The Δe13 isoform of the calcitonin receptor forms a six-transmembrane domain receptor with dominant-negative effects on receptor surface expression and signaling

Molecular Endocrinology

Volumn 19, Issue 8, 2005, Pages 2132-2144

  Seck, Thomas ^a,b   Pellegrini, Maria ^c   Florea, Ana Maria ^b   Grignoux, Veronique ^a   Baron, Roland ^a   Mierke, Dale F ^c   Horne, William C ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b RUHR UNIVERSITY BOCHUM   (Germany)

^c BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITONIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE;

ARTICLE; CALCIUM CELL LEVEL; CARBOXY TERMINAL SEQUENCE; CELL SURFACE; CONTROLLED STUDY; ENZYME ACTIVATION; EXON; FLUORESCENCE ACTIVATED CELL SORTER; HUMAN; HUMAN CELL; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION;

ANIMALS; BLOTTING, WESTERN; CALCIUM; CELL LINE; CELL MEMBRANE; CELL SEPARATION; CYCLIC AMP; CYTOPLASM; DNA; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLOW CYTOMETRY; GENES, DOMINANT; HUMANS; IMMUNOPRECIPITATION; MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDES; PHOSPHORYLATION; PROTEIN FOLDING; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; RABBITS; RECEPTORS, CALCITONIN; SIGNAL TRANSDUCTION; TEMPERATURE; TRANSFECTION;

ORYCTOLAGUS CUNICULUS;

EID: 23744461839     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2004-0472     Document Type: Article

References (38)

