 1999;140:1349-1355.
20. Huang HFS, Li MT, Giglio, Anesetti R, Pogach LM, Ottenweller JE. Alteration of cAMP signaling in rat testicular cells after spinal cord injury. J Spinal Cord Med. 2003a;26:69-78.
21. Huang HFS, Li M-T, Wang S-L, Barton B, Anesetti R, Jetko JA. Effects of exogenous testosterone on testicular function during the chronic phase of spinal cord injury. Dose effects on spermatogenesis, Sertoli cell and sperm function. J Spinal Cord Med. 2004a;27:55-62.
22. Huang HFS, Li M-T, Wang S-L, Wang GC, Ottenweller JE. Spinal cord contusion impairs sperm motility in the rat without disrupting spermatogenesis. J Androl. 2003b;24:371-380.
23. Huang HFS, Linsenmeyer TA, Anesetti R, Giglio W, Ottenweller JE, Pogach LM. Suppression and recovery of spermatogenesis following spinal cord injury in the rat. J Androl. 1998;19:72-80.
24. Huang HFS, Linsenmeyer TA, Li MT, Giglio W, Anesetti R, von Hagen J, Ottenweller JE, Pogach L. Acute effects of spinal cord injury on the pituitary-testicular hormone axis and Sertoli cell functions: a time course study. J Androl. 1995;16:148-157.
25. Huang HFS, Pogach L, Nathan E, Giglio W, Seebode JJ. Synergistic effects of FSH and testosterone upon the maintenance of spermiogenesis in hypophysectomized rats. Relationship with the androgen binding protein status. Endocrinology. 1991;128:3152-3161.
26. Huang HFS, Wang S-L, Molina CA, Ottenweller JE, Anesetti R. Preservation of spermatogenesis in spinal cord injured rats with exogenous testosterone. Relationship with serum testosterone levels and cellular localization of cAMP responsive element modulator. J Androl. 2004b;25:95-103.
27. Jaiswal BS, Conti M. Calcium regulation of the soluble adenylyl cyclase expressed in mammalian spermatozoa. Proc Natl Acad Sci U S A. 2003;100:10676-10681.
28. Kempinas WG, Suarez JD, Roberts NL, Strader L, Ferrell J, Goldman JM, Klinefelter GR. Rat epididymal sperm quantity, quality, and transit time after guanethidine-induced sympathectomy. Biol Reprod. 1998;59:890-896.
29. Kistler MK, Sassone-Corsi P, Kistler WS. Identification of a functional cyclic adenosine 3′,5′monophosphate response element in the 5′ flanking region of the gene for transition protein 1 (TP1), a basic chromosomal protein of mammalian spermatids. Biol Reprod. 1994;51:1322-1329.
30. Kopf GS, Vacquier VD. Characterization of a calmodulin-stimulated adenylate cyctase from abalone spermatozoa. J Biol Chem. 1984;259: 7590-7596.
31. Kwo S, Young W, De Crescito V. Spinal cord sodium, potassium, calcium, and water concentration changes in rats after graded contusion injury. J Neurotrauma. 1989;6:13-24.
32. Linsenmeyer TA, Perkash I. Infertility in men with spinal cord injury. Arch Phys Med Rehab. 1991;72:747-754.
33. Linsenmeyer TA, Pogach LM, Ottenweller JE, Huang HFS. Spermatogenesis and the pituitary testicular hormone axis in rats during the acute phase of spinal cord injury. J Urol. 1994;152:1302-1307.
34. Luconi M, Porazzi I, Ferruzzi P, Marchiani S, Forti G, Baldi E. Tyrosine phosphorylation of the A kinase anchoring protein 3 (AKAP3) and soluble adenylate cyctase are involved in the increase of human sperm motility by bicarbonate. Biol Reprod. 2005;72:22-32.
35. Mahony MC, Gwathmey TY. Protein tyrosine phosphorylation during hyperactivated motility of cynomolgus monkey (Macaca fascicularis) spermatozoa. Biol Reprod. 1999;60:1239-1243.
36. Miki K, Eddy EM. Identification of tethering domains for protein kinase A type Ia regulatory subunits on sperm fibrous sheath protein FSC1. J Biol Chem. 1998;273:34 384-34 390.
37. Moss SB, Turner MO, Burkert KL, Butt BH, Gerton GL. Conservation and function of a bovine sperm A-kinase anchor protein homologous to mouse AKAP82. Biol Reprod. 1999;61:335-342.
38. Okamura N, Tajima Y, Onoe S, Sugita Y. Purification of bicarbonate-sensitive sperm adenylyl cyclase by 4-acetamido-4′- isothiocyanostilbene-2,2′-disulfonic acid-affinity chromatography. J Biol Chem. 1991;266:17754-17759.
39. Oyen O, Myklebust F, Scott JD, Cadd GG, McKnight S, Hannson V, Jahnsen T. Subunits of cyclic adenosine 3′,5′-monophosphate-dependent protein kinase show differential and distinct expression patterns during germ cell differentiation: alternative polyadenylation in germ cells gives rise to unique smaller-sized mRNA species. Biol Reprod. 1990;43:46-54.
40. Ricker DD, Chamness SL, Hinton BT, Chang TSK. Changes in luminal fluid protein composition in the rat cauda epididymidis following partial sympathetic denervation. J Androl. 1996;17:117-126.
41. Rojas FJ, Patirzio P, Do J, Silber S, Asch RH, Moretti-Rojas I. Evidence for a novel adenylyl cyclase in human epididymal sperm. Endocrinology. 1993;133:3030-3033.
42. Salanova M, Chun S-Y, Iona S, Puri C, Stefanini M, Conti M. Type 4 cyclic adenosine monophosphate-specific phosphodiesterases are expressed in discrete subcellualr compartments during rat spermiogenesis. Endocrinology. 1999;140:2297-2306.
43. Steger K. Transcriptional and translational regulation of gene expression in haploid spermatids. Anat Embryol. 1999;199:471-487.
44. Taussig R, Gilman AG. Mammalian membrane-bound adenylyl cyclases. J Biol Chem. 1995;270:1-4.
45. Vijayaraghavan S, Hoskins DD. Regulation of bovine sperm motility and cyclic adenosine 3,′5′-monophosphate by adenosine and its analogues. Biol Reprod. 1986;34:468-477.
46. Visconti PE, Kopf GS. Regulation of protein phosphorylation during sperm capacitation. Biol Reprod. 1998;59:1-6.
47. Wu G, Fan SF, Lu Z-H, Ledeen RW, Grain SM. Chronic opioid treatment of neuroblastoma X dorsal root ganglion neuron hybrid F11 cells results in elevated GM1 ganglioside and cyclic adenosine monophosphate levels and onset of naloxone-evoked decreases in membrane K+ currents. J Neurosci Res. 1995;42:493-503.