Fibrogenesis in the pancreas after acinar cell injury

Scandinavian Journal of Surgery

Volumn 94, Issue 2, 2005, Pages 108-111

  Patel, M ^a   Fine, David R ^a,b  

^a UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

^b Liver Fibrosis Research Group   (United Kingdom)

Author keywords

Apoptosis; Cytokine; Fibrosis; Pancreas; Pancreatic stellate cell; Transdifferentiation; Transforming Growth Factor Beta

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA;

ACINAR CELL; APOPTOSIS; CELL ACTIVATION; CELL DAMAGE; CELL FUNCTION; CELL MIGRATION; CELL PROLIFERATION; CHRONIC PANCREATITIS; EXTRACELLULAR MATRIX; FIBRIN FORMATION; FIBROSIS; HUMAN; NONHUMAN; PANCREAS; PHENOTYPE; REVIEW; SIGNAL TRANSDUCTION; STELLATE CELL;

EID: 23844553542     PISSN: 14574969     EISSN: None     Source Type: Journal    
DOI: 10.1177/145749690509400205     Document Type: Review

References (22)

1. Apte MV, Haber PS, Applegate TL, Norton ID, McCaughan GW, Korsten MA, Pirola RC, Wilson JS: Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture. Gut 1998 July;43(1):128-133
2. Bachem MG, Schneider E, Gross H, Weidenbach H, Schmid RM, Menke A, Siech M, Beger H, Grunert A, Adler G: Identification, culture, and characterization of pancreatic stellate cells in rats and humans. Gastroenterology 1998 August; 115(2):421-432
3. Han B, Bai XH, Lodyga M, Xu J, Yang BB, Keshavjee S, Post M, Liu M: Conversion of mechanical force into biochemical signaling. J Biol Chem 2004 December 24;279(52):793-801
4. Sakata R, Ueno T, Nakamura T, Ueno H, Sata M: Mechanical stretch induces TGF-beta synthesis in hepatic stellate cells. Eur J Clin Invest 2004 February;34(2):129-136
5. Watanabe S, Nagashio Y, Asaumi H, Nomiyama Y, Taguchi M, Tashiro M, Kiharra Y, Nakumara H, Otsuki M: Pressure activates rat pancreatic stellate cells. Am J Physiol Gastrointest Liver Physiol 2004 August;287:G1175-G1181
6. Apte MV, Haber PS, Darby SJ, Rodgers SC, McCaughan GW, Korsten MA, Pirola RC, Wilson JS: Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis. Gut 1999 April;44(4):534-541
7. Luttenberger T, Schmid-Kotsas A, Menke A, Siech M, Beger H, Adler G, Grunert A, Bachem MG: Platelet-derived growth factors stimulate proliferation and extracellular matrix synthesis of pancreatic stellate cells: implications in pathogenesis of pancreas fibrosis. Lab Invest 2000 January;80(1):47-55
8. Mews P, Phillips P, Fahmy R, Korsten M, Pirola R, Wilson J, Apte M: Pancreatic stellate cells respond to inflammatory cytokines: potential role in chronic pancreatitis. Gut 2002 April;50(4):535-541
9. Schneider E, Schmid-Kotsas A, Zhao J, Weidenbach H, Schmid RM, Menke A, Adler G, Waltenberger J, Grunert A, Bachem MG: Identification of mediators stimulating proliferation and matrix synthesis of rat pancreatic stellate cells. Am J Physiol Cell Physiol 2001 August;281(2):C532-C543
10. Blinman TA, Gukovsky I, Mouria M, Zaninovic V, Livingston E, Pandol S, Gukovoskaya A: Activation of pancreatic acinar cells on isolation from tissue: cytokine upregulation via p38 MAP kinase. Am J Physiol Cell physiol 2000;279:C1993-C2003
11. Hasel C, Durr S, Rau B, Strater J, Schmid RM, Walczak H, Bachem MG, Moller P: In chronic pancreatitis, widespread emergence of TRAIL receptors in epithelia coincides with neoexpression of TRAIL by pancreatic stellate cells of early fibrotic areas. Lab Invest. 2003 Jun;83(6):825-836
12. Phillips PA, Wu MJ, Kumar RK, Doherty E, McCarroll JA, Park S, Pirola RC, Wilson JS, Apte MV: Cell migration: a novel aspect of pancreatic stellate cell biology. Gut 2003 May;52(5): 677-682
13. Shek FW, Benyon RC, Walker FM, McCrudden PR, Pender SL, Williams EJ, Johnson PA, Johnson CD, Bateman AC, Fine DR, Iredale JP: Expression of transforming growth factor-beta 1 by pancreatic stellate cells and its implications for matrix secretion and turnover in chronic pancreatitis. Am J Pathol 2002 May;160(5):1787-1798
14. Elsasser HP, Haake T, Grimmig M, Adler G, Kern HF: Repetitive cerulein-induced pancreatitis and pancreatic fibrosis in the rat. Pancreas 1992;7(3):385-390
15. Vaquero E, Molero X, Tian X, Salas A, Malagelada JR: Myofibroblast proliferation, fibrosis, and defective pancreatic repair induced by cyclosporin in rats. Gut 1999;45:269-277
16. Yoo BM, Yeo M, Oh TY, Choi JH, Kim WW, Kim JH, Cho SW, Kim SJ, Hahm KB: Amelioration of pancreatic fibrosis in mice with defective TGF-beta signaling. Pancreas 2005 Apr;30(3): e71-79
17. Phillips PA, McCarroll JA, Park S, Wu MJ, Pirola R, Korsten M, Wilson JS, Apte MV: Rat pancreatic stellate cells secrete matrix metalloproteinases: implications for extracellular matrix turnover. Gut 2003 February;52(2):275-282
18. van Westerloo DJ, Florquin S, de Boer AM, Daalhuisen J, de Vos AF, Bruno MJ, van der Poll T: Therapeutic effects of troglitazone in experimental chronic pancreatitis in mice. Am J Pathol. 2005 Mar;166(3):721-728
19. Jaster R, Hilgendorf I, Fitzner B, Brock P, Sparmann G, Emmrich J, Liebe S: Regulation of pancreatic stellate cell function in vitro: biological and molecular effects of all-trans retinoic acid. Biochem Pharmacol. 2003 Aug 15;66(4):633-641
20. Klonowski-Stumpe H, Fischer R, Reinehr R, Luthen R, Haussinger D: Apoptosis in activated rat pancreatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2002 Sep;283(3): G819-26
21. Trim N, Morgan S, Evans M, Issa R, Fine D, Afford S, Wilkins B, Iredale J: Hepatic stellate cells express the low affinity nerve growth factor receptor p75 and undergo apoptosis in response to nerve growth factor stimulation. Am J Pathol. 2000 Apr; 156(4):1235-1243
22. Iredale JP, Benyon RC, Pickering J, McCullen M, Northrop M, Pawley S, Hovell C, Arthur MJ: Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. J Clin Invest. 1998 Aug 1;102(3):538-549