Model systems: Mechanisms involved in the loss of sensitivity to letrozole

Journal of Steroid Biochemistry and Molecular Biology

Volumn 95, Issue 1-5, 2005, Pages 41-48

  Brodie, Angela ^a   Jelovac, Danijela ^a   Sabnis, Gauri ^a   Long, Brian ^a   Macedo, Luciana ^a   Goloubeva, Olga ^b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

Author keywords

Antiestrogens; Aromatase inhibitors; Tumor models

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ANASTROZOLE; ANTIESTROGEN; AROMATASE; AROMATASE INHIBITOR; ESTROGEN RECEPTOR; FULVESTRANT; GEFITINIB; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; LETROZOLE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; PROTEIN SHC; RAF PROTEIN; TAMOXIFEN; WORTMANNIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; BREAST CANCER; CANCER INHIBITION; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFICACY; DRUG MEGADOSE; DRUG POTENTIATION; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; TUMOR GROWTH; UPREGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTINEOPLASTIC AGENTS; AROMATASE INHIBITORS; BREAST NEOPLASMS; DRUG RESISTANCE, NEOPLASM; ESTRADIOL; FEMALE; GRB2 ADAPTOR PROTEIN; HUMANS; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED BALB C; MODELS, BIOLOGICAL; NITRILES; RECEPTORS, ESTROGEN; SIGNAL TRANSDUCTION; TAMOXIFEN; TRIAZOLES; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 23744479819     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2005.04.026     Document Type: Conference Paper

References (27)

