Regulation of testis-specific carnitine transporter (octn3) gene by proximal cis-acting elements Sp1 in mice

Biochemical Pharmacology

Volumn 70, Issue 6, 2005, Pages 858-868

  Maeda, Tomoji ^a   Hirayama, Masamichi ^a   Kobayashi, Daisuke ^a   Tamai, Ikumi ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Carnitine; octn3; Promoter; Sp1; Testis

Indexed keywords

CARNITINE; CIS ACTING ELEMENT; GENE PRODUCT; LUCIFERASE; PALMITIC ACID; TRANSCRIPTION FACTOR SP1;

5' UNTRANSLATED REGION; AMINO ACID TRANSPORT; ANIMAL CELL; ARTICLE; BINDING SITE; CELL LINE; CONTROLLED STUDY; DELETION MUTANT; EMBRYO; GEL MOBILITY SHIFT ASSAY; GENE; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE LOCATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HOST CELL; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OCTN 2 GENE; OCTN 3 GENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REGULATORY MECHANISM; SERTOLI CELL; TESTIS; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION TERMINATION; UPREGULATION;

ANIMALS; BASE SEQUENCE; CLONING, MOLECULAR; DNA; GENE EXPRESSION REGULATION; MALE; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; ORGANIC CATION TRANSPORT PROTEINS; PROMOTER REGIONS (GENETICS); REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SP1 TRANSCRIPTION FACTOR; TESTIS; TRANSCRIPTION, GENETIC;

EID: 23744497058     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2005.06.014     Document Type: Article

References (35)