1. Copp DH 1969 Calcitonin and parathyroid hormone. Annu Rev Pharmacol 9:327-344
2. Azria M 1989 The calcitonins: physiology and pharmacology. Basel, Switzerland: Karger; 43-58
3. Zaidi M, Datta HK, Moonga BS, MacIntyre I 1990 Evidence that the action of calcitonin on rat osteoclasts is mediated by two G proteins acting via separate post-receptor pathways. J Endocrinol 126:473-481
4. Su Y, Chakraborty M, Nathanson MH, Baron R 1992 Differential effects of the 3′,5′-cyclic adenosine monophosphate and protein kinase C pathways on the response of isolated rat osteoclasts to calcitonin. Endocrinology 131:1497-1502
5. Lin HY, Harris TL, Flannery MS, Aruffo A, Kaji EH, Gorn A, Kolakowski Jr LF, Lodish HF, Goldring SR 1991 Expression cloning of an adenylate cyclase-coupled calcitonin receptor. Science 254:1022-1024
6. Christopoulos G, Perry KJ, Morfis M, Tilakaratne N, Gao Y, Fraser NJ, Main MJ, Foord SM, Sexton PM 1999 Multiple amylin receptors arise from receptor activitymodifying protein interaction with the calcitonin receptor gene product. Mol Pharmacol 56:235-242
7. Dacquin R, Davey RA, Laplace C, Levasseur R, Morris HA, Goldring SR, Gebre-Medhin S, Galson DL, Zajac JD, Karsenty G 2004 Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo. J Cell Biol 164:509-514
8. Albrandt K, Mull E, Brady EMG, Herich J, Moore CX, Beaumont K 1993 Molecular cloning of two receptors from rat brain with high affinity for salmon calcitonin. FEBS Lett 325:225-232
9. Shyu J-F, Inoue D, Baron R, Horne WC 1996 The deletion of 14 amino acids in the seventh transmembrane domain of a naturally occurring calcitonin receptor isoform alters ligand binding and selectively abolishes coupling to phospholipase C. J Biol Chem 271:31127-31134
10. + exchange and metabolic acid production: effects mediated selectively by the C1a CT receptor isoform. Endocrinology 142:4401-4413
11. Seck T, Baron R, Horne WC 2003 The alternatively spliced Δe13 transcript of the rabbit calcitonin receptor dimerizes with the C1a isoform and inhibits its surface expression. J Biol Chem 278:23085-23093
12. Grammatopoulos DK, Dai Y, Randeva HS, Levine MA, Karteris E, Easton AJ, Hillhouse EW 1999 A novel spliced variant of the type 1 corticotropin-releasing hormone receptor with a deletion in the seventh transmembrane domain present in the human pregnant term myometrium and fetal membranes. Mol Endocrinol 13:2189-2202
13. Grinninger C, Wang W, Oskoui KB, Voice JK, Goetzl EJ 2004 A natural variant type II G protein-coupled receptor for vasoactive intestinal peptide with altered function. J Biol Chem 279:40259-40262
14. Ding C, Racusen L, Wilson P, Burrow C, Levine MA 1995 J Bone Miner Res 10(Suppl 1):S484
15. Pellegrini M, Bisello A, Rosenblatt M, Chorev M, Mierke DF 1998 Binding domain of human parathyroid hormone receptor: from conformation to function. Biochemistry 37:12737-12743
16. Seck T, Baron R, Horne WC 2003 Binding of filamin to the C-terminal tail of the calcitonin receptor controls recycling. J Biol Chem 278:10408-10416
17. Loffing-Cueni D, Loffing J, Shaw C, Taplin AM, Govindan M, Stanton CR, Stanton BA 2001 Trafficking of GFP-tagged ΔF508-CFTR to the plasma membrane in a polarized epithelial cell line. Am J Physiol Cell Physiol 281:C1889-C1897
18. Denlinger LC, Sommer JA, Parker K, Gudipaty L, Fisette PL, Watters JW, Proctor RA, Dubyak GR, Bertics PJ 2003 Mutation of a dibasic amino acid motif within the C terminus of the P2X7 nucleotide receptor results in trafficking defects and impaired function. J Immunol 171:1304-1311
19. Heding A, Vrecl M, Bogerd J, McGregor A, Sellar R, Taylor PL, Eidne KA 1998 Gonadotropin-releasing hormone receptors with intracellular carboxyl-terminal tails undergo acute desensitization of total inositol phosphate production and exhibit accelerated internalization kinetics. J Biol Chem 273:11472-11477
20. Huang Z, Chen Y, Nissenson RA 1995 The cytoplasmic tail of the G-protein-coupled receptor for parathyroid hormone and parathyroid hormone-related protein contains positive and negative signals for endocytosis. J Biol Chem 270:151-156
21. Le Gouill C, Parent J-L, Rola-Pleszczynski M, Stankova J 1997 Structural and functional requirements for agonist-induced internalization of the human platelet-activating factor receptor. J Biol Chem 272:21289-21295
22. Alblas J, van Etten I, Moolenaar WH 1996 Truncated, desensitization- defective neurokinin receptors mediate sustained MAP kinase activation, cell growth and transformation by a Ras-independent mechanism. EMBO J 15:3351-3360
23. Hashido K, Adachi M, Gamou T, Watanabe T, Furuichi Y, Miyamoto C 1993 Identification of specific intracellular domains of the human ETA receptor required for ligand binding and signal transduction. Cell Mol Biol Res 39:3-12
24. Hipkin RW, Liu X, Ascoli M 1995 Truncation of the C-terminal tail of the follitropin receptor does not impair the agonist- or phorbol ester-induced receptor phosphorylation and uncoupling. J Biol Chem 270: 26683-26689
25. 2 receptor are essential for cell surface transport in COS.M6 cells. Mol Pharmacol 54:525-535
26. Bermak JC, Li M, Bullock C, Zhou Q-Y 2001 Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein. Nat Cell Biol 3:492-498
27. Gorn AH, Lin HY, Yamin M, Auron PE, Flannery MR, Tapp DR, Manning CA, Lodish HF, Krane SM, Goldring SR 1992 Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line. J Clin Invest 90:1726-1735
28. Moore EE, Kuestner RE, Stroop SD, Grant FJ, Matthewes SL, Brady CL, Sexton PM, Findlay DM 1995 Functionally different isoforms of the human calcitonin receptor result from alternative splicing of the gene transcript. Mol Endocrinol 9:959-968
29. Findlay DM, Houssami S, Lin HY, Myers DE, Brady CL, Darcy PK, Ikeda K, Martin TJ, Sexton PM 1994 Truncation of the porcine calcitonin receptor cytoplasmic tail inhibits internalization and signal transduction but increases receptor affinity. Mol Endocrinol 8:1691-1700
30. Nussenzveig DR, Thaw CN, Gershengorn MC 1994 Inhibition of inositol phosphate second messenger formation by intracellular loop one of a human calcitonin receptor. Expression and mutational analysis of synthetic receptor genes. J Biol Chem 269:28123-28129
31. Hirst RA, Smart D, Devi LA, Lambert DG 1998 Effects of C-terminal truncation of the recombinant δ-opioid receptor on phospholipase C and adenylyl cyclase coupling. J Neurochem 70:2273-2278
32. i, protein kinase C, and calcium. J Biol Chem 273:19809-19816
33. Lefkowitz RJ, Pierce KL, Luttrell LM 2002 Dancing with different partners: protein kinase A phosphorylation of seven membrane-spanning receptors regulates their G protein-coupling specificity. Mol Pharmacol 62:971-974
34. Delaglio F, Grzesiek S, Vuister GW, Zhu G, Pfeifer J, Bax A 1995 NMRPipe: a multidimensional spectral processing system based on UNIX pipes. J Biomol NMR 6:277-293
35. Piotto M, Saudek V, Sklenar V 1992 Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions. J Biomol NMR 2:661-665
36. Havel TF 1991 An evaluation of computational strategies for use in determination of protein structure from distance geometry constraints obtained by nuclear magnetic resonance. Prog Biophys Mol Biol 56:43-78
37. Lindahl E, Hess B, Van der Spoel D 2001 GROMACS 3.0: A package for molecular simulation and trajectory analysis. J Mol Mod 7:306-317
38. Cas family member HEF1 downstream of the G protein-coupled calcitonin receptor. Calcitonin induces the association of HEF1, paxillin, and focal adhesion kinase. J Biol Chem 274:25093-250938