Linkage disequilibrium inflates type I error rates in multipoint linkage analysis when parental genotypes are missing

Human Heredity

Volumn 59, Issue 4, 2005, Pages 220-227

  Boyles, Abee L ^a   Scott, William K ^a   Martin, Eden R ^a   Schmidt, Silke ^a   Li, Yi Ju ^a   Ashley Koch, Allison ^a   Bass, Meredyth P ^a   Schmidt, Michael ^a   Pericak Vance, Margaret A ^a   Speer, Marcy C ^a   Hauser, Elizabeth R ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

False positive rate; Linkage analysis; Linkage disequilibrium; Measures of linkage disequilibrium; Parameter misspecification

Indexed keywords

ANALYTICAL ERROR; ARTICLE; FAMILY; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC PARAMETERS; GENOME ANALYSIS; GENOTYPE; HAPLOTYPE; LINKAGE ANALYSIS; MARKER GENE; NONPARAMETRIC TEST; PARENT; POPULATION GENETIC PARAMETERS; PREDICTION; SCORING SYSTEM; SIMULATION; SINGLE NUCLEOTIDE POLYMORPHISM;

COMPUTER SIMULATION; FALSE POSITIVE REACTIONS; GENE FREQUENCY; GENETIC MARKERS; GENOTYPE; HUMANS; LINKAGE (GENETICS); LINKAGE DISEQUILIBRIUM; LOD SCORE; NUCLEAR FAMILY; PARENTS; STATISTICS, NONPARAMETRIC;

EID: 23844506823     PISSN: 00015652     EISSN: None     Source Type: Journal    
DOI: 10.1159/000087122     Document Type: Article

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