Oxymetazoline solutions inhibit middle ear pathogens and are not ototoxic

Annals of Otology, Rhinology and Laryngology

Volumn 114, Issue 8, 2005, Pages 645-651

  Isaacson, Glenn ^a   Buttaro, Bettina A ^a   Mazeffa, Valorie ^a   Li, Geming ^b   Frenz, Dorothy A ^b  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Antimicrobial activity; Otorrhea; Ototopical drops; Ototoxicity; Oxymetazoline

Indexed keywords

CIPROFLOXACIN; DRUG PRESERVATIVE; EYE DROPS; GENTAMICIN; NASAL RELIEF SPRAY; NOSE SPRAY; OFLOXACIN; OXYMETAZOLINE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SODIUM CHLORIDE; TETRYZOLINE; VISINE LR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIMICROBIAL ACTIVITY; ARTICLE; CELL LOSS; COCHLEA FENESTRA; CONTROLLED STUDY; GUINEA PIG; HAEMOPHILUS INFLUENZAE; HAIR CELL; MIDDLE EAR; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; OTITIS MEDIA; OTOTOXICITY; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; SCANNING ELECTRON MICROSCOPY; TYMPANOSTOMY TUBE;

EID: 23844537865     PISSN: 00034894     EISSN: None     Source Type: Journal    
DOI: 10.1177/000348940511400811     Document Type: Article

References (24)

1. Isaacson G, Rosenfeld RM. Care of the child with tympanostomy tubes. Pediatr Clin North Am 1996;43:1183-93.
2. Hester TO, Jones RO, Archer SM, Haydon RC. Prophylactic antibiotic drops after tympanostomy tube placement. Arch Otolaryngol Head Neck Surg 1995;121:445-8.
3. Charnock DR. Early postoperative otorrhea after tympanostomy tube placement: a comparison of topical ophthalmic and otic drops. Ear Nose Throat J 1997;76:870-1.
4. Shinkwin CA, Murty GE, Simo R, Jones NS. Per-operative antibiotic/steroid prophylaxis of tympanostomy tube otorrhoea: chemical or mechanical effect? J Laryngol Otol 1996;110: 531-3.
5. Schrader N, Isaacson G. Fungal otitis externa - its association with fluoroquinolone eardrops. Pediatrics 2003;111: 1123.
6. Schrader N, Isaacson G. Prevalence of resistant pathogens after ototopical fluoroquinolone use [Abstract]. In: Abstracts of the Eastern Sectional Meeting, Triological Society, New York, NY, 2004.
7. Jang CH, Park SY. Emergence of ciprofloxacin-resistant pseudomonas in chronic suppurative otitis media. Clin Otolaryngol 2004;29:321-3.
8. Kumar VV, Gaughan J, Isaacson G, Szeremeta W. Oxymetazoline is equivalent to ciprofloxacin in preventing postoperative otorrhea or tympanostomy tube obstruction. Laryngoscope 2005;115:363-5.
9. Staecker H, Kopke R, Malgrange B, Lefebvre P, Van de Water TR. NT-3 and/or BDNF therapy prevents loss of auditory neurons following loss of hair cells. Neuroreport 1996;7: 889-94.
10. Riegle EV, Gunter JB, Lusk RP, Muntz HR, Weiss KL. Comparison of vasoconstrictors for functional endoscopic sinus surgery in children. Laryngoscope 1992;102:820-3.
11. Meyer DR. Comparison of oxymetazoline and lidocaine versus cocaine for outpatient dacryocystorhinostomy. Ophthal Plast Reconstr Surg 2000;16:201-5.
12. Johnson PE, Belafsky PC, Postma GN. Topical nasal anesthesia and laryngopharyngeal sensory testing: a prospective, double-blind crossover study. Ann Otol Rhinol Laryngol 2003; 112:14-6.
13. Altman JS, Haupert MS, Hamaker RA, Belenky WM. Phenylephrine and the prevention of postoperative tympanostomy tube obstruction. Arch Otolaryngol Head Neck Surg 1998; 124:1233-6.
14. Jamal TS. Avoidance of postoperative blockage of ventilation tubes. Laryngoscope 1995;105:833-4.
15. Scott BA, Strunk CL Jr. Post-tympanostomy otorrhea: a randomized clinical trial of topical prophylaxis. Otolaryngol Head Neck Surg 1992;106:34-41.
16. Francois M, Mariani-Kurkdjian P, Doit C, Benzekri P, Bingen E, Mace JG. Tympanostomy tube otorrhea: microbiological epidemiology, pathogen susceptibility to local antibiotics and bactericidal power of the rifamycin-ofloxacin combination [in French]. Ann Otolaryngol Chir Cervicofac 2001;118: 278-82.
17. Zipfel TE, Wood WE, Street DF, et al. The effect of topical ciprofloxacin on postoperative otorrhea after tympanostomy tube insertion. Am J Otol 1999;20:416-20.
18. Morpeth JF, Bent JP, Watson T. A comparison of cortisporin and ciprofloxacin otic drops as prophylaxis against post-tympanostomy otorrhea. Int J Pediatr Otorhinolaryngol 2001;61: 99-104.
19. Kruszewska H, Zareba T, Tyski S. Search of antimicrobial activity of selected non-antibiotic drugs. Acta Pol Pharm 2002;59:436-9.
20. Thorp MA, Kruger J, Oliver S, Nilssen EL, Prescott CA. The antibacterial activity of acetic acid and Burow's solution as topical otological preparations. J Laryngol Otol 1998;112: 925-8.
21. Rutala WA, Barbee SL, Aguiar NC, Sobsey MD, Weber DJ. Antimicrobial activity of home disinfectants and natural products against potential human pathogens. Infect Control Hosp Epidemiol 2000;21:33-8.
22. Kite P, Eastwood K, Sugden S, Percival SL. Use of in vivo-generated biofilms from hemodialysis catheters to test the efficacy of a novel antimicrobial catheter lock for biofilm eradication in vitro. J Clin Microbiol 2004;42:3073-6.
23. Matz G, Rybak L, Roland PS, et al. Ototoxicity of ototopical antibiotic drops in humans. Otolaryngol Head Neck Surg 2004;130(suppl):S79-S82.
24. Myer CM III. The evolution of ototopical therapy: from cumin to quinolones. Ear Nose Throat J 2004;83(suppl):9-11.