Dermal uptake of chloroform and haloketones during bathing

Journal of Exposure Analysis and Environmental Epidemiology

Volumn 15, Issue 4, 2005, Pages 289-296

  Xu, Xu ^a   Weisel, Clifford P ^a,b  

^a RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

Bath; Dermal absorption; Disinfection by products; Expired air; Haloketones; Skin permeability

Indexed keywords

1,1 DICHLOROPROPANONE; 1,1,1 TRICHLOROPROPANONE; ACETONE; CHLOROFORM; HALOKETONE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BATH; BREATH ANALYSIS; CHLORINATION; COMPARTMENT MODEL; DISINFECTION; ENVIRONMENTAL EXPOSURE; EXPIRED AIR; FEMALE; HEALTH HAZARD; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; RISK ASSESSMENT; SKIN ABSORPTION; SKIN PERMEABILITY;

ACETONE; ADULT; BATHS; BREATH TESTS; CHLOROFORM; DISINFECTION; ENVIRONMENTAL MONITORING; FEMALE; HUMANS; MALE; SKIN ABSORPTION; WATER POLLUTANTS, CHEMICAL; WATER PURIFICATION;

EID: 23744483863     PISSN: 10534245     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jea.7500404     Document Type: Article

References (43)

1. Aggazzotti G., Fantuzzi G., Righi E., Tartoni P., Cassinadri T., and Predieri G. Chloroform in alveolar air of individuals attending indoor swimming pools. Arch Environ Health 1993: 48(4): 250-254.
2. Aggazzotti G., Fantuzzi G., Tartoni P.L., and Predieri G. Plasma chloroform concentrations in swimmers using indoor swimming pools. Arch Environ Health 1990: 45: 175-179.
3. Bull R.J., and Robinson M Carcinogenic activity of haloacetonitrile and haloacetone derivatives in the mouse skin and lung. In: Jolley R.L., Bull R.J., Davis W.P., et al. (eds). Water Chlorination: Environmental Impact and Health Effects, Vol. 5. Lewis Publishers, Chelsea, MI, 1985, pp. 221-227.
4. Cantor K.P., Lynch C.F., Hildesheim M.E., Dosemeci M., Lubin J., Alavanja M., and Craun G. Drinking water source and chlorination byproducts. I. Risk of bladder cancer. Epidemiology 1998: 9(1): 21-28.
5. Christman R.F., Norwood D.L., Millington D.S., and Johnson J.D. Identity and yields of major halogenated products of aquatic fulvic add chlorination. Environ Sci Technol 1983: 17(10): 625-628.
6. Clemens M., and Scholer H.F. Halogenated organic compounds in swimming pool water. Zentralblatt fur Hygiene und Umwehmedizin 1992: 193(1): 91-98 (in German).
7. Comroe J.H. Physiology of Respiration, 2nd edn. Year Book Medical Publishers, Chicago, IL, 1974.
8. Corley R.A., Gordon S.M., and Wallace L.A Physiologically based pharmacokinetic modeling of the temperature-dependent dermal absorption of chloroform by humans following bath water exposures. Toxicol Sci 2000: 53(1): 13-23.
9. Crank J The Mathematics of Dilution. Oxford University Press, London, 1975.
10. U.S. EPA. Development of statistical distributions or ranges of standard factors used in exposure assessment. 600/8-85-010. Office of Research and Development, Office of Health and Environmental Assessment, Washington, DC, 1985.
11. U.S. EPA. Information Collection Rule: Federal Regulation 61:94:24354. U.S. Environmental Protection Agency, Cincinnati, OH, 1996.
12. Gehan E. A., and George S.L. Estimation of human body surface area from height and weight. Cancer Chemother Rep 1970: 54(4): 225-235.
13. Gordon S.M., Wallace L.A., Callahan P.J., Kenny D.V., and Brinkman M.C. Effect of water temperature on dermal exposure to chloroform. Environ Health Perspect 1998: 106: 337-345.
14. Heinicke K., Wolfarth B., Winchenbach P., Biermann B., Schmid A., Huber G., Friedmann B., and Schmidt W. Blood volume and hemoglobin mass in elite athletes of different disciplines. Int J Sports Med 2001: 22(7): 504-512.
15. Hildesheim M.E., Cantor K.P., Lynch C.F., Dosemeci M., Lubin J., Alavanja M., and Craun G. Drinking water source and chlorination byproducts. 11. Risk of colon and rectal cancers. Epidemiology 1998: 9(1): 29-35.
16. Jo W.K., Weisel C.P., and Lioy P.J Routes of chloroform exposure and body burden from showering with chlorinated tap water. Risk Anal 1990: 10: 575-580.
17. Kim H., Shim J., and Lee S. Formation of disinfection by-products in chlorinated swimming pool water. Chemosphere 2002: 46: 123-130.
18. Krasner S.W., McGuire M.J., Jacongelo J.G., Patania N.L., Reagan K.M., and Aieta E.M. The occurrence of disinfection by-products in US drinking water. J. AWWA 1989: 81(8): 41-53.
19. LeBel G.L., Benoit F.M., and Williams D.T. A one-year survey of halogenated DBPs in the distribution system of treatment plants using three different disinfection processes. Chemosphere 1997: 34: 2301-2317.