1. I.B. Fritz, and K.T. Yue Effects of carnitine on acetyl-CoA oxidation by heart muscle mitochondria Am J Physiol 206 1964 531 535
2. J. Bremer Carnitine - metabolism and functions Physiol Rev 63 1983 1420 1480
3. W.R. Treem, C.A. Stanley, D.N. Finegold, D.E. Hale, and P.M. Coates Primary carnitine deficiency due to a failure of carnitine transport in kidney, muscle, and fibroblasts N Engl J Med 319 1988 1331 1336
4. C. Jeulin, and L.M. Lewin Role of free l-carnitine and acetyl-l-carnitine in post-gonadal maturation of mammalian spermatozoa Hum Reprod Update 2 1996 87 102
5. C. Jeulin, J.L. Dacheux, and J.C. Soufir Uptake and release of free l-carnitine by boar epididymal spermatozoa in vitro and subsequent acetylation rate J Reprod Fertil 100 1994 263 271
6. B.T. Hinton, A.M. Snoswell, and B.P. Setchell The concentration of carnitine in the luminal fluid of the testis and epididymis of the rat and some other mammals J Reprod Fertil 56 1979 105 111
7. I. Tamai, R. Ohashi, J. Nezu, Y. Sai, D. Kobayashi, and A. Oku Molecular and functional characterization of organic cation/carnitine transporter family in mice J Biol Chem 275 2000 40064 40072
8. - coupled active transport of carnitine by the amino acid transporter ATB(0,+) from mouse colon expressed in HRPE cells and Xenopus oocytes J Physiol 532 2001 297 304
9. A.M. Lamhonwah, J. Skaug, S.W. Scherer, and I. Tein A third human carnitine/organic cation transporter (OCTN3) as a candidate for the 5q31 Crohn's disease locus (IBD5) Biochem Biophys Res Commun 251 2003 98 101
10. I. Tamai, R. Ohashi, J. Nezu, H. Yabuuchi, A. Oku, and M. Shimane Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2 J Biol Chem 273 1998 20378 20382
11. H. Yabuuchi, I. Tamai, J. Nezu, K. Sakamoto, A. Oku, and M. Shimane Novel membrane transporter OCTN1 mediates multispecific, bi-directional, and pH-dependent transport of organic cations J Pharmacol Exp Ther 289 1999 768 773
12. I. Tamai, H. Yabuuchi, J. Nezu, Y. Sai, A. Oku, and M. Shimane Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1 FEBS Lett 419 1997 107 111
13. A. Enomoto, M.F. Wempe, H. Tsuchida, H.J. Shin, S.H. Cha, and N. Anzai Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition J Biol Chem 277 2002 36262 36271
14. T. Koizumi, H. Nikaido, J. Hayakawa, A. Nonomura, and T. Yoneda Infantile disease with microvesicular fatty infiltration of viscera spontaneously occurring in the C3H-H-2(O) strain of mouse with similarities to Reye's syndrome Lab Anim 22 1988 83 87
15. K. Toshimori, M. Kuwajima, K. Yoshinaga, Y. Wakayama, and K. Shima Dysfunctions of the epididymis as a results of primary carnitine deficiency in juvenile visceral steatosis mice FEBS Lett 446 1999 323 326
16. A.F.R. Stewart, J. Suzow, T. Kubota, T. Ueyama, and H.H. Chen Transcription factor RTEF-1 mediates alpha-adrenergic reactivation of the fetal gene program in cardiac myocytes Circ Res 83 1998 43 49
17. M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72 1976 248 254
18. T. Maeda, J.R. Mazzulli, A.F. Farrance, and A.F.R. Stewart Mouse DTEF-1 (ETFR-1, TEF-5) is a transcriptional activator in alpha 1-adrenergic agonist-stimulated cardiac myocytes J Biol Chem 277 2002 24346 24352
19. J.T. Kadonaga, K.R. Carner, F.R. Masiarz, and R. Tjian Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain Cell 51 1987 1079 1090
20. J. Nezu, I. Tamai, A. Oku, R. Ohashi, H. Yabuuchi, and N. Hashimoto Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter Nat Genet 21 1999 91 94
21. M. Goto, Y. Masamune, and Y. Nakanishi A factor stimulating transcription of the testis-specific Pgk-2 gene recognizes a sequence similar to the binding site for a transcription inhibitor of the somatic-type Pgk-1 gene Nucl Acids Res 21 1993 209 214
22. P. Koopman, J. Gubbay, N. Vivian, P. Goodfellow, and R. Lovell-Badge Male development of chromosomally female mice transgenic for Sry Nature 351 1991 117 121
23. R.F. McClure, C.J. Heppelmann, and C.V. Paya Constitutive Fas ligand gene transcription in Sertoli cells is regulated by Sp1 J Biol Chem 274 1999 7756 7762
24. G. Vescovo, B. Ravara, V. Gobbo, M. Sandri, A. Angelini, and M. Della Barbera l-Carnitine: a potential treatment for blocking apoptosis and preventing skeletal muscle myopathy in heart failure Am J Physiol Cell Physiol 283 2002 C802 C810
25. J.F. Louet, F. Chatelain, J.F. Decaux, E.A. Park, C. Kohl, and T. Pineau Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome-proliferator-activated receptor alpha (PPARalpha)-independent pathway Biochem J 354 2001 189 197
26. E. Roche, J. Buteau, I. Aniento, J.A. Reig, B. Soria, and M. Prentki Palmitate and oleate induce the immediate-early response genes c-fos and nur-77 in the pancreatic beta-cell line INS-1 Diabetes 48 1999. 2007 2014
27. L. Lania, B. Majello, and P. DeLuca Transcriptional regulation by the Sp family proteins Int J Biochem Cell Biol 29 1997 1313 1323
28. J.D. Saffer, S.P. Jackson, and M.B. Annarella Developmental expression of Sp1 in the mouse Mol Cell Biol 11 1991 2189 2199
29. M. Suzuki, E. Oda, T. Nakajima, S. Sekiya, and K. Oda Induction of Sp1 in differentiating human embryonal carcinoma cells triggers transcription of the fibronectin gene Mol Cell Biol 18 1998 3010 3020
30. N. Lei, and L.L. Heckert Gata4 regulates testis expression of Dmrt1 Mol Cell Biol 24 2004 377 388
31. A.J. Courey, and R. Tjian S.L. McKnight K.R. Yamamoto Transcriptional regulation vol. 2 1993 Cold Spring Harbor Laboratory Press Cold Spring Harbor, NY 743 771
32. P.S. Burgoyne, M. Buehr, P. Koopman, J. Rossant, and A. McLaren Cell-autonomous action of the testis-determining gene: Sertoli cells are exclusively XY in XX⋯XY chimera mouse testes Development 102 1988 443 450
33. A.K. Busch, D. Cordery, G.S. Denyer, and T.J. Biden Expression profiling of palmitate- and oleate-regulated genes provides novel insights into the effects of chronic lipid exposure on pancreatic beta-cell function Diabetes 51 2002 977 987
34. F. Chatelain, C. Kohl, V. Esser, J. McGarry, J. Girard, and J.P. Pegorier Cyclic AMP and fatty acids increase carnitine palmitoyltransferase I gene transcription in cultured fetal rat hepatocytes Eur J Biochem 235 1996 789 798
35. G. Kwon, L.K. Pappan, A.C. Marshall, J.E. Schaffer, and M.L. McDaniel cAMP dose-dependently prevents palmitate-induced apoptosis by both protein kinase A- and cAMP-guanine nucleotide exchange factor-dependent pathways in beta-cells J Biol Chem 279 2004 8938 8945