1. V.C. Jordan Lab models of breast cancer to aid the elucidation of antiestrogenation J. Lab. Clin. Med. 106 1987 267 277
2. A.M.H. Brodie, W.C. Schwarzel, and H.J. Brodie Studies on the mechanism of estrogen biosynthesis in the rat ovary - 1 J. Steroid Biochem. 7 1976 87 793
3. T. Zaccheo, D. Giudici, and E. DiSalle Inhibitory effects of combining treatment with aromatase inhibitor exemestane and tamoxifen on DMBA-induced mammary tumors in rats J. Steroid Biochem. Mol. Biol. 44 1993 677 680
4. R.R. Tekmal, N. Ramachandra, S. Gubba, V.R. Durgam, J. Mantione, K. Toda, Y. Shizuta, and D.L. Dillehay Overexpression of int-5/aromatase in mammary glands of transgeneic mice results in the induction of hyperplasia and nuclear abnormalities Cancer Res. 56 1996 3180 3185
5. R. Luthra, N. Kirma, J. Jones, and R.R. Tekmal Use of letrozole as a chemopreventative agent in aromatase overexpressing transgenic mice J. Steroid Biochem. Mol. Biol. 86 2003 461 467
6. J. Mattern, M. Bak, E.W. Hahn, and M. Volm Human tumor xenografts as model for drug testing Cancer Metas. Rev. 7 1988 263 284
7. R.M. O'Regan, M.E. England, J.I. MacGreger, K.A. Yao, H.D. Muenzner, H. Takei, and V.C. Jordan Lab models of breast and endometrial cancer to develop strategies for antiestrogen therapy Br Cancer. 5 1998 211 217
8. E.S. Lee, J.M. Schafer, K. Yao, G. England, R.M. O'Regan, A. DeLosReyes, and V.C. Jordan Cross-resistance of triph... type antiestrogens but not ICI 182, 780 in tamoxifen stimulated breast cancer tumors grown in athymic mice Clin. Cancer Res. 6 2000 4893 4899
9. C.K. Osborne, E.B. Coronado-Heinsohn, S.G. Hilsenbeck, B.L. McCue, A.E. Wakeling, R.A. McClelland, D.L. Manning, and R.I. Nicholson Comparison of the effects of a pure steroidal antiestrogen with those of tamoxifen in a model of human breast cancer J. Natl. Cancer Inst. 87 1995 746 750
10. Q. Lu, J. Nakamura, A. Savinov, W. Yue, J. Weisz, D.J. Dabbs, G. Wolz, and A. Brodie Expression of aromatase protein and mRNA in tumor epithelial cells and evidence of functional significance of locally produced estrogen in human breast cancer Endocrinol. 137 1996 3061 3068
11. D. Zhou, D. Pompon, and S. Chen Stable expression of human aromatase complementary DNA in mammalian cells: A useful system for aromatase inhibitor screening Cancer Res. 50 1990 6949 6954
12. W. Yue, D.J. Zhou, S. Chen, and A.M.H. Brodie A new nude mouse model for postmenopausal breast cancer using MCF-7 cells transfected with the human aromatase gene Cancer Res. 54 1994 5092 5095
13. W. Yue, J. Wang, A. Savinov, and A. Brodie Effect of aromatase inhibitors on the growth of mammary tumors in a nude mouse model Cancer Res. 55 1995 3073 3077
14. D. Jelovac, L. Macedo, O. Goloubeva, V. Handratta, B. Long, and A. Brodie Effects of exemestane and tamoxifen in a postmenopausal breast cancer model Clin. Cancer Res. 10 2004 7375 7381
15. Q. Lu, J. Wang, Y. Liu, B. Long, and A. Brodie A The effects of aromatase and antiestrogens in the nude mouse model Breast Cancer Res. Treat. 50 1998 63 71
16. Q. Lu, W. Yue, Y. Liu, B.J. Long, D. Grigoryev, M. Gimbel, and A. Brodie The effect of combining aromatase inhibitors with antiestrogens on tumor growth in a nude mouse model for breast cancer Breast Cancer Res. Treat. 57 1999 183 192
17. M. Baum, A.U. Buzdar, J. Cuzick, J. Forbes, J. Houghton, J.G. Klijn, T. Sahmoud ATAC Trialists' Group Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomized trial Lancet 359 2002 2131 2139
18. B.J. Long, D. Jelovac, V. Handratta, A. Thiantanawat, N. MacPherson, J. Ragaz, and A.M. Brodie Therapeutic strategies using the aromatase inhibitor letrozole and tamoxifen in breast cancer model J. Nat. Cancer Inst. 96 6 2004 456 465
19. J. Shou, S. Massarweh, C.K. Osborne, A.E. Wakeling, S. Ali, H. Weiss, and R. Schiff Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer J. Nat. Cancer Inst. 96 2004 926 935
20. B.J. Long, D. Jelovac, A. Thiantanawat, and A.M. Brodie The effect of second-line antiestrogen therapy on breast tumor growth after first-line treatment with the aromatase inhibitor letrozole: long-term studies using the intratumoral aromatase postmenopausal breast cancer model Clin. Cancer Res. 8 2002 2378 2388
21. J.C. Pinheiro, and D.M. Bates Mixed-Effects Models in S and S-Plus 2000 Springer-Verlag New York (NY) pp. 21-45, 174-96
22. C.W. Dunnett A multiple comparisons procedure for comparing several treatments with control J. Am. Stat. Assoc. 50 1955 1096 1121
23. H. Scheffe A method of judging all contrasts in the analysis of variance Biometrica 40 1959 87 104
24. D. Jelovac, L. Macedo, O.G. Goloubeva, V. Handratta, A.M.H. Brodie, Additive antitumor effect of aromatase inhibitor letrozole and antiestrogen fulvestrant in a postmenopausal breast cancer model. Cancer Res., in press.
25. D. Jelovac, G. Sabnis, B.J. Long, O.G. Goloubeva, A.M.H. Brodie, Activation of MAPK in xenografts and cells during prolonged treatment with aromatase inhibitor letrozole. Cancer Res., in press.
26. Q. Lu, Y. Liu, B.J. Long, D. Grigoryev, M. Gimbel, and A. Brodie A The effect of combining aromatase inhibitors with antiestrogens on tumor growth in a nude mouse model for breast cancer Breast Cancer Res. Treat. 57 1999 183 192
27. W. Yue, J.P. Wang, M.R. Conaway, Y. Li, and R.J. Santen Adaptive hypersensitivity following long-term estrogen deprivation: Involvement of multiple signal pathways J. Steroid Biochem. Mol. Biol. 86 2003 265 274