20. Levesque B., Ayotte P., LeBlanc A., Dewailly E., Prud'Homme D., Lavoie R., Allaire S., and Levallois P. Evaluation of dermal and respiratory chloroform exposure in humans. Environ Health Perspect 1994: 102(12): 1082-1087.
21. Lindstrom A.B., Pleil J.D., and Berko D.C. Alveolar breath sampling and analysis to assess trihalomethane exposures during competitive swimming training. Environ Health Perspect 1997: 105: 636-642.
22. McKone T.E. Linking a PBPK model for chloroform with measured breath concentrations in showers: implications for dermal exposure models. J Expo Anal Environ Epidemiol 1993: 3: 339-365.
23. McKone T.E., and Howd R.A. Estimating dermal uptake of nonionic organic chemicals from water and soil: I. Unified fugacity-based models for risk assessments. Risk Anal 1992: 12(4): 543-557.
24. Meier J.R., Ringhand H.P., Coleman W.E., Munch J.W., Streicher R.P., Kaylor W.H., and Schenck K.M. Identification of mutagenic compounds formed during chlorination of humic acid. Mutat Res 1985: 157: 111-122.
25. Parry G.E., Bunge A.L., Silcox G.D., Penning L.K., and Pershing D.W. Percutaneous absorption of benzoic acid across human skin. I. In vitro experiments and mathematical modeling. PharmRes 1990: 7(3): 230-236.
26. Pirot F., Kalia Y.N., Stinchcomb A.L., Keating G., Bunge A., and Guy R.H Characterization of the permeability barrier of human skin in vivo. Proc Natl Acad Sci USA 1997: 94(4): 1562-156.
27. Pleil J.D., and Lindstrom A.B. Exhaled human breath measurement method for assessing expo to halogenated volatile organic compounds. Clin Chem 1997: 43(5): 723-730.
28. Quimby B.D., Delaney M.F., Uden P.C., and Barnes R.M. Determination of the aqueous chlo products of humic substances by gas chromatography with microwave emission detection. Anal Chem 1980: 52: 259-263.
29. Raymer J.H., Pellizzari E.D., Thomas K.W., and Cooper S.D. Elimination of volatile organic compounds in breath after exposure to occupational and environmental microenvironments. J Expo Anal Environ Epidemiol 1991: 1(4): 439-451.
30. Raymer J.H., Thomas K.W., and Cooper S.D. A device for sampling of human alveolar breath for the measurement of expired volatile organic compounds. J Anal Toxicol 1990: 14(6): 337-344.
31. Roy A., Weisel C.P., Lioy P.J., and Georgopoulos P.G. A distributed parameter physiologically-based pharmacokinetic model for dermal and inhalation exposure to volatile organic com. Risk Anal 1996: 16(2): 147-160.
32. Scheuplein R.J. Permeability of the skin. Physiol Rev 1971: 51(4): 702-747.
33. Shatkin J.A., and Brown H.S. Pharmacokinetics of the dermal route of exposure to volatile or chemicals in water: a computer simulation model. Environ Res 1991: 56(1): 90-108.
34. Simpson K.J., and Haves K.P. Drinking water disinfection by-products: an Australian perspective. Water Res 1998: 32: 1522-1528.
35. Steven A.A., Moore L.A., Slocum C.J., Smith B.L., Seeger D.R., and and Ireland J.C. By-products of chlorination at ten operating utilities. In: Jolley RL, Condie LW, Katz S (eds.). Water Chlo-rination: Environmental Impact and Health Effects. Vol. 6. Lewis Publishers, Chelsea, MI, 1990, pp. 579-604.
36. Wallace L.A. Human exposure and body burden for chloroform and other trihalomethanes. Environ Sci Technol 1997: 27: 113-194.
37. Wallace L.A., Nelson W.C., Pellizzari E.D., and Raymer J.H. Uptake and decay of volatile organic compounds at environmental concentrations: application of a four-compartment model to a chamber study of five human subjects. J Expo Anal Environ Epidemiol 1997: 7: 141-163.
38. Wallace L.A., Pellizzari E.D., and Gordon S.M. A linear model relating breath concentrations to environmental exposures: application to a chamber study of four volunteers exposured to volatile organic chemicals. J Expo Anal Environ Epidemiol 1993: 3: 75-102.
39. Weisel C.P., Jo W.K., and Lioy P.J. Utilization of breath analysis for exposure and dose estimate of chloroform. J Expo Anal Environ Epidemiol Supp 1992: 1: 55-69.
40. Weisel C.P., and Shepard T.A. Chloroform exposure and the body burden associated with swim in chlorinated pools. In: Wang R (ed.). Water Contamination and Health: Integration of Exposure Assessment Toxicology and Risk Assessment. Marcel Dekker, New York, 1994. 135-148.
41. Xu X., Mariano T., Laskin J.D., and Weisel C.P. Percutaneous absorption of trihalomethanes, haloacetic acids and haloketones. Toxicol Appl Pharmacol 2002: 184: 19-26.
42. Xu X., and Weisel C.P. Inhalation exposure to haloacetic acids and haloketones during showering. Environ Sci Technol 2003: 37(3): 569-576.
43. Xu X., and Weisel C.P. Respiratory uptake of disinfection by-products in drinking water: breath measurements. J Expo Anal Environ Epidemiol 2004 (in press).