Clostridium difficile among hospitalized patients receiving antibiotics: A case-control study

Infection Control and Hospital Epidemiology

Volumn 26, Issue 8, 2005, Pages 685-690

  Modena, Scott ^a   Bearelly, Dilip ^a   Swartz, Kenneth ^b   Friedenberg, Frank K ^a  

^a TEMPLE UNIVERSITY HOSPITAL   (United States)

^b TEMPLE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTIDIARRHEAL AGENT; BETA LACTAM ANTIBIOTIC; CLINDAMYCIN; HISTAMINE H2 RECEPTOR ANTAGONIST; LAXATIVE; MACROLIDE; OPIATE; PROTON PUMP INHIBITOR; QUINOLONE; SULFONAMIDE; VANCOMYCIN;

ADULT; AGED; ARTICLE; CASE CONTROL STUDY; CELLULITIS; CLINICAL ARTICLE; CLOSTRIDIUM DIFFICILE; CONTROLLED STUDY; DIARRHEA; ENZYME IMMUNOASSAY; FEMALE; GASTROINTESTINAL INFECTION; HOSPITAL PATIENT; HOSPITALIZATION; HUMAN; INTENSIVE CARE UNIT; LENGTH OF STAY; LOGISTIC REGRESSION ANALYSIS; MALE; MEDICAL RECORD; RISK FACTOR; UROGENITAL TRACT INFECTION;

ADULT; AGED; ANTI-BACTERIAL AGENTS; CASE-CONTROL STUDIES; CLOSTRIDIUM DIFFICILE; DIARRHEA; FEMALE; HUMANS; INPATIENTS; MALE; MEDICAL AUDIT; MIDDLE AGED; PENNSYLVANIA;

EID: 23844457677     PISSN: 0899823X     EISSN: None     Source Type: Journal    
DOI: 10.1086/502603     Document Type: Article

References (21)

1. Fekety R. Guidelines for the diagnosis and management of Clostridium difficile-associated diarrhea and colitis. Am J Gastroenterol 1997;92:739-750.
2. Mcfarland L, Surawicz C, Greenberg R, et al. A randomized placebo-controlled trial of Saccharomyces boulardii in combination with standard antibiotics for Clostridium difficile disease. JAMA 1994;271:1913-1918.
3. Bartlett JG. Antibiotic-associated diarrhea. N Engl J Med 2002;346:334-339.
4. Thomas C, Stevenson M, Riley T. Antibiotics and hospitalized-acquired Clostridium difficile-associated diarrhea: a systemic review. J Antimicrob Chemother 2003;51:1339-1350.
5. Buchner A, Sonnenberg A. Medical diagnoses and procedures associated with Clostridium difficile colitis. Am J Gastroenterol 2001;96:766-772.
6. Buchner A, Sonnenberg A. Epidemiology of Clostridium difficile infection in a large population of hospitalized US military veterans. Dig Dis Sci 2002;47:201-207.
7. Dial S, Alrasadi K, Manoukian C, et al. Risk of Clostridium difficile diarrhea among hospital inpatients prescribed proton pump inhibitors: cohort and case control studies. CMAJ 2004;171:33-38.
8. Barbut F, Petit JC. Epidemiology of Clostridium difficile-associated infections. Clin Microbiol Infect 2001;7:405-410.
9. Aziz EE, Ayis S, Gould FK, et al. Risk factors for the development of Clostridium difficile toxin-associated diarrhea: a pilot study. Pharmacoepidemiol Drug Saf 2001;10:303-308.
10. Mcfarland LV, Surawicz CM, Stamm WE. Risk factors for Clostridium difficile carriage and Clostridium difficile-associated diarrhea in a cohort of hospitalized patients. J Infect Dis 1990;162:678-684.
11. Guyot A, Rawlins M, Barrett S. Clarithromycin appears to be linked with Clostridium difficile-associated diarrhea in the elderly. J Antimicrob Chemother 2000;46:642-643.
12. Starr J, Martin H, McCoubrey J, et al. Risk factors for Clostridium difficile colonization and toxin production. Age Ageing 2003;32:657-660.
13. Schwaber MJ, Simhon A, Block C, et al. Factors associated with nosocomial diarrhea and Clostridium difficile-associated disease on the adult wards of an urban tertiary care hospital. Eur J Clin Microbiol Infect Dis 2000;19:9-15.
14. Cunningham R, Dale B, Undy B, et al. Proton pump inhibitors as a risk factor for Clostridium difficile diarrhea. J Hosp Infect 2003;54:243-245.
15. Kyne L, Sougioultzis S, Mcfarland L, et al. Underlying disease severity as a major risk factor for nosocomial Clostridium difficile diarrhea. Infect Control Hosp Epidemiol 2002;23:653-659.
16. Bliss DZ, Johnson S, Savik K, et al. Acquisition of Clostridium difficile and Clostridium difficile-associated diarrhea in hospitalized patients receiving tube feeding. Ann Intern Med 1998;129:1012-1019.
17. El-Serag HB. Barrett's esophagus, hiatal hernia, and logistic regression analysis. Am J Gastroenterol 1999;94:3395-3396.
18. Peduzzi P, Concato J, Kemper E, et al. A simulation study of the number of events per variable in logistic regression analysis. J Clin Epidemiol 1996;49:1373-1379.
19. Wilcox M. Clarithromycin and risk of Clostridium difficile-associated diarrhea. J Antimicrob Chemother 2001;47:358-359.
20. Kyne L, Warny M, Qamar A, et al. Asymptomatic carriage of Clostridium difficile and serum levels of IgG antibody against toxin A. N Engl J Med 2000;342:390-397.
21. Elmer GW, Surawicz CM, McFarland LV. Biotherapeutic agents: a neglected modality for the treatment and prevention of selected intestinal and vaginal infections. JAMA 1996;275:870-876.