Ototoxicity of ototopical antibiotic drops in humans

Otolaryngology - Head and Neck Surgery

Volumn 130, Issue 3 SUPPL., 2004, Pages

  Matz, Greg ^a,h   Rybak, Leonard ^b   Roland, Peter S ^c   Hannley, Maureen ^d   Friedman, Rick ^e   Manolidis, Spiros ^f   Stewart, Michael G ^f   Weber, Peter ^g   Owens, Fred ^h  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

^b SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d Amer Acad Otolaryngol Hd/Neck S   (United States)

^e HOUSE EAR INSTITUTE   (United States)

^f BAYLOR COLLEGE OF MEDICINE   (United States)

^g LERNER RESEARCH INSTITUTE   (United States)

^h Apt 1119 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; DIHYDROSTREPTOMYCIN; GENTAMICIN; KANAMYCIN; NEOMYCIN; POLYMYXIN B; STREPTOMYCIN; TOBRAMYCIN;

ANTIBIOTIC RESISTANCE; AUDIOGRAPHY; CLINICAL TRIAL; COCHLEA INJURY; EVIDENCE BASED MEDICINE; HEARING LOSS; HUMAN; MEDLINE; META ANALYSIS; OTOTOXICITY; PUBLICATION; REVIEW; VESTIBULAR DISORDER; VESTIBULAR FUNCTION;

EID: 1842480256     PISSN: 01945998     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.otohns.2003.12.007     Document Type: Article

References (17)

1. Govaerts PJ, Clafs J, Van de Heyning PFI, et al. Aminoglycoside induced ototoxicity. Toxicology 1990;52:227-51.
2. Roland PS. Characteristics of systemic and topical agents implicated in toxicity of the middle and inner ear. ENT J 2003;(suppl 1):3-8.
3. Hawkins JE, Johnson LG. Histopathology of cochlear and vestibular ototoxicity in laboratory animals in aminoglycoside's ototoxicity. Boston: Little, Brown and Co; 1981. pp 175-97.
4. Hawkins JE, Johnson LG. Prospective studies of aminoglycoside ototoxicity in adults. Boston: Little, Brown and Co; 1981. pp 327-39.
5. Lancaster JL, Mortimore S, McCormick M, et al. Systemic absorption of gentamicin in the management of active mucosal chronic otitis media. Clin Otolaryngol 1999;24:435-9.
6. Lancaster JL, Makura ZG, Porter G, et al. Topical aminoglycosides in the management of active mucosal chronic suppurative otitis media. J Laryngol Otol 1999;113:10-12.
7. Longridge NS. Topical gentamicin vestibular toxicity. J Otolaryngol 1994;23:444-6.
8. Chen JM, Wiliamson PA, Hutchin T, et al. Topical gentamicin-induced hearing loss: a mitochondrial ribosomal RNA study of genetic susceptibility. Am J Otol 1996;17:850-2.
9. Marais J, Rutka JA. Ototoxicity and topical eardrops. Clin Otolaryngol 1998;23:360-7.
10. Bath AP, Walsh RM, Bance ML, et al. Ototoxicity of topical gentamicin preparations. Laryngoscope 1999;109:1088-93.
11. Kaplan DM, Hehar SS, Bance ML, et al. Intentional ablation of vestibular function using commercially available topical gentamicin-betamethasone eardrops in patients with Meniere's disease: further evidence for topical eardrop ototoxicity. Laryngoscope 2002;112:689-95.
12. Dumas G, Bessard G, Gavend M, et al. Risk of deafness following ototopical administration of aminoglycoside antibiotic. Therapie 1980;35:357-63.
13. Linder TE, Zwicky S, Brandle P. Ototoxicity of ear drops: a clinical perspective. Am J Otol 1995;16:653-7.
14. Lind O, Kristiansen B. Deafness after treatment with ear drops containing neomycin, gramicidin and dexamethasone. A case report. ORL J Otorinolaryngol Relat 1986;48:52-4.
15. Rakover Y, Keywan K, Rosen G. Safety of topical ear drops containing ototoxic antibiotics. J Otolaryngol 1997;26:194-6.
16. Merifield DO, Parker NJ, Nicholson NC. Therapeutic management of chronic suppurative otitis media with otic drops. Otolaryngol Head Neck Surg 1993;109:77-82.
17. Welling DB, Forest AL, Groll F 3ed. Safety of ototopical antibiotics. Laryngoscope 1995;105:472-